Presentation
It is most commonly diagnosed after a patient presents with an opportunistic infection and can also be associated with malignancies and autoimmune diseases. [ncbi.nlm.nih.gov]
In our patients, the prevalence of leukopenia ( 9 /l) was only 27%, whereas lymphopenia ( 9 /l) was present in 62% of patients at presentation ( Table 1 ). [doi.org]
Entire Body System
- Malnutrition
She had no history of diabetes, malnutrition or chronic kidney disease. [ncbi.nlm.nih.gov]
Lymphocytopenia is associated with a variety of conditions, ranging from malnutrition to rare inherited disorders such as ataxia-telangiectasia or severe combined immunodeficiency syndrome. [britannica.com]
Lymphocytopenia, but not idiopathic CD4+ lymphocytopenia, is associated with corticosteroid use, infections with HIV and other viral, bacterial, and fungal agents, malnutrition, systemic lupus erythematosus, severe stress, intense or prolonged physical [diki.pl]
Irradiation Drugs, especially Corticosteroids Cytotoxic drugs HIV infection Hodgkin lymphoma Malnutrition / Anorexia nervosa Renal failure; acute and chronic. [rcpa.edu.au]
- Falling
Patients with idiopathic CD4+ lymphocytopenia may have either abnormally low but stable CD4+ cell counts, or abnormally low and progressively falling CD4+ cell counts; the latter condition is terminal. [checkorphan.org]
I've been looking over my medical history and my lymphocyte count has been falling for the last three years. With each test it is lower. It's only slightly below normal range now but if this keeps up it will be very low soon. [forums.phoenixrising.me]
Abstract In fall 2009 the emergency department of a clinic in Greece with increased patient visits due to influenza-like illness observed a particular pattern in the complete blood count (CBC) of these patients. [ncbi.nlm.nih.gov]
- Pallor
However, findings of an associated disorder may include Absent or diminished tonsils or lymph nodes, indicative of cellular immunodeficiency Skin abnormalities (eg, alopecia, eczema, pyoderma, telangiectasia) Evidence of hematologic disease (eg, pallor [msdmanuals.com]
Physical findings included a low-grade fever, pallor, and decreased breath sounds and crackles in the lung. Laboratory results are summarized in Table 1. HIV antibody was negative by ELISA and HIV viral load was undetectable (< 400 copies/mL). [haematologica.org]
Case Presentation A 30-year-old Tunisian man presented in October 2007 with a one week history of fatigue and skin pallor. He was born from a consanguineous marriage. His mother has rheumatoid arthritis. [pubs.sciepub.com]
- Swelling
They are round and pink], this accompanied by swelling on dauily basis. It is all so very strange but I want your opinion. I can tell from this website I would not be the only one interested in your answer. [thebody.com]
Skin
- Purpura
Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. [books.google.com]
Garcia-Suarez J, Prieto A, Reyes E, et al: Persistent lymphocytosis of natural killer cells in autoimmune thrombocytopenic purpura (ATP) patients after splenectomy. Br J Haematol 89:653, 1995. 70. [medtextfree.wordpress.com]
Workup
Further radiologic studies, hemato-oncologic, and autoimmune workups were normal. The patient was discharged on the treatment for tuberculosis. Follow-up after 8 weeks revealed a persistent low CD4+ count, and the repeated HIV tests were negative. [dovepress.com]
Workup included a punch biopsy of the left medial thigh ulcer which revealed necrotizing granulomatous dermatitis with acid-fast bacilli detected on Fite stain ( Figure 1B–D ). [haematologica.org]
Further workup ensued and he was found to have at that time asymptomatic cryptococcal meningitis [ 8 ]. Learning Points/Take Home Message 1. [omicsonline.org]
At any rate, viral-type-and-strain testing could be conducted on the extremely remote chance something was missed in your initial workup. [thebody.com]
Despite whatever symptoms and signs might be presenting themselves, the answers are all in the blood—that is, the only way low lymphocytes can be diagnosed is through a complete blood panel workup done by your doctor. [doctorshealthpress.com]
Serum
- Cytopenia
