Only minor shares of gastrointestinal NET ever become symptomatic and if patients experience complaints, they have usually been living with carcinoid tumors for years. NET may cause local and systemic symptoms, whereby the former are generally not considered part of the MCS. Either type of symptom may dominate the clinical picture and thus, MCS-associated complaints may be the cause of initial presentation. In these cases, a diagnosis of gastrointestinal NET has not been established previously.

The most characteristic symptoms of MCS are flushing, diarrhea, cardiac insufficiency, and bronchoconstriction.

• Flushing may be restricted to face and neck or extend to shoulders, arms, and thorax. In some cases, flushing is intermittent and subsides spontaneously after a few minutes. In other patients, vasodilation persists for hours. Hypotension may or may not occur.
• Diarrhea is generally severe and debilitating; patients may be dehydrated and lose weight. In some cases, abdominal pain and other gastrointestinal symptoms worsen after meals, particularly if they are accompanied by alcohol. Because the combination of chronic diarrhea and abdominal pain that aggravates after food ingestion is also typical for irritable bowel syndrome, MCS patients have repeatedly been misdiagnosed with irritable bowel syndrome [9].
• Tricuspid valve stenosis is the most frequent cause of cardiac insufficiency in MCS patients [10]. This condition is related to symptoms of right heart failure, i.e., to dyspnea that worsens under exercise, unproductive cough and edema.
• Bronchoconstriction is usually intermittent and patients claim asthma attacks during which wheezing, dyspnea, cyanosis and tachycardia can be observed.

Less commonly, myalgia, arthralgia, loss of libido and erectile dysfunction are reported by MCS patients.

With regards to local symptoms induced by the respective primary tumor, appendiceal carcinoids may mimic acute appendicitis, i.e., they may cause an acute onset of abdominal pain in the lower right quadrant, nausea, vomiting and/or acute abdomen.

• Weight Loss

  Any therapeutic gain experienced by these patients seemed to be outweighed by the frequency and severity of toxic reactions, which consisted primarily of chills and fever, fatigue, anorexia, weight loss, leukopenia, and abnormalities of liver function [ncbi.nlm.nih.gov]

  Clinical features WDHA syndrome (Watery Diarrhea, Hypokalemia, Achlorhydria) Weight loss Abdominal pain, nausea, vomiting Achlorhydria → ↓ iron and B12 absorption → anemia Diagnosis ↑ Serum VIP concentration (> 75 pg/mL) Hypokalemia, hypercalcemia, hyperglycemia [amboss.com]

  This can cause diarrhea and weight loss. [cancer.org]

  Colonic carcinoid tumours tend to be associated with weight loss and anorexia and are often larger and multiple at diagnosis. [healthed.com.au]

• Pulmonary Valve Stenosis

  […] or stenosis of either bioprosthesis. [doi.org]

  Clinical features Because the pulmonary circulation is a low-pressure system, many patients may tolerate gradual and progressive increases of tricuspid or pulmonary valve stenosis or regurgitation. [ecancer.org]

• Cough

  Pulmonary adenosquamous carcinoma with hepatic metastasis was found in a 60-year-old Japanese male who was complaining of fever, cough and haemosputum. [ncbi.nlm.nih.gov]

  When symptoms are present, usually there is coughing or wheezing. The cough might produce blood in the phlegm or sputum. If the tumor is large enough to block an air passage, a person might develop an infection called post-obstructive pneumonia. [my.clevelandclinic.org]

  which may make you cough up blood, and cause wheezing, shortness of breath, chest pain and tiredness a tumour in the stomach may cause pain, weight loss, tiredness and weakness Some tumours may not cause any symptoms and are discovered by chance. [nhs.uk]

  and you sometimes might cough up some bloody mucus. [webmd.com]

  A lung carcinoid tumour may cause a cough, which may make you cough up blood, and cause wheezing, breathlessness, chest pain and tiredness. A stomach carcinoid tumour may cause pain, weight loss, tiredness and weakness. [nhsinform.scot]

• Dyspnea

  Carcinoid syndrome – characterized by diarrhea, flushing, dyspnea, and wheezing – may occur if a serotonin-producing tumor has metastasized to the liver, bypassing first-pass metabolism. Elevated 5-HIAA in the urine helps to establish the diagnosis. [amboss.com]

  […] prostaglandins) from a functional neuroendocrine tumor (particularly from the midgut), typically manifesting with increased bowel movements and diarrhea, episodic vasoactive flushes (particularly of the face), hypotension, tachycardia, venous telangiectasia, dyspnea [orpha.net]

