Presentation
CASE PRESENTATION: We present here a case of primary actinomycosis of the parotid gland presenting with a parotid mass lesion with erosion of skull bones. [ncbi.nlm.nih.gov]
The data presented in the Global Cancer Observatory are the best available for each country worldwide. [globocan.iarc.fr]
An inflammatory component is present also in the microenvironment of tumours that are not epidemiologically related to inflammation. [doi.org]
Immune System
- Splenomegaly
FL is characterized by diffuse lymphoadenopathy, involvement of bone marrow, splenomegaly, and less commonly other extranodal sites of involvement. [doi.org]
Entire Body System
- Pain
Although rare, myositis ossificans is one of the potential causes of painful swelling in the chest wall, and can be mistaken for a malignant neoplasm. [ncbi.nlm.nih.gov]
Coughing, chest pain and breathlessness Visit your GP if you've had a cough for more than 3 weeks. Symptoms such as shortness of breath or chest pain may be a sign of a severe (acute) condition, such as pneumonia. [nhs.uk]
Symptoms of prostate cancer may include Problems passing urine, such as pain, difficulty starting or stopping the stream, or dribbling Low back pain Pain with ejaculation To diagnose prostate cancer, you doctor may do a digital rectal exam to feel the [icdlist.com]
In case if the tumor has spread to other parts of the body then the following symptoms may be experienced by the individual: Low back pain or pain in the pelvis to bone metastasis Abdominal pain and jaundice due to liver metastasis Persistent coughing [epainassist.com]
Symptoms may include a heavy feeling in the pelvis pain in the lower abdomen bleeding from the vagina weight gain or loss abnormal periods unexplained back pain that gets worse gas, nausea, vomiting, or loss of appetite to diagnose ovarian cancer, doctors [icd10data.com]
- Fatigue
Global quality of life, functioning domains and symptom scores - such as appetite loss, fatigue and pain - were the most important indicators, individually or in combination, for predicting survival times in cancer patients after adjusting for one or [ncbi.nlm.nih.gov]
Fatigue (7.8% v 3.3%), ataxia (11.1% v 3.3%), and neurosensory events (8.9% v 0%) were greater in the maintenance arm. There were three grade 5 events in each arm. [doi.org]
Diarrhea or constipation A feeling that your bowel does not empty completely Blood (either bright red or very dark) in your stool Stools that are narrower than usual Frequent gas pains or cramps, or feeling full or bloated Weight loss with no known reason Fatigue [icdlist.com]
CAR T-Cell-Related Toxicities Prevention and Treatment of Cancer-Related Infections Survivorship NCCN Guidelines Late Effects/Long-Term Psychosocial and Physical Problems Anthracycline-Induced Cardiac Toxicity Anxiety and Depression Cognitive Function Fatigue [nccn.org]
- Weight Loss
[…] with that in women who do not take part in the weight loss program. [cancer.gov]
Unexplained weight loss You should also see your GP if you've lost a lot of weight over the last couple of months that can't be explained by changes to your diet, exercise or stress. Read about unintentional weight loss. [nhs.uk]
Intestinal obstruction, weight loss, and, in two patients, rectal bleeding with radiologic evidence of a mass lesion that involved the rectosigmoid were present at initial evaluation. [ncbi.nlm.nih.gov]
- Fever
Symptoms may include pain on one side of the back, blood in the urine, high blood pressure, and fever. Diagnosis is carried out through blood tests, IVP, ultrasound, urine tests, selective renal arteriography, CT scan, kindey scan and MRI. [ugr.es]
[…] under their individual headings, e.g. pharyngeal, adenocarcinoma. benign neoplasm a neoplasm having none of the characteristics of a malignant neoplasm (see below), i.e. it grows slowly, expands without metastasis, and usually does not recur. neoplasm fever [medical-dictionary.thefreedictionary.com]
Common initial symptoms of infection including pain, fever, erythema, oedema, and suppuration may be absent [ 5 ]. Histopathological feature are similar to that of chronic inflammatory disease. [bmccancer.biomedcentral.com]
