Presentation of lung cancer in primary care. npj Prim. Care Respir. [nature.com]

Read more » DOH presents new cigarette graphic warnings Mark Demayo, ABS-CBN News Posted at Mar 06 07:16 PM Health Secretary Francisco Duque III presents the new graphic health warnings mandated to be printed on cigarette packs beginning March 3, 2018 [news.abs-cbn.com]

This webinar will consist on a presentation and the attendees will be able to make their questions live to the doctor. The webinar is intended for an audience of advocates, patients and caregivers. [lungcancereurope.eu]

The algorithms presented in this paper will be released as Open Source Software under the GNU lesser GPL v3. [bjgp.org]

Treatment decisions in lung cancer depend first on whether SCLC or non-small cell lung cancer is present. Treatment also depends on tumor stage. [emedicinehealth.com]

• Weight Loss

  […] that may include: Abdominal pain Abdominal swelling Unexplained weight loss Doctors use a physical exam, imaging tests, blood and biomarker tests and biopsies to diagnose mesothelioma. [iaslc.org]

  There are usually no signs or symptoms in the early stages of lung cancer, but many people with the condition eventually develop symptoms including: a persistent cough coughing up blood persistent breathlessness unexplained tiredness and weight loss an [nhs.uk]

  Lung cancer symptoms Symptoms of lung cancer can include a cough that won't go away, coughing up blood, breathlessness and weight loss. Find out more about these and other symptoms. [cancerresearchuk.org]

  However, chemotherapy is a powerful intervention and can have side effects including extreme nausea and weight loss. Radiation therapy: This approach uses high-energy rays to kill cancerous cells. [medicalnewstoday.com]

• Fatigue

  Like many other types of cancer, lung cancer may also cause systemic symptoms, like loss of appetite or general fatigue. [cancercenter.com]

  Even when symptoms—such as coughing and fatigue—do occur, people think they are due to other causes. For this reason, early-stage lung cancer (stages I and II) is difficult to detect. [lungcancer.org]

  […] breathlessness and wheezing coughing up blood-stained phlegm (sputum) chest or shoulder pain a hoarse voice a dull ache or a sharp pain when you cough or take a deep breath loss of appetite and loss of weight difficulty swallowing feeling extremely tired (fatigue [christie.nhs.uk]

  This fatigue gradually increases as treatment continues and may become severe, seriously limiting the ability to engage in normal daily activities. Typically, fatigue lessens one to two months after radiotherapy is completed. [radiologyinfo.org]

  Hoarseness Blood in phlegm or sputum that is expelled by coughing Weakness Wheezing Infections that return or will not clear Chest pain that gets worse with cough or laugh Advanced lung cancer symptoms include coughing, shortness of breath, chest pain, fatigue [my.clevelandclinic.org]

• Weakness

  Symptoms of paraneoplastic syndromes include muscle cramps, muscle weakness, elevation of calcium in the blood and clubbing, which refers to a change in the shape of the finger tips. [cancercenter.com]

  In this syndrome, muscles around the hips become weak.” [express.co.uk]

  Signs and symptoms that might appear if the cancer has spread to other places include bone pain, headache, muscle weakness and/or eyelid drooping. [my.clevelandclinic.org]

  Early symptoms may include: lingering or worsening cough coughing up phlegm or blood chest pain that worsens when you breathe deeply, laugh, or cough hoarseness shortness of breath wheezing weakness and fatigue loss of appetite and weight loss You might [healthline.com]

  Symptoms that suggest the presence of metastatic disease include weight loss, bone pain and neurological symptoms (headaches, fainting, convulsions, or limb weakness). [oncologica.com]

• Fever

  Endobronchial obstruction from any of the primary or metastatic tumors may present with symptoms of pneumonia, including fever, sweats, and/or pleurisy. [pulmonologyadvisor.com]

  Less common symptoms of lung cancer include: changes in the appearance of your fingers, such as becoming more curved or their ends becoming larger (this is known as finger clubbing) a high temperature (fever) of 38C (100.4F) or above difficulty swallowing [nidirect.gov.uk]

  Many of the symptoms of lung cancer (poor appetