We propose that cross-presentation has evolved to sustain the presentation of stable viral proteins when their neosynthesis has ceased in infected donor cells. [ncbi.nlm.nih.gov]

Role of Lymphocytic Choriomeningitis Virus (LCMV) in Understanding Viral Immunology: Past, Present and Future. Viruses 2012, 4, 2650-2669. Show more citation formats [Return to top] [doi.org]

• Fever

  Arenaviruses such as Lassa fever virus (LASV) and lymphocytic choriomeningitis virus (LCMV) are benign in their natural reservoir hosts, and can occasionally cause severe viral hemorrhagic fever (VHF) in non-human primates and in human beings. [ncbi.nlm.nih.gov]

  […] cho·rio·men·in·gi·tis | \ -ˌkȯr-ē-ō-ˌme-nən-ˈjī-təs \ Definition of lymphocytic cho rio men in gi tis : an acute disease that is caused by an arenavirus (species Lymphocytic choriomeningitis virus of the genus Arenavirus ), that is characterized by fever [merriam-webster.com]

• Malaise

  We present a 38-year old man suffering from a biphasic illness with fever and malaise, who developed a mild aseptic meningitis during the second phase. Lymphocytic choriomeningitis virus was found to be the causative agent. [ncbi.nlm.nih.gov]

  […] the Arenaviridae family Risk Factors Immunocompromised state Pregnancy Clinical Presentation Symptoms develop 5-10 days after exposure Presents as an acute influenza -like illness – fever of 101-104° F with chills and muscle rigidity Other symptoms – malaise [arupconsult.com]

  Other symptoms may include malaise, retro-orbital headache, photophobia, weakness, anorexia, nausea, and light-headedness. Some patients may experience sore throat. [loinc.org]

  This initial phase, which may last as long as a week, typically begins with any or all of the following symptoms: fever, malaise, lack of appetite, muscle aches, headache, nausea, and vomiting. [cdc.gov]

• Weakness

  Immunocompromised state Pregnancy Clinical Presentation Symptoms develop 5-10 days after exposure Presents as an acute influenza -like illness – fever of 101-104° F with chills and muscle rigidity Other symptoms – malaise, retro-orbital headache, photophobia, weakness [arupconsult.com]

  Other symptoms may include malaise, retro-orbital headache, photophobia, weakness, anorexia, nausea, and light-headedness. Some patients may experience sore throat. [loinc.org]

  In rare instances, infection results in myelitis (inflammation of the spinal cord) and presents with symptoms such as muscle weakness, paralysis, or changes in body sensation. [cdc.gov]

• Chills

  […] transplant transmission Organism RNA virus in the Arenaviridae family Risk Factors Immunocompromised state Pregnancy Clinical Presentation Symptoms develop 5-10 days after exposure Presents as an acute influenza -like illness – fever of 101-104° F with chills [arupconsult.com]

  Most patients develop fevers of 101-104 degrees F with chills and muscle rigidity. Other symptoms may include malaise, retro-orbital headache, photophobia, weakness, anorexia, nausea, and light-headedness. Some patients may experience sore throat. [loinc.org]

  Some people have a flu-like illness, with fever, chills, a general feeling of illness (malaise), weakness, muscle aches (especially in the lower back), and pain behind the eyes. [merckmanuals.com]

• Veterinarian

  I’m sitting in my usual study spot, at my favorite cafe, composing my final post for Merck Manuals Vet Student Stories as a student veterinarian. I’m in shock that these... More Featured [merckvetmanual.com]

  Persons who no longer wish to keep their pet rodent should consult a veterinarian. [cdc.gov]

  Do not kiss pet rodents or hold them close to your face.Rodent owners who no longer wish to keep their pet should consult a veterinarian. Pets should not be released into the wild for humane, legal, and ecological reasons. [en.wikipedia.org]

• Cough

  In addition to getting a flu shot, it's important to take everyday preventative actions to stop the spread of germs, including: • washing your hands often • covering mouth and nose with a tissue when sneezing or coughing • avoiding touching your eyes, [health.pa.gov]

  Other symptoms appearing less frequently include sore throat, cough, joint pain, chest pain, testicular pain, and parotid (salivary gland) pain. Following a few days of recovery, a second phase of illness may occur. [cdc.gov]

  There is often stiffness and myalgia (muscle aches), headache, light-headedness, loss of appetite, sore throat and cough. In severe cases an aseptic meningitis may develop. [web.archive.org]

• Nausea

  […] rio·men·in·gi·tis | \ -ˌkȯr-ē-ō-ˌme-nən-ˈjī-təs \ Definition of lymphocytic cho rio men in gi tis : an acute disease that is caused by an arenavirus (species Lymphocytic choriomeningitis virus of the genus Arenavirus ), that is characterized by fever, nausea [merriam-webster.com]

