To report an unusual presentation of a case of Lymphomatoid papulosis(LyP) in a young girl. A 14-year-old female presented with a history of swelling of the left upper eyelid of two weeks duration. [ncbi.nlm.nih.gov]

• Hodgkin Lymphoma

  — The association of lymphomatoid papulosis (LyP) with Hodgkin's lymphoma or other lymphomas is well recognized. [jamanetwork.com]

  Of the 35 LyP patients, 3 (9%) developed a malignant lymphoma; all were diagnosed as having non-Hodgkin lymphoma. [arizona.pure.elsevier.com]

  ＊Nodular lymphocyte predominant Hodgkin lymphoma ＊Classical Hodgkin lymphoma Nodular sclerosis Lymphocyte-rich classical Hodgkin lymphoma Mixed cellularity classical Hodgkin lymphoma Lymphocyte-depleted classical Hodgkin lymphoma HISTIOCYTIC AND DENDRIC [med.osaka-cu.ac.jp]

  There are 2 types of lymphoma: Hodgkin lymphoma Non-Hodgkin lymphoma The cause of Lymphomatoid Papulosis is unknown. There may be certain genetic defects, such as translocation, which is a juxtaposition of regions of the chromosomes. [dovemed.com]

  Ten to twenty percent of cases, however, are associated with a lymphoma, typically systemic or cutaneous anaplastic large cell lymphoma, mycosis fungoides, or Hodgkin lymphoma. [ncbi.nlm.nih.gov]

• Lymphadenopathy

  A 44-year-old Japanese male presented with lymphadenopathy followed by skin involvement. [ncbi.nlm.nih.gov]

  The patient had no lymphadenopathy or hepatosplenomegaly. He was otherwise in good health, and his general examination was completely normal. [dermatology.cdlib.org]

• Weight Loss

  Contact your doctor if you experience any fever, weight loss, night sweating or if any existing lesions do not heal within 2 to 3 months. [dermcoll.edu.au]

  Three months later, though his skin remained clear, he developed sudden weight loss (10 lbs in 1 month), night sweats and fatigue. [ispub.com]

  There was no history of insect bite or unexplained fever and weight loss. [ijdvl.com]

  […] in size Any skin part on the body may be affected But as they grow they can ulcerate and spread to other parts of the body In rare cases, if other organs are involved, the following general signs and symptoms may be seen, which include: Unintentional weight [dovemed.com]

• Weakness

  Although all cases of LyP showed sharp cytoplasmic membrane staining with perinuclear Golgi accentuation with CD30, the recategorized case of aggressive epidermotropic CD8 cytotoxic T-cell lymphoma manifested only a weak cytoplasmic staining pattern. [ncbi.nlm.nih.gov]

  […] affected But as they grow they can ulcerate and spread to other parts of the body In rare cases, if other organs are involved, the following general signs and symptoms may be seen, which include: Unintentional weight loss; changes in appetite Fatigue and weakness [dovemed.com]

  The one weak point in this treatment is that the lesions treated with methotrexate will generally return several weeks after therapy. Another strong, aggressive treatment is oral psoralen plus ultraviolet light, so-called PUVA therapy. [lymphedemapeople.com]

• Swelling

  A 14-year-old female presented with a history of swelling of the left upper eyelid of two weeks duration. There was a history of trivial trauma prior to the swelling. [ncbi.nlm.nih.gov]

  There is a superficial and deep perivascular granulomatous infiltrate with endothelial swelling. A hard crust covers the surface ectimei ulcer. [medicaldb.blogspot.com]

• Rhinitis

  Lee Outcome of Moderate and Severe Traumatic Brain Injury Amongst the Elderly in Singapore BK Gan, JHG Lim, IHB Ng Comparison of Completely versus Incompletely Excised Cutaneous Squamous Cell Carcinomas P Ang, AWH Tan, CL Goh Familial Risk of Allergic Rhinitis [annals.edu.sg]

  At the interview, more than two thirds of the participants reported having atopic dermatitis, seasonal allergies (rhinitis and/or conjunctivitis),and/or asthma diagnosed by a physician. [jamanetwork.com]

We recommend that a search for thymoma be included in the workup of LyP. Further chemokine profiling in other cases of LyP may assist in understanding their role in this disease. [ncbi.nlm.nih.gov]

Histologic examination is the first diagnostic step in the diagnostic workup of clinically suspected CD30 + LPDs. [bloodjournal.org]