Other symptoms may include fatigue, fever, weight loss and anemia. Additionally, the presence of a painless lump which could eventually become sore or painful is something that an oncologist should check. [sarcomaoncology.com]
- Weight Gain
Does avoiding weight gain or losing weight decrease the risk of cancer? Most of the data about whether avoiding weight gain or losing weight reduces cancer risk comes from cohort and case-control studies. [cancer.gov]
Symptoms may include a heavy feeling in the pelvis pain in the lower abdomen bleeding from the vagina weight gain or loss abnormal periods unexplained back pain that gets worse gas, nausea, vomiting, or loss of appetite to diagnose ovarian cancer, doctors [icd10data.com]
Forgetfulness 0.99 0.98 0.85 Gastrointestinal 0.11 0.11 0.86 Musculoskeletal 1.10 1.15 0.002 Dyspareunia 0.68 0.78 Weight gain 0.76 0.82 Vasomotor 0.96 0.85 Bladder 0.88 0.73 Leg cramps 1.10 0.91 Gynecological 0.29 0.19 Table 3. [doi.org]
Respiratoric
- Cough
Coughing, chest pain and breathlessness Visit your GP if you've had a cough for more than 3 weeks. Symptoms such as shortness of breath or chest pain may be a sign of a severe (acute) condition, such as pneumonia. [nhs.uk]
In late stages, when the cancer cells have spread or metastasized to other body parts, these symptoms may include: Low back or pelvic pain – due to bone metastasis Abdominal pain and yellowing of skin – due to liver metastasis Coughing and chest pain [healthguideinfo.com]
- Pleural Effusion
Pleural effusion Fluid accumulates in the bag like structure around the lungs (pleural sac), causing shortness of breath. [msdmanuals.com]
Maribel Botana-Rial, Loretta De Chiara, Diana Valverde, Virginia Leiro-Fernández, Cristina Represas-Represas, Victor del Campo-Pérez and Alberto Fernández-Villar, Prognostic value of aberrant hypermethylation in pleural effusion of lung adenocarcinoma [doi.org]
Similar mechanisms may also operate in the generation of pleural effusions often seen in breast cancer patients or ascites in patients with PDAC [ 49 ]. [biosignaling.com]
- Dyspnea
PATIENTS AND METHODS: A 10-year-old girl presented with dyspnea 5 years after the diagnosis of stage III favorable histology Wilms' tumor and was found to have a right intrathoracic mass arising from the eighth and ninth ribs. [ncbi.nlm.nih.gov]
In rare cases such as ours, however, they present with paresthesia of the arm, mild dyspnea and lung dysfunction. 3,4 Peripheral pulmonary lipomas are indistinguishable from malignant tumors on chest X-ray. [archbronconeumol.org]
Maisey et al. [ 73 ] 2002 501 locally advanced and metastatic colorectal EORTC QLQ-C30 Baseline physical, role, social, emotional functioning, global QOL and pain, nausea, dyspnea, and sleep difficulties were strong independent predictors of survival. [doi.org]
- Sore Throat
Change in bowel or bladder habits A sore throat that does not heal Unusual bleeding or discharge (for example, nipple secretions or a "sore" that will not heal that oozes material) Thickening or lump in the breast, testicles, or elsewhere Indigestion [medicinenet.com]
- Hoarseness
"sore" that will not heal that oozes material) Thickening or lump in the breast, testicles, or elsewhere Indigestion (usually chronic) or difficulty swallowing Obvious change in the size, color, shape, or thickness of a wart or mole Nagging cough or hoarseness [medicinenet.com]
Gastrointestinal
- Nausea
Dogs handle these treatments well. 95% of Boxer dog do not suffer through severe nausea, diarrhea or a drop in blood counts that must lead to a hospital stay. [allboxerinfo.com]
Many different symptoms can occur, including confusion, drowsiness, agitation, headaches, abnormal vision, abnormal sensations, weakness, nausea, vomiting, and seizures. [msdmanuals.com]
Symptoms may include a heavy feeling in the pelvis pain in the lower abdomen bleeding from the vagina weight gain or loss abnormal periods unexplained back pain that gets worse gas, nausea, vomiting, or loss of appetite to diagnose ovarian cancer, doctors [icd10data.com]
