Presentation
This article, the second in a 3-part series, presents information about Mal de Debarquement syndrome (MDD, also known as disembarkment sickness) and presents a case study of a patient who was relieved of MDD symptoms. [hearingreview.com]
Depression and anxiety are not related to the condition even though some MDS patients may present with these conditions. They are a consequence of debilitation, our patient however did not present with these conditions [14]. [hindawi.com]
Disembarkment syndrome MdD MdDS Sickness of disembarkment Prevalence: Unknown Inheritance: Not applicable Age of onset: All ages ICD-10: H81.8 OMIM: - UMLS: C1608983 MeSH: C537840 GARD: 6959 MedDRA: 10064924 The documents contained in this web site are presented [orpha.net]
Entire Body System
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Fatigue
The feeling of being in motion and dealing with the associated nausea, disorientation and fatigue that comes with MdDS can be debilitating for sufferers. [myphiladelphiadisabilitylawyer.com]
Manifestations begin shortly after the stimulus, persist for 6 months to years and may be associated with anxiety, fatigue and impaired cognition. [orpha.net]
Secondary symptoms of MdDS may include: Depression Feeling confused or having anxiety Fatigue Difficulty focusing Symptoms may subside when riding in a car or a train, but they may come back when you stop moving. [mercy.com]
Other common symptoms include fatigue, confusion, memory problems and a decrease in cognitive function. [ruthkolb.com]
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Swelling
One blustery, winter night I lay awake as my raft bounced up and down on colossal swells. Gripping the bed, I tried to stop resisting the motion, telling myself over and over again I wasn’t really in danger. Not an easy task. [liferaftmdds.com]
Gastrointestinal
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Nausea
Their symptoms, which include dizziness, nausea and a persistent feeling of rocking from side to side, can continue for decades after the fateful voyage that initiates them... ... [neurocritic.blogspot.com]
The feeling of being in motion and dealing with the associated nausea, disorientation and fatigue that comes with MdDS can be debilitating for sufferers. [myphiladelphiadisabilitylawyer.com]
The most prevalent symptom of the condition is constant motion sickness or nausea. Other common symptoms include fatigue, confusion, memory problems and a decrease in cognitive function. [ruthkolb.com]
It is common for people to experience travel sickness, such as nausea, especially for motion intolerant individuals during a long journey. [dizzinessandvertigo.weebly.com]
Cardiovascular
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Vascular Disease
Migraine in women: the role of hormones and their impact on vascular diseases. J. Headache Pain 13(3), 177–189 (2012).Crossref, Medline, CAS, Google Scholar 7 Vincent K, Tracey I. Hormones and their interaction with the pain experience. [future-science.com]
Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain (2012) 13(3):177–89. doi:10.1007/s10194-012-0424-y PubMed Abstract CrossRef Full Text Google Scholar 23. Park JH, Viirre E. [frontiersin.org]
Face, Head & Neck
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Facial Pain
Not Available, Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain: Headache Classification Committee of the International Headache Society Cephalalgia. 1988;8(suppl 7)1- 96 Google Scholar Crossref 10. [archotol.ama-assn.org]
Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache Classification Committee of the International Headache Society. Cephalalgia. 1988;8 Suppl 7:1-96. Barmack, N.H. and H. [dizziness-and-balance.com]
Neurologic
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Seizure
[…] may reoccur following another motion experience or during periods of stress or illness. [1] Although there is no known cure for mal de debarquement syndrome, there is evidence that some patients have responded positively to antidepressants or anti- seizure [rarediseases.info.nih.gov]
Personal history of seizures or a first-degree relative with epilepsy Medications known to lower seizure threshold such as: typical (high-potency) neuroleptics and tricyclic antidepressants: Subjects who take one or a combination of the following drugs [clinicaltrials.gov]
During the epochs there was no tinnitus, orthostatic hypertension, visual obscuration, loss of consciousness, syncope, seizures, weakness or falls. [cambridge.org]
He put me on an anti seizure/migraine medication, AcetaZOLAMIDE (125 MG), once a day for the first 10 days. He said to also keep the Valium on board for the first three days. [thehouseofwhimsy.blogspot.com]
Is there a correlations with particular medication intake (e.g. for migraine, seizures, psychiatric conditions) and prevalence of MdDS ? The following are some recent links. An abstract concerning the research project in Ohio is here. [dizziness-and-balance.com]
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Pendular Nystagmus
While the appearance of a rocking sensation as a result of adaptation might seem implausible, as it implies the initiation of an oscillating pattern, experimentally a pendular nystagmus lasting up to 60 minutes can be induced in rabbits by 24 hours of [archotol.ama-assn.org]
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Postural Instability
Flanagan MB, May JG, Dobie TG (2004)The role of vection, eye movementsand postural instability in the etiologyof motion sickness. J Vest Res 14:335–346 Google Scholar 5. [doi.org]
Postural Instability and Subjective Improvement Static posturography was recorded before and a week after treatment for 105 patients, and the relationship in improvement between the subjective measure and postural stability was determined for patients [frontiersin.org]
