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Macrocytic Anemia

Anemias Macrocytic


Presentation

  • The anemia of hypothyroidism may present with macrocytic indices and this diagnosis should be suspected when this finding is noted.[ncbi.nlm.nih.gov]
  • Children 10y presented a lower prevalence (p 65y, 60.2%). II. The overall subsample presented 24.7% low B-12, 8.1% low folate, 22.2% anemia and 3.7% macrocytosis, 1.3% macrocytic anemia.[b12-institute.nl]
  • This patient's clinical presentation does not fit any know mtDNA deletion syndrome. We present a case of a novel mtDNA deletion in a child who initially presented with MA.[aspergillus.org.uk]
Hemophilia A
  • ., anemia caused by sudden blood loss, as in a bleeding peptic ulcer, most cases of hemophilia,… Read More[britannica.com]
Cough
  • A female rheumatoid arthritis patient was admitted for productive cough and general fatigue that had gradually developed after leflunomide therapy.[ncbi.nlm.nih.gov]
Pneumonia
  • Leflunomide-eliminating cholestyramine therapy successfully treated all conditions excluding severe hypoxia, which occurred owing to deteriorating interstitial pneumonia and complicated bacterial pneumonia following antibiotic treatment.[ncbi.nlm.nih.gov]
Productive Cough
  • A female rheumatoid arthritis patient was admitted for productive cough and general fatigue that had gradually developed after leflunomide therapy.[ncbi.nlm.nih.gov]
Flushing
  • In this test, a so-called flushing dose of 1000 mug of nonradioactive vitamin B 12 is injected intramuscularly at the same time as, or 1 to 2 hours after, 0.5 to 2.0 mug of the labeled vitamin is given orally.[enotes.tripod.com]
Long Arm
  • Abstract The clinical, hematologic and histologic characteristics of six patients with refractory anemia with deletion of the long arm of chromosome No. 5 are described.[ncbi.nlm.nih.gov]

Workup

Abnormal Schilling Test
  • Pernicious anemia is suggested by the finding of Histalog fast achlorhydria, deficiency of intrinsic factor in gastric juice, positive anti intrinsic antibody in blood (in 75% of pts), anti parietal cell antibodies , also abnormal Schilling test (poor[enotes.tripod.com]
Thrombocytosis
  • After initiation of the prednisolone therapy, reticulocyte counts increased and macrocytic anemia as well as thrombocytosis disappeared.[ncbi.nlm.nih.gov]
  • […] functioning spleen Clinical Presentation Childhood on may present with vascular occlusion causing severe pain which lasts hours to days A common finding is avascular necrosis of the femoral head Labs CBC Elevated white count Decreased hemoglobin Possible thrombocytosis[physicianassistantexamreview.com]
Lymphocytopenia
  • Side effects including severe hypoxia, thrombocytopenia, lymphocytopenia, and macrocytic anemia with schistocytes (probably drug-induced megaloblastic anemia) were noted.[ncbi.nlm.nih.gov]
Hepatocellular Carcinoma
  • In 25 patients (22 with hepatocellular carcinoma, 3 with cholangiocellular carcinoma) treated with cisplatinum (10mg/day) and 5-Fluorouracil (5-FU) (250 mg/day), the frequency of anemia and its etiologies were evaluated.[ncbi.nlm.nih.gov]

Treatment

  • Treatment with levothyroxine led to correction of the hematologic abnormalities over a four-month period. The anemia of hypothyroidism may present with macrocytic indices and this diagnosis should be suspected when this finding is noted.[ncbi.nlm.nih.gov]
  • HbS in red cells Treatment There is no specific treatment for the disease.[physicianassistantexamreview.com]
  • The material on this page is educational and does not constitute medical advice, diagnosis or treatment. Please consult your physician if medical advice, diagnosis or treatment is needed.[healthtestingcenters.com]