  This condition is related to symptoms of right heart failure, i.e., to dyspnea that worsens under exercise, unproductive cough and edema. [symptoma.com]

  History Part I: Pattern Recognition: Episodic flushing is the key symptom, although bronchial carcinoids typically present with wheezing and dyspnea as major symptoms. Flushing is usually confined to the face, neck and upper trunk. [cancertherapyadvisor.com]

• Bronchial Spasm

  spasm, mental aberration, and excretion of large quantities of 5-hydroxyindoleacetic acid. [medical-dictionary.thefreedictionary.com]

  Symptoms may include flushing of the face, flat angiomas (small collections of dilated blood vessels) of the skin, diarrhea, bronchial spasms, rapid pulse, and sudden drops in blood pressure A symptom complex associated with carcinoid tumor and characterized [icd9data.com]

• Diarrhea

  One cohort study found that healthcare costs are 1.5-fold higher and the risk of hospitalization is twofold higher in patients with carcinoid syndrome diarrhea than in those without diarrhea.7 The pathophysiology of carcinoid syndrome diarrhea involves [uspharmacist.com]

  Chemotherapy can be used with metastatic disease, and other drugs are prescribed as indicated to manage the hypotension, diarrhea, flushing, and other symptoms. [medical-dictionary.thefreedictionary.com]

  Morse: “It’s important to realize that in a patient with carcinoid syndrome diarrhea that they could have other reasons for their diarrhea. [gotoper.com]

  The FDA has approved a drug for the treatment of carcinoid syndrome diarrhea. [pharmacytimes.com]

  In a patient presenting with secretory diarrhea, episodic flushing, wheezing, and cardiac valvular abnormalities, consider a carcinoid tumor! [amboss.com]

• Abdominal Pain

  Signs and symptoms of carcinoid syndrome include: Skin flushing Facial skin lesions Diarrhea Breathing difficulty Rapid heartbeat Abdominal pain Bronchoconstriction Nausea and vomiting Various complications in patients that may be caused by carcinoid [primeoncology.org]

  Carcinoid syndrome may cause signs and symptoms such as facial flushing due to widened blood vessels on the face, abdominal pain, diarrhea, and rapid heart rate. [medicinenet.com]

  The right upper quadrant abdominal pains accompanied by symptoms that resemble even part of the carcinoid syndrome should initiate the investigational process including proximal gastrointestinal endoscopy to avoid delay in diagnosis of duodenal carcinoid [ncbi.nlm.nih.gov]

  References:[3][4][5][1][6][7] Clinical features Asymptomatic Abdominal pain Carcinoid syndrome Diarrhea and abdominal cramps Cutaneous flushing Possible triggers: alcohol consumption, food intake, stress In severe cases, may be accompanied by tachycardia [amboss.com]

  Case 2: a 39-year-old woman presents with a 2 yr. history of abdominal pain and flushing. A single lesion is found near the left kidney. Both had elevated Chromogranin A but normal U-5HIAA. [enets.org]

• Nausea

  High acid levels can lead to irritation of the lining of the stomach and even stomach ulcers, which can cause pain, nausea, and loss of appetite. Severe ulcers can start bleeding. [cancer.org]

  Signs and symptoms of carcinoid syndrome include: Skin flushing Facial skin lesions Diarrhea Breathing difficulty Rapid heartbeat Abdominal pain Bronchoconstriction Nausea and vomiting Various complications in patients that may be caused by carcinoid [primeoncology.org]

  The most common adverse events associated with Xermelo include nausea, headache, increased levels of the liver enzyme gamma-glutamyl transferase, depression, accumulation of fluid causing swelling (peripheral edema), flatulence, decrease appetite, and [pharmacytimes.com]

  […] symptoms occur if liver metastases are present or if tumor venous blood flow bypasses the liver Symptoms Vasomotor disturbances (cutaneous flushes, cyanosis of face and anterior chest, intermittent hypertension), palpitations, intestinal hypermotility (nausea [pathologyoutlines.com]

  Usual side effects were mild sedation and dry mouth, but three patients found it impossible to sustain treatment due to nausea and vomiting. Most patients had significant relief of diarrhea, frequently associated with weight gain. [ncbi.nlm.nih.gov]

• Abdominal Cramps

  Carcinoid syndrome develops in some people with carcinoid tumors and is characterized by cutaneous flushing, abdominal cramps, and diarrhea. Right-sided valvular heart disease may develop after several years. [msdmanuals.com]