  Fever, headache, nausea, vomiting, and occasional photophobia are prominent symptoms. As in our patient, significant CSF pleocytocytosis may occur, which is unusual in other viral infections. [doi.org]

  Pregnancy Clinical Presentation Symptoms develop 5-10 days after exposure Presents as an acute influenza -like illness – fever of 101-104° F with chills and muscle rigidity Other symptoms – malaise, retro-orbital headache, photophobia, weakness, anorexia, nausea [arupconsult.com]

• Vomiting

  ·tis | \ -ˌkȯr-ē-ō-ˌme-nən-ˈjī-təs \ Definition of lymphocytic cho rio men in gi tis : an acute disease that is caused by an arenavirus (species Lymphocytic choriomeningitis virus of the genus Arenavirus ), that is characterized by fever, nausea and vomiting [merriam-webster.com]

  Fever, headache, nausea, vomiting, and occasional photophobia are prominent symptoms. As in our patient, significant CSF pleocytocytosis may occur, which is unusual in other viral infections. [doi.org]

  This initial phase, which may last as long as a week, typically begins with any or all of the following symptoms: fever, malaise, lack of appetite, muscle aches, headache, nausea, and vomiting. [cdc.gov]

• Abdominal Pain

  The transplant recipients had abdominal pain, altered mental status, thrombocytopenia, elevated aminotransferase levels, coagulopathy, graft dysfunction, and either fever or leukocytosis within three weeks after transplantation. [ncbi.nlm.nih.gov]

• Slow Pulse

  Definition of lymphocytic cho rio men in gi tis : an acute disease that is caused by an arenavirus (species Lymphocytic choriomeningitis virus of the genus Arenavirus ), that is characterized by fever, nausea and vomiting, headache, stiff neck, and slow [merriam-webster.com]

• Arthritis

  The metacarpophalangeal joint and the proximal interphalangeal joint are the most common sites of arthritis caused by LCMV. [emedicine.medscape.com]

  It usually causes a flu-like illness or aseptic meningitis, sometimes with rash, arthritis, orchitis, parotitis, or encephalitis. Diagnosis is by viral isolation, PCR, or indirect immunofluorescence. Treatment is supportive. [msdmanuals.com]

• Myalgia

  Abstract On April 20, 2015, a female aged 15 years sought care at her pediatrician's office after 5 days of fever, myalgia, left parietal headache, and photophobia. [ncbi.nlm.nih.gov]

  Twenty-one of the infections were associated with recent febrile illness with myalgia. [academic.oup.com]

  There is often stiffness and myalgia (muscle aches), headache, light-headedness, loss of appetite, sore throat and cough. In severe cases an aseptic meningitis may develop. [web.archive.org]

  Patients with meningitis may have a stiff neck, fever, headache, myalgia, nausea and malaise. In some occasions, meningitis occurs without a prodromal syndrome. [en.wikipedia.org]

• Arthralgia

  We report a documented case of lymphocytic choriomeningitis in which a previously healthy 17-year-old girl experienced debilitating recurrent headaches and arthralgias for more than a year after discharge. [ncbi.nlm.nih.gov]

• Photophobia

  Abstract On April 20, 2015, a female aged 15 years sought care at her pediatrician's office after 5 days of fever, myalgia, left parietal headache, and photophobia. [ncbi.nlm.nih.gov]

  Factors Immunocompromised state Pregnancy Clinical Presentation Symptoms develop 5-10 days after exposure Presents as an acute influenza -like illness – fever of 101-104° F with chills and muscle rigidity Other symptoms – malaise, retro-orbital headache, photophobia [arupconsult.com]

  Other symptoms may include malaise, retro-orbital headache, photophobia, weakness, anorexia, nausea, and light-headedness. Some patients may experience sore throat. [loinc.org]

  Fever, headache, nausea, vomiting, and occasional photophobia are prominent symptoms. As in our patient, significant CSF pleocytocytosis may occur, which is unusual in other viral infections. [doi.org]

• Meningism

  meningitis Lymphocytic meningoencephalitis Applies To Lymphocytic: meningitis (serous) (benign) meningoencephalitis (serous) (benign) ICD-9-CM Volume 2 Index entries containing back-references to 049.0 : [icd9data.com]

  Lymphocytic choriomeningitis virus is a rare cause of aseptic meningitis that should be considered in the symptomatic immunocompromised patient with an appropriate exposure history. [ncbi.nlm.nih.gov]