Limits of the Study We investigated the relationship between self-scored severity and postural instability in patients we have treated successfully (Figure 1 ). [ncbi.nlm.nih.gov]
Workup
A thorough history, physical examination, and diagnostic workup will be required to make a diagnosis; however nothing will be revealed after extensive workup [1]. If this syndrome is well comprehended, it may be more appropriately diagnosed [1]. [hindawi.com]
Overview The author explains the clinical presentation, pathophysiology, diagnostic workup, and management of mal de debarquement syndrome. [medlink.com]
An extensive workup, consisting of magnetic resonance imaging (MRI) brain (Figure 1 ), video-nystagmography (VNG), oculomotor testing, positional testing, and audiogram were all normal. [cureus.com]
Treatment
We will provide you with specific instructions if the home treatment is necessary when you return home. The home treatment is individually tailored based on the results of lab treatments. [labs.icahn.mssm.edu]
After treatment, the rhythmic oscillations present before the treatment disappeared. [doi.org]
The underlying neural mechanisms are unknown, and to date there have been no effective treatments for this condition. [ncbi.nlm.nih.gov]
New treatment successful for the rare and debilitating Mal de Debarquement Syndrome (MdDS). [health-innovations.org]
Though not measured, the patient noted during treatment she was symptom free for the duration of every 4 min treatment session, including the initial trial of counterclockwise treatments. [academic.oup.com]
Prognosis
Prognosis Many people do feel unsteady for a few minutes but the symptoms of mal de debarquement syndrome can persist for more than thirty days and sometimes for years. [mddk.com]
Prognosis - Mal de debarquement Not supplied. Treatment - Mal de debarquement Resources - Mal de debarquement Not supplied. [checkorphan.org]
Etiology
Objectives: To better define real de debarquement ('sickness of disembarkment') syndrome, to understand the etiology or mechanism of this disorder, and to seek better prevention and treatment options for this disorder. [scholars.northwestern.edu]
Discussion MDS is a disorder of false perception of movement, its true incidence is unknown; its true etiology is also unknown [10]. [hindawi.com]
We undertook a patient survey to better define MDD, to understand the etiology or mechanism of this disorder, and to seek better prevention and treatment options. [archotol.ama-assn.org]
These tests are important in excluding other etiologies for the patient’s symptoms. Standard Therapies Treatment MDD is very difficult to treat, with little effectiveness of most treatments. [rarediseases.org]
Epidemiology
The epidemiology of vestibular dysfunction in women with perimenopausal period. Crimean J Exp Clin Med (2013) 3 N(1–2):14–7. Google Scholar 18. Lempert T, Neuhauser H. Epidemiology of vertigo, migraine and vestibular migraine. [frontiersin.org]
Epidemiology The condition is thought to be under-reported in the medical literature. A study of 27 cases, conducted by Timothy C Hain in 1999, noted all but one patient to be female. [ipfs.io]
Results Epidemiology & diagnosis A total of 18 respondents were included in the study as per the described inclusion and exclusion criteria. [future-science.com]
A single Benadryl gel tab at the beginning of flight and at each 4 hour interval for longer flight. [ medical citation needed ] Epidemiology [ edit ] The condition is thought to be under-reported in the medical literature. [en.wikipedia.org]
Pathophysiology
2018 3 Treatment of Mal de Debarquement Syndrome in a Deployed Environment. ( 29788412 ) 2018 4 Hypothesis: The Vestibular and Cerebellar Basis of the Mal de Debarquement Syndrome. ( 29459843 ) 2018 5 Perspective: Stepping Stones to Unraveling the Pathophysiology [malacards.org]
MT, SO 15 2018 Perspective: Stepping Stones to Unraveling the Pathophysiology of Mal de Debarquement Syndrome with Neuroimaging. --- 16 2018 Sham-Controlled Study of Optokinetic Stimuli as Treatment for Mal de Debarquement Syndrome. [allie.dbcls.jp]
A new recent hypothesis has been formulated considering the two pathophysiological theories previously described [13,19,21,25]. [future-science.com]
However, more research is needed to evaluate the actual effect of estrogen on MdDS pathophysiology. [frontiersin.org]
Overview The author explains the clinical presentation, pathophysiology, diagnostic workup, and management of mal de debarquement syndrome. [medlink.com]
Prevention
Hence, preventing MDDS is also an area of active concern. Once again, possible prevention is largely speculative, but medications which diminish the response of the vestibular system may be useful. [checkorphan.org]
Preventing Occurrences of MDDS While MDDS usually eventually disappears, it also more often than not seems to return once a former MDDS sufferer takes another long boat or plane trip. Hence, preventing MDDS is also an area of active concern. [etete.com]
Objectives: To better define real de debarquement ('sickness of disembarkment') syndrome, to understand the etiology or mechanism of this disorder, and to seek better prevention and treatment options for this disorder. [scholars.northwestern.edu]
Prevention of MdDS Medications taken prior and during boat travel might prevent development of MdDS. According to Cha and others (2009), having migraine increases the probability of recurrent MdDS. [dizziness-and-balance.com]
In general, one might consider treatments aimed at preventing MDD and treatments aimed at ameliorating the effects of MDD once it has occurred. We know of no studies to date regarding prevention of MDD through medication. [archotol.ama-assn.org]