Presentation
We report here a patient with adenocarcinoma of the lung who, after declining chemotherapy and radiotherapy, presented with tumour response following self-administration of cannabidiol, a non-psychoactive compound present in Cannabis sativa. [cannabis-med.org]
The only exception is when the patient presents solely for administration of chemotherapy, immunotherapy, or radiation therapy. [hcpro.com]
[…] before the discovery of the primary tumor. [3] In contrast to other orbital metastases, breast carcinoma can have a bilateral presentation in up to 15-20% of cases. [eyewiki.aao.org]
Case presentation A 58-year-old premenopausal female with underlying diseases of Chiari I malformation with syringomyelia C1-T10 levels presented to the outpatient surgical unit in a Thai provincial hospital. [dovepress.com]
Entire Body System
- Pathologist
A device used by pathologists to examine tissue on slides; the microscope magnifies the tissue so that pathologist can examine the individual cells and make a diagnosis. [pathology.jhu.edu]
The pathologist also determines the tumor’s grade and identifies other characteristics of the tumor. [cancer.gov]
The slide is then given to the pathologist, who examines the tissue under a microscope, looking for any abnormal findings. The pathologist then prepares a report that lists any abnormal or important findings from the biopsy. [en.wikipedia.org]
Even when a biopsy is negative for cancer, the pathologist often needs to look at the whole tumor under the microscope to be sure about the diagnosis. [hopkinsmedicine.org]
Once the tissue is removed, a provider known as a pathologist will review the specimen. [oncolink.org]
- Lymphedema
More common but less serious ones include skin burns, irritation or discoloration, fatigue, and lymphedema. Some types of hormone therapy lower estrogen levels in women, and increase the risk for osteoporosis. [healthline.com]
NLN: Position Statement Paper by the National Lymphedema Network: Lymphedema Risk Reduction Practices. May 2010. Accessed 8/31/20. 3. [msdmanuals.com]
We evaluate secondary lymphedema that results from anticancer therapy for breast cancer under 13.10E if the lymphedema is treated by surgery to salvage or restore the functioning of an upper extremity. [ssa.gov]
- Asymptomatic
BRCA1 and ER/PR negativity histology shows fleshy, cellular, lymphatic infiltrate Inflammatory poor prognosis (50% survival at 5 years) histology shows dermal lymphatic invasion by tumor peau d'orange seen on exam see below Presentation Symptoms often asymptomatic [medbullets.com]
Breast Implants To indicate the presence of asymptomatic breast implants, assign code Z98.82 (Breast implant status). [rccb.org]
She was on regular follow-up for the next 7 years and was asymptomatic. During her follow-up, her hemogram was normal on all the subsequent visits. In February 2014, she noticed a lump in the left breast, about the size of a lemon. [ccij-online.org]
CBCs, chemistry panels, bone scans, chest radiographs, liver UTZ, CT scans, PET scanning, MRI, or tumor markers (CEA, CA 15-3, and CA 27.29) is not recommended for routine breast cancer follow-up in an asymptomatic patient with no specific findings [slideplayer.com]
Most patients present with an asymptomatic mass discovered during examination or screening mammography. Diagnosis is confirmed by biopsy. [msdmanuals.com]
- Falling
Pre-Cancerous Tumors Precancerous tumors fall between benign and malignant. These types of growths have the markers to be malignant but are not yet apparent. They will not be characterized as malignant unless irrepressible cell growth ensues. [thetruthaboutcancer.com]
It's hard to truly appreciate the bitterly cold rain and sleet that was falling intermittently between the 3 peaks! [munromagic.com]
Like many conditions, risk factors for breast cancer fall into the categories of things you can control and things that you cannot control. [my.clevelandclinic.org]
T4: The tumor falls into 1 of the following groups: T4a means the tumor has grown into the chest wall. T4b is when the tumor has grown into the skin. T4c is cancer that has grown into the chest wall and the skin. T4d is inflammatory breast cancer. [cancer.net]
- Infertility
Fertility: A testicular biopsy is used for evaluating the fertility of men and find out the cause of a possible infertility, e.g. when sperm quality is low, but hormone levels still are within normal ranges.[22][failed verification] Biopsied sites[edit [en.wikipedia.org]
Chemotherapy can cause infertility and early menopause by destroying the eggs in the ovaries. Chemotherapy may also suppress the production of blood cells by the bone marrow and thus cause anemia or bleeding or increase the risk of infections. [msdmanuals.com]