• Lymphocytosis

  […] lymphoma with iAMP21 3）T-lymphoblastic leukaemia/lymphoma a）Early T-cell precursor lymphoblastic leukaemia 4）NK-lymphoblastic leukaemia/lymphoma 13．Mature B-cell neoplasms 1）Chronic lymphocytic leukaemia/Small lymphocytic lymphoma a）Monoclonal B-cell lymphocytosis [chugaiigaku.jp]

Review 11 months post-photodynamic therapy demonstrated complete clinical clearance at the treatment site. [ncbi.nlm.nih.gov]

Successful treatment of recalcitrant lymphomatoid papulosis in a child with PUVA-bath photochemotherapy. Eur J Dermatol. 2009 Nov-Dec. 19(6):646-7. [Medline]. Hughes PS. Treatment of lymphomatoid papulosis with imiquimod 5% cream. [emedicine.com]

IMPLICATIONS FOR PRACTICE: The management of lymphomatoid papulosis (LyP) is that of an indolent cutaneous lymphoma, based on its excellent prognosis. However, this good prognosis is altered if LyP is associated with lymphoma. [ncbi.nlm.nih.gov]

What is the Prognosis of Lymphomatoid Papulosis? (Outcomes/Resolutions) The prognosis of Lymphomatoid Papulosis in a majority of individuals is excellent, since LyP is a self-limiting condition that resolves on its own. [dovemed.com]

Even though the etiology of LYP is, in this case, uncertain, it should be considered as a clinical association of nephrotic syndrome in children and also included among potential triggers of the disease. [ncbi.nlm.nih.gov]

Etiology Etiology is unknown. In some reports, a correlation has been found between the use of immunosuppressive medication (e.g. anti-tumor necrosis factor (TNF) agents) for the treatment of chronic inflammatory diseases and the occurrence of LyP. [orpha.net]

Etiology No etiologic factors are known. Epidemiology All reported cases occurred in elderly adults (67-88 years, mean 75 years) with strong male predominance (9M:2F) (Karai et al., 2013). [atlasgeneticsoncology.org]

ETIOLOGY Lymphomatoid papulosis is characterized by chronic, recurrent and self-limited papulonodular skin eruptions.1 It may occur at any age but is most frequently seen in 20- to 40-year-old adults. Systemic symptoms are typically minimal. [the-dermatologist.com]

Although the etiology of localized LyP remains unknown, considering that 2 of 5 reported patients developed widespread lesions regional LyP may be the initial presentation of typical LyP. © 2002 S. [karger.com]

AIM: To analyse a cohort of Asian patients with LyP, diagnosed from 1987 to 2007 at the National Skin Centre (NSC), Singapore, in terms of epidemiology, treatment and association with a second lymphoma. [ncbi.nlm.nih.gov]

Beth Israel Deaconess Medical Center Research Abstract My research has been in three general areas: epidemiology of chronic diseases, gastrointestinal pathology, and cytopathology. [dfhcc.harvard.edu]

Summary Epidemiology Exact prevalence is unknown. [orpha.net]

[…] primary cutaneous anaplastic large cell lymphoma [C-ALCL], and borderline cases) ETIOLOGY/PATHOGENESIS Idiopathic Viral infection, chronic antigenic stimulation, and immunosuppression have all been implicated as factors in some cases CLINICAL ISSUES Epidemiology [basicmedicalkey.com]

The pathophysiology of CD30 + LPDs, including lymphomatoid papulosis (LyP), is largely unknown. [emedicine.com]

JAMA (1986) [ Pubmed ] CD30-CD30 ligand interaction in primary cutaneous CD30(+) T-cell lymphomas: A clue to the pathophysiology of clinical regression. [wikigenes.org]

Our results provide new insights on MC distribution in CTCL reappraising their role in the pathophysiology of CTCL. [journals.plos.org]

Treatment provided symptomatic relief but did not prevent progression to lymphoma. LIMITATIONS: The limitation of this study is the retrospective study design. CONCLUSION: Patients with LyP are at increased risk of associated lymphomas. [ncbi.nlm.nih.gov]

By following a healthy diet and exercise, symptoms of lymphomatoid papulosis can be prevented therefore check-ups are mostly the best preventive measures you can take. [epainassist.com]

Steroid creams do not prevent the development of new lesions but may be helpful in reducing the lesion symptoms. Cortisone treatments have been suggested to help heal the condition. [streetdirectory.com]

How can Lymphomatoid Papulosis be Prevented? Currently, the cause of Lymphomatoid Papulosis is unknown; hence, there are no known methods to prevent the tumor occurrence. [dovemed.com]