Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities. [uniprot.org]

It is associated with brachydactyly and nail abnormalities. Mental retardation may also occur. [genome.jp]

Brachydactyly with short cone-shaped fingers and nail abnormalities, such as koilonychia or pachyonychia, are frequently associated features. [jamanetwork.com]

Other features of this disorder can include short fingers and toes (brachydactyly), nail abnormalities, red skin around the mouth, and excessive sweating (hyperhidrosis). Mal de Meleda is a rare disorder; its prevalence is unknown. [ghr.nlm.nih.gov]

In addition, patients may develop keratotic plaques over joints, nail abnormalities, brachydactyly, pseudoanihum and perioral erythema. [1] In 2001, mutations in the gene encoding secreted Ly-6/uPAR-related protein 1 (SLURP-1) located on the chromosome [idoj.in]

Available from: Sir, Two siblings female and male of age 12 and 10 years born out of a second degree consanguineous marriage presented with a small patch of asymptomatic peeling of the skin over the palms since birth. [idoj.in]

On clinical examination she had severe anemia. The skin on palms and soles were thick, waxy and yellow with loss of dermatoglyphics. [jemds.com]

Another interesting feature being acquired black pigmentation of fingers and nails which was due to cashew shell paste application mistaken for dry gangrene was saved. [jemds.com]

high arched palate and corneal lesion. [jemds.com]

Other rare features include lingua plicata, syndactyly, high arched palate and left handedness, and hair on the palms and soles. [2] Case Report Three sisters (out of five), aged six, four & one year and born of a consanguinous marriage between first [ijdvl.com]

There was no history of hearing impairment, eye problem, or dental caries. [idoj.in]

There was no history of hearing impairment, eye problem, or dental caries. [idoj.in]

There was no history of hearing impairment and eye problems. Two other siblings, parents and relatives did not have similar complaints. On clinical examination she had severe anemia. [jemds.com]

Abstract Meleda disease (mal de Meleda) MIM *248300 is an autosomal recessive disorder, clinically characterised by transgressive palmoplantar keratoderma, hyperhidrosis and perioral erythema. [nature.com]

There was hyperhidrosis of palms and soles & a history of similar palmoplantar thickening in the paternal grandmother of the children. The pedigree was as shown in [Figure - 1]. [ijdvl.com]

Hyperhidrosis with maceration is feature of MDM and is often accompanied by malodour. [idoj.in]

The disease can be associated to hyperhidrosis, lichenoid plaques and perioral erythema. [monarchinitiative.org]

Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities. [uniprot.org]

It may be associated with hyperkeratotic plaques on the dorsa of hands, feet, knees, elbows and medial malleoli, erythema of palms and soles, erythema of nose, cheek and perioral eczema, hyperhidrosis and slow progression. [ijdvl.com]

Of the keratodermas with recessive inheritance, differential diagnosis was easily made both from Papillon-Lefevre syndrome in which peridontopathy always occurs and with Richner-Hanhart syndromes in which mental impairment and corneal ulcers is present [jemds.com]

It may be associated with hyperkeratotic plaques on the dorsa of hands, feet, knees, elbows and medial malleoli, erythema of palms and soles, erythema of nose, cheek and perioral eczema, hyperhidrosis and slow progression. [ijdvl.com]

The fingers were short. Nails were normal. Circular hyperkeratotic knuckle-pad like thickenings were present on all proximal interphalangeal joints and some knuckles [Figure - 4]. [ijdvl.com]