Symptoma

Lymphocyte-Rich Classical Hodgkin Lymphoma

Lymphocyte-Rich Classic Hodgkin Lymphoma

Presentation of patients with LRCHL is similar to patients with NLPHL B symptoms in 10% of patents with LRCHL Less frequent compared with other types of CHL Stage I or II disease in 70% of patients Peripheral lymph node involvement is typical Especially [basicmedicalkey.com]

A 57-year-old male patient presented with neck masses. Neck computed tomography showed enlargement of multiple lymph nodes in right Level II and III. [ijpmonline.org]

B-cell follicles and reactive germinal centers are present in most cases; the Reed-Sternberg cells in such cases are located mainly at the periphery of the B-cell follicles. [clinicaladvisor.com]

LRCHL may hypothetically be an early presentation of cHL in which tumour cells have lost the B-cell phenotype but coexpress CD30 and the B-cell transcription program (Younes et al., 2014). [atlasgeneticsoncology.org]

[…] a low grade of malignancy; it represents the neoplastic proliferation of well-differentiated B lymphocytes and may present with either focal lymph node enlargement or generalized lymphadenopathy and splenomegaly. [medical-dictionary.thefreedictionary.com]

  • Aspiration

    […] present around nodules; usually infrequent Diffuse variant Uncommon compared with nodular variant Diffuse replacement of lymph node architecture Cytologic composition is similar to that seen in nodules of nodular variant Cytologic Features Fine needle aspiration [basicmedicalkey.com]

    Lymph node biopsy or tissue biopsy: excision biopsy preferred over fine needle aspiration biopsy, Full blood count, Blood film, Erythrocyte sedimentation rate, Bone marrow biopsy (aspiration and trephine). See also Lymphoma (classification). [rcpa.edu.au]

    Single cells were mobilized, aspirated, and transferred into PCR tubes containing 20 μl of Expand high-fidelity PCR buffer (Roche, Mannheim, Germany) with a hydraulic micromanipulator as described previously (26). Cells were stored at 20 C. [cancerres.aacrjournals.org]

  • Suggestibility

    […] effective immunologic strategy for the treatment of HL. [1] However, the observation of a higher number of PD-1 ( ) lymphocytes in lymphocyte-rich cHL (LRCHL) and nodular lymphocyte predominant HL (NLPHL), which have better prognosis than other types, [2] suggests [ijpmonline.org]

    Their presence also resembles the findings in classical Hodgkin's lymphoma, suggesting that mononuclear Hodgkin's cells and multinucleated Reed–Sternberg cells in lymphocyte-rich classical Hodgkin's lymphoma derive from germinal-center B-cells that silence [nature.com]

    There is a threefold increased risk of development of Hodgkin's disease in first-degree relatives, suggesting an unknown genetic mechanism. [medical-dictionary.thefreedictionary.com]

    Atlas of Genetics and Cytogenetics in Oncology and Haematology indexed on : Mon Mar 25 16:48:17 CET 2019 Home Genes Leukemias Solid Tumors Cancer-Prone Deep Insight Case Reports Journals Portal Teaching For comments and suggestions or contributions, please [atlasgeneticsoncology.org]

    This picture may suggest a lymphocyte depletion. Extremely numerous CD30 positive RSH cell may suggest a lymphocyte depletion. [eurocytology.eu]

  • Neck Mass

    A 57-year-old male patient presented with neck masses. Neck computed tomography showed enlargement of multiple lymph nodes in right Level II and III. [ijpmonline.org]

  • Meningism

    Complications as a result of the malignancy: Neurological symptoms such as headaches, changes in vision, or numbness of face Meningitis Anemia Intestinal blockage Kidney disease Bone marrow involvement (in very rare cases) Complications due to treatment [dovemed.com]

  • Dizziness

    […] symptoms such as headaches, changes in vision, or numbness of face Meningitis Anemia Intestinal blockage Kidney disease Bone marrow involvement (in very rare cases) Complications due to treatment of the cancer: An allergic reaction to therapy Fatigue, dizziness [dovemed.com]

Chapters discuss current treatment options—including combination chemotherapy, radiation therapy, novel treatment techniques, and hematopoietic stem cell transplantation—and offer guidelines for treatment selection. [books.google.com]

[…] may be used for diagnostic as well as for treatment purposes. [dovemed.com]

Radiotherapy, using a covering mantle to protect other organs, is the treatment of choice for early stages of the disease; combination chemotherapy is the treatment for advanced disease. [medical-dictionary.thefreedictionary.com]

