Presentation
General observations are presented emphasizing the relevance of close clinical and dermatologic follow-up in high-risk SOT patients with specific comments regarding treatment regimens and outcomes. [ncbi.nlm.nih.gov]
No correlation has been found between a certain histological presentation and the specific organism involved. 6 Also, there are no specific histological changes found in more immunocompromised patients, but more organisms are usually present and there [the-dermatologist.com]
Pus was obtained from the pustular lesions present on the back and legs. [ijmm.org]
Pustules may also be present. 5 Immunocompromised patients may present similar symptoms as immunocompetent patients or with subcutaneous nodules and abscesses. 6 - 8 Trauma is also considered an incitation factor in these cases. [doi.org]
The pubic tinea clinically presented in conjunction with fever, lymphadenopathy, inflammatory plaques, follicular lesions and subcutaneous nodules. [karger.com]
Entire Body System
- Inflammation
Majocchi's granuloma is an intracutaneous or subcutaneous granulomatous inflammation caused by invasion of dermatophytic fungus, especially Trichophyton rubrum. This type of lesion is misdiagnosed frequently without proper auxiliary examination. [ncbi.nlm.nih.gov]
Abstract Majocchi granuloma is an uncommon deep follicular inflammation caused by dermatophytes and affects immunocompetent and immunocompromised patients. [actasdermo.org]
We then performed a skin biopsy, which showed granulomatous inflammation and fungi in the deep dermis, conclusive for Majocchi granuloma, an infrequent deep dermatophytosis. [cmaj.ca]
- Asymptomatic
[…] granuloma, is often KOH- and culture-negative and must be diagnosed with a biopsy. 4 Some individuals appear susceptible to dermatophytic infections, either because of the types of lipids their skin produces or because they are able to carry T. rubrum asymptomatically [clinicaladvisor.com]
The reason for this finding is unknown, except that some wrestlers may be asymptomatic carriers. (3) In a study looking at 100 renal transplant recipients, a population used to represent immunocompromised patients, dermatophytosis was found in 42% of [the-medical-dictionary.com]
Histopathological pattern and humoral immune response to a crude exo-antigen and purified keratinase of Microsporum canis in symptomatic and asymptomatic infected cats. Med Mycol. 1999;37:1–9. CAS Article PubMed Google Scholar 41. Romani L. [link.springer.com]
- Constitutional Symptom
There was no history of constitutional symptoms, previous immunosuppression, topical corticosteroid use or exposure to household pets. Our patient had interdigital scaling of his toes, suggesting tinea pedis, yet signs of tinea manuum were absent. [cmaj.ca]
Skin
- Papule
The papules will be pink-red, and, along with the pustules, will be located in a perifollicular location. Hair shafts can be easily removed from the pustules and papules. [dermatologyadvisor.com]
The lesions were described as purple or dark red plaques and papules with a discrete circular pattern, without underlying erythema. In addition, some of the papules had minimal pustular drainage. [docksci.com]
A 48-year-old female patient who had undergone liver transplantation nine months earlier, presented with red papules and nodular lesions on her back, buttock and thigh of two months duration. [ncbi.nlm.nih.gov]
The features of cellulitis, such as indurated plaques without papules, nodules, or pustules, are observed in 5.4% of all cases. [academic.oup.com]
- Erythema
Case Report A 46-year-old male patient presented with one-year history of erythema, papule and nodules, and desquamation over his whole face, accompanied with pruritus. [ncbi.nlm.nih.gov]
[…] of children and adults, associated with excessive heat and humidity; scaly red annular plaques (ringworm) Tinea cruris: "jock itch", infection of inguinal area of obese men during warm weather Tinea pedis: "athletes foot", infection causing diffuse erythema [pathologyoutlines.com]
Type of lesion Differential diagnosis Papule Folliculitis Acne vulgaris Lupus miliaris disseminatus facii Insect bite Cutaneous leishmaniasis Granulomatous rosacea Disseminated toxoplasmosis Kaposi sarcoma Nodule Erythema nodosum Erythema induratum Bazin [academic.oup.com]
- Skin Disease
It is a very comprehensive and practical guide and should not be missed by those treating patients with skin diseases. [books.google.de]
Lesions can mimic various skin diseases such as bacterial cellulitis, atypical mycobacterial infections, and noninfectious skin diseases, thereby delaying correct diagnosis and adequate treatment.3,4 We report 2 cases of MG in immunocompetent adults attended [actasdermo.org]
On DermNet NZ Tinea infections Other websites Majocchi Granuloma – Medscape Drugs & Diseases Books about skin diseases Books about the skin Dermatology Made Easy book [dermnetnz.org]
St Louis Missouri: Mosby. 8-Ackerman AB.(1997).Histologic Diagnosis of Inflammatory Skin Diseases.2ed.Baltimore, Maryland. Williams and Welkins. 9-Jordaan HF, Van Niekerk DJ, Louw M.(1994). Papulonecrotic tuberculid. [conganat.org]
- Skin Plaque
In pregnant women with complex, inflammatory, and erythematous skin plaques, a punch biopsy should be considered to diagnose disseminated dermatophyte Majocchi granuloma. [journals.lww.com]
Workup
What was missing from this patient’s workup was a definitive diagnosis, which could have been obtained with a biopsy, culture or KOH preparation to identify fungal elements. [clinicaladvisor.com]
In severe or recurrent cases, further workup may be required. This disease commonly affects both immunocompetent and immunocompromised hosts. However, immunocompromised individuals have a higher risk. [en.wikipedia.org]