If the CD4 cytopenia is very low, i.e. below 100 and there is a presence of recalcitrant infections, then treatment with interleukin-2 is warranted; [7] however, this therapy has its own set of side effects and needs an informed written consent, depicting [ijccm.org]
The differential features then rely on an awareness of MonoMAC and multidisciplinary correlation including family history and peripheral blood findings, especially the presence or absence of cytopenia and profound monocytopenia. [haematologica.org]
These prognostic models for MDS consider the number and severity of cytopenias, including anemia, thrombocytopenia and neutropenia, need for red blood cell transfusions, karyotype, bone marrow and peripheral blood blast percentage, leukocytosis, morphological [nature.com]
Assessment of Relation between Cytopenia and LS The long-term lymphocytopenia caused by HBI seemed to be related to a longer LS (Table 2; p = 0.055). [article.sapub.org]
- Leukopenia
In our patients, the prevalence of leukopenia ( 9 /l) was only 27%, whereas lymphopenia ( 9 /l) was present in 62% of patients at presentation ( Table 1 ). [doi.org]
Elevated levels of 6TG have been found to be associated with bone marrow toxicity manifest as leukopenia. Elevated 6-MMP levels have been associated with hepatotoxicity. [utmb-ir.tdl.org]
The most common abnormalities detected during blood testing were anemia, lymphocytopenia, leukopenia, thrombocytopenia and neutropenia. There is profound monocytopenia, B lymphocytopenia and NK lymphocytopenia. [diki.pl]
- Monocytosis
In 90% of all patients with probable influenza, lymphopenia and/or monocytosis were present. [ncbi.nlm.nih.gov]
Another cause is infection with Influenza A virus subtype H1N1 (and other subtypes of the Influenza A virus ) and is then often associated with Monocytosis ; [9] H1N1 was responsible for the Spanish flu, the 2009 flu pandemic and in 2016 for the Influenza-epidemic [en.wikipedia.org]
[…] leukocytes D72.8 Other specified disorders of white blood cells D72.81 Decreased white blood cell count D72.810 Lymphocytopenia D72.818 Other decreased white blood cell count D72.82 Elevated white blood cell count D72.820 Lymphocytosis (symptomatic) D72.821 Monocytosis [icd10data.com]
- Neutrophilia
Moreover, they cause lymphocytopenia, eosinopenia, neutrophilia and polycythemia. Ananda informs her that he is suffering from ' Lymphocytopenia ' a medical condition for which he would survive only for two more years. [diki.pl]
It may be associated with agranulocytosis, hyperadrenocorticism, leukemia, advanced Hodgkin disease, irradiation, and acute infections with neutrophilia. lymphocytopenia see lymphopenia. lymphopenia, lymphocytopenia decrease in the number of lymphocytes [medical-dictionary.thefreedictionary.com]
In a follow-up study, Wyllie and colleagues showed that CRP alone performed no better in bacteremia prediction than either a model combining lymphocytopenia and neutrophilia, or lymphocytopenia alone [ 6 ]. [ccforum.biomedcentral.com]
Microbiology
- Human Parvovirus B19
After cord blood transplantation, CD4(+) lymphocytopenia from unknown causes was observed, and persistent infections with human parvovirus B19 (B19) occurred. [ncbi.nlm.nih.gov]
Treatment
Many treatment options were tried for the warts, with the most significant response to acitretin. [ncbi.nlm.nih.gov]
This binary treatment destination was used as a marker of disease activity. [doi.org]
The treatment for this condition also depends on its cause and severity. Mild lymphocytopenia may not require treatment. If an underlying condition is successfully treated, lymphocytopenia will likely improve. [daviddarling.info]
In many cases, this means drug or radiation therapy must be stopped and antibiotic treatment begun immediately, even while awaiting test results. Treatment may also include antifungal preparations. [checkorphan.org]
Given that AmBisome treatment has a 95% cure rate [ 12 ], patients who relapse following treatment should be investigated for underlying immunodeficiency. [journals.plos.org]
Prognosis
Prognosis Those suffering from lymphopenia have a dependent prognosis. This condition can come and go; especially when a person is in treatment for cancer. [healthosphere.com]