  References:[3][4][5][1][6][7] Clinical features Asymptomatic Abdominal pain Carcinoid syndrome Diarrhea and abdominal cramps Cutaneous flushing Possible triggers: alcohol consumption, food intake, stress In severe cases, may be accompanied by tachycardia [amboss.com]

  Frequent, watery stools sometimes accompanied by abdominal cramps may occur in people who have carcinoid syndrome. Difficulty breathing. [mayoclinic.org]

  Diarrhea - Frequent and watery stools, sometimes accompanied by abdominal cramps Breathing Difficulty - Asthma-like symptoms, such as wheezing and shortness of breath, which may occur with skin flushing. [general.surgery.ucsf.edu]

• Chronic Diarrhea

  Practice CMAJ June 23, 2009 180 (13) 1329; DOI: https://doi.org/10.1503/cmaj.081214 A 72-year-old man was admitted to hospital with congestive heart failure, weight loss and chronic diarrhea. [cmaj.ca]

  This may be counterintuitive as the body loses bicarbonate during diarrhea, but if the diarrhea is chronic there are other mechanisms in the body. [lecturio.com]

  Carcinoid syndrome causes redness or a feeling of warmth in your face and neck (skin flushing), chronic diarrhea, and difficulty breathing, among other signs and symptoms. Carcinoid heart disease. [mayoclinic.org]

  Given the chronic diarrhea and the mesenteric mass, carcinoid syndrome was suspected. [karger.com]

  Chronic diarrhea can result in nutritional deficiencies. Talk to your doctor about multivitamins or other dietary supplements that may help. [healthline.com]

• Hepatomegaly

  […] hypertension), palpitations, intestinal hypermotility (nausea, vomiting, diarrhea, cramps) Also asthmatic attacks with bronchospasm, fibrosclerosis of AV and tricuspid valves, elastotic sclerosis of mesenteric vessels causing ischemia, dermal sclerosis, hepatomegaly [pathologyoutlines.com]

  […] due to tricuspid stenosis from serotonin action Other common problems – Asthma, wheezing, palpitations, hypotension, dizziness Physical Pay attention to: heart murmur, asthma-like symptoms, pellagra, electrolyte deficieny/dehydration from diarrhea, hepatomegaly [openanesthesia.org]

  She was found to have non-tender hepatomegaly. Therefore, referred pain to the right shoulder from underlying hepatomegaly versus bone pain from metastasis was suspected. [jmedicalcasereports.biomedcentral.com]

  […] metastatic carcinoid tumours, increased conversion of tryptophan to serotonin may lead to tryptophan and niacin deficiency, presenting as hypoalbuminaemia and pellagra. [ 4, 8 ] Examination is often normal but may reveal a right-sided abdominal mass, hepatomegaly [patient.info]

  Abdominal computed tomography (CT) and magnetic resonance imaging (MRI) demonstrated hepatomegaly and numerous liver lesions. [academic.oup.com]

• Hypertension

  Intraoperative handling of tumor Histamine releasing drugs (probably should be avoided in patients with carcinoid tumors, although these drugs have been used frequently in the past without complications) Diagnosis Severe hypotension/hypertension Flushing [openanesthesia.org]

  […] bradykinin, others) released from carcinoid tumors Clinical symptoms occur if liver metastases are present or if tumor venous blood flow bypasses the liver Symptoms Vasomotor disturbances (cutaneous flushes, cyanosis of face and anterior chest, intermittent hypertension [pathologyoutlines.com]

  Surgery and anaesthesia can trigger carcinoid crises that can cause hypo- or hypertension, bronchoconstriction and cardiac arrhythmias [8, 13]. [academic.oup.com]

  Nearly 95% of patients with present with right-sided heart valve disease, characterized by tricuspid insufficiency and pulmonary stenosis and the subsequent development of pulmonary hypertension. [endocrinediseases.org]

  Uses of "malignant" in oncology: * Malignancy, malignant neoplasm and malignant tumor are synonymous with cancer * Malignant ascites * Malignant transformation Non-oncologic disorders referred to as "malignant": * Malignant hypertension * Malignant hyperthermia [dbpedia.org]

• Palpitations

  […] released from carcinoid tumors Clinical symptoms occur if liver metastases are present or if tumor venous blood flow bypasses the liver Symptoms Vasomotor disturbances (cutaneous flushes, cyanosis of face and anterior chest, intermittent hypertension), palpitations [pathologyoutlines.com]

