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Lymphocytic Choriomeningitis


Presentation

  • We propose that cross-presentation has evolved to sustain the presentation of stable viral proteins when their neosynthesis has ceased in infected donor cells.[ncbi.nlm.nih.gov]
  • INTERPRETATION: Congenital LCMV infection can have diverse presenting signs, neuroimaging abnormalities, and clinical outcomes.[ncbi.nlm.nih.gov]
  • The present study reported the case of a 4‑year‑old male who presented with a high fever, hypogammaglobulinemia, diffuse lung disease and encephalitis.[ncbi.nlm.nih.gov]
  • Thus the ER is a cellular compartment that can provide antigen for cross-presentation, and modifications affecting stability and subcellular localization of the antigen significantly increase its availability for MHC class I cross-presentation.[ncbi.nlm.nih.gov]
  • We present a 38-year old man suffering from a biphasic illness with fever and malaise, who developed a mild aseptic meningitis during the second phase. Lymphocytic choriomeningitis virus was found to be the causative agent.[ncbi.nlm.nih.gov]
Fever
  • Arenaviruses such as Lassa fever virus (LASV) and lymphocytic choriomeningitis virus (LCMV) are benign in their natural reservoir hosts, and can occasionally cause severe viral hemorrhagic fever (VHF) in non-human primates and in human beings.[ncbi.nlm.nih.gov]
  • We present a 38-year old man suffering from a biphasic illness with fever and malaise, who developed a mild aseptic meningitis during the second phase. Lymphocytic choriomeningitis virus was found to be the causative agent.[ncbi.nlm.nih.gov]
  • LCMV infection in humans can be asymptomatic or cause a spectrum of illness ranging from isolated fever to meningitis and encephalitis. Overall case fatality is 1%. Fetal infections can result in congenital abnormalities or death.[ncbi.nlm.nih.gov]
  • We report a case of 15-year-old girl with T-cell acute lymphoblastic leukemia who had fever, neutropenia, and severe headache while receiving maintenance chemotherapy.[ncbi.nlm.nih.gov]
  • The present study reported the case of a 4‑year‑old male who presented with a high fever, hypogammaglobulinemia, diffuse lung disease and encephalitis.[ncbi.nlm.nih.gov]
Malaise
  • We present a 38-year old man suffering from a biphasic illness with fever and malaise, who developed a mild aseptic meningitis during the second phase. Lymphocytic choriomeningitis virus was found to be the causative agent.[ncbi.nlm.nih.gov]
  • […] the Arenaviridae family Risk Factors Immunocompromised state Pregnancy Clinical Presentation Symptoms develop 5-10 days after exposure Presents as an acute influenza -like illness – fever of 101-104 F with chills and muscle rigidity Other symptoms – malaise[arupconsult.com]
  • This initial phase, which may last as long as a week, typically begins with any or all of the following symptoms: fever, malaise, lack of appetite, muscle aches, headache, nausea, and vomiting.[cdc.gov]
Veterinarian
  • I’m sitting in my usual study spot, at my favorite cafe, composing my final post for Merck Manuals Vet Student Stories as a student veterinarian. I’m in shock that these... More Featured[merckvetmanual.com]
  • Persons who no longer wish to keep their pet rodent should consult a veterinarian.[cdc.gov]
  • Do not kiss pet rodents or hold them close to your face.Rodent owners who no longer wish to keep their pet should consult a veterinarian. Pets should not be released into the wild for humane, legal, and ecological reasons.[en.wikipedia.org]
Chills
  • […] transplant transmission Organism RNA virus in the Arenaviridae family Risk Factors Immunocompromised state Pregnancy Clinical Presentation Symptoms develop 5-10 days after exposure Presents as an acute influenza -like illness – fever of 101-104 F with chills[arupconsult.com]
Rigor
  • A high fever (101-104 F, 38.5-40 C) and rigor are the commonest symptoms. Physical findings are few, often influenza-like, and not strong enough for diagnosis. Virus isolation from cerebrospinal fluid.[web.archive.org]
