We propose that cross-presentation has evolved to sustain the presentation of stable viral proteins when their neosynthesis has ceased in infected donor cells. [ncbi.nlm.nih.gov]

Role of Lymphocytic Choriomeningitis Virus (LCMV) in Understanding Viral Immunology: Past, Present and Future. Viruses 2012, 4, 2650-2669. Show more citation formats [Return to top] [doi.org]

• Fever

  Arenaviruses such as Lassa fever virus (LASV) and lymphocytic choriomeningitis virus (LCMV) are benign in their natural reservoir hosts, and can occasionally cause severe viral hemorrhagic fever (VHF) in non-human primates and in human beings. [ncbi.nlm.nih.gov]

  […] cho·rio·men·in·gi·tis | \ -ˌkȯr-ē-ō-ˌme-nən-ˈjī-təs \ Definition of lymphocytic cho rio men in gi tis : an acute disease that is caused by an arenavirus (species Lymphocytic choriomeningitis virus of the genus Arenavirus ), that is characterized by fever [merriam-webster.com]

• Malaise

  We present a 38-year old man suffering from a biphasic illness with fever and malaise, who developed a mild aseptic meningitis during the second phase. Lymphocytic choriomeningitis virus was found to be the causative agent. [ncbi.nlm.nih.gov]

  Other symptoms may include malaise, retro-orbital headache, photophobia, weakness, anorexia, nausea, and light-headedness. Some patients may experience sore throat. [loinc.org]

  […] the Arenaviridae family Risk Factors Immunocompromised state Pregnancy Clinical Presentation Symptoms develop 5-10 days after exposure Presents as an acute influenza -like illness – fever of 101-104° F with chills and muscle rigidity Other symptoms – malaise [arupconsult.com]

  This initial phase, which may last as long as a week, typically begins with any or all of the following symptoms: fever, malaise, lack of appetite, muscle aches, headache, nausea, and vomiting. [cdc.gov]

• Chills

  Most patients develop fevers of 101-104 degrees F with chills and muscle rigidity. Other symptoms may include malaise, retro-orbital headache, photophobia, weakness, anorexia, nausea, and light-headedness. Some patients may experience sore throat. [loinc.org]

  […] transplant transmission Organism RNA virus in the Arenaviridae family Risk Factors Immunocompromised state Pregnancy Clinical Presentation Symptoms develop 5-10 days after exposure Presents as an acute influenza -like illness – fever of 101-104° F with chills [arupconsult.com]

  Some people have a flu-like illness, with fever, chills, a general feeling of illness (malaise), weakness, muscle aches (especially in the lower back), and pain behind the eyes. [merckmanuals.com]

• Rigor

  A high fever (101-104°F, 38.5-40°C) and rigor are the commonest symptoms. Physical findings are few, often influenza-like, and not strong enough for diagnosis. Virus isolation from cerebrospinal fluid. [web.archive.org]

• Cough

  There is often stiffness and myalgia (muscle aches), headache, light-headedness, loss of appetite, sore throat and cough. In severe cases an aseptic meningitis may develop. [web.archive.org]

  Other symptoms appearing less frequently include sore throat, cough, joint pain, chest pain, testicular pain, and parotid (salivary gland) pain. Following a few days of recovery, a second phase of illness may occur. [cdc.gov]

  In addition to getting a flu shot, it's important to take everyday preventative actions to stop the spread of germs, including: • washing your hands often • covering mouth and nose with a tissue when sneezing or coughing • avoiding touching your eyes, [health.pa.gov]

• Nausea

  […] rio·men·in·gi·tis | \ -ˌkȯr-ē-ō-ˌme-nən-ˈjī-təs \ Definition of lymphocytic cho rio men in gi tis : an acute disease that is caused by an arenavirus (species Lymphocytic choriomeningitis virus of the genus Arenavirus ), that is characterized by fever, nausea [merriam-webster.com]

  Other symptoms may include malaise, retro-orbital headache, photophobia, weakness, anorexia, nausea, and light-headedness. Some patients may experience sore throat. [loinc.org]

  Pregnancy Clinical Presentation Symptoms develop 5-10 days after exposure Presents as an acute influenza -like illness – fever of 101-104° F with chills and muscle rigidity Other symptoms – malaise, retro-orbital headache, photophobia, weakness, anorexia, nausea [arupconsult.com]

• Vomiting

  ·tis | \ -ˌkȯr-ē-ō-ˌme-nən-ˈjī-təs \ Definition of lymphocytic cho rio men in gi tis : an acute disease that is caused by an arenavirus (species Lymphocytic choriomeningitis virus of the genus Arenavirus ), that is characterized by fever, nausea and vomiting [merriam-webster.com]

  This initial phase, which may last as long as a week, typically begins with any or all of the following symptoms: fever, malaise, lack of appetite, muscle aches, headache, nausea, and vomiting. [cdc.gov]

• Abdominal Pain

  The transplant recipients had abdominal pain, altered mental status, thrombocytopenia, elevated aminotransferase levels, coagulopathy, graft dysfunction, and either fever or leukocytosis within three weeks after transplantation. [ncbi.nlm.nih.gov]

• Slow Pulse

  Definition of lymphocytic cho rio men in gi tis : an acute disease that is caused by an arenavirus (species Lymphocytic choriomeningitis virus of the genus Arenavirus ), that is characterized by fever, nausea and vomiting, headache, stiff neck, and slow [merriam-webster.com]

• Hydrops Fetalis

  In addition to ventriculomegaly, one had nonimmune hydrops fetalis and the other had intracranial hemorrhage. [ncbi.nlm.nih.gov]

• Arthritis

  It usually causes a flu-like illness or aseptic meningitis, sometimes with rash, arthritis, orchitis, parotitis, or encephalitis. Diagnosis is by viral isolation, PCR, or indirect immunofluorescence. Treatment is supportive. [msdmanuals.com]

  The metacarpophalangeal joint and the proximal interphalangeal joint are the most common sites of arthritis caused by LCMV. [emedicine.medscape.com]

• Myalgia

  Abstract On April 20, 2015, a female aged 15 years sought care at her pediatrician's office after 5 days of fever, myalgia, left parietal headache, and photophobia. [ncbi.nlm.nih.gov]

  Twenty-one of the infections were associated with recent febrile illness with myalgia. [academic.oup.com]

  There is often stiffness and myalgia (muscle aches), headache, light-headedness, loss of appetite, sore throat and cough. In severe cases an aseptic meningitis may develop. [web.archive.org]

• Arthralgia

  We report a documented case of lymphocytic choriomeningitis in which a previously healthy 17-year-old girl experienced debilitating recurrent headaches and arthralgias for more than a year after discharge. [ncbi.nlm.nih.gov]

• Photophobia

  Abstract On April 20, 2015, a female aged 15 years sought care at her pediatrician's office after 5 days of fever, myalgia, left parietal headache, and photophobia. [ncbi.nlm.nih.gov]

  Other symptoms may include malaise, retro-orbital headache, photophobia, weakness, anorexia, nausea, and light-headedness. Some patients may experience sore throat. [loinc.org]

  Factors Immunocompromised state Pregnancy Clinical Presentation Symptoms develop 5-10 days after exposure Presents as an acute influenza -like illness – fever of 101-104° F with chills and muscle rigidity Other symptoms – malaise, retro-orbital headache, photophobia [arupconsult.com]

• Meningism

  Lymphocytic choriomeningitis virus is a rare cause of aseptic meningitis that should be considered in the symptomatic immunocompromised patient with an appropriate exposure history. [ncbi.nlm.nih.gov]

  meningitis Lymphocytic meningoencephalitis Applies To Lymphocytic: meningitis (serous) (benign) meningoencephalitis (serous) (benign) ICD-9-CM Volume 2 Index entries containing back-references to 049.0 : [icd9data.com]

• Headache

  Abstract On April 20, 2015, a female aged 15 years sought care at her pediatrician's office after 5 days of fever, myalgia, left parietal headache, and photophobia. [ncbi.nlm.nih.gov]

  ˌkȯr-ē-ō-ˌme-nən-ˈjī-təs \ Definition of lymphocytic cho rio men in gi tis : an acute disease that is caused by an arenavirus (species Lymphocytic choriomeningitis virus of the genus Arenavirus ), that is characterized by fever, nausea and vomiting, headache [merriam-webster.com]

• Intracranial Hemorrhage

  In addition to ventriculomegaly, one had nonimmune hydrops fetalis and the other had intracranial hemorrhage. [ncbi.nlm.nih.gov]

• Irritability

  The patient's hospital course was notable for hypotension (blood pressure 81/50), irritability, and pancreatitis with a peak lipase of 8,627 U/L. [ncbi.nlm.nih.gov]

Since congenital LCMV infection may mimic Aicardi syndrome, serologic testing should be considered in the workup of patients with Aicardi syndrome to rule out LCMV infection. [ncbi.nlm.nih.gov]

• Complement Fixing Antibody

  Virus was isolated from their patient's blood and urine, and complement fixing antibodies were demonstrated in the patient's serum during convalescence. [jamanetwork.com]

Education and awareness of the medical community as well as the general public will be critical in prevention as well as advancing future treatment modalities of lymphocytic choriomeningitis virus. [ncbi.nlm.nih.gov]

Treatment is supportive. Lymphocytic choriomeningitis virus (LCMV) is endemic in rodents. [msdmanuals.com]

Abstract Vesicular stomatitis virus (VSV)-based oncolytic virotherapy has the potential to significantly improve the prognosis of aggressive malignancies such as brain cancer. [ncbi.nlm.nih.gov]

The epidemiological association between LCMV and other zoonoses which can be expected in this community as well as the etiology of summer influenza-like illness along the coastal area of Croatia has to be explored further. [ncbi.nlm.nih.gov]

The epidemiological association between LCMV and other zoonoses which can be expected in this community as well as the etiology of summer influenza‐like illness along the coastal area of Croatia has to be explored further. J. Med. [doi.org]

[…] of diseases in human communities. 2. the field of medicine concerned with the determination of the specific causes of localized outbreaks of infection, such as hepatitis, of toxic disorders, such as lead poisoning, or any other disease of recognized etiology [vdh.virginia.gov]

In contrast to current candidates such as Epstein-Barr virus, the distribution of LCMV is consistent with epidemiological features of MS, including concentration in the temperate zone, higher prevalence farther from the equator, and increased prevalence [ncbi.nlm.nih.gov]

Bulletin Archive Contact Us Laurie Forlano, DO, MPH, State Epidemiologist Director, Office of Epidemiology 109 Governor Street, 6th Floor East Richmond, VA 23219 Phone: (804) 864-8141 Fax: (804) 864-8139 Contact Us by Email [vdh.virginia.gov]

The virus can also infect monkeys, dogs, field mice, guinea pigs, and hamsters, the latter an epidemiologically important host. [profiles.umassmed.edu]

We review measures undertaken to prevent a similar event and propose a follow-up protocol in the event of accidental LCMV exposure. [ncbi.nlm.nih.gov]