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2.1
Lymphocytic Myocarditis

Presentation

A patient with Whipple's disease presented with a long prodromal period characterized by granulomatous lymphadenitis and progressive lymphedema of the extremities. [ncbi.nlm.nih.gov]

Entire Body System

  • Congestive Heart Failure

    […] for congestive heart failure. [ncbi.nlm.nih.gov]

  • Amyloidosis

    […] valves Pericardium Myocardium Coronary arteries Vessels Digestive system Endocrine system Locomotory system Nervous system Reproductive system Respiratory system Skin Urinary system Search: Also in this section myocardial interstitial deposits cardiac amyloidosis [humpath.com]

    […] cause restrictive cardiomyopathy what is the cause of cardiac amyloidosis 1) amyloid transthyretin (AS/senile amyloid) 2) amyloid light chains (AL) in the interstitium what is the typical histological characteristics of cardiac amyloidosis 1) congo red [quizlet.com]

    […] by, last update March 24, 2019 OVERVIEW inflammation of heart muscle -> lymphocytic and fibroblast infiltration + myocyte necrosis CAUSES (HIGAAP) hypersensitivity infectious/infiltrative (haemochromatosis or amyloidosis) giant cell myocarditis autoimmune [lifeinthefastlane.com]

    Myocarditis can also exacerbate the cardiac damage from other rare heart diseases such as amyloidosis. [myocarditisfoundation.org]

  • Anemia

    These findings were accompanied by abnormal laboratory tests including anemia (hemoglobin: 7.6 g/dl), leukocytosis (16.25/nl) and elevated levels of C-reactive protein (27.6 mg/dl), troponin-I (7.6 ng/ml), myoglobin (664 g/dl), brain natriuretic peptide [eurjmedres.biomedcentral.com]

    Ganciclovir 1000 mg/24 h intravenously 5 days Then: valganciclovir 900 mg/ 24 h or 1800 mg/24 h • For 6 months • Follow-up laboratory tests 2 weeks after initiation (including Cr, liver enzymes, blood count), then monthly • Stop treatment if: neutropenia, anemia [revespcardiol.org]

  • Atrial Septal Defect

    septal defect asymmetrical septal hypertrophy hypertrophic cardiomyopathy heart dissection myocardial Fabry disease basophilic degeneration of the myocardium cardiomyocytic disarray Keywords Mophological syndrome 1996 - 2019 Humpath.com - Human pathology [humpath.com]

Respiratoric

  • Exertional Dyspnea

    Cardiac involvement is often considered as the differential diagnosis only when cardiac symptoms, such as palpitations, angina, and/or exertional dyspnea, persist for a long period after the underlying infection has resolved, or if they develop de novo [aerzteblatt.de]

Gastrointestinal

  • Abdominal Pain

    Six months after the first incident, the patient presented to our hospital with mild dyspnea on exertion and slight abdominal pain without bloody diarrhea. [eurjmedres.biomedcentral.com]

    pain, and chronic cough. [en.wikipedia.org]

Cardiovascular

  • Heart Disease

    A 14-year-old boy without overt heart disease underwent encircling ventriculotomy and cryoablation because of ventricular tachycardia resistant to antiarrhythmic therapy. [ncbi.nlm.nih.gov]

    diseases I51.81 Takotsubo syndrome I51.89 Other ill-defined heart diseases I51.9 Heart disease, unspecified I52 Other heart disorders in diseases classified elsewhere I60 Nontraumatic subarachnoid hemorrhage I60.0 Nontraumatic subarachnoid hemorrhage [icd10data.com]

    Additionally, medical procedures such as electrical cardioversion, and long-lasting illnesses such as kidney disease and heart disease, can cause high levels of troponin in the blood. [aviationtravelwriter.wordpress.com]

  • Tachycardia

    CONCLUSIONS: We conclude that unexplained ventricular tachycardia may be the only manifestation of clinically silent myocarditis. [ncbi.nlm.nih.gov]

