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Malignant Mesonephroma of the Ovary

Malignant Mesonephroma of Ovary


Presentation

  • Modern Surgical Pathology, 2nd Edition presents today's most complete, current, and practical assistance in evaluating and signing out surgical specimens.[books.google.de]
  • Ascites without peritoneal tumor was present at operation.[documents.tips]
  • Case 3 A 48 years old, P5L5, postmenopausal since 9 months, a known case of carcinoma ovary presented with abdominal pain since 15 days.[casereports.in]
  • A 7-year-old female child was presented to the emergency room with acute abdominal pain and vaginal bleeding.[pubfacts.com]
  • In some cases, glandular spaces containing mucin are present.[clinicalgate.com]
Surgical Procedure
  • Unilateral salpingo-oophorectomy is the recommended surgical procedure. Although these tumors are highly malignant, cisplatin-based combination chemotherapy has resulted in some long-term survivors.[clinicalgate.com]
  • A second surgical procedure may be required, depending on the tumor type and histologic grade. The approach to extend surgical staging in children is controversial.[glowm.com]
  • procedure to inspect the abdomen is required.[en.wikipedia.org]
Pathologist
  • Edited by four leading surgical pathologists - Noel Weidner, MD, Richard J. Cote, MD, Saul Suster, MD and Lawrence M.[books.google.de]
  • Abstract Gonadal germ cell tumors continue to be the cause of diverse, diagnostically challenging issues for the pathologist, and their correct resolution often has major important therapeutic and prognostic implications.[nature.com]
Physician
  • Last Revised: 02/06/2014 a b c Society of Gynecologic Oncology (February 2014), "Five Things Physicians and Patients Should Question" , Choosing Wisely : an initiative of the ABIM Foundation , Society of Gynecologic Oncology, archived from the original[en.wikipedia.org]
  • (ICON-3), was conducted as 4 parallel trials across 130 centers in eight countries in Europe to compare carboplatin (AUC 5) and paclitaxel (175 mg/M2 over 3 h) to regimens that did not contain paclitaxel. 262 Prior to randomization, each patient and physician[ncbi.nlm.nih.gov]
Splenectomy
  • Depending on the extent of the cancer, procedures may include a bilateral salpingo-oophorectomy, biopsies throughout the peritoneum and abdominal lymphatic system, omentectomy , splenectomy , bowel resection , diaphragm stripping or resection , appendectomy[en.wikipedia.org]
Disability
  • "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015" .[en.wikipedia.org]
Pleural Effusion
  • effusion , and mucositis .[en.wikipedia.org]
  • Pleural effusion may lead to dyspnea as the first complaint. Acute symptoms, such as those of adnexal rupture or torsion, are uncommon.[ncbi.nlm.nih.gov]
  • A chest radiograph may show a pleural effusion consistent with Demons-Meigs syndrome or pulmonary metastasis. Intravenous pyelography and barium enema rule out intrinsic urinary or gastrointestinal tract pathology.[glowm.com]
Nausea
  • Symptoms may include a heavy feeling in the pelvis pain in the lower abdomen bleeding from the vagina weight gain or loss abnormal periods unexplained back pain that gets worse gas, nausea, vomiting, or loss of appetite to diagnose ovarian cancer, doctors[icd10data.com]
  • Of mature teratomas, 30% are detected by acute onset of abdominal pain, often accompanied by nausea; vomiting; and radiation of pain to the groin, lower extremity, or costovertebral areas—all of which are subsequent to torsion. 10, 11, 23 Isosexual precocious[glowm.com]
  • […] bloating , abdominal or pelvic pain or discomfort, back pain, irregular menstruation or postmenopausal vaginal bleeding, pain or bleeding after or during sexual intercourse , loss of appetite , fatigue , diarrhea , indigestion , heartburn , constipation , nausea[en.wikipedia.org]
  • By the early 1990s a combination of carboplatin and cyclophosphamide was found to be as effective as cisplatin and cyclophosphamide, but substantially less toxic, with less nausea, renal toxicity and neurotoxicity.[ncbi.nlm.nih.gov]
Constipation
  • A 15-year-old girl was referred to our department because of persistent constipation and abdominal distension.[pubfacts.com]
  • […] include bloating , abdominal or pelvic pain or discomfort, back pain, irregular menstruation or postmenopausal vaginal bleeding, pain or bleeding after or during sexual intercourse , loss of appetite , fatigue , diarrhea , indigestion , heartburn , constipation[en.wikipedia.org]
Lower Abdominal Pain
  • The average patient age is 22 years. 23 Most patients present with a rapidly growing abdominal mass that often causes lower abdominal pain or pressure and may simulate pregnancy.[clinicalgate.com]
Severe Abdominal Pain
  • Other common symptoms include hirsutism , abdominal pain, virilization , and an adnexal mass . [22] Children [ edit ] In adolescents or children with ovarian tumors, symptoms can include severe abdominal pain, irritation of the peritoneum , or bleeding[en.wikipedia.org]
Diarrhea
  • PI3 kinase inhibitors have been of interest, but they tend to be highly toxic and cause diarrhea . Another investigated drug is selumetinib , a MAPK inhibitor.[en.wikipedia.org]
Bone Pain
  • ; pain, fever, and leukocytosis are prominent symptoms exenteration process of removing a tumor together with the organ from which it originated and all surrounding tissue in the body space fibromatosis the formation of a fibrous, tumor-like nodule arising[quia.com]
Adnexal Mass
  • Página 406 - Goldstein SR, Subramanyam B, Snyder JR et al: The postmenopausal cystic adnexal mass, the potential role of ultrasound in conservative management. Obstet Gynaecol 73:8, 1989. ‎ Página 46 - Kelly, SJ (1977).[books.google.es]
  • "The adnexal mass and the early ovarian cancer " Clin Gynecol Oncol, 3rd ed. , 316-317, 1989 6. Disaia, , Creaseman, W . "Cancer in pregnancy" Clin Gynecol Oncol, 3rd ed , 523-528, 1989 7. Desaia, , Creaseman, W .[herdin.ph]
  • mass is a significant finding that often indicates ovarian cancer, especially if it is fixed, nodular, irregular, solid, and/or bilateral. 13–21% of adnexal masses are caused by malignancy; however, there are other benign causes of adnexal masses, including[en.wikipedia.org]
  • Elevated CA125 levels are most frequently associated with malignant adnexal masses in postmenopausal women. In women over 50 years of age whose serum CA125 level is greater than 35 U/mL the adnexal mass is malignant in about 80% of cases.[ncbi.nlm.nih.gov]

Workup

  • […] to determine the extent of its spread (which is a form of tumor staging ). [16] Risk scoring [ edit ] A widely recognized method of estimating the risk of malignant ovarian cancer is the risk of malignancy index (RMI), calculated based on an initial workup[en.wikipedia.org]
Ovarian Mass
  • Exploratory laprotomy with debulking of ovarian mass with hysterectomy with omentectomy with bilateral pelvic lymph node dissection was done.[casereports.in]
  • Ultrasound examination revealed a right-sided ovarian mass with multiple omental deposits and liver metastases.[jpma.org.pk]
  • Ovarian Gcts : Represent 30% of GCTs and 70% of neoplastic ovarian masses, being the most common ovarian neoplasms in children and teenagers. Read More Neo-adjuvant chemotherapy in the treatment of advanced malignant germ cell tumors of ovary.[pubfacts.com]
  • About 20% to 30% of ovarian masses found in postmenopausal women are malignant, whereas only 7% of ovarian masses in premenopausal women are malignant.[ncbi.nlm.nih.gov]
  • This helps to determine if an ovarian mass is benign or malignant. [16] Ovarian cancer's early stages (I/II) are difficult to diagnose because most symptoms are nonspecific and thus of little use in diagnosis; as a result, it is rarely diagnosed until[en.wikipedia.org]
Pleural Effusion
  • effusion , and mucositis .[en.wikipedia.org]
  • Pleural effusion may lead to dyspnea as the first complaint. Acute symptoms, such as those of adnexal rupture or torsion, are uncommon.[ncbi.nlm.nih.gov]
  • A chest radiograph may show a pleural effusion consistent with Demons-Meigs syndrome or pulmonary metastasis. Intravenous pyelography and barium enema rule out intrinsic urinary or gastrointestinal tract pathology.[glowm.com]

Treatment

  • There is no agreement as to how to treat an ovarian neoplasm; by surgery alone, or, by using radiation and chemotherapy as a complement to the operative treatment.[books.google.de]
  • "Treatment of malignant ovarian germ cell tumor" Cancer 42, 390, 1978 27. Slayton, et al. "Vincristine, dactinomycin, and cylosphamide in the treatment of malignant germ cell tumors of the ovary" Cancer 56, 243-248, 1985 28.[herdin.ph]
  • Treatment Unilateral salpingo-oophorectomy is the treatment of choice for sex-cord stromal tumors.[glowm.com]
  • Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. ‎[books.google.es]

