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Malignant Neoplasm of the Breast

Hereditary Breast Cancer

Breast cancer is the most frequently diagnosed life-threatening cancer in women worldwide. Infiltrating ductal carcinoma is the most commonly diagnosed breast tumor, found in about 75% of cases and infiltrating lobular, infiltrating medullary, colloid, comedo or papillary carcinomas in the others. Inflammatory carcinomas account for approximately 1% of cases. The first noticeable symptom of breast cancer is usually a lump.


Presentation

  • More then one type of breast cancer can be present in any one case of breast cancer.[breastnotes.com]
  • She is at present on regular follow-up after the completion of adjuvant treatment and is disease-free till the date of writing this article. Discussion The second- and higher-order malignancies comprise about 18% of all cancers.[ccij-online.org]
  • At this stage, the cancer cells have usually not spread to more distant sites in the body, but they are present in several axillary (underarm) lymph nodes.[cancercenter.com]
  • The sentinel lymph nodes are examined in the laboratory to see if there are any cancer cells present. This provides a good indicator of whether the cancer has spread.[nhs.uk]
  • Endnote 2—Abbreviation key o order(s) ad added or inserted Ord Ordinance am amended orig original amdt amendment par paragraph(s)/subparagraph(s) c clause(s) /sub‑subparagraph(s) C[x] Compilation No. x pres present Ch Chapter(s) prev previous def definition[legislation.gov.au]
Fishing
  • People who follow the Mediterranean diet choose healthy fats, such as olive oil, over butter and fish instead of red meat.[mayoclinic.org]
  • "Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies". BMJ. 346 : f3706. doi : 10.1136/bmj.f3706. PMID 23814120.[en.wikipedia.org]
Falling
  • Pre-Cancerous Tumors Precancerous tumors fall between benign and malignant. These types of growths have the markers to be malignant but are not yet apparent. They will not be characterized as malignant unless irrepressible cell growth ensues.[thetruthaboutcancer.com]
Pneumonia
  • […] service) under the VEA; (b) defence service (other than hazardous service and British nuclear test defence service) under the VEA; or (c) peacetime service under the MRCA; "terminal event" means the proximate or ultimate cause of death and includes: (a) pneumonia[legislation.gov.au]
Breast Mass
  • At stage 0, the breast mass is noninvasive. At this stage, there is no indication that the tumor cells have spread to other parts of the breast or other parts of the body.[cancercenter.com]
  • We describe an MGCT that presented as a right breast mass in a 79-year-old Japanese woman. Local excision was performed for the primary tumor, which was diagnosed as an atypical GCT, but 15 months later, the tumor recurred at the same site.[link.springer.com]
Nipple Discharge
  • discharge other than breast milk Irritated or itchy breasts Signs and symptoms of metastatic breast cancer may include: Swelling or lumps in the lymph nodes Unexplained pain in other areas of the body, such as the bone Difficulty breathing or a persistent[cancercenter.com]
  • , discharge from nipple/s, constant pain in part of the breast or armpit, and swelling beneath the armpit or around the collarbone. [21] Pain (" mastodynia ") is an unreliable tool in determining the presence or absence of breast cancer, but may be indicative[en.wikipedia.org]
Mastodynia
  • […] changing position or shape or becoming inverted, skin puckering or dimpling, a rash on or around a nipple, discharge from nipple/s, constant pain in part of the breast or armpit, and swelling beneath the armpit or around the collarbone. [21] Pain (" mastodynia[en.wikipedia.org]
Tingling
  • As Paget's disease of the breast advances, symptoms may include tingling, itching, increased sensitivity, burning, and pain. There may also be discharge from the nipple.[en.wikipedia.org]

Workup

  • She was diagnosed as AML - M2 in the year 2007 after a complete workup. She was treated with the standard induction chemotherapy regimen of 3 7 daunomycin and cytarabine.[ccij-online.org]

Treatment

  • Radiation treatments used to last for several weeks, but advances in radiation treatments has lead to very targeted treatments that may only take one week.[knowcancer.com]
  • Often different types of treatment are used together to achieve the best result.[hopkinsmedicine.org]
  • Treatment-related leukemia typically occurs in the first 10 years after treatment after which risk tapers a little.[ccij-online.org]
  • How your body reacts to a treatment plan however, can be different from someone else. It all depends on the type of breast cancer treatment being administered to you.[healthline.com]

Prognosis

  • Prognosis The prognosis for people with breast tumors depends largely on the size, type and staging of the tumor. When detected early enough, the prognosis for people with breast tumors is generally very good.[knowcancer.com]
  • These differences often affect prognosis. Tumor characteristics, such as hormone receptor status and HER2 status, also affect prognosis. Learn more about factors that affect prognosis.[ww5.komen.org]
  • For example, Ductal Carcinoma In Situ (DCIS) involving the entire breast will still be stage zero and consequently an excellent prognosis with a 10-year disease free survival of about 98%. [140] Stage 1 cancers (and DCIS, LCIS) have an excellent prognosis[en.wikipedia.org]
  • Compared to more common types of breast cancers, papillary breast cancers are less likely to involve the lymph nodes, are more responsive to treatment, and may have a better prognosis than more common types of invasive ductal cancer.[hopkinsmedicine.org]
  • However, all women with stage I breast cancer are considered to have a good prognosis. At stage I, TNM designations help describe the extent of the disease.[cancercenter.com]

Etiology

  • […] factor: Treatment-related, syndromic, and due to shared etiologic influences. [8] Although a causal link has not been proven, these neoplasms are thought to be a direct consequence of mutational events caused by cytotoxic therapy.[ccij-online.org]

Epidemiology

  • Cancer Epidemiology, Biomarkers & Prevention. 8 (10): 843–54. PMID 10548311.[en.wikipedia.org]
Sex distribution
Age distribution

Pathophysiology

  • Breast Cancer Pathophysiology Breast cancer is a malignant tumor that starts in the cells of the breast. Like other cancers, there are several factors that can raise the risk of getting breast cancer.[news-medical.net]
  • Diabetes mellitus might also increase the risk of breast cancer. [73] Autoimmune diseases such as lupus erythematosus seem also to increase the risk for the acquisition of breast cancer. [74] Pathophysiology [ edit ] Overview of signal transduction pathways[en.wikipedia.org]

Prevention

  • Papillary Breast Cancer Treatment Local therapy is aimed at preventing the cancer from coming back in the breast. Local therapy includes surgery (lumpectomy or mastectomy), and may include radiation.[hopkinsmedicine.org]
  • Cancer Epidemiology, Biomarkers & Prevention. 8 (10): 843–54. PMID 10548311.[en.wikipedia.org]
  • Preventive surgery. Women with a very high risk of breast cancer may choose to have their healthy breasts surgically removed (prophylactic mastectomy).[mayoclinic.org]
  • Chemotherapy treatments are sometimes given in an effort to prevent future breast tumors from developing. Since some breast tumors require estrogen to continue growing hormone-blocking therapy is used to deter this.[knowcancer.com]
  • Side effects include: infections loss of appetite nausea and vomiting tiredness hair loss sore mouth Many side effects can be prevented or controlled with medicines that your doctor can prescribe.[nhs.uk]

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Last updated: 2019-06-28 09:34