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Malignant Hepatic Neoplasm


Presentation

  • Pathology of Liver Diseases is a rapid reference consultation tool that uses both book and online material to present a whole range of liver disorders.[books.google.com]
  • The patient presented the following health conditions: Hepatic Neoplasm Malignant . Urso 250 dosage: 600mg, Oral.[patientsville.com]
  • HCC presents a variable appearance at CT and MRI.[rb.org.br]
  • May present with severe, acute abdominal pain with bleeding into the abdomen, leading to shock. Other rare presentations include obstructive jaundice.[patient.info]
  • Fibro-Lamellar CarcinomaFibro-Lamellar Carcinoma Presents in young pt (5-35)Presents in young pt (5-35) Not related to cirrhosisNot related to cirrhosis AFP is normalAFP is normal CT shows typical stellate scar with radialCT shows typical stellate scar[slideshare.net]
Fatigue
  • Side effects of sorafenib (Nexavar) include fatigue, rash, high blood pressure, sores on the hands and feet, and loss of appetite.[medicinenet.com]
  • Patients may experience nausea, vomiting, and fatigue. Chemotherapy: Medications are injected into the liver to kill cancer cells.[medicalnewstoday.com]
  • When signs and symptoms do appear, they may include: Losing weight without trying Loss of appetite Upper abdominal pain Nausea and vomiting General weakness and fatigue Abdominal swelling Yellow discoloration of your skin and the whites of your eyes ([mayoclinic.org]
  • […] appear in a patient with liver cancer are a loss of appetite, weight loss, right upper quadrant abdominal pain (which may extend into the back and right shoulder blade), bleeding or bruising that occurs easily, nausea and vomiting, general weakness and fatigue[fortherecordmag.com]
  • The side effects of a hepatectomy may include pain, weakness, fatigue, and temporary liver failure. The health care team will watch for signs of bleeding, infection, liver failure, or other problems that need immediate treatment.[cancer.net]
Noncompliance
  • […] effects in 21 year old male Reported by a individual with unspecified qualification from France on 2011-12-21 Patient: 21 year old male Reactions: Hepatic Neoplasm Malignant, Haemorrhage, Amino Acid Level Increased, Succinylacetone Increased, Treatment Noncompliance[druglib.com]
Malignant Pleural Effusion
  • Soon after starting Urso 250 treatment, the consumer experienced several side effects, including: Hepatic Neoplasm Malignant Pleural Effusion Ascites Alopecia .[patientsville.com]
Abdominal Pain
  • Hepatic cysts (large) Abdominal pain or fullness A palpable mass Testing for benign liver masses Differentiating benign liver lesions from cancers can sometimes be done by radiologic imaging studies alone.[upmc.com]
  • May present with severe, acute abdominal pain with bleeding into the abdomen, leading to shock. Other rare presentations include obstructive jaundice.[patient.info]
  • Abdominal pain can have many sources including but not limited to dyspepsia, peptic ulcer disease, inflammatory bowel disease, and irritable bowel disease.[clinicaladvisor.com]
  • The patient developed the following symptoms/conditions: aspartate aminotransferase increased , musculoskeletal pain ,decreased appetite,prophylaxis,abdominal pain upper,hepatitis and was treated with Ursodeoxycholic Acid (dosage: 10 Mg, 3x/day) starting[patientsville.com]
  • Complications of embolization include fever, abdominal pain, nausea, and vomiting. Radiation therapy : Radiation uses high-energy rays directed to the cancer to kill cancer cells. Normal liver cells are also very sensitive to radiation.[medicinenet.com]
Nausea
  • The patient presented the following health conditions: Liver Disorder Rash Hepatic Neoplasm Malignant Nausea . Urso 250 dosage: Since Before Administration.[patientsville.com]
  • Complications of chemotherapy include fatigue, easy bruising, hair loss, nausea and vomiting, swollen legs, diarrhea, and mouth sores. These side effects are usually temporary.[medicinenet.com]
  • Patients may experience nausea, vomiting, and fatigue. Chemotherapy: Medications are injected into the liver to kill cancer cells.[medicalnewstoday.com]
  • When signs and symptoms do appear, they may include: Losing weight without trying Loss of appetite Upper abdominal pain Nausea and vomiting General weakness and fatigue Abdominal swelling Yellow discoloration of your skin and the whites of your eyes ([mayoclinic.org]
  • Symptoms Common signs and symptoms that may appear in a patient with liver cancer are a loss of appetite, weight loss, right upper quadrant abdominal pain (which may extend into the back and right shoulder blade), bleeding or bruising that occurs easily, nausea[fortherecordmag.com]
Acute Abdomen
  • abdomen and new material on CT and MR angiography, lung cancer screening, pulmonary embolism, coronary artery calcium screening, and interventional CT techniques including radiofrequency ablation and CT fluoroscopy.[books.google.com]
Musculoskeletal Pain
  • The patient developed the following symptoms/conditions: aspartate aminotransferase increased , musculoskeletal pain ,decreased appetite,prophylaxis,abdominal pain upper,hepatitis and was treated with Ursodeoxycholic Acid (dosage: 10 Mg, 3x/day) starting[patientsville.com]
Yellow Discoloration of the Skin
  • When signs and symptoms do appear, they may include: Losing weight without trying Loss of appetite Upper abdominal pain Nausea and vomiting General weakness and fatigue Abdominal swelling Yellow discoloration of your skin and the whites of your eyes ([mayoclinic.org]
Cognitive Disorder
  • Disorder, Treatment Noncompliance Drug(s) suspected as cause: Orfadin Other drugs received by patient: Vitamin D (Vitamin D) (Solution FOR Injection); Vitamin K (Vitamin K) (Solution FOR Injection) Possible Orfadin side effects in 19 year old male Reported[druglib.com]