Chemotherapy can produce significant side effects, including nausea and vomiting, temporary hair loss, mouth or vaginal sores, fatigue, weakened immune system, and infertility. [medical-dictionary.thefreedictionary.com]
Respiratoric
- Pleural Effusion
INTRODUCTION The first step in the etiological investigation of a pleural effusion is to determine whether the effusion is a transudate or an exudate. [scielo.br]
Pleural effusion, ascites, pathological fracture, and spinal compression can occur with advanced disease. interventions The treatment of choice is resection of the lump with removal of varying amounts of surrounding healthy tissue, ranging from a margin [medical-dictionary.thefreedictionary.com]
Most of the available breast cancer cell lines issued from metastatic tumors, mainly from pleural effusions. [en.wikipedia.org]
Skin
- Erythema
Both local and systemic toxicities were mild, consisting of transient erythema at the vaccination site; fever occurred in a minority of patients. Three mixed responses were recorded. Seven patients were evaluable for immunological studies. [liebertpub.com]
[…] diagnosis of inflammatory and infiltrative orbital processes encountered in adult female patients. [5] Idiopathic orbital inflammation (IOI) - most commonly presents as a unilateral painful ophthalmopathy in adults, with sudden onset of progressive erythema [eyewiki.aao.org]
[…] fixed to surrounding skin and soft tissue, poorly defined or irregular margins. 20 LikelyLess likely Infection Abscess Hidradenitis suppurativa Mondor’s disease mass/lump tenderness mass/lump chronic condition tenderness cord-like structure no signs of erythema [slideplayer.com]
Paget disease of the nipple manifests as skin changes, including erythema, crusting, scaling, and discharge; these changes usually appear so benign that the patient ignores them, delaying diagnosis for a year or more. [msdmanuals.com]
- Eczema
Paget’s disease of the breast This shows as a red, scaly rash (like eczema) on the skin of the nipple. Women with Paget’s disease may have DCIS or invasive breast cancer. [macmillan.org.uk]
Symptoms commonly include itching and burning and an eczema-like condition around the nipple, sometimes accompanied by oozing or bleeding. [icd10data.com]
A rare type of breast cancer, it is often ignored and misdiagnosed as a simple case of eczema. Aggressive treatment is usually called for. Accounts for less then one percent of the breast cancer cases. [breastnotes.com]
Clinically, it presents as nipple erythema or eczema, and is sometimes associated with nipple discharge, ulceration, and inversion. Usually the finding of PD of the nipple indicates an underlying breast CA, which is mostly high-grade DCIS or IDC. [sigmaaldrich.com]
This syndrome presents as skin changes resembling eczema; such as redness, discoloration or mild flaking of the nipple skin. As Paget's disease of the breast advances, symptoms may include tingling, itching, increased sensitivity, burning, and pain. [en.wikipedia.org]
- Skin Edema
[…] changes redness, ulcerations, edema, and nodularity axillary lymphadenopathy in more advanced cases breast skin edema with dimpling ( peau d' orange ) represents obstruction of the lymphatics by cancer Evaluation Fine needle aspiration can identify whether [medbullets.com]
More advanced breast cancers are characterized by one or more of the following: Fixation of the mass to the chest wall or to overlying skin Satellite nodules or ulcers in the skin Exaggeration of the usual skin markings resulting from skin edema caused [msdmanuals.com]
Skin dimpling or nipple retraction in the presence of an underlying breast mass on examination is a more advanced finding. Actual skin involvement, with swelling (edema) or ulceration of the skin, are late findings. [medical-dictionary.thefreedictionary.com]
- Alopecia
Acute adverse effects depend on the regimen but usually include nausea, vomiting, mucositis, fatigue, alopecia, myelosuppression, cardiotoxicity, and thrombocytopenia. [msdmanuals.com]
Eyes
- Blurred Vision
Women should promptly report certain symptoms to their doctor: Any changes in their breasts Pain Loss of appetite or weight Changes in menstruation Bleeding from the vagina (if not associated with menstrual periods) Blurred vision Any symptoms that seem [msdmanuals.com]
Musculoskeletal
- Osteoporosis
Women who experience chemotherapy- induced menopause may also face a higher risk of osteoporosis. Most people find that side effects go away after the treatment is finished. [healthline.com]
Both drugs may also increase bone density and thus benefit women who have osteoporosis. [msdmanuals.com]
Patients taking aromatase inhibitors may experience bone or joint pain, and are at increased risk for thinning of the bones (osteopenia or osteoporosis). [oncolink.org]
- Back Pain