With modern risk-adjusted treatment, survival and relapse free survival are slightly better than the other subtypes of CHL. [seer.cancer.gov]

However, he underwent autologous stem-cell transplantation after high-dose chemotherapy owing to a relapse 10 months after primary treatment. [ncbi.nlm.nih.gov]

[…] than other types of classical Hodgkin lymphoma (95% complete remission rate, 17% relapse rate) Similar prognosis as NLPHL but relapses less frequently ( Blood 2000;96:1889 ) Microscopic (histologic) description Two growth patterns: nodular (common) and [pathologyoutlines.com]

Abstract Lymphocyte-rich classical Hodgkin lymphoma (LRCHL) is a rare subtype of Hodgkin lymphoma with a favorable prognosis, and an aggressive clinical course of LRCHL is uncommon. [jstage.jst.go.jp]

Prognosis Most LRCHLs have a better prognosis than do other cHLs. See the pertinent sections within the CARDS describing the general features of NLPHL and cHL (Küppers, 2011; Carbone and Gloghini, 2016; Gloghini and Carbone, 2016). [atlasgeneticsoncology.org]

If the cancer is diagnosed in its early stages, the prognosis is reported to be excellent. [dovemed.com]

[…] symptoms uncommon Peripheral lymph nodes •Survival curves of patients with lymphocyte-rich CHL similar to patients with other types of CHL Early relapses followed by plateau (implying cure) Unlike NLPHL patients who have late relapses without plateau Prognosis [quizlet.com]

More than 100 recognized authorities from all parts of the world provide comprehensive, current information on every aspect of Hodgkin lymphoma, including etiology, epidemiology, biology, pathology, evaluation, staging, treatment, and follow-up. [books.google.com]

Definitions LRCHL is type of classic Hodgkin lymphoma (CHL) in which small reactive lymphocytes associated with Hodgkin and Reed-Sternberg (HRS) cells predominate Neutrophils and eosinophils are rare or absent in background 2 variants: Nodular and diffuse ETIOLOGY [basicmedicalkey.com]

Despite recent advances and although there is good evidence that most if not all Hodgkin lymphomas are B-cell in origin, the etiology and pathogenesis of Hodgkin lymphoma remains largely unknown. [med-ed.virginia.edu]

Etiology of Hodgkin’s Disease Causes of Hodgkin’s disease To date, the etiology of Hodgkin’s disease is not fully understood. [lecturio.com]

(Etiology) The exact cause of Lymphocyte-Rich Classical Hodgkin Lymphoma is not known. [dovemed.com]

More than 100 recognized authorities from all parts of the world provide comprehensive, current information on every aspect of Hodgkin lymphoma, including etiology, epidemiology, biology, pathology, evaluation, staging, treatment, and follow-up. [books.google.com]

[…] absence of neutrophils and eosinophils (WHO 2008) Terminology 30% of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) cases diagnosed in the past were found to be LRCHL Also known as follicular Hodgkin lymphoma ( Am J Clin Pathol 2002;117:29 ) Epidemiology [pathologyoutlines.com]

Fatigue Fever (for no known reason) Pain in the chest, abdomen, or bone s (for no known reason) Skin rash or itchy skin Weight loss (for no known reason) Diagnostic Exams Erythrocyte sedimentation rate Immunophenotyping Progression and Transformation None Epidemiology [seer.cancer.gov]

[…] malignant transformation of B cells HRS cells regulate host response Through expression &/or secretion of chemokines and surface ligands Interplay of HRS cells and reactive cells determines tumor growth and local and systemic symptoms CLINICAL ISSUES Epidemiology [basicmedicalkey.com]

Comparing adult and pediatric Hodgkin lymphoma in the Surveillance, Epidemiology and End Results Program, 1988–2005: an analysis of 21 734 cases. Leuk Lymphoma. 2010;51:2198–207. [link.springer.com]

Thus, no indication was found that the tumor cells of the three types of lymphomas show a disease-specific gene expression pattern, which would have supported a distinct pathogenesis and pathophysiology of the tumor cells. [journals.plos.org]

The exact cause of Lymphocyte-Rich Classical Hodgkin Lymphoma is unknown, and hence, no guidelines exist for the prevention of this type of cancer. [dovemed.com]

Patient care: major problems presented by the patient with non-Hodgkin's lymphoma include the management of side effects associated with treatment and the prevention of infection. small lymphocytic lymphoma a diffuse form of non-Hodgkin's lymphoma with [medical-dictionary.thefreedictionary.com]