Cough
  • There is often stiffness and myalgia (muscle aches), headache, light-headedness, loss of appetite, sore throat and cough. In severe cases an aseptic meningitis may develop.[web.archive.org]
  • Other symptoms appearing less frequently include sore throat, cough, joint pain, chest pain, testicular pain, and parotid (salivary gland) pain. Following a few days of recovery, a second phase of illness may occur.[cdc.gov]
  • Other symptoms that appear less frequently include sore throat, cough, joint pain, chest pain, testicular pain, and parotid (salivary gland) pain.[web.archive.org]
  • Less frequent symptoms include a sore throat and cough, as well as joint, chest, and parotid pain. The onset of the second phase occurs several days after recovery, and consists of symptoms of meningitis or encephalitis.[en.wikipedia.org]
Nausea
  • […] rio·men·in·gi·tis \ -ˌkȯr-ē-ō-ˌme-nən-ˈjī-təs \ Definition of lymphocytic cho rio men in gi tis : an acute disease that is caused by an arenavirus (species Lymphocytic choriomeningitis virus of the genus Arenavirus ), that is characterized by fever, nausea[merriam-webster.com]
  • Fever, headache, nausea, vomiting, and occasional photophobia are prominent symptoms. As in our patient, significant CSF pleocytocytosis may occur, which is unusual in other viral infections.[doi.org]
  • Pregnancy Clinical Presentation Symptoms develop 5-10 days after exposure Presents as an acute influenza -like illness – fever of 101-104 F with chills and muscle rigidity Other symptoms – malaise, retro-orbital headache, photophobia, weakness, anorexia, nausea[arupconsult.com]
Vomiting
  • […] gi·tis \ -ˌkȯr-ē-ō-ˌme-nən-ˈjī-təs \ Definition of lymphocytic cho rio men in gi tis : an acute disease that is caused by an arenavirus (species Lymphocytic choriomeningitis virus of the genus Arenavirus ), that is characterized by fever, nausea and vomiting[merriam-webster.com]
  • Fever, headache, nausea, vomiting, and occasional photophobia are prominent symptoms. As in our patient, significant CSF pleocytocytosis may occur, which is unusual in other viral infections.[doi.org]
  • This initial phase, which may last as long as a week, typically begins with any or all of the following symptoms: fever, malaise, lack of appetite, muscle aches, headache, nausea, and vomiting.[cdc.gov]
Abdominal Pain
  • The transplant recipients had abdominal pain, altered mental status, thrombocytopenia, elevated aminotransferase levels, coagulopathy, graft dysfunction, and either fever or leukocytosis within three weeks after transplantation.[ncbi.nlm.nih.gov]
Slow Pulse
  • Definition of lymphocytic cho rio men in gi tis : an acute disease that is caused by an arenavirus (species Lymphocytic choriomeningitis virus of the genus Arenavirus ), that is characterized by fever, nausea and vomiting, headache, stiff neck, and slow[merriam-webster.com]
Photophobia
  • Abstract On April 20, 2015, a female aged 15 years sought care at her pediatrician's office after 5 days of fever, myalgia, left parietal headache, and photophobia.[ncbi.nlm.nih.gov]
  • Factors Immunocompromised state Pregnancy Clinical Presentation Symptoms develop 5-10 days after exposure Presents as an acute influenza -like illness – fever of 101-104 F with chills and muscle rigidity Other symptoms – malaise, retro-orbital headache, photophobia[arupconsult.com]
  • Fever, headache, nausea, vomiting, and occasional photophobia are prominent symptoms. As in our patient, significant CSF pleocytocytosis may occur, which is unusual in other viral infections.[doi.org]
Arthritis
  • The metacarpophalangeal joint and the proximal interphalangeal joint are the most common sites of arthritis caused by LCMV.[emedicine.medscape.com]
  • Nerve deafness and arthritis have been reported. Women who become infected with LCMV during pregnancy may pass the infection on to the fetus.[cdc.gov]
Myalgia
  • Abstract On April 20, 2015, a female aged 15 years sought care at her pediatrician's office after 5 days of fever, myalgia, left parietal headache, and photophobia.[ncbi.nlm.nih.gov]