Microbiology
- Trichophyton Rubrum
Trichophyton rubrum infection progressed, while itraconazole treatment was varied in dose and delivery form. [jdcr.eu]
The authors report a case of Majocchi's granuloma and onychomycosis in a liver transplant recipient caused by a Trichophyton spp., phenotypically consistent with Trichophyton rubrum var. raubitschekii. [ncbi.nlm.nih.gov]
MAIN OBSERVATION: We report on a heart transplant recipient who developed widespread Trichophyton rubrum infection presenting as Majocchi's granuloma. Itraconazole treatment was complicated by drug interactions. [zora.uzh.ch]
- Trichophyton Tonsurans
Trichophyton tonsurans is an uncommon cause of tinea corporis, and an even more uncommon cause of Majocchi's granuloma. We report a patient who developed tinea corporis with Majocchi's granuloma from T. tonsurans infection. [ncbi.nlm.nih.gov]
Majocchi’s granuloma caused by Trichophyton tonsurans in a cardiac transplant recipient. Br J Dermatol 1999; 140: 1194-1196. Gupta AK, Groen K, Woestenbroghs R et al. [medigraphic.com]
November 2005 | Volume 4 | Issue 6 | Case Report | 767 | Copyright © 2005 Vidya Rajpara MD, Stacy Frankel MD, Cindy Rogers MD, Keyvan Nouri MD Abstract Trichophyton tonsurans is an uncommon cause of tinea corporis, and an even more uncommon cause of Majocchi [jddonline.com]
Majocchis Granuloma Caused by Trichophyton mentagrophytes in 2 Immunocompetent Patients. Actas Dermosifiliogr. 2016 Mar 4. [Medline]. Chen HH, Chiu HC. Facial Majocchi's granuloma caused by Trichophyton tonsurans in an immunocompetent patient. [emedicine.medscape.com]
Treatment
It is important to perform a thorough examination for latent dermatophyte infection, including skin and nail lesions, before treatment with TNF-alpha inhibitors and during traditional psoriasis treatment. [ncbi.nlm.nih.gov]
Itraconazole treatment was complicated by drug interactions. Tricho-phyton rubrum infection progressed, while itraconazole treatment was varied in dose and delivery form. [zora.uzh.ch]
Itraconazole treatment was complicated by drug interactions. Trichophyton rubrum infection progressed, while itraconazole treatment was varied in dose and delivery form. [jdcr.eu]
Prognosis
However, there are only a few reports in the literature of facial involvement. [2],[3],[4] The prognosis of MG can be regarded as good, because there is effective pharmacotherapy available for it. [ijdvl.com]
A patient was recently described in Brazil. [2] Prognosis Majocchi granuloma cure is expected with appropriate systemic antifungal therapy. [emedicine.medscape.com]
Etiology
Onychomycosis - Etiology en_US dc.subject.mesh Tinea - Etiology en_US dc.subject.mesh Tinea Pedis - Etiology en_US dc.title Majocchi's granuloma and posttransplant lymphoproliferative disease in a renal transplant recipient. en_HK dc.type Article en_HK [hub.hku.hk]
Although primarily caused by keratinophilic dermatophytes such as anthropophilic Trichophyton rubrum, species from the Aspergillus and Phoma genera have been occasionally detected as etiologic agents of MG. [ncbi.nlm.nih.gov]
Epidemiology Commonly occurs in young women that shave their legs frequently Etiology Linked to Trichophyton Rubrum infection, also occurs when potent topical steroids are used on unsuspected tinea Pathogenesis Begins as a suppurative folliculitis and [dermpathdiagnostics.com]
Table 3 Etiologic agent of 79 cases of Majocchi’s granuloma and their frequency. [academic.oup.com]
Epidemiology
It provides a comprehensive review of the epidemiology, diagnosis, and management of opportunistic infections and presents strategies for infection prevention and control. [books.google.com]
Epidemiology Commonly occurs in young women that shave their legs frequently Etiology Linked to Trichophyton Rubrum infection, also occurs when potent topical steroids are used on unsuspected tinea Pathogenesis Begins as a suppurative folliculitis and [dermpathdiagnostics.com]
Epidemiology To the authors' knowledge, no specific data on the incidence and prevalence of Majocchi granuloma exist. [emedicine.medscape.com]
Pathophysiology
Pathophysiology The pathophysiology of the fungal infection and defense mechanisms against superficial dermatomycosis has been studied. [7] Two series of experimental infections of T mentagrophytes were made on the forearm of a male volunteer with topical [emedicine.medscape.com]
^ a b c "Majocchi Granuloma: Background, Pathophysiology, Epidemiology". 2017-07-14. ^ a b "Majocchi's Granuloma (Granuloma trichophyticum)". www.mdedge.com. [en.wikipedia.org]
Prevention
Abstract BACKGROUND: Solid organ transplant recipients are at an increased risk for infections because of long-term immunosuppression to prevent graft rejection. [zora.uzh.ch]
Hofbauer Abstract Background: Solid organ transplant recipients are at an increased risk for infections because of long-term immunosuppression to prevent graft rejection. [jdcr.eu]
Physical barrier of the dermis, degree of hydration and lipid composition of the stratum corneum play a major role in preventing such dermal invasions. [8] However, disruption of such mechanism can allow the persistence and widespread dissemination of [ijmm.org]
It provides a comprehensive review of the epidemiology, diagnosis, and management of opportunistic infections and presents strategies for infection prevention and control. [books.google.com]
There is no known preventive for granuloma inguinale, although it is rare where sanitary living conditions prevail. The drainage from lesions may be infectious and handwashing and basic cleanliness are required. [medical-dictionary.thefreedictionary.com]