[…] constipation A feeling that your bowel does not empty completely Blood (either bright red or very dark) in your stool Stools that are narrower than usual Frequent gas pains or cramps, or feeling full or bloated Weight loss with no known reason Fatigue Nausea [icdlist.com]
- Loss of Appetite
Symptoms may include a heavy feeling in the pelvis pain in the lower abdomen bleeding from the vagina weight gain or loss abnormal periods unexplained back pain that gets worse gas, nausea, vomiting, or loss of appetite to diagnose ovarian cancer, doctors [icd10data.com]
These include the following: Unexplained loss of weight or loss of appetite A new type of pain in the bones or other parts of the body that may be steadily worsening, or come and go, but is unlike previous pains one has had before Persistent fatigue, [medicinenet.com]
It may appear with loss of appetite (anorexia) and weight loss. It is likely that a chemical mediator called tumour necrosis factor-alpha is one of the multiple molecules that bring about wasting effects. [britannica.com]
In addition, most studies have shown that pain and appetite loss are independent determinants of overall survival. [doi.org]
- Rectal Bleeding
Intestinal obstruction, weight loss, and, in two patients, rectal bleeding with radiologic evidence of a mass lesion that involved the rectosigmoid were present at initial evaluation. [ncbi.nlm.nih.gov]
FJP, also described in the literature as juvenile polyposis, is characterized by multiple inflammatory polyps throughout the colon that are associated with painless rectal bleeding (rare serious hemorrhage), rectal prolapse, and failure to thrive. [emedicine.medscape.com]
Ulceration can cause bleeding that, if it occurs in the lung, will lead to coughing up blood, in the bowels to anemia or rectal bleeding, in the bladder to blood in the urine and in the uterus to vaginal bleeding. [en.wikipedia.org]
- Dysphagia
In this report, we describe a patient with acute dysphagia in whom a lower esophageal mass was detected radiographically. [ncbi.nlm.nih.gov]
Efficace et al. [ 41 ] 2006 391 advanced non-small-cell lung cancer EORTC QLQ-C30 + EORTC QLQ-LC13 Pain, and dysphagia were significant prognostic factors for survival. [doi.org]
- Failure to Thrive
FJP, also described in the literature as juvenile polyposis, is characterized by multiple inflammatory polyps throughout the colon that are associated with painless rectal bleeding (rare serious hemorrhage), rectal prolapse, and failure to thrive. [emedicine.medscape.com]
Liver, Gall & Pancreas
- Jaundice
Some common signs of metastatic cancer include: Pain and fractures, when cancer has spread to the bone Headache, seizures, or dizziness, when cancer has spread to the brain Shortness of breath, when cancer has spread to the lung Jaundice or swelling in [cancer.gov]
In case if the tumor has spread to other parts of the body then the following symptoms may be experienced by the individual: Low back pain or pain in the pelvis to bone metastasis Abdominal pain and jaundice due to liver metastasis Persistent coughing [epainassist.com]
Jaw & Teeth
Cardiovascular
- Chest Pain
Coughing, chest pain and breathlessness Visit your GP if you've had a cough for more than 3 weeks. Symptoms such as shortness of breath or chest pain may be a sign of a severe (acute) condition, such as pneumonia. [nhs.uk]
pain. 5 Approximately 6 million patients are evaluated annually for chest pain in US emergency departments, and while only 15% to 25% are ultimately diagnosed with an acute coronary syndrome, depending on the setting, up to 72% will be admitted to the [jama.ama-assn.org]
In late stages, when the cancer cells have spread or metastasized to other body parts, these symptoms may include: Low back or pelvic pain – due to bone metastasis Abdominal pain and yellowing of skin – due to liver metastasis Coughing and chest pain [healthguideinfo.com]
- Hypertension
OBJECTIVES: To investigate the cause of reduced malignant neoplasm-related mortality in hypertensive outpatients. [ncbi.nlm.nih.gov]
Kentaro Takeshita, Satoru Takahashi, Mingxi Tang, Azman Seeni, Makoto Asamoto and Tomoyuki Shirai, Hypertension is positively associated with prostate cancer development in the TRAP transgenic rat model, Pathology International, 61, 4, (202-209), (2011 [doi.org]