  […] appendectomy Rectum – 1.5 cm abdominoperineal resection Chemoembolization of liver lesions Anesthetic Considerations History Some develop right heart problems due to tricuspid stenosis from serotonin action Other common problems – Asthma, wheezing, palpitations [openanesthesia.org]

  Palpitations are a common symptom of hormone overproduction, often reported as occurring spontaneously or following a stressful episode. The palpitations can be short in duration or persist for longer periods of time, up to 30 minutes [19, 29]. [hindawi.com]

  […] cramps Cutaneous flushing Possible triggers: alcohol consumption, food intake, stress In severe cases, may be accompanied by tachycardia and fluctuating blood pressure Dyspnea, wheezing (asthma-like attacks) Possible weight loss despite normal appetite Palpitations [amboss.com]

  […] aberration, and excretion of large quantities of 5-hydroxyindoleacetic acid. carcinoid syndrome the systemic effects of serotonin-secreting carcinoid tumors, which include flushing, diarrhea, cramps, skin lesions resembling pellagra, labored breathing, palpitations [medical-dictionary.thefreedictionary.com]

• Cyanosis

  He had flushing of the face and cyanosis, and telangiectasia were present in the cheek area ( Figure 1 ). Figure 1: A 72-year-old man with carcinoid syndrome, showing flushing, cyanosis and telangiectasia. [cmaj.ca]

  […] vasoactive amines (serotonin, histamine, bradykinin, others) released from carcinoid tumors Clinical symptoms occur if liver metastases are present or if tumor venous blood flow bypasses the liver Symptoms Vasomotor disturbances (cutaneous flushes, cyanosis [pathologyoutlines.com]

  Bronchoconstriction is usually intermittent and patients claim asthma attacks during which wheezing, dyspnea, cyanosis and tachycardia can be observed. [symptoma.com]

  […] of the small intestine with metastases to the liver, valvular disease of the right side of the heart (pulmonary stenosis and tricuspid regurgitation without septal defects), peripheral vasomotor symptoms, bronchoconstriction, and an unusual type of cyanosis [wikiecho.org]

• Heart Murmur

  […] problems due to tricuspid stenosis from serotonin action Other common problems – Asthma, wheezing, palpitations, hypotension, dizziness Physical Pay attention to: heart murmur, asthma-like symptoms, pellagra, electrolyte deficieny/dehydration from diarrhea [openanesthesia.org]

  Over a long time, these hormone-like substances can damage heart valves, causing shortness of breath, weakness, and a heart murmur (an abnormal heart sound). Not all GI carcinoid tumors cause the carcinoid syndrome. [cancer.org]

  Facial flushing, which is redness and a warm feeling over the face Sweating Diarrhea Shortness of breath Wheezing or asthma-like symptoms Unexplained weight gain Weakness Fast heartbeat Heart murmur High blood pressure and significant fluctuations in [cancer.net]

  […] valves, heart murmur, heart failure blocked arteries in the liver bowel obstruction In extremely rare cases, acute symptoms such as low blood pressure, palpitations, faintness, and shortness of breath may become life-threatening. [healthline.com]

  Patients with valvular lesions may have a heart murmur. A few patients have wheezing due to bronchospasm, and some have decreased libido and erectile dysfunction. Pellagra develops rarely. [msdmanuals.com]

• Systolic Murmur

  Examination findings included a systolic murmur and a soft abdomen, with pain on deep palpation of the right iliac fossa. The next morning, abdominal pain and diarrhoea were already resolving, with unremarkable abdominal X-ray and faecal studies. [academic.oup.com]

  Systolic murmur along the lower left sternal border suggestive of tricuspid regurgitation. Pellagra, due to increased utilization of tryptophan by the carcinoid tumor that results in reduced nicotinic acid production and niacin deficiency. [cancertherapyadvisor.com]

• Arthritis

  These cause symptoms such as flushing, diarrhoea, cramping abdominal pain, serious heart damage, arthritis and asthma. [medical-dictionary.thefreedictionary.com]

  He endorsed a 40-pound unintentional weight loss over 2 years and use of NSAIDs for arthritis, but was unable to quantify NSAID use. [karger.com]

  […] chromogranin A levels include the following: chronic atrophic gastritis, liver cirrhosis, chronic hepatitis, pancreatitis, inflammatory bowel disease, heart failure, renal failure, hyperthyroidism, chronic obstructive pulmonary disease (COPD), and rheumatoid arthritis [cancertherapyadvisor.com]

