Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk for lymphoma. [uniprot.org]

Abdomen Fulminant hepatitis Liver failure Gastrointestinal Hepatomegaly Splenomegaly General Reduced life expectancy, death by 10 years of age in 70% of patients Hematologic Anemia Atypical lymphocytosis Pancytopenia Thrombocytopenia Immunologic System [datagenno.com]

Autoimmunity ; Autosomal recessive inheritance ; Decreased circulating IgG level ; Elevated erythrocyte sedimentation rate ; Hepatomegaly ; Juvenile onset ; Lymphadenopathy ; Lymphoma ; Pancytopenia ; Recurrent aphthous stomatitis ; Recurrent infections ; Splenomegaly [mousephenotype.org]

Clinical features include lymphadenopathy; splenomegaly; and autoimmunity. [icd10data.com]

CHU Hedi Chaker, Sfax 2 Institut Pasteur, Tunis, Tunisia Abstract Background The Autoimmune Lymphoproliferative Syndrome (ALPS) is an impairment of lymphocyte apoptosis expressed by generalized non-malignant lymphoproliferation, lymphadenopathy and/or splenomegaly [adc.bmj.com]

Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk for lymphoma. [uniprot.org]

Phenotypes Anemia ; Autoimmunity ; Autosomal recessive inheritance ; Decreased circulating IgG level ; Elevated erythrocyte sedimentation rate ; Hepatomegaly ; Juvenile onset ; Lymphadenopathy ; Lymphoma ; Pancytopenia ; Recurrent aphthous stomatitis ; Recurrent [mousephenotype.org]

Features are compatible with immune dysregulation and include hemophagocytic lymphohistiocytosis (HLH), often associated with chronic Epstein-Barr virus (EBV) infection, splenomegaly, fever, colitis or inflammatory bowel disease (IBD), and recurrent infections [diseaseinfosearch.org]

Some patients have recurrent infections, and there may be an increased risk of hematologic malignancy (summary by Oliveira, 2013 and Niemela et al., 2010 ).The disorder shows significant overlap with autoimmune lymphoproliferative syndrome ( ALPS ) and [mendelian.co]

infections bleeding Evaluation Diagnosis with light microscopy of peripheral blood smear eosinophilic peroxidase-positive giant granules in neutrophils and platelets Bone marrow smear giant lysosomes in leukocyte precursor cells CBC showing pancytopenia [medbullets.com]

While mathematically rigorous, the book stresses an intuitive understanding of digital filters and signal processing systems, with numerous realistic and relevant examples. [books.google.ro]

This gene CASP10 gene this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma Distal arthrogryposis type 1 Distal arthrogryposis type 1 is a disorder characterized by joint deformities (contractures) that 1 [ghr.nlm.nih.gov]

Proper domains will make people exciting to do business with you. Credibility, reliability, trustworthy and other business predicates can be achieved by buying a proper domain name. [domains4u.org]

[…] antimalarial pyrimethamine, has been effective in reducing severe lymphadenopathy in some patients 9, 10 but not others. 11 The search for alternative drug targets has revealed that the double-negative (DN) T cells’ proliferative activity is associated with hyperactive [bloodadvances.org]

[…] virus [HIV] disease ( B20 ) Certain disorders involving the immune mechanism D89 ICD-10-CM Diagnosis Code D89 Other disorders involving the immune mechanism, not elsewhere classified 2016 2017 2018 2019 Non-Billable/Non-Specific Code Type 1 Excludes hyperglobulinemia [icd10data.com]

Caspase-8 Deficiency Presenting as Late-Onset Multi-Organ Lymphocytic Infiltration with Granulomas in two Adult Siblings. Journal Of Clinical Immunology. 2015 May 35(4):348-55.25814141 Shah S et al. [genedx.com]