The hormone is circulated in the bloodstream and acts at a distance from the tumour, stimulating the adrenal glands to oversecrete corticosteroids that in turn produces Cushing syndrome —characterized by such symptoms as muscle weakness, hypertension, [britannica.com]
Musculoskeletal
- Back Pain
Symptoms may include a heavy feeling in the pelvis pain in the lower abdomen bleeding from the vagina weight gain or loss abnormal periods unexplained back pain that gets worse gas, nausea, vomiting, or loss of appetite to diagnose ovarian cancer, doctors [icd10data.com]
These include: blood in the urine persistent back pain fatigue unexplained weight loss painful or frequent urination These symptoms are associated with malignant cancer of the ureter, but they’re also associated with other health conditions. [healthline.com]
In case if the tumor has spread to other parts of the body then the following symptoms may be experienced by the individual: Low back pain or pain in the pelvis to bone metastasis Abdominal pain and jaundice due to liver metastasis Persistent coughing [epainassist.com]
Symptoms of prostate cancer may include Problems passing urine, such as pain, difficulty starting or stopping the stream, or dribbling Low back pain Pain with ejaculation To diagnose prostate cancer, you doctor may do a digital rectal exam to feel the [icdlist.com]
- Arthralgia
Less common side effects included mild gastrointestinal symptoms, headaches, myalgia/arthralgia, and fatigue. [doi.org]
Muss, Randomized Controlled Trial of a Home‐Based Walking Program to Reduce Moderate to Severe Aromatase Inhibitor‐Associated Arthralgia in Breast Cancer Survivors, The Oncologist, 22, 10, (1238-1249), (2017). N. Weidner, J.P. Woods, P. Conlon, K.A. [dx.doi.org]
Skin
- Night Sweats
Some tumors can also cause fevers and night sweats. Many patients will not experience any symptoms, but will instead note a painless mass. Medical history and physical exam: Tell the doctor your complete medical history. [health.uconn.edu]
Breast
- Nipple Discharge
For example, breast cancer may present as a lump in the breast or as nipple discharge while metastatic breast cancer may present with symptoms of pain (if spread to bones), extreme fatigue ( lungs ), or seizures (brain). [medicinenet.com]
Neurologic
- Paresthesia
In rare cases such as ours, however, they present with paresthesia of the arm, mild dyspnea and lung dysfunction. 3,4 Peripheral pulmonary lipomas are indistinguishable from malignant tumors on chest X-ray. [archbronconeumol.org]
Visual disturbances and paresthesias are not uncommon. On occasion, malocclusive phenomenon occurs with a notable mass effect arising from the floor of the maxilla and hard palate. [emedicine.medscape.com]
- Peripheral Neuropathy
Notably, the clinical trial data used to establish guidelines for duration of first-line chemotherapy involve drugs such as mitomycin, taxanes, vinca alkaloids, and platinum drugs, all of which cause cumulative toxicity, including peripheral neuropathy [doi.org]
- Asthenia
Figures and Tables - Analysis 3.8 Comparison 3 5‐alpha‐reductase Inhibitors versus alpha‐blockers (24 to 52 weeks), Outcome 8 Asthenia. [doi.org]
Urogenital
- Urinary Retention
These outcomes included 1) change in urinary symptom scale scores (IPSS/AUA); 2) BPH progression; 3) development of acute urinary retention; and 4) need for interventions for treatment of LUTS. [doi.org]
Workup
Pleura
- Pleural Effusion
Pleural effusion Fluid accumulates in the bag like structure around the lungs (pleural sac), causing shortness of breath. [msdmanuals.com]
Maribel Botana-Rial, Loretta De Chiara, Diana Valverde, Virginia Leiro-Fernández, Cristina Represas-Represas, Victor del Campo-Pérez and Alberto Fernández-Villar, Prognostic value of aberrant hypermethylation in pleural effusion of lung adenocarcinoma [doi.org]
Similar mechanisms may also operate in the generation of pleural effusions often seen in breast cancer patients or ascites in patients with PDAC [ 49 ]. [biosignaling.com]
Treatment
Sheena advocates for the best possible treatment for her mother's glioblastoma. Read her story. Sheena advocates for the best possible treatment for her mother's glioblastoma. Read her story. [cancercommons.org]
