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Lymphocytopenia

Lymphopenia


Presentation

  • It is most commonly diagnosed after a patient presents with an opportunistic infection and can also be associated with malignancies and autoimmune diseases.[ncbi.nlm.nih.gov]
  • We reviewed the case records of 91 Chinese SLE patients, presenting 12 months after SLE diagnosis.[ncbi.nlm.nih.gov]
  • RESULTS: Anti B2-GPI was present in 18.6% of the whole sample and in 29.4% of those with secondary APS.[ncbi.nlm.nih.gov]
  • In our patients, the prevalence of leukopenia ( 9 /l) was only 27%, whereas lymphopenia ( 9 /l) was present in 62% of patients at presentation ( Table 1 ).[doi.org]
  • Data on 392 HF reduced ejection fraction (HFREF) patients from 8 HF centers are presented here.[ncbi.nlm.nih.gov]
Turkish
  • METHODS: The Turkish Research Team-HF (TREAT-HF) is a network which undertakes multi-center observational studies in HF. Data on 392 HF reduced ejection fraction (HFREF) patients from 8 HF centers are presented here.[ncbi.nlm.nih.gov]
  • The Turkish Journal of Pediatrics reported that a low lymphocyte count because of fighting the bacterial disease can also further weaken the immune system. 10 Stress It is known that stress can weaken the immune system and cause you to get more infections[healthyandnaturalworld.com]
Progressive Dementia
  • The patient was admitted to our hospital because of progressive dementia and gait disturbance. T2-weighted MR images showed high-intensity lesions in his left frontal white matter thalamus, cerebellum and brainstem.[ncbi.nlm.nih.gov]
Oral Ulcers
  • Table 1 Presenting features and the cumulative occurrence of ACR criteria in the SLE cohort ( n 91) Feature Presentation Cumulative Clinical Malar rash 38 (42%) 38 (42%) Discoid lesions 3 (3%) 3 (3%) Photosensitivity 23 (25%) 25 (28%) Oral ulcers 8 (9%[doi.org]
Photosensitivity
  • She subsequently developed photosensitive rash, proteinuria with positive ANA and anti-DNA.[doi.org]
Discoid Rash
  • rash, photosensitivity, oral ulcers, arthritis, serositis, renal disorders, neurologic disorders, haematological disorders and immunological disorders); and (iii) SLEDAI at the time of diagnosis of SLE.[doi.org]
Agalactia
  • 20 (32.2) Cutaneous (18) Herpes zoster 11 (17.7) Staphylococcus aureus 1 (1.6) Mixed growth ( Morganella morganii, Klebsiella pneumoniae ) 1 (1.6) No organism identified 5 (8.1) Urinary (9) E. coli 5 (8.1) Enterococcus faecalis 1 (1.6) Strepotococcus agalactiae[doi.org]
Malar Rash
  • Table 1 Presenting features and the cumulative occurrence of ACR criteria in the SLE cohort ( n 91) Feature Presentation Cumulative Clinical Malar rash 38 (42%) 38 (42%) Discoid lesions 3 (3%) 3 (3%) Photosensitivity 23 (25%) 25 (28%) Oral ulcers 8 (9%[doi.org]

Workup

  • Further radiologic studies, hemato-oncologic, and autoimmune workups were normal. The patient was discharged on the treatment for tuberculosis. Follow-up after 8 weeks revealed a persistent low CD4 count, and the repeated HIV tests were negative.[dovepress.com]
  • Workup included a punch biopsy of the left medial thigh ulcer which revealed necrotizing granulomatous dermatitis with acid-fast bacilli detected on Fite stain ( Figure 1B–D ).[haematologica.org]
  • At any rate, viral-type-and-strain testing could be conducted on the extremely remote chance something was missed in your initial workup.[thebody.com]
  • Despite whatever symptoms and signs might be presenting themselves, the answers are all in the blood—that is, the only way low lymphocytes can be diagnosed is through a complete blood panel workup done by your doctor.[doctorshealthpress.com]
Air Bronchogram
  • The most common CT findings were lobar consolidation with air bronchogram and ground-glass opacities. For 7 recovering patients, the time to resolution of the chest CT findings was 10-90 days.[ncbi.nlm.nih.gov]
Haemophilus Parainfluenzae
  • parainfluenzae 2 (3.2) Influenza A 1 (1.6) No organism identified 20 (32.2) Cutaneous (18) Herpes zoster 11 (17.7) Staphylococcus aureus 1 (1.6) Mixed growth ( Morganella morganii, Klebsiella pneumoniae ) 1 (1.6) No organism identified 5 (8.1) Urinary[doi.org]
Listeria Monocytogenes
  • There was one case of Listeria monocytogenes bacteraemia, a classic intracellular organism requiring intact cell-mediated immunity for body defense. 6 Krau et al. reported seven cases of listeriosis in SLE patients, all having severe lymphopenia and receiving[doi.org]
Human Parvovirus B19
  • After cord blood transplantation, CD4( ) lymphocytopenia from unknown causes was observed, and persistent infections with human parvovirus B19 (B19) occurred.[ncbi.nlm.nih.gov]

Treatment

  • Many treatment options were tried for the warts, with the most significant response to acitretin.[ncbi.nlm.nih.gov]
  • This binary treatment destination was used as a marker of disease activity.[doi.org]
  • For both groups, neutrophil, monocyte, eosinophil, and hemoglobin levels did not change significantly during the treatment.[ncbi.nlm.nih.gov]
  • The treatment for this condition also depends on its cause and severity. Mild lymphocytopenia may not require treatment. If an underlying condition is successfully treated, lymphocytopenia will likely improve.[daviddarling.info]
  • In many cases, this means drug or radiation therapy must be stopped and antibiotic treatment begun immediately, even while awaiting test results. Treatment may also include antifungal preparations.[checkorphan.org]