  • Cardiomegaly

    Cardiomegaly with biatrial enlargement. Abnormal hyperintense signals involving the myocardium on T2 DIR, as compared to the skeletal muscle, the ratio is 3:1. Early enhancement when comparedT1 DIR pre to post contrast. [radiopaedia.org]

    […] growth of the ventricles what patient demographic is most likely to get hypertrophic cardiomyopathy male patients 20-50 years old what gross and histological changes are seen in hypertrophic cardiomyopathy Gross: Lack of LV compliance, LA dilation, cardiomegaly [quizlet.com]

  • Cardiac Signs and Symptoms

    The book and DVD package is designed to provide comprehensive coverage of every aspect of cardiovascular medicine from cardiac signs and symptoms and the full range of cardiac imaging techniques through management of peripheral vascular disease and the [books.google.com]

Neurologic

  • Akinesia

    TTE verified LV dysfunction with advanced hypokinesia to akinesia of the basal/middle-inferior/septal/anterior wall resulting in an EF of 13% and revealed pericardial effusion (PE) of 1.6 cm (Figure 1 A,B). [eurjmedres.biomedcentral.com]

Workup

Microbiology

  • Human Herpesvirus 6

    Furthermore, PCR analysis of the tissue did not detect any adenovirus DNA, parvovirus B19 DNA, human herpesvirus 6 DNA, Epstein-Barr virus DNA, varicella zoster virus DNA, herpes simplex virus DNA, cytomegalovirus DNA or enterovirus RNA including Coxsackie [eurjmedres.biomedcentral.com]

    Chromosomally integrated human herpesvirus 6: Questions and answers. Rev Med Virol. 2012;22:144-55. Medline 43. Escher F, Kuhl U, Gross U, Westermann D, Poller W, Tschope C, et al. [revespcardiol.org]

  • Bartonella Henselae

    Pathology by systems > Cardiovascular system > Heart > lymphocytic myocarditis Sunday 9 January 2005 Etiology direct infection Viral infection Bacterial infection Bartonella henselae myocarditis postinfectious autoimmune reaction E. [humpath.com]

T Wave

  • T Wave Inversion

    Markers of myocardial damage ( troponin or creatine kinase cardiac isoenzymes) are elevated. [10] The ECG findings most commonly seen in myocarditis are diffuse T wave inversions; saddle-shaped ST-segment elevations may be present (these are also seen [en.wikipedia.org]

Treatment

DATA SYNTHESIS: In survivors, left ventricular function in myocarditis improved approximately 10% over 6 months without immunosuppressive treatment. Prednisone alone did not improve survival (P >0.2) or left ventricular function (P >0.11). [ncbi.nlm.nih.gov]

Holmes Springer Science & Business Media, ٠٦‏/١٢‏/٢٠٠٧ - 2926 من الصفحات Cardiovascular Medicine, 3rd Edition offers the most up-to-date, user-friendly guidance on the evaluation, diagnosis and medical and surgical treatment of heart and vascular disease [books.google.com]

Computed tomographic scans of the liver before nivolumab treatment ( A ) and at 5 months after discharge ( B ). [circheartfailure.ahajournals.org]

In this uncontrolled treatment study, almost exclusively virus-negative patients had improved after 12 months under immunosuppressant treatment (LV-EF rise 21.4%). [aerzteblatt.de]

Data Synthesis: In survivors, left ventricular function in myocarditis improved approximately 10% over 6 months without immunosuppressive treatment. Prednisone alone did not improve survival ( P >0.2) or left ventricular function ( P >0.11). [annals.org]

Prognosis

Routine measurement of CRP may be a useful tool for determining the prognosis in patients with LM. [ncbi.nlm.nih.gov]

This disease in contrast to fulminant myocarditis carries a poor prognosis. Treatment should include steroids with immunosuppressive therapy including cyclosporine and/or azathioprine that significantly improves prognosis 8. [escardio.org]

SCHLUSSFOLGERUNGEN: Eine fulminante Myokarditis stellt im Akutstadium eine lebenbedrohliche Erkrankung dar, die Prognose nach Ausheilung gilt aber als gut. en CONCLUSIONS: Although fulminant myocarditis is a life -threatening condition in its initial phase, the prognosis [glosbe.com]