  • There is often stiffness and myalgia (muscle aches), headache, light-headedness, loss of appetite, sore throat and cough. In severe cases an aseptic meningitis may develop.[web.archive.org]
  • Twenty-one of the infections were associated with recent febrile illness with myalgia.[academic.oup.com]
  • Patients with meningitis may have a stiff neck, fever, headache, myalgia, nausea and malaise. In some occasions, meningitis occurs without a prodromal syndrome.[en.wikipedia.org]
Arthralgia
  • We report a documented case of lymphocytic choriomeningitis in which a previously healthy 17-year-old girl experienced debilitating recurrent headaches and arthralgias for more than a year after discharge.[ncbi.nlm.nih.gov]
Severe Mental Retardation
  • We performed complete ophthalmologic surveys of all residents at Misericordia, a home for the severely mentally retarded in Chicago, and prospectively evaluated all patients with chorioretinitis or chorioretinal scars during a 36-month period at Children's[ncbi.nlm.nih.gov]
Meningism
  • We describe a case of lymphocytic choriomeningitis virus (LCMV) meningitis in a New York, NY, resident who had no apparent risk factors.[ncbi.nlm.nih.gov]
  • If meningitis is a common symptom, adopt level 3 practices. Rodent control should be practiced.[web.archive.org]
  • Lymphocytic choriomeningitis virus is a rare cause of aseptic meningitis that should be considered in the symptomatic immunocompromised patient with an appropriate exposure history.[ncbi.nlm.nih.gov]
  • meningitis Lymphocytic meningoencephalitis Applies To Lymphocytic: meningitis (serous) (benign) meningoencephalitis (serous) (benign) ICD-9-CM Volume 2 Index entries containing back-references to 049.0 :[icd9data.com]
  • In immunocompetent adults, symptoms can range from mild febrile illness to meningeal symptoms (e.g., headache, stiff neck, or sensitivity to light).[ncbi.nlm.nih.gov]
Headache
  • Abstract On April 20, 2015, a female aged 15 years sought care at her pediatrician's office after 5 days of fever, myalgia, left parietal headache, and photophobia.[ncbi.nlm.nih.gov]
  • We report a case of 15-year-old girl with T-cell acute lymphoblastic leukemia who had fever, neutropenia, and severe headache while receiving maintenance chemotherapy.[ncbi.nlm.nih.gov]
  • We report a documented case of lymphocytic choriomeningitis in which a previously healthy 17-year-old girl experienced debilitating recurrent headaches and arthralgias for more than a year after discharge.[ncbi.nlm.nih.gov]
  • ., headache, stiff neck, or sensitivity to light). Congenitally infected infants can have a range of severe birth defects including hydrocephalus, chorioretinitis, blindness, and mental retardation (1).[ncbi.nlm.nih.gov]
  • ˌkȯr-ē-ō-ˌme-nən-ˈjī-təs \ Definition of lymphocytic cho rio men in gi tis : an acute disease that is caused by an arenavirus (species Lymphocytic choriomeningitis virus of the genus Arenavirus ), that is characterized by fever, nausea and vomiting, headache[merriam-webster.com]
Lethargy
  • She was readmitted 3 weeks posttransplant with lethargy and anorexia; she developed low-grade fever and shock, followed by hepatic insufficiency and multisystem organ failure. She died 4 weeks posttransplant.[cdc.gov]
  • The onset of the infection is nonspecific and may include fever, anorexia, dyspnea, weakness and lethargy. Jaundice is characteristic and petechial hemorrhages may develop.[en.wikipedia.org]
Irritability
  • The patient's hospital course was notable for hypotension (blood pressure 81/50), irritability, and pancreatitis with a peak lipase of 8,627 U/L.[ncbi.nlm.nih.gov]
  • Products include devices that emit ultrasonic sound that allegedly irritates mice and drives them away, and more swift, painless means of death such as mini electrocution or gas chambers.[en.wikipedia.org]
Hyperreflexia
  • Physical examination was remarkable only for persistent hyperreflexia and moderate nystagmus on lateral gaze.[doi.org]