Felt upper back pain and numbness of Left arm 5 Consulted at a private clinic. FNAB was done showing malignant cells. Advised surgery. 1 mo PTA – Sought second opinion at PGH. Slide review done. Mammogram requested. [slideplayer.com]
Psychiatrical
- Aggressive Behavior
In general, a higher tumor grade is associated with more aggressive behavior. Tissues in the body that make protein secretions; glands are shaped like small round structures. [pathology.jhu.edu]
Breast
- Nipple Discharge
Another symptom is bloody nipple discharge if the tumor is positioned beneath the nipple, which is the case in 50 percent of papillary carcinomas. [breasthealthandhealing.org]
[…] changes, no nipple discharge Left: 3.5x4.5cm firm slightly tender slightly moveable mass at the 11 o clock direction 10 cm from the nipple, no axillary nodes, no skin and nipple changes, no nipple discharge 14 Cardio vascular: Adynamic precordium, distinct [slideplayer.com]
discharge Physical exam firm immobile, painless lump some skin changes redness, ulcerations, edema, and nodularity axillary lymphadenopathy in more advanced cases breast skin edema with dimpling ( peau d' orange ) represents obstruction of the lymphatics [medbullets.com]
Women should still be familiar with their normal breast tissue and report any changes in appearance, size, or feel of the tissue or nipples, or any nipple discharge to their health care provider. [oncolink.org]
[…] zazy OH Joined: Nov 2009 Posts: 14 Latest activity: Jan 1, 2010 Log in to post a reply Jan 1, 2010 12:41PM zazy wrote: Just had a duct excision for spontaneous nipple discharge. [community.breastcancer.org]
- Breast Mass
The breast mass was initially misdiagnosed as invasive ductal carcinoma. [nature.com]
Signs and symptoms Characteristics Benign Malignant Breast mass – a dominant mass is a distinct mass that is asymmetric with the other breast. Benign findings are often associated with cysts, fibroadenomas, or fibrocystic changes. [pathophys.org]
This is in contrast to ICD-9-CM, where lumps and masses are reported with code 611.72 ( Lump or mass in breast ), but nodule is reported with code 793.89 [ Other (abnormal) findings on radiological examination of breast ]. [rccb.org]
We describe an MGCT that presented as a right breast mass in a 79-year-old Japanese woman. Local excision was performed for the primary tumor, which was diagnosed as an atypical GCT, but 15 months later, the tumor recurred at the same site. [link.springer.com]
She had a 2-month history of a mass in her left breast and eruption of the mass with pus through the skin for 1 month. [dovepress.com]
- Mastodynia
Common examples include: N63 – Unspecified lump in breast N64.52 – Nipple discharge N64.4 - Mastodynia R92.0 – Mammographic microcalcification found on diagnostic imaging of breast R92.1 – Mammographic calcification found on diagnostic imaging of breast [rccb.org]
[…] nipple changing position or shape or becoming inverted, skin puckering or dimpling, a rash on or around a nipple, discharge from nipple/s, constant pain in part of the breast or armpit and swelling beneath the armpit or around the collarbone.[20] Pain ("mastodynia [en.wikipedia.org]
Workup
She was diagnosed as AML - M2 in the year 2007 after a complete workup. She was treated with the standard induction chemotherapy regimen of 3 + 7 daunomycin and cytarabine. [ccij-online.org]
Patients require a systemic workup to evaluate for metastases to other organ systems, and a multidisciplinary team including oncology, radiation oncology, and ophthalmology are necessary. [eyewiki.aao.org]
Immunohistochemical studies are often employed in the workup of spindle cell lesions of breast, especially in the group with a monophasic pattern. The most important task is to exclude the potential diagnosis of metaplastic CA. [sigmaaldrich.com]
(See Workup.) Increased public awareness and improved screening have led to earlier diagnosis, at stages amenable to complete surgical resection and curative therapies. [emedicine.medscape.com]
Pleura
- Pleural Effusion
INTRODUCTION The first step in the etiological investigation of a pleural effusion is to determine whether the effusion is a transudate or an exudate. [scielo.br]
Pleural effusion, ascites, pathological fracture, and spinal compression can occur with advanced disease. interventions The treatment of choice is resection of the lump with removal of varying amounts of surrounding healthy tissue, ranging from a margin [medical-dictionary.thefreedictionary.com]
Most of the available breast cancer cell lines issued from metastatic tumors, mainly from pleural effusions. [en.wikipedia.org]
Treatment
Radiation treatments used to last for several weeks, but advances in radiation treatments has lead to very targeted treatments that may only take one week. [knowcancer.com]