Ninety per cent are diagnosed at surgery for treatment of bleeding, perforation, or obstruction. Surgery remains the primary treatment. [ncbi.nlm.nih.gov]
Information on conventional, integrative, experimental, complementary, CAM, dietary, and alternative cancer treatments that have been scientifically validated. Which treatments lack scientific credibility. [cancerdecisions.com]
Cancer Advice UK Advice and information about diagnosis and treatment issues. Includes leaflets, book suggestions, links and support groups. [curlie.org]
Prognosis
Prognosis The prognosis for people with breast tumors depends largely on the size, type and staging of the tumor. When detected early enough, the prognosis for people with breast tumors is generally very good. [knowcancer.com]
CONCLUSIONS: The decreased malignant neoplasm-related mortality ratio in hypertensive outpatients was indicative of an improved prognosis and likely benefited from close medical surveillance. [ncbi.nlm.nih.gov]
Central to this vision is the need to initiate what admittedly can be difficult conversations regarding prognosis, preferences, and options with our patients earlier in the course of illness. [doi.org]
What is the Prognosis of Malignant Neoplasm of Prostate? The overall prognosis of a patient with Malignant Neoplasm of the Prostate depends on the age, overall health of the patient, and stage of the disease process. [epainassist.com]
Etiology
ICD-10-CM Codes › C00-D49 Neoplasms › C51-C58 Malignant neoplasms of female genital organs › Use Additional Use Additional Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10data.com]
Cancer Etiology. Cancer Biology. Cancer Prevention. Cancer by Organ Site. Cancer Control [searo.who.int]
In this paper, we review recently published literature to identify important etiologic factors affecting the cancer risk in Asian populations. [ncbi.nlm.nih.gov]
Cancer Epidemiology compiles areas of research which cover etiological factors or determinants that contribute to the development of cancer and describe the the latest technologies in cancer epidemiology. [books.google.com]
Epidemiology
Wolfgang Ahrens, Klaus Krickeberg and Iris Pigeot, An Introduction to Epidemiology, Handbook of Epidemiology, 10.1007/978-3-540-26577-1_1, (1-40), (2005). Patricia M. Heavey, Declan McKenna and Ian R. [doi.org]
The results from these epidemiologic studies were evaluated and summarized in this review. [ncbi.nlm.nih.gov]
In Volume 2, Modifiable Factors, leading experts provide chapters on modifiable factors in cancer epidemiology, epidemiology of organ specific cancer, and environmental and life style factors. [books.google.com]
Pathophysiology
Pathophysiology of neurofibromatosis type 1. Ann Intern Med. 2006; 144:842-9 [ Links ] 24. Katz D, Lazar A, Lev D. Malignant peripheral nerve sheath tumour (MPNST): the clinical implications of cellular signalling pathways. [scielo.org.mx]
Pathophysiology Approximately 64% of all small-bowel tumors are malignant, and approximately 40% of these tumors are adenocarcinomas. Epidemiologically, small-bowel adenocarcinomas have a striking resemblance to large-bowel adenocarcinomas. [emedicine.medscape.com]
Anindya Roy Chowdhury, Pathophysiological responses from human gut microbiome, World Journal of Translational Medicine, 3, 3, (133), (2014). [dx.doi.org]
Prevention
In cancer prevention, an initial trial carried out among over 14,000 men aged at least 50 showed that neither vitamin E, nor vitamin C had any impact on preventing prostate or any other cancer. [english.prescrire.org]
By Mayo Clinic Staff You've probably heard conflicting reports about cancer prevention. Sometimes a specific cancer-prevention tip recommended in one study is advised against in another. Often, what's known about cancer prevention is still evolving. [mayoclinic.com]
[…] and early detection of cervical cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. [nccn.org]
"To achieve this, WHO supports countries in developing comprehensive national cancer prevention and control plans, which are essential to prevent millions of cancer deaths each year." [who.int]