  Some people will have fatigue, edema, some muscle pain, or finally arthritis. The problem with carcinoid is both the good news and the bad news. [carcinoid.org]

• Arthralgia

  Other symptoms include fatigue, palpitation, hypotension and aesthenia, and rarely irritability, myopathy and arthralgia. [healthed.com.au]

  Less commonly, myalgia, arthralgia, loss of libido and erectile dysfunction are reported by MCS patients. [symptoma.com]

• Flushing

  Flushing episodes were best controlled in the 20-mg LAR and SC groups; the 10-mg LAR treatment was least effective in the control of flushing. Treatment was well tolerated by patients in all four groups. [ncbi.nlm.nih.gov]

  Flushing is the most common symptom of carcinoid syndrome, and often the symptom that presents first. However, there are many other conditions that can cause flushing. It might also be caused by side effects of medications you may be taking. [carcinoidsyndrome.org]

  Midgut (small bowel, appendix) carcinoid tumors cause the classic carcinoid flush that is best described as cyanotic. The flush lasts 30 seconds to 30 minutes. [cancertherapyadvisor.com]

  These cause symptoms such as flushing, diarrhoea, cramping abdominal pain, serious heart damage, arthritis and asthma. [medical-dictionary.thefreedictionary.com]

• Sweating

  Eccrine sweat gland coil “bound down” by the abnormal surrounding collagen, with a commensurate loss of the normal surrounding contingent of adipocytes. Fig. 5. [karger.com]

  Facial flushing, which is redness and a warm feeling over the face Sweating Diarrhea Shortness of breath Wheezing or asthma-like symptoms Unexplained weight gain Weakness Fast heartbeat Heart murmur High blood pressure and significant fluctuations in [cancer.net]

  But the flushing I had was, in some instances, intense enough to create nausea, vomiting, chest pain, sweating, and absolute loss of energy for several hours. In other cases, the flushing was fairly mild. [curetoday.com]

  VIPomas also may cause facial flushing, profuse sweating, and achlorhydria. Signs and symptoms of carcinoid tumors Most carcinoid tumors are asymptomatic and are found incidentally during surgery or imaging. [lecturio.com]

  The symptoms of carcinoid syndrome include the following: Facial flushing (redness and a warm feeling that may last hours to days) Sweating Diarrhea Fast heartbeat Weight gain Increased facial and body hair Increased skin pigmentation In persons with [emedicinehealth.com]

• Pruritus

  2019 Vol. 381 No. 19 October 31, 2019 Vol. 381 No. 18 October 24, 2019 Vol. 381 No. 17 Browse full issue index Browse recently published Browse full issue index Recently Published Articles A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus [nejm.org]

  Gastric neuroendocrine tumors can cause patchy, well demarcated, serpiginous, cherry red flushing with intense pruritus due to secretion of histamine. [ncbi.nlm.nih.gov]

  In January 1998, he presented with flushing, pruritus, and watery diarrhea. [bcmj.org]

  […] tract, the sites most commonly affected are the small bowel, the rectum and the stomach. 4 The vasoactive hormones secreted by the tumour give rise to the so-called “carcinoid syndrome”, characterised by facial flushing, arterial hypotension, diarrhoea, pruritus [elsevier.es]

• Alopecia

  […] registration; in addition, prior treatment (somatostatin analogs excepted) must be completed at least 4 weeks prior to initiation of study drug; treatment-related toxicities must have improved to =< grade 1 prior to registration, with the exception of alopecia [clinicaltrials.gov]

  Although these agents are more toxic than somatostatin analogs, they may exhibit greater antitumor activity, but substantial adverse effects include fever, fatigue, anorexia, and weight loss as well as alopecia, autoimmune diseases and myelosuppression [scielo.br]

• Skin Rash

  Histamine secretion can lead to itching and skin rashes [28]. Palpitations are a common symptom of hormone overproduction, often reported as occurring spontaneously or following a stressful episode. [hindawi.com]

  Taking medicine for skin rashes. Taking medicine to breathe easier. Taking medicine before having anesthesia for a medical procedure. [cancer.gov]

• Facial Edema

  Carcinoid of the foregut produces a more intense and erythematous flush, sometimes associated with itching, conjunctival suffusion, and facial edema suggestive of histamine.Occasionally, gastric carcinoids cause an urticarial reaction, which may be inhibited [aboutcancer.com]

  The following clinical manifestations (if present) would support this disease: Facial cyanosis, pallor, flushing, esp. with eating, alcohol or exertion. Facial edema, macular erythema, periorbital edema. Steatorrhea, chronic diarrhea. Pulm. [enotes.tripod.com]

• Facial Redness

  redness, abdominal pain and diarrhea). [ncbi.nlm.nih.gov]

• Loss of Libido

  Less commonly, myalgia, arthralgia, loss of libido and erectile dysfunction are reported by MCS patients. [symptoma.com]

• Sexual Dysfunction

  After evaluation of side effects, the patient underwent several medication changes until he was stable with minimal side effects and no reports of sexual dysfunction on a regimen of 10 mg/day of escitalopram and 1 mg of clonazepam twice daily. [healio.com]

  It also measures dysfunction in daily activities, work capacity, family life and psychosocial activities ( Figure 5 ). 99, 103 A direct comparison of these two scales (EORTC QLQ-C30/GINET21 and Norfolk QLQ-NET) was performed in a sample of 29 patients [dovepress.com]

If a patient's medical history comprises a previous diagnosis of gastrointestinal NET, diagnosis of MCS is largely facilitated. In most cases, though, the treating physician has to make both the diagnosis of malignant NET and MCS.

With regards to the former, magnetic resonance imaging and computed tomography scans are first-line diagnostic tools to detect gastrointestinal tumors, hepatic and extra-hepatic metastases. It is not uncommon to see multiple carcinoid tumors in the digestive tract and multiple metastases. Findings obtained by diagnostic imaging are very helpful when establishing a therapeutic plan.

Diagnosis of MCS is based on the presence of characteristic symptoms in a patient who has been shown to suffer from metastatic NET. In order to assess which mediators account for the observed symptoms, laboratory analyses of blood samples should be conducted.

• Hypoglycemia

  […] expressed biochemically by the tryptophan-serotonin pathway, histamine, the kinin-kallikrien system, and probably other vasoactive amines.2 The malignant carcinoid syndrome has been associated with tumor production of immunoreactive insulin, secondary hypoglycemia [jamanetwork.com]

  الصفحة 100 - Nesidioblastosis: The pathologic basis of persistent hyperinsulinemic hypoglycemia in infants. Morphologic and quantitative analysis of seven cases based on specific immunostaining and electron microscopy - Heitz PU. [books.google.com]

  The patient’s daughter presented with hypoglycemia due to an insulinoma in 1982 at age 11. In 1983, she had 85% of her pancreas removed. Post-operatively, she continued to have episodes of hypoglycemia. [bcmj.org]

  […] cases observed which may specifically simulate more common benign conditions. [6] Endocrine [ edit ] The following diseases manifest by means of endocrine dysfunction: Cushing syndrome, syndrome of inappropriate antidiuretic hormone, hypercalcemia, hypoglycemia [en.wikipedia.org]

• Thrombocytosis

  Laboratory data were remarkable for significant anemia with hemoglobin of 5.9 g/dL (3 years prior: 11.7 g/dL; normal: 14.0–17.5 g/dL), leukocytosis with a WBC of 24,000/µL, and thrombocytosis of 722,000/µL. [karger.com]

  […] syndrome was a group of syndrome,which was defined by the presence of a peripheral neuropathy(P),monoclonal plasma cell dyscrasias(M),and other paraneoplastic features,such as organomegaly(O),endocrinopathy(E),skin changes(S),papilledema,ascites,and thrombocytosis [dict.cnki.net]

  […] neuroleptic malignant syndrome includes the following: Increased LDH Increased creatine kinase (50-100% of cases) Increased AST and ALT Increased alkaline phosphatase Hyperuricemia Hyperphosphatemia Hyperkalemia Myoglobinemia Leukocytosis (70-98% of cases) Thrombocytosis [emedicine.medscape.com]

• Leukocytosis

  Two (or more) of the following:  (1) Diaphoresis  (2) Dysphagia  (3) Tremor  (4) Incontinence  (5) Changes in level of consciousness ranging from confusion to coma  (6) Mutism  (7) Tachycardia  (8) Elevated or labile blood pressure  (9) Leukocytosis [ncbi.nlm.nih.gov]

  Laboratory data were remarkable for significant anemia with hemoglobin of 5.9 g/dL (3 years prior: 11.7 g/dL; normal: 14.0–17.5 g/dL), leukocytosis with a WBC of 24,000/µL, and thrombocytosis of 722,000/µL. [karger.com]

  […] abnormalities that may be found in neuroleptic malignant syndrome includes the following: Increased LDH Increased creatine kinase (50-100% of cases) Increased AST and ALT Increased alkaline phosphatase Hyperuricemia Hyperphosphatemia Hyperkalemia Myoglobinemia Leukocytosis [emedicine.medscape.com]

  Necrosis of hepatic tumor masses may produce an acute syndrome of abdominal pain, tenderness, fever, and leukocytosis. [enotes.tripod.com]

MCS treatment consists in a cure of the underlying disease and symptomatic therapy of MCS-associated disturbances as long as they persist.