OBJECTIVE: In heart failure (HF) patients, functional capacity has been demonstrated to be a marker of poor prognosis, independent of left ventricular ejection fraction (EF). [ncbi.nlm.nih.gov]
Patterns of Anatomic Distribution 280 Clinical Staging Classification 340 Radiotherapy 366 Chemotherapy 442 Selection of Optimal Treatment 478 Chapter 10 Chapter 11 Chapter 12 Chapter 13 Historical Aspects 15 Etiology and Epidemiology 16 Pathology 52 Prognosis [books.google.com]
Prognosis - Lymphocytopenia Lymphocytopenia that is caused by infections tends to resolve once the infection has cleared. [checkorphan.org]
Etiology
KEYWORDS: cytomegalovirus; epstein barr virus infection; herpesvirus 6, acquired cellular immunodeficiency HIV negative; herpesvirus 7, human; idiopathic CD4-positive; lymphocytopenia etiology [ncbi.nlm.nih.gov]
If a particular clinical context is not found, it is necessary to know to seek infectious, dysimmune or neoplastic etiology. [pubs.sciepub.com]
ICL is now considered to an underdiagnosed etiology for atypical fungal infections. [1] It is most likely not caused by a response to infectious etiologies (which are characterized by transient suppression of T-Cell subsets). [2] The severity of ICL varies [cytojournal.com]
Background: Idiopathic CD4 lymphocytopenia (ICL) is a rare disorder of unknown etiology. [ingentaconnect.com]
The Nature of the Immunologic Defect 236 Patterns of Anatomic Distribution 280 Clinical Staging Classification 340 Radiotherapy 366 Chemotherapy 442 Selection of Optimal Treatment 478 Chapter 10 Chapter 11 Chapter 12 Chapter 13 Historical Aspects 15 Etiology [books.google.com]
Epidemiology
B Jones, DVM, Div of Epidemiology, Bur of HIV/AIDS, Pennsylvania Dept of Health. Div of HIV/AIDS, National Center for Infectious Diseases, CDC. [cdc.gov]
[…] the Immunologic Defect 236 Patterns of Anatomic Distribution 280 Clinical Staging Classification 340 Radiotherapy 366 Chemotherapy 442 Selection of Optimal Treatment 478 Chapter 10 Chapter 11 Chapter 12 Chapter 13 Historical Aspects 15 Etiology and Epidemiology [books.google.com]
Epidemiologic, clinical and immunological characteristics of the syndrome were described in 1993 and ICL is now considered a heterogeneous syndrome not caused by an infectious agent. [clinicaltrials.gov]
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China:a descriptive study. Lancet. 2020;395(10223):507-13. [ Links ] 3. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. [scielo.org.mx]
Rezza G, Pezzotti P, Aiuti F: Acquired immunodeficiency without HIV infection: Epidemiology and clinical outcome in Italy. The Italian Study Group on Non-HIV AIDS. BMJ 1995;311:785–786. [karger.com]
Pathophysiology
Few studies have focused on the pathophysiology of ICL. CD4+ T-lymphocyte phenotyping revealed increased CD95 expression that could be responsible for excess apoptosis leading to lymphocytopenia. [clinicaltrials.gov]
[…] clonal hematopoietic stem cell disorders with an inherent tendency for leukemic transformation. 1 MDS is characterized by ineffective hematopoiesis, manifested by morphological dysplasia in the bone marrow and by peripheral blood cytopenia(s). 2 The pathophysiology [nature.com]
[…] ultimately will develop monoclonal B-cell lymphoma or B-cell leukemia.38,39 SECONDARY (REACTIVE) LYMPHOCYTOSIS Secondary lymphocytosis defines conditions associated with an increase in the absolute number of lymphocytes secondary to a physiologic or pathophysiologic [medtextfree.wordpress.com]
Prevention
Consume enough protein Making sure that your diet contains enough protein will help to prevent low lymphocytes. [healthyandnaturalworld.com]
Lifestyle Remedies to Prevent Lymphocytopenia There are also a number of lifestyle changes that could help you prevent lymphocytopenia, or low lymphocyte levels. [doctorshealthpress.com]
Provides guidance on error detection, correction, and prevention, as well as cost-effective test selection. Features a full-color layout, illustrations and visual aids, and an organization based on organ system. [books.google.com]
If you have lymphocytopenia, you may get treatment to prevent infections or to treat infections you already have. You also can take other steps to prevent infections. For example: Stay away from people who are sick, and avoid large crowds of people. [daviddarling.info]