Prognosis

  • Google Scholar Hasuike Y, Nonoguchi H, Tokuyama M, Ohue M, Nagai T, Yahiro M, Nanami M, Otaki Y, Nakanishi T: Serum ferritin predicts prognosis in hemodialysis patients: the Nishinomiya study.[bmcnephrol.biomedcentral.com]
  • What should you tell the patient and the family about prognosis? The vast majority of patients with vitamin B12 deficiency will respond to vitamin B12 replacement with a dramatically improved sense of well being.[cancertherapyadvisor.com]

Etiology

  • Nine cases (36%) showed macrocytic anemia without any evident etiologies during therapy. The cumulative appearance rate of anemia was 19% at 12 weeks and 51% at 18 weeks.[ncbi.nlm.nih.gov]
  • The common theme of etiologies that give rise to macrocytic anemias are their capacity to interfere with DNA Synthesis. This results in ineffective erythropoiesis within the bone marrow and over time, anemia.[pathwaymedicine.org]
  • Etiology and diagnostic evaluation of macrocytosis. Am J Med Sci. 2000;319(6):343-52. Savage DG, Lindenbaum J, Stabler SP, Allen RH.[msjonline.org]
  • Megaloblastiac anemias of unknown etiology Refractory megaloblastic anemia DiGuglielmo's syndrome The Schilling urinary excretion test By far the most popular method for testing vitamin B 12 absorption has been the Schilling urinary excretion test , which[enotes.tripod.com]
  • Megaloblastic anemia is characterized by macro-ovalocytes, in contrast to the round macrocytes usually found in macrocytosis of nonmegaloblastic etiology [1].[path.upmc.edu]

Epidemiology

  • […] size of the red cell is useful in diagnosis: Microcytic red cells are seen in iron deficiency and thalassemia Normocytic red cells are observed in bone marrow, inflammatory or renal disorders Macrocytic red cells are a feature of vitamin deficiencies Epidemiology[lecturio.com]
  • In patients with liver disease and obstructive jaundice, cholesterol and/or phospholipids become deposited on the membranes of circulating red blood cells, leading to larger than normal cells. [ 1 ] Epidemiology [ 2 ] One study found that the most common[patient.info]
  • Pantelis Andreou, Department of Community Health and Epidemiology, Dalhousie University, Nova Scotia, Canada, for his assistance with the statistical analysis.[bmcnephrol.biomedcentral.com]
Sex distribution
Age distribution

Pathophysiology

  • This mouse model suggests that a p53-dependent mechanism underlies the pathophysiology of the 5q- syndrome.[ncbi.nlm.nih.gov]
  • Pathophysiology Etio-pathophysiologic classification of vitamin B12 deficiency Nutritional vitamin B12 deficiency (insufficient intake of vitamin B12-rich animal source foods) Vegetarians, near-vegetarians, breast-fed infants of mothers with pernicious[cancertherapyadvisor.com]
  • Alcohol 26 65 15 36 B 12 and/or folate deficiency 6 9 28 21 Medications 37* 3 2 11 Hypothyroidism — 1 12 5 Bone marrow dysplasias 6 1 5 5 Liver disease (nonalcoholic) 6 — 2 6 Reticulocytosis 8 — — 7 Miscellaneous 3 21 13 7 Not established 7 — 22 12 Pathophysiology[aafp.org]

Prevention

  • […] corpuscular volume [MCV] 100 fl) and macrocytic anemia (MCV 100 fl and hemoglobin CONCLUSIONS: These results suggest that the erythrocyte abnormalities in alcoholics are attributable to high AcH exposure as well as to nutritional deficiencies and may be prevented[ncbi.nlm.nih.gov]
  • Now in its second edition, this popular and essential comprehensive resource provides a detailed analysis of how to identify, prevent, and manage drug-induced diseases. Edited by James E. Tisdale and Douglas A.[books.google.de]
  • You can’t always prevent macrocytic anemia, particularly when it’s caused by underlying conditions out of your control. However, you can prevent the anemia from becoming severe in most cases.[healthline.com]
  • Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission.[scholarlypages.org]
  • Long-Term Control Patients with a vitamin B-12 deficiency may suffer from an underlying disorder that prevents the body from absorbing B-12, MedLinePlus says.[livestrong.com]

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