Workup

Hypertriglyceridemia
  • These lesions are associated with obesity, diabetes mellitus, hypertriglyceridemia, alcoholism, AIDS, TPN, steroids, chemotherapy, and malnutrition. On ultrasound, the fatty areas are hyperechoic and ill defined.[clinicaladvisor.com]

Treatment

  • The patient presented with: Hepatic Neoplasm Malignant Off Label Use which developed after the beginning of treatment.[patientsville.com]
  • TAB; Vitamin D Possible Orfadin side effects in 21 year old male Reported by a health professional (non-physician/pharmacist) from France on 2011-12-20 Patient: 21 year old male Reactions: Haemorrhage, Hepatic Neoplasm Malignant, Cognitive Disorder, Treatment[druglib.com]
  • Doctors want to learn whether the new treatment is safe, effective, and possibly better than the standard treatment. Clinical trials can test a new drug, a new combination of standard treatments, or new doses of standard drugs or other treatments.[cancer.net]
  • When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial.[cancer.gov]
  • What is the medical treatment for liver cancer? The medical treatment chosen depends upon how much the cancer has spread and the general health of the liver.[medicinenet.com]

Prognosis

  • The TNM system may predict prognosis better than other systems for patients who are having tumor resection (and possibly transplantation ), whereas the Barcelona system may predict prognosis better for patients who are not having surgery(for more information[merckmanuals.com]
  • Patients with compensated liver cirrhosis, whose prognosis is mostly determined by the cancer, should be considered for antitumour treatment.[esmoopen.bmj.com]
  • Prognosis of liver cancer Prognosis means the expected outcome of a disease. An individual's prognosis depends on the type and stage of cancer, as well as their age and general health at the time of diagnosis.[cancer.org.au]
  • (ACS, Cancer Facts & Figures 2012) Prognosis The prognosis of patients is clearly related to the depth of tumour invasion in the intestinal wall, the number of regional lymph nodes involved, and the presence or absence of distant metastases, as defined[bead.btg-im.com]
  • Most often these subtypes do not affect treatment or prognosis (outlook). But one of these subtypes, fibrolamellar, is important to recognize. It is rare, making up less than 1% of HCCs and is most often seen in women younger than age 35.[cancer.org]