With respect to the primary NET and its metastases, only surgical resection has been proven effective. Neither radiation therapy nor chemotherapy is indicated in case of carcinoids; symptoms relieve may be achieved by applying these techniques, but recurrence has to be expected. Resection of regional lymph nodes and hepatic metastases is usually a greater challenge than complete removal of the primary tumor. Nevertheless, surgery is recommended and patients may even benefit from incomplete resection: Symptoms subside and life quality improves. Because NET are very slow growing tumors, survival times can be significantly prolonged by such measures. Complete resection often leads to a permanent cure.

Distinct drugs are available to counteract peripheral effects of hormones and hormone-like substances produced by the tumor. Octreotide is a somatostatin analogue that binds to surface receptors expressed by NET cells and thereby inhibits release of the aforementioned substances, mainly of serotonin [11]. It is currently the mainstay of drug therapy of MCS. Serotonin synthesis inhibitors like telotristat etiprate may be used in patients who don't respond satisfactorily to octreotide [12]. Conventional antihistamines may be applied to further reduce flushing and bronchoconstriction. MCS-related diarrhea may be treated with antidiarrheals like loperamide, diphenoxylate, and opiates.

According to the pathophysiological mechanisms that lead to MCS, the vast majority of patients presenting with this syndrome suffers from a malignant neoplasm that already spread to the liver and/or regional lymph nodes. However, these tumors are generally very slow growing and thus, the overall prognosis is relatively good when compared with individuals affected by other types of cancer.

The individual prognosis of a patient may depend on whether the primary tumor and all metastases can be removed surgically. If the entire tumor tissue can be resected, complete cure is possible. Life quality and life expectancy can also be improved or prolonged by debulking, i.e., by removal of as much cancerous tissue as possible. A 5-year survival rate of 76% has been reported for those patients whose primary tumor has been resected [3]. This value decreases drastically if untreated patients are considered. Urinary excretion of serotonin metabolites has been proposed as a prognostic factor whereby excretion of high quantities of 5-hydroxyindoleacetic acid relates to a worse outcome.

Precise triggers of carcinoid development or malignant degeneration of NET are not known. In some cases, they may be presented by patients who suffer from multiple endocrine neoplasia, a genetic disorder characterized by multiple tumors of endocrine glands.

MCS, in turn, does directly result from metastasizing NET. The primary tumor is most often located in ileum or cecum, but may also be encountered in the colon. Rectal carcinoids are rarely associated with MCS. Of note, malignant NET may also originate from other tissues, namely from the lungs, ovaries, and testes. Malignant carcinoids in other organs have only been described in isolated cases.

Epidemiological data regarding NET and MCS are scarce and their reliability is doubtful. With respect to gastrointestinal NET, annual incidence rates of 1-2 per 100,000 inhabitants have been reported [4]. These values are most likely underestimates since the majority of NET patients never manifests any symptoms. Thus, retrospective studies can only be based on symptomatic NET.

Soga and colleagues conducted such a study and reported the following [3]:

• About 8% of symptomatic NET patients developed MCS.
• Metastatic spread, particularly to the liver, strongly predisposes for MCS.
• MCS prevalence increased with age.
• MCS was associated with higher serotonin activity.

Neither racial nor gender predilections have been reported.

The likelihood of developing MCS in the case of NET correlates well with the presence of metastases. MCS is most commonly described in patients who present hepatic metastases of gastrointestinal NET; some MCS patients suffer from NET that spread to the regional lymph nodes, and in few cases, metastases cannot be encountered. The latter presumably results from the inability to detect small metastases with available imaging techniques. Induction of MCS by primary gastrointestinal tumors is unlikely since vasoactive substances secreted by these neoplasms are degraded upon the first pass through the liver and won't reach peripheral organs [5].

NET and their metastases may produce a plethora of biogenic amines, protein and peptide hormones, kinins, eicosanoids, growth factors and enzymes. The interested reader is referred to a recently published review regarding this broad topic [6].