Etiology

/pathophysiology, what is the clinical presentation, what is the pathological presentation, what are the potential outcomes what: rare, fatal myocarditis patient: adults 20-50 etiology: unknown, but most likely autoimmune clinical: sudden onset heart [quizlet.com]

Pathology by systems > Cardiovascular system > Heart > lymphocytic myocarditis Sunday 9 January 2005 Etiology direct infection Viral infection Bacterial infection Bartonella henselae myocarditis postinfectious autoimmune reaction E. [humpath.com]

[…] has been suggested for GCM, based on the antimyosin GCM Lewis rat model and a high prevalence of associated autoimmune disorders, especially inflammatory bowel disease Diagrams / tables Images hosted on other servers: Etiology of Myocarditis Clinical [pathologyoutlines.com]

Etiology From an etiologic perspective, myocarditis cases usually fall into 1 of the following 4 main categories: Infectious Postviral autoimmune-related Autoimmune-mediated (lupus myocarditis, giant-cell myocarditis [GCM]) Drug-associated (hypersensitivity [emedicine.medscape.com]

Other etiologic agents responsible for myocarditis include drugs, toxic substances, or autoimmune conditions. [revespcardiol.org]

Epidemiology

We chose to study the epidemiologic grounds and all major aspects of differential pathogenesis and treatment of this serious health problem. [ncbi.nlm.nih.gov]

[…] eosinophilic and giant cell myocarditis (GCM) Terminology GCM has been termed idiopathic GCM, pernicious myocarditis, Fiedler myocarditis, acute idiopathic interstitial myocarditis, giant cell granulomatous myocarditis, and granulomatous myocarditis Epidemiology [pathologyoutlines.com]

[…] catecholamine-induced injury and reperfusion injury) Pathologic classification is complicated, however, because tissue biopsies often are not obtained, and a presumptive clinical diagnosis must sometimes be confirmed by means of indirect methods such as serology. [1] Epidemiology [emedicine.medscape.com]

Pathophysiology

[…] time what is the typical pathological presentation of lymphocytic myocarditis Gross: Flabby, dilated heart Microscopic: T cell infiltrate with myocyte necrosis what is lymphocytic myocarditis, what type of patient is it common in, what is the etiology/pathophysiology [quizlet.com]

[…] myocarditis, Fiedler myocarditis, acute idiopathic interstitial myocarditis, giant cell granulomatous myocarditis, and granulomatous myocarditis Epidemiology Incidence difficult to determine as most cases are believed to be subclinical or underdiagnosed Pathophysiology [pathologyoutlines.com]

The present article will focus on the discussion of pathophysiological insights, indications, and options for myocardial biopsy, considering existing guidelines for biopsy ( 4 ) and the therapeutic options in acquired myocardial disorders based thereon [aerzteblatt.de]

Prevention

[…] dangerous and life-threatening situation: in particular, the inflammation of the myocardial tissue of the heart may lead to severe consequences since the clinical history of the disease may be completely asymptomatic, any clinical sign may be lacking, thus preventing [ncbi.nlm.nih.gov]

Prevention There's no specific prevention for myocarditis. However, taking these steps to prevent infections might help: Avoid people who have a viral or flu-like illness until they've recovered. [mayoclinic.org]

Página 487 - Diphtheria, tetanus, and pertussis: recommendations for vaccine use and other preventive measures. Recommendations of the Immunization Practices Advisory Committee (ACIP). ‎ [books.google.es]

[…] comprehensive coverage of every aspect of cardiovascular medicine from cardiac signs and symptoms and the full range of cardiac imaging techniques through management of peripheral vascular disease and the genetic basis for cardiovascular disease to preventive [books.google.com]

Prevention Although myocarditis is an unpredictable disease, the following measures may help prevent its onset. Individuals should: Take extra measures to avoid infections, and obtain appropriate treatment for infections. [medical-dictionary.thefreedictionary.com]

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