Prognosis

  • OBJECTIVE: In heart failure (HF) patients, functional capacity has been demonstrated to be a marker of poor prognosis, independent of left ventricular ejection fraction (EF).[ncbi.nlm.nih.gov]
  • Prognosis Those suffering from lymphopenia have a dependent prognosis. This condition can come and go; especially when a person is in treatment for cancer.[healthosphere.com]
  • Because of the fundamental role of lymphocytes in suppressing anticancer immunity, RT-induced lymphocytopenia could negatively influence the prognosis of cancer patients and the therapeutic efficacy of RT itself.[ncbi.nlm.nih.gov]
  • Patterns of Anatomic Distribution 280 Clinical Staging Classification 340 Radiotherapy 366 Chemotherapy 442 Selection of Optimal Treatment 478 Chapter 10 Chapter 11 Chapter 12 Chapter 13 Historical Aspects 15 Etiology and Epidemiology 16 Pathology 52 Prognosis[books.google.com]
  • Prognosis - Lymphocytopenia Lymphocytopenia that is caused by infections tends to resolve once the infection has cleared.[checkorphan.org]

Etiology

  • KEYWORDS: cytomegalovirus; epstein barr virus infection; herpesvirus 6, acquired cellular immunodeficiency HIV negative; herpesvirus 7, human; idiopathic CD4-positive; lymphocytopenia etiology[ncbi.nlm.nih.gov]
  • If a particular clinical context is not found, it is necessary to know to seek infectious, dysimmune or neoplastic etiology.[pubs.sciepub.com]
  • Background: Idiopathic CD4 lymphocytopenia (ICL) is a rare disorder of unknown etiology.[ingentaconnect.com]
  • The Nature of the Immunologic Defect 236 Patterns of Anatomic Distribution 280 Clinical Staging Classification 340 Radiotherapy 366 Chemotherapy 442 Selection of Optimal Treatment 478 Chapter 10 Chapter 11 Chapter 12 Chapter 13 Historical Aspects 15 Etiology[books.google.com]
  • […] initially described in individuals whose low CD4 T-cell counts and opportunistic infections suggested human immunodeficiency virus (HIV) disease but in whom no evidence of viral infection could be established. 1, 2 ICL remains a disorder of unknown etiology[doi.org]

Epidemiology

  • B Jones, DVM, Div of Epidemiology, Bur of HIV/AIDS, Pennsylvania Dept of Health. Div of HIV/AIDS, National Center for Infectious Diseases, CDC.[cdc.gov]
  • […] the Immunologic Defect 236 Patterns of Anatomic Distribution 280 Clinical Staging Classification 340 Radiotherapy 366 Chemotherapy 442 Selection of Optimal Treatment 478 Chapter 10 Chapter 11 Chapter 12 Chapter 13 Historical Aspects 15 Etiology and Epidemiology[books.google.com]
  • Epidemiologic, clinical and immunological characteristics of the syndrome were described in 1993 and ICL is now considered a heterogeneous syndrome not caused by an infectious agent.[clinicaltrials.gov]
  • Rezza G, Pezzotti P, Aiuti F: Acquired immunodeficiency without HIV infection: Epidemiology and clinical outcome in Italy. The Italian Study Group on Non-HIV AIDS. BMJ 1995;311:785–786.[karger.com]
  • […] cases of autoimmune disease Sjogren’s syndrome . [3] [19] Because all of the reported autoimmune diseases and lymphomas involve B cells , one hypothesis proposes that ICL’s narrow T cell repertoire predisposes the immune system to B cell disorders. [3] Epidemiology[checkrare.com]
Sex distribution
Age distribution

Pathophysiology

  • Few studies have focused on the pathophysiology of ICL. CD4 T-lymphocyte phenotyping revealed increased CD95 expression that could be responsible for excess apoptosis leading to lymphocytopenia.[clinicaltrials.gov]
  • […] clonal hematopoietic stem cell disorders with an inherent tendency for leukemic transformation. 1 MDS is characterized by ineffective hematopoiesis, manifested by morphological dysplasia in the bone marrow and by peripheral blood cytopenia(s). 2 The pathophysiology[nature.com]
  • […] ultimately will develop monoclonal B-cell lymphoma or B-cell leukemia.38,39 SECONDARY (REACTIVE) LYMPHOCYTOSIS Secondary lymphocytosis defines conditions associated with an increase in the absolute number of lymphocytes secondary to a physiologic or pathophysiologic[medtextfree.wordpress.com]

Prevention

  • Consume enough protein Making sure that your diet contains enough protein will help to prevent low lymphocytes.[healthyandnaturalworld.com]
  • Treat your inpatient and ambulatory patients more effectively with the absolute latest on new topics such as quality improvement and patient care safety *school violence and bullying * preventive measures * vitamin deficiencies * adolescent rape * effect[books.google.com]
  • Lifestyle Remedies to Prevent Lymphocytopenia There are also a number of lifestyle changes that could help you prevent lymphocytopenia, or low lymphocyte levels.[doctorshealthpress.com]
  • A comparison of filtered leukocyte-reduced and cytomegalovirus (CMV) seronegative blood products for the prevention of transfusion-associated CMV infection after marrow transplant. Blood 1995; 86:3598-3603. ‏[books.google.com]
  • If you have lymphocytopenia, you may get treatment to prevent infections or to treat infections you already have. You also can take other steps to prevent infections. For example: Stay away from people who are sick, and avoid large crowds of people.[daviddarling.info]

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