Etiology

  • The book emphasizes not only the pathology seen in biopsy and surgical material, but also the most pertinent clinical and laboratory findings including epidemiology, etiologic and pathophysiologic concepts, and the differential diagnoses.[books.google.com]
  • The median survival is approximately 6 months, with 5-year survival of 29 Etiology Possible etiologic factors are much less well established than for HCC, and most cases have no known etiology, but it is clear that disorders that cause chronic inflammation[nature.com]
  • Etiology Hepatocellular carcinoma is usually a complication of cirrhosis . The presence of HBV increases risk of hepatocellular carcinoma by 100-fold among HBV carriers.[merckmanuals.com]
  • The combination of findings from different sequences often helps pinpoint the etiology of a liver mass.[appliedradiology.com]
  • No definite underlying etiologic factors are known, and the tumor is not associated with cirrhosis, although thorotrast associated lesions and an AIDS-related case in a young girl have been reported 11, 13 ).[kjim.org]

Epidemiology

  • The book emphasizes not only the pathology seen in biopsy and surgical material, but also the most pertinent clinical and laboratory findings including epidemiology, etiologic and pathophysiologic concepts, and the differential diagnoses.[books.google.com]
  • Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors. Clin Colon Rectal Surg. 2009 November; 22(4): 191–197.[bead.btg-im.com]
  • "Hepatocellular carcinoma: epidemiology and molecular carcinogenesis". Gastroenterology. 132 (7): 2557–76. doi : 10.1053/j.gastro.2007.04.061. PMID 17570226. Khan, SA; Toledano, MB; Taylor-Robinson, SD (2008).[en.wikipedia.org]
  • American journal of epidemiology, 155(4): 323-31 [ CR ] [ PM ] [ EČ ][ GS ] Fan, Z., Rijn, M., Montgomery, K., Rouse, R.V. (2003) Hep par 1 antibody stain for the differential diagnosis of hepatocellular carcinoma: 676 tumors tested using tissue microarrays[scindeks.ceon.rs]
  • The Evolving epidemiology of hepatocellular carcinoma: a global perspec- tive. Expert Rev Gastroenterol Hepatol. 2015;1:1-15. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011;61:69.[revistagastrocol.com]
Sex distribution
Age distribution

Pathophysiology

  • The book emphasizes not only the pathology seen in biopsy and surgical material, but also the most pertinent clinical and laboratory findings including epidemiology, etiologic and pathophysiologic concepts, and the differential diagnoses.[books.google.com]

Prevention

  • Abuse and Neglect in Healthcare 2.00 ADD COURSE Preventing Allergic Reactions to Natural Rubber Latex in the Workplace 2.00 ADD COURSE Preventing Needlestick Injuries in Health Care Settings 2.00 ADD COURSE Prevention of Hepatitis A Through Active or[ceuprofessoronline.com]
  • News View all News Emory Healthcare news from the Emory News Center News Emory Genetics Metabolic Nutrition Program launches new website for Medical Nutrition Therapy for Prevention Program March 14, 2018 News Emory Healthcare is the official healthcare[emoryhealthcare.org]
  • : Hepatitis vaccination recommended in childhood fpr preventing HBV infection, cirrhosis, HCC, liver failure, and death.[medbullets.com]
  • These tumour markers are found in primary liver cancers, as well as in other cancers and certain other disorders. [34] [35] Prevention [ edit ] Prevention of cancers can be separated into primary, secondary, and tertiary prevention.[en.wikipedia.org]
  • When doctors discover a large adenoma, they may recommend that it be surgically removed to prevent that possibility.[liverfoundation.org]

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