• Headache

  Abstract On April 20, 2015, a female aged 15 years sought care at her pediatrician's office after 5 days of fever, myalgia, left parietal headache, and photophobia. [ncbi.nlm.nih.gov]

  ˌkȯr-ē-ō-ˌme-nən-ˈjī-təs \ Definition of lymphocytic cho rio men in gi tis : an acute disease that is caused by an arenavirus (species Lymphocytic choriomeningitis virus of the genus Arenavirus ), that is characterized by fever, nausea and vomiting, headache [merriam-webster.com]

• Ataxia

  Some children had isolated cerebellar hypoplasia, with jitteriness as their presenting sign and ataxia as their principal long-term neurological dysfunction. [ncbi.nlm.nih.gov]

  Clinical manifestations include an influenza-like syndrome followed by stiff neck, alterations of mentation, ataxia, and incontinence. [icd10data.com]

  Less severe cases with isolated cerebellar hypoplasia and symptoms of ataxia and jitteriness have been reported occasionally. There have also been rare cases with evidence of chorioretinitis but without neurological signs. [en.wikipedia.org]

• Irritability

  The patient's hospital course was notable for hypotension (blood pressure 81/50), irritability, and pancreatitis with a peak lipase of 8,627 U/L. [ncbi.nlm.nih.gov]

  Products include devices that emit ultrasonic sound that allegedly irritates mice and drives them away, and more swift, painless means of death such as mini electrocution or gas chambers. [en.wikipedia.org]

• Lethargy

  She was readmitted 3 weeks posttransplant with lethargy and anorexia; she developed low-grade fever and shock, followed by hepatic insufficiency and multisystem organ failure. She died 4 weeks posttransplant. [cdc.gov]

  The onset of the infection is nonspecific and may include fever, anorexia, dyspnea, weakness and lethargy. Jaundice is characteristic and petechial hemorrhages may develop. [en.wikipedia.org]

Since congenital LCMV infection may mimic Aicardi syndrome, serologic testing should be considered in the workup of patients with Aicardi syndrome to rule out LCMV infection. [ncbi.nlm.nih.gov]

• Complement Fixing Antibody

  Virus was isolated from their patient's blood and urine, and complement fixing antibodies were demonstrated in the patient's serum during convalescence. [jamanetwork.com]

Education and awareness of the medical community as well as the general public will be critical in prevention as well as advancing future treatment modalities of lymphocytic choriomeningitis virus. [ncbi.nlm.nih.gov]

Please consult your own licensed physician regarding diagnosis and treatment of any medical condition! Please see also our disclaimer. This site complies with the HONcode standard for health information: verify here. Database updated 2019-02-19. [diseasesdatabase.com]

Abstract Vesicular stomatitis virus (VSV)-based oncolytic virotherapy has the potential to significantly improve the prognosis of aggressive malignancies such as brain cancer. [ncbi.nlm.nih.gov]

The prognosis for severely affected infants appears to be poor. [en.wikipedia.org]

The epidemiological association between LCMV and other zoonoses which can be expected in this community as well as the etiology of summer influenza-like illness along the coastal area of Croatia has to be explored further. [ncbi.nlm.nih.gov]

The epidemiological association between LCMV and other zoonoses which can be expected in this community as well as the etiology of summer influenza‐like illness along the coastal area of Croatia has to be explored further. J. Med. [doi.org]

[…] of diseases in human communities. 2. the field of medicine concerned with the determination of the specific causes of localized outbreaks of infection, such as hepatitis, of toxic disorders, such as lead poisoning, or any other disease of recognized etiology [vdh.virginia.gov]

Bulletin Archive Contact Us Laurie Forlano, DO, MPH, State Epidemiologist Director, Office of Epidemiology 109 Governor Street, 6th Floor East Richmond, VA 23219 Phone: (804) 864-8141 Fax: (804) 864-8139 Contact Us by Email [vdh.virginia.gov]

In contrast to current candidates such as Epstein-Barr virus, the distribution of LCMV is consistent with epidemiological features of MS, including concentration in the temperate zone, higher prevalence farther from the equator, and increased prevalence [ncbi.nlm.nih.gov]

Therefore, evidence for transmission from donor to recipient was mainly based on epidemiologic data and on the genetic identity of the virus detected in transplanted organs. [doi.org]

The breeding colonies were depopulated to prevent further human infections. Future outbreaks can be prevented with monitoring and management, and employees should be made aware of LCMV risks and prevention. [ncbi.nlm.nih.gov]

A sensitive, enzyme-linked immunosorbent assay, which measures LCMV IgM and IgG is also available and performed at the Centers for Disease Control and Prevention. 2 LCMV infections may be prevented by public education of the need to avoid contact with [doi.org]