Prognosis

  • Clear cell epithelial ovarian cancer (mesonephroid): bad prognosis only in early stages. Gynecol Oncol.1993;49:250-254. Sugawa T, Umesaki N, Yajima A, Satoh S, Terashima Y, Ochiai K, et al. A group study on prognosis of ovarian cancer.[casereports.in]
  • The prognosis is stage dependent 1 Tavassoli FA, Devilee P (Eds.) World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. 3rd Edition IARC Press: Lyon 2003.[codes.iarc.fr]
  • It seems that the site of origin of ovarian carcinoma is an important factor in the prognosis. Factors influencing the prognosis of ovarian carcinoma are protean and have been studied extensively by several authors.[docslide.com.br]
  • The prognosis for the sex-cord stromal tumors is generally excellent.[glowm.com]
  • Treatment and Prognosis The treatment of patients with dysgerminoma is primarily surgical, including the resection of the ovarian tumor and complete surgical staging.[clinicalgate.com]

Etiology

  • ICD-10-CM Codes › C00-D49 Neoplasms › C51-C58 Malignant neoplasms of female genital organs › Use Additional Use Additional Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10data.com]
  • […] predominate hemangioblastoma a capillary hemanioma of the brain consisting of proliferated blood vessel cells or angioblasts hepatocellular carcinoma a malignant tumor of the liver hepatoma a tumor of the liver Hodgkin's disease a disease of unknown etiology[quia.com]
  • ETIOLOGIC FACTORS T h e age distribution of the patients (Table 1) was similar to that of the solid and papil- lary ovarian carcinomas and older than that of the embryonal carcinomas of the ovary.5f8 T h e youngest patient was 30 years of age and the[documents.tips]
  • Etiology and Epidemiology The cause of ovarian cancer is unknown. 5 Some have speculated that an etiologic agent or a potentiator of oncogenesis could enter the peritoneal cavity through the lower genital canal and spread through the uterus and the fallopian[ncbi.nlm.nih.gov]

Epidemiology

  • Epidemiologic studies suggest that ovulation is an important co-factor in the development of ovarian cancer.[ncbi.nlm.nih.gov]
  • Epidemiologic pathology of ovarian tumors: a histopathologic review of primary ovarian neoplasms diagnosed in the Denver standard metropolitan statistical area, 1 July–31 December 1969 and 1 July–31 December 1979.[nature.com]
  • "Age at menarche and risk of ovarian cancer: a meta-analysis of epidemiological studies" . International Journal of Cancer . 132 (12): 2894–2900. doi : 10.1002/ijc.27952 . ISSN 0020-7136 . PMC 3806278 . PMID 23175139 . Manson JE, Bassuk SS (2012).[en.wikipedia.org]
Sex distribution
Age distribution

Pathophysiology

  • […] though research is still ongoing in this area. [24] Higher caffeine intake and consumption of more than two cups of tea a day have both been associated with lower ovarian cancer risk. [21] Smoking tobacco is protective for sex cord-stromal tumors. [22] Pathophysiology[en.wikipedia.org]

Prevention

  • A laparotomy was planned for her as the pelvic mass was preventing the descent of fetal head thus hindering vaginal delivery. Biopsy from the tumor mass revealed yolk sac tumor of the ovary.[ijrcog.org]
  • Archived from the original on 2016-09-19. a b c d "Ovarian Cancer Prevention (PDQ )" . NCI . December 6, 2013. Archived from the original on 6 July 2014 . Retrieved 1 July 2014 . a b c "Ovarian Cancer Prevention (PDQ )" . NCI . 2014-06-20.[en.wikipedia.org]
  • Benefits would decrease if institution of these preventive measures were delayed beyond age 30.[ncbi.nlm.nih.gov]
  • Adjuvant chemotherapy will almost always prevent relapse in patients with germ cell tumors other than dysgerminoma; data are limited in dysgerminoma but are equally favorable.[glowm.com]
  • […] monomorphic, making them apt to be mistaken for usual seminoma or embryonal carcinoma, although the characteristic polymorphic appearance in some foci, absence of intratubular germ cell neoplasia, unclassified type, and immunohistochemical stains should prevent[nature.com]

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