Workup

  • Since congenital LCMV infection may mimic Aicardi syndrome, serologic testing should be considered in the workup of patients with Aicardi syndrome to rule out LCMV infection.[ncbi.nlm.nih.gov]
  • Because its consequences for visual and psychomotor development are devastating, we conclude that the workup for congenital chorioretinitis should include lymphocytic choriomeningitis virus serology, especially if T. gondii, rubella virus, cytomegalovirus[ncbi.nlm.nih.gov]
Complement Fixing Antibody
  • Virus was isolated from their patient's blood and urine, and complement fixing antibodies were demonstrated in the patient's serum during convalescence.[jamanetwork.com]
Brain Edema
  • Diabetic ketoacidosis developed in the organ donor in December 2010; she died with generalized brain edema after a short hospitalization.[ncbi.nlm.nih.gov]

Treatment

  • Education and awareness of the medical community as well as the general public will be critical in prevention as well as advancing future treatment modalities of lymphocytic choriomeningitis virus.[ncbi.nlm.nih.gov]
  • By monitoring system-wide changes in physiology and gene expression in a controlled experimental setting, it is possible to identify events that are pathognomonic for developing VHF and potential treatment targets. Copyright 2011 Elsevier B.V.[ncbi.nlm.nih.gov]
  • Please consult your own licensed physician regarding diagnosis and treatment of any medical condition! Please see also our disclaimer . This site complies with the HONcode standard for health information: verify here . Database updated 2019-02-19.[diseasesdatabase.com]
  • Moreover, a treatment of MaTu-MX-infected HeLa cells with ribavirin eliminated the virus, but did not reduce the MN/CA IX expression.[ncbi.nlm.nih.gov]
  • In the chronic LCMV model, cytokine treatment was started during the early replication phase (i.e., on day 7 post-infection [pi]).[ncbi.nlm.nih.gov]

Prognosis

  • Abstract Vesicular stomatitis virus (VSV)-based oncolytic virotherapy has the potential to significantly improve the prognosis of aggressive malignancies such as brain cancer.[ncbi.nlm.nih.gov]
  • MN protein was later identified as the carbonic anhydrase isoform IX (CA IX), whose expression has been predominantly associated with hypoxic tumors of poor prognosis.[ncbi.nlm.nih.gov]
  • The prognosis for severely affected infants appears to be poor.[en.wikipedia.org]

Etiology

  • The epidemiological association between LCMV and other zoonoses which can be expected in this community as well as the etiology of summer influenza-like illness along the coastal area of Croatia has to be explored further.[ncbi.nlm.nih.gov]
  • The etiology of multiple sclerosis (MS) involves both genetic and environmental factors. Genetically, the strongest link is with HLA DRB1*1501, but the environmental trigger, probably a virus, remains uncertain.[ncbi.nlm.nih.gov]
  • Screening by real-time RT-PCR assay is of interest in the case of aseptic meningitis of unknown etiology.[ncbi.nlm.nih.gov]
  • The epidemiological association between LCMV and other zoonoses which can be expected in this community as well as the etiology of summer influenza‐like illness along the coastal area of Croatia has to be explored further. J. Med.[doi.org]
  • […] all prenatal brain infections In addition, because LCMV induces delayed-onset neuronal loss after the virus has been cleared, the neonatal rat infected with LCMV may be an excellent model system to study neurodegenerative or psychiatric diseases whose etiologies[ncbi.nlm.nih.gov]

Epidemiology

  • In contrast to current candidates such as Epstein-Barr virus, the distribution of LCMV is consistent with epidemiological features of MS, including concentration in the temperate zone, higher prevalence farther from the equator, and increased prevalence[ncbi.nlm.nih.gov]
  • Bulletin Archive Contact Us Laurie Forlano, DO, MPH, State Epidemiologist Director, Office of Epidemiology 109 Governor Street, 6th Floor East Richmond, VA 23219 Phone: (804) 864-8141 Fax: (804) 864-8139 Contact Us by Email[vdh.virginia.gov]
  • The epidemiological association between LCMV and other zoonoses which can be expected in this community as well as the etiology of summer influenza-like illness along the coastal area of Croatia has to be explored further.[ncbi.nlm.nih.gov]
  • Epidemiologic investigations, including interviews, environmental assessments, and medical-record reviews, were performed to characterize clinical courses and to determine the cause of the illnesses.[ncbi.nlm.nih.gov]
  • Epidemiologic investigation traced the source of the virus to a pet hamster purchased by the donor from a local pet store.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Prevention

  • However, the depletion of these cells in LCMV-infected STAT1 KO mice was delayed, but did not prevent, lethality.[ncbi.nlm.nih.gov]
  • The breeding colonies were depopulated to prevent further human infections. Future outbreaks can be prevented with monitoring and management, and employees should be made aware of LCMV risks and prevention.[ncbi.nlm.nih.gov]
  • This report summarizes the ongoing investigation and provides information on exposure risks and possible prevention measures.[ncbi.nlm.nih.gov]
  • A report in May 2005 from the Centers for Disease Control and Prevention describing a cluster of lymphocytic choriomeningitis virus (LCMV) infections among 4 solid organ recipients has increased awareness of and clinical interest in this pathogen.[ncbi.nlm.nih.gov]
  • Deep understanding of these strategies is inevitable for the development of approaches towards restricting the virus spread and/or preventing its harmful reactivation.[ncbi.nlm.nih.gov]

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