To report an unusual presentation of a case of Lymphomatoid papulosis(LyP) in a young girl. A 14-year-old female presented with a history of swelling of the left upper eyelid of two weeks duration. [ncbi.nlm.nih.gov]

• Constitutional Symptom

  Unless accompanied by systemic lymphoma, most patients have no constitutional symptoms, and physical findings are limited to the skin. [ncbi.nlm.nih.gov]

  Clinical evaluation should include a complete history assessing for atypical features, including previous lymphoid neoplasms, constitutional symptoms, lymphadenopathy, or laboratory abnormalities on complete blood counts, blood chemistry, and lactate [clinicalgate.com]

• Abdominal Lymphadenopathy

  Chest CT-Scan did not find mediastinal or abdominal lymphadenopathy. Histopathological examination of a skin biopsy taken from a cheek lesion revealed an epidermal hyperplasia and a dense infiltrate in the dermis with epidermotropism. [dermatology.cdlib.org]

  Radiologic examination of chest revealed fibrostreaky densities in right upper lobe and CT scan of abdomen showed no intra-abdominal lymphadenopathy. [kjim.org]

• Oral Ulcers

  We report a 72-year-old patient who presented with a 1-week history of a solitary oral ulcer on the lateral tongue, which had raised and indurated borders. [ncbi.nlm.nih.gov]

  Solitary oral ulceration as the first appearance of lymphomatoid papulosis: a diagnostic challenge. Clin Exp Dermatol. 2009 May 21. [Medline]. Wang HH, Lach L, Kadin ME. Epidemiology of lymphomatoid papulosis. Cancer. 1992 Dec 15. 70(12):2951-7. [emedicine.medscape.com]

• Suggestibility

  Persistent agmination of lymphomatoid papulosis (PALP) has been a matter of controversy in the literature, some authors suggesting that it represents composite lymphoma, others localized lymphomatoid papulosis (LyP). [ncbi.nlm.nih.gov]

• Oliguria

  METHODS: A 74-year-old man with a 3-year history of LP presented with oliguria. He was found to have acute renal failure and 37 g of proteinuria. [ncbi.nlm.nih.gov]

We recommend that a search for thymoma be included in the workup of LyP. Further chemokine profiling in other cases of LyP may assist in understanding their role in this disease. [ncbi.nlm.nih.gov]

Histologic examination is the first diagnostic step in the diagnostic workup of clinically suspected CD30 LPDs. [bloodjournal.org]

Review 11 months post-photodynamic therapy demonstrated complete clinical clearance at the treatment site. [ncbi.nlm.nih.gov]

Successful treatment of recalcitrant lymphomatoid papulosis in a child with PUVA-bath photochemotherapy. Eur J Dermatol. 2009 Nov-Dec. 19(6):646-7. [Medline]. Hughes PS. Treatment of lymphomatoid papulosis with imiquimod 5% cream. [emedicine.com]

IMPLICATIONS FOR PRACTICE: The management of lymphomatoid papulosis (LyP) is that of an indolent cutaneous lymphoma, based on its excellent prognosis. However, this good prognosis is altered if LyP is associated with lymphoma. [ncbi.nlm.nih.gov]

What is the Prognosis of Lymphomatoid Papulosis? (Outcomes/Resolutions) The prognosis of Lymphomatoid Papulosis in a majority of individuals is excellent, since LyP is a self-limiting condition that resolves on its own. [dovemed.com]

Even though the etiology of LYP is, in this case, uncertain, it should be considered as a clinical association of nephrotic syndrome in children and also included among potential triggers of the disease. [ncbi.nlm.nih.gov]

Etiology Etiology is unknown. In some reports, a correlation has been found between the use of immunosuppressive medication (e.g. anti-tumor necrosis factor (TNF) agents) for the treatment of chronic inflammatory diseases and the occurrence of LyP. [orpha.net]

Etiology No etiologic factors are known. Epidemiology All reported cases occurred in elderly adults (67-88 years, mean 75 years) with strong male predominance (9M:2F) (Karai et al., 2013). [atlasgeneticsoncology.org]

ETIOLOGY Lymphomatoid papulosis is characterized by chronic, recurrent and self-limited papulonodular skin eruptions.1 It may occur at any age but is most frequently seen in 20- to 40-year-old adults. Systemic symptoms are typically minimal. [the-dermatologist.com]

Although the etiology of localized LyP remains unknown, considering that 2 of 5 reported patients developed widespread lesions regional LyP may be the initial presentation of typical LyP [ 2, 7, 6, 9 ]. [dermatology.cdlib.org]

AIM: To analyse a cohort of Asian patients with LyP, diagnosed from 1987 to 2007 at the National Skin Centre (NSC), Singapore, in terms of epidemiology, treatment and association with a second lymphoma. [ncbi.nlm.nih.gov]

Summary Epidemiology Exact prevalence is unknown. [orpha.net]

[…] primary cutaneous anaplastic large cell lymphoma [C-ALCL], and borderline cases) ETIOLOGY/PATHOGENESIS Idiopathic Viral infection, chronic antigenic stimulation, and immunosuppression have all been implicated as factors in some cases CLINICAL ISSUES Epidemiology [basicmedicalkey.com]

Epidemiology of lymphomatoid papulosis. Cancer. 1992 Dec 15. 70(12):2951-7. [Medline]. Moura FN, Thomas L, Balme B, Dalle S. Dermoscopy of lymphomatoid papulosis. Arch Dermatol. 2009 Aug. 145(8):966-7. [Medline]. Vonderheid EC, Kadin ME, Gocke CD. [emedicine.com]

The pathophysiology of CD30 LPDs, including lymphomatoid papulosis (LyP), is largely unknown. [emedicine.com]

JAMA (1986) [ Pubmed ] CD30-CD30 ligand interaction in primary cutaneous CD30( ) T-cell lymphomas: A clue to the pathophysiology of clinical regression. [wikigenes.org]

CD30-CD30 ligand interaction in primary cutaneous CD30 T-cell lymphomas: a clue to the pathophysiology of clinical regression Blood. 1999;943077- 3083 PubMed Google Scholar 33. Beljaards RCKaudewitz PBerti E et al. [jamanetwork.com]

Treatment provided symptomatic relief but did not prevent progression to lymphoma. LIMITATIONS: The limitation of this study is the retrospective study design. CONCLUSION: Patients with LyP are at increased risk of associated lymphomas. [ncbi.nlm.nih.gov]

By following a healthy diet and exercise, symptoms of lymphomatoid papulosis can be prevented therefore check-ups are mostly the best preventive measures you can take. [epainassist.com]

Steroid creams do not prevent the development of new lesions but may be helpful in reducing the lesion symptoms. Cortisone treatments have been suggested to help heal the condition. [streetdirectory.com]

Topical bexarotene, in a region of localized disease, may prevent recurrence of the condition. Similarly, topical imiquimod cream 5% can hasten resolution of lesions. [clinicalgate.com]