Serotonin activity seems to play a major role in MCS pathophysiology and in general, serotonin activity is higher in NET patients with MCS than in those that do not present the syndrome [3]. In fact, not too long ago a case report has been published about an older woman who manifested MCS because of a serotonin-secreting pituitary tumor [7]. Serotonin has been shown to induce cardiac valve lesions and heart failure is the main cause of premature death in MCS patients. Although serotonin release has also been related to MCS-associated diarrhea, tachykinins may significantly contribute to it [8]. Serotonin and tachykinins are also implied in bronchoconstriction [5]. Flushing, in contrast, is primarily mediated by histamine. Therefore, histamine-producing stomach carcinoids may mimic an incomplete MCS.

MCS patients should avoid situations or drugs that may contribute to increased serotonin activity. Both physical and psychological stress, as well as monoamine oxidase inhibitors and selective serotonin reuptake inhibitors, should be avoided [13].

Carcinoid, carcinoid tumor and neuroendocrine tumor (NET) are all medical termini referring to neoplasms originating from the neuroendocrine system. The vast majority of NET are located in the gastrointestinal tract, mainly in ileum and cecum, but such tumors may also be encountered in more proximal or distal parts of the digestive tract, in pancreas or lungs.

Most NET are functionally active, i.e., they produce hormones and hormone-like substances that may be released into circulation. Biogenic amines serotonin and histamine, as well as kinins, shall be mentioned as examples, but individual NET may differ largely regarding their secretory profiles. If the aforementioned mediators reach the bloodstream, they may exert distinct effects in peripheral organs, namely in the cardiovascular system, in the respiratory tract or in the gastrointestinal tract. This results in flushing, cardiac insufficiency, bronchoconstriction, and diarrhea, respectively. The entirety of these symptoms is known as carcinoid syndrome.

NET may be benign or malignant neoplasms. It has generally been assumed that NET who measure less than a centimeter in diameter are most likely benign; they have rarely been shown to grow invasively and spread lymphogenically or hematogenously. However, this hypothesis has recently been challenged [1]. Retrospective studies have shown that 12% of small NET metastasize, mainly into local lymph nodes. The share of malignant tumors is even greater among NET measuring more than a centimeter in diameter.

According to current knowledge, carcinoid syndrome preferentially occurs in patients suffering from malignant NET, which is why this symptom complex is also designated as malignant carcinoid syndrome (MCS). Strictly speaking, MCS can only be diagnosed in patients who have previously been shown to suffer from malignant NET, which is most commonly achieved by demonstrating the existence of hepatic metastases [2] [3]. Carcinoid syndrome in patients diagnosed with non-metastatic or benign NET is rare.

Ideally, gastrointestinal primary tumors and all metastases are surgically removed - if this can be achieved, complete cure of NET and MCS is possible. MCS itself is treated with medication that counteracts the effects of serotonin, histamine and possibly other mediators released by tumor metastases. Additionally, symptomatic treatment may be indicated to relieve cardiac disorders and diarrhea.

Carcinoid, carcinoid tumor and neuroendocrine tumor (NET) are all medical termini referring to neoplasms originating from hormone-producing cells located in distinct organs. Many NET develop in the gastrointestinal tract, and they may be either of benign nature or malignant.

NET often produce hormones and hormone-like substances themselves, in an uncontrolled manner. As long as the tumor does not spread from the intestines to other tissues, these substances are transported to the liver and degraded there before they can reach peripheral organs. However, malignant NET tend to spread to regional lymph nodes and the liver. Functionally active tumors may now release serotonin, histamine and a variety of other compounds that are directly secreted into the circulation. They easily reach the cardiovascular system, the bronchial tubes or different parts of the digestive tract. Here, they mediate flushing, cardiac insufficiency, bronchoconstriction, and diarrhea, respectively. The entirety of these symptoms is known as malignant carcinoid syndrome (MCS).

MCS may only be diagnosed in patients who have previously been found to suffer from NET. But because NET are generally very slow growing tumors, they may not cause symptoms for years, and MCS may be the first manifestation of this pathology. Thus, diagnostic imaging, localization of primary tumor and metastases, along with laboratory analyses of blood samples is applied to assess the dissemination of tumor cells and to identify those hormone-like substances that cause complaints.

Treatment consists in surgical resection of the primary tumor and all metastases as well as reduction of serotonin- and histamine-mediated effects. Life quality and life expectancy can be significantly improved by these measures; if all tumors can be resected, complete cure is possible.

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