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Male Infertility due to Globozoospermia


Presentation

  • In this study, we present a consanguineous family with three affected brothers, in whom we have identified a homozygous mutation in the spermatogenesis-specific gene SPATA16.[ncbi.nlm.nih.gov]
  • Because sperm development takes over 2 months, illness that was present during the first cycle may affect mature sperm, regardless of a man's health at the time of examination.[healthcommunities.com]
  • In Figure 47-2, several similar examples are presented. In Patient A, the effective sperm count was 30,000/cc. In Patient B, the ESC was 116,850/cc and in Patient C, the ESC was 50,000/cc.[naprotechnology.com]
  • The present finding explains a common defect in male infertility associated with both asthenozoospermia and leukocytospermia, indicating a dual role of DEFB1 in defending male fertility.[stm.sciencemag.org]
  • The results will be presented Thursday at the Endocrine Society's 97th annual meeting in San Diego.[eurekalert.org]
Anemia
  • . · Exposure to environmental hazards and toxins such as pesticides, lead, paint, radiation, radioactive substances, mercury, benzene, boron, and heavy metals · Malnutrition and anemia. · Excessive stress![web.stanford.edu]
Falling
  • The Association of Reproductive Health Professionals highlights concerning trends [i] in male reproductive health, including: Rising rates of testicular cancer Falling sperm counts Decline in testosterone levels Fewer males being born Increases in certain[psr.org]
Low Set Ears
  • These individuals are characterized by short stature, webbed neck, low-set ears, and cardiovascular abnormalities. Other chromosomal abnormalities include myotonic dystrophy, bilateral anorchia, sertoli-cell-only syndrome.[ucdenver.edu]
Confusion
  • Male infertility should not be confused with erectile dysfunction, which is the inability to get or keep an erection long enough for sex and usually is treatable.[uabmedicine.org]
  • Two thirds of male patients don't know they're sterile because doctors use confusing language when diagnosing infertility rather than giving the facts, said Barnes. They use metaphors like “engines” and “baseball,” she added.[abcnews.go.com]
Cryptorchidism
  • Systemic Disease Systemic disease that may affect male fertility include Renal failure, Cirrhosis of the liver, Sickle-cell disease, Defective androgen synthesis, Cryptorchidism, Varicocele.[ucdenver.edu]
  • […] transmitted diseases, can interfere with sperm production or damage the tubes that carry sperm Other causes of male infertility include: Hormone imbalance, including low testosterone (hypogonadism) Developmental problems, including undescended testicles (cryptorchidism[uwhealth.org]
  • He had no previous history of cryptorchidism or varicocele and was not exposed to environmental and/or workplace gonadotoxins (i.e. heat, heavy metal, radiation, pesticides, etc.).[humrep.oxfordjournals.org]
Premature Ejaculation
  • Premature Ejaculation: Is defined as an inability to control the ejaculatory response for at least thirty seconds following penetration.[web.stanford.edu]
  • This includes premature ejaculation. A natural decline in fertility, caused by aging How does my doctor tell if I have male infertility? If a couple is having trouble becoming pregnant, the man is usually referred to an urologist.[dartmouth-hitchcock.org]