Often different types of treatment are used together to achieve the best result. [hopkinsmedicine.org]
Talk to your doctor to determine the best course of treatment for your situation. [webmd.com]
Treatment-related leukemia typically occurs in the first 10 years after treatment after which risk tapers a little. [ccij-online.org]
Prognosis
Prognosis The prognosis for people with breast tumors depends largely on the size, type and staging of the tumor. When detected early enough, the prognosis for people with breast tumors is generally very good. [knowcancer.com]
These differences often affect prognosis. Tumor characteristics, such as hormone receptor status and HER2 status, also affect prognosis. Learn more about factors that affect prognosis. [ww5.komen.org]
The prognosis of Paget’s disease depends on the prognosis of the underlying carcinoma. [med-ed.virginia.edu]
Our experience indicated that surgical treatment of malignant phyllodes tumor might be an option for improving patients' quality of life, regardless of the extremely poor prognosis. KEY WORDS: Breast, Malignant phyllodes tumor, Surgical treatment. [ncbi.nlm.nih.gov]
Patients should talk with their doctor for more information about tumor grade and how it relates to their treatment and prognosis. [cancer.gov]
Etiology
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]
The detection of high-oncogenic HPV genotypes in patients with breast cancer supports the hypothesis of an etiologic role for the virus in breast cancer development. [ncbi.nlm.nih.gov]
[…] factor: Treatment-related, syndromic, and due to shared etiologic influences. [8] Although a causal link has not been proven, these neoplasms are thought to be a direct consequence of mutational events caused by cytotoxic therapy. [ccij-online.org]
ICD-10-CM Codes › C00-D49 Neoplasms › C50-C50 Malignant neoplasms of breast › Use Additional Use Additional Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10data.com]
The etiology of MPMTs remains unclear. [journals.plos.org]
Epidemiology
Introduction Epidemiology breast cancer is the most common cancer and second most common cause of death in adult women Risk factors BRCA1 and BRCA2 mutations associated with multiple / early onset breast and ovarian cancer other genetic relationships [medbullets.com]
The explanation for these epidemiologic findings is not known, but the parallelism between the DMBA-induced rat mammary carcinoma model and the human situation is striking. ... [en.wikipedia.org]
An analysis of Surverllance, Epidemiology, and End Results Program Data. Cancer 68: 2069–2073. pmid:1913556 View Article PubMed/NCBI Google Scholar 15. [journals.plos.org]
The international variation in breast cancer rates: an epidemiological assessment. Breast Cancer Res Treat. 1991 May. 18 Suppl 1:S11-7. [Medline]. Kaaks R. Nutrition, hormones, and breast cancer: is insulin the missing link?. [emedicine.medscape.com]
The predominance of females among patients with cancer observed in the present study is in contrast to international epidemiological data. [scielo.br]
Pathophysiology
Breast Cancer Pathophysiology Breast cancer is a malignant tumor that starts in the cells of the breast. Like other cancers, there are several factors that can raise the risk of getting breast cancer. [news-medical.net]
Types of invasive breast carcinoma include ductal, lobular, and mixed. [5] Pathophysiology To date, the basis for breast carcinoma as the most common primary metastatic process to the orbit is unclear. [eyewiki.aao.org]
Pathophysiology The current understanding of breast cancer etiopathogenesis is that invasive cancers arise through a series of molecular alterations at the cell level. [emedicine.medscape.com]
[…] the risk of breast cancer.[73] Autoimmune diseases such as lupus erythematosus seem also to increase the risk for the acquisition of breast cancer.[74] Hormone therapy to treat menopause is also associated with an increase risk of breast cancer.[75] Pathophysiology [en.wikipedia.org]
Prevention
Related information Information for Health Professionals – Recommendations on Prevention and Screening for Breast Cancer Cancer Prevention Series 4 – Breast Cancer Prevention and Screening For further information about women's health, please visit the [chp.gov.hk]
Unfortunately, cost sometimes prevents women from choosing breast-conserving surgery. [stopcancerfund.org]
Preventive surgery is an option for women at high risk. [medicalnewstoday.com]
Papillary Breast Cancer Treatment Local therapy is aimed at preventing the cancer from coming back in the breast. Local therapy includes surgery (lumpectomy or mastectomy), and may include radiation. [hopkinsmedicine.org]
Preventive surgery. Women with a very high risk of breast cancer may choose to have their healthy breasts surgically removed (prophylactic mastectomy). [mayoclinic.org]