Workup

Hyperprolactinemia
  • Bromocriptine therapy is useful for men in whom impaired sperm production is due to hyperprolactinemia (high blood level of prolactin).The customary daily dose of bromocriptine is 5-10 mg.[maleinfertilityhouston.com]
  • The following is a list of hormonal disorders which can disrupt male infertility: Hyperprolactinemia: Elevated prolactin--a hormone associated with nursing mothers, is found in 10 to 40 percent of infertile males.[web.stanford.edu]
Estrogen Decreased
  • The level of estradiol, a type of estrogen, decreased substantially in most men as well. Three couples conceived (one of whom used in vitro fertilization), and four pregnancies ensued, Salgado reported. Two pregnancies were successful births.[eurekalert.org]
Chlamydia
  • Causes of infertility in cis women Some common reasons for infertility in cis women include: untreated chlamydia or gonorrhea not ovulating (not releasing eggs from your ovaries) your fallopian tubes are blocked so sperm can’t get to your egg poor egg[plannedparenthood.org]
  • Some STDs like gonorrhea and chlamydia can cause infertility by blocking the epididimis or tubes. These conditions are usually treated by hormonal replacement therapy and surgery in the case of tubular blockage.[web.stanford.edu]
  • […] disease have poor nutrition are significantly overweight are exposed to toxins, such as pesticides or lead had one or two undescended testicles when you were a baby or child have a hernia in your groin have had a sexually transmitted infection, such as chlamydia[babycenter.com]

Treatment

  • Home » Fertility Treatments Fertility Treatments - Step by Step Almost 60% of couples are able to conceive with these types of Fertility treatments suggesting that the majority of couples are able to conceive with basic fertility treatment interventions[floridafertility.com]
  • One man did not tolerate the treatment because of headaches and switched to treatment with another aromatase inhibitor drug, anastrozole, but was included in the analysis. A different man did not respond to letrozole treatment.[eurekalert.org]
  • At MFS we offer the following treatments: Spinal Cord Injury Treatments Electroejaculation Therapy (EEJ) Hormone Deficiency Treatments Clomiphene Citrate (Clomid, Serophene) For Unexplained Low Sperm Count For Genetic Defects Varicocele Ligation Sperm[malefertility.md]
  • Treatment for male infertility Most treatments for male infertility need to be prescribed by a specialist fertility doctor.[bupa.co.uk]

Prognosis

  • This treatment may be necessary as globozoospermic sperm can be less likely to activate the oocyte, an important stage in fertilisation.The treatment options currently available focus on overcoming the prognosis of infertility which is associated with[en.wikipedia.org]

Etiology

  • For couples who are having problems conceiving, approximately 40% of the time the etiology is related to the male partner. In another 20% of cases a combination of both male and female factors are responsible.[nashvillefertility.com]
  • See all Hide authors and affiliations Science Translational Medicine 13 Aug 2014: Vol. 6, Issue 249, pp. 249ra108 DOI: 10.1126/scitranslmed.3009071 Abstract Genital tract infection and reduced sperm motility are considered two pivotal etiological factors[stm.sciencemag.org]
  • Male infertility is estimated to represent about 20% of the etiologies. Among them, a rare type of teratozoospermia known as globozoospermia leads to disappointing pregnancy outcomes.[ncbi.nlm.nih.gov]
  • Although globozoospermia is thought to be an inherited disorder ( 2 ), the etiology of globozoospermia is not known.[doi.org]

Pathophysiology

  • Léandri, Sperm morphology: assessment, pathophysiology, clinical relevance, and state of the art in 2017, Andrology, 5, 5, (845-862), (2017). E. Moretti, N. A. Pascarelli, G. Belmonte, T. Renieri and G.[doi.org]

Prevention

  • Vasectomy Varicocele Sperm production problems Ejaculatory disorders These prevent sperm from reaching the female.[resolve.org]
  • Can male infertility be prevented or avoided? You cannot always prevent male infertility. However, there are factors that can affect this condition that you should avoid.[familydoctor.org]
  • In men, hormone disorders; illness; reproductive anatomy, trauma, and obstruction; and sexual dysfunction can temporarily or permanently affect sperm and prevent conception.[healthcommunities.com]
  • Some cases of male infertility are due to mutations in the maternal X chromosome that prevent development of viable sperm, according to a study led by researchers at the University of Pittsburgh School of Medicine and the Magee-Womens Research Institute[sciencedaily.com]
  • Centers for Disease Control and Prevention. During ICSI, a single sperm is injected directly into an egg. The procedure, which was introduced in 1992, made it possible for many infertile men to father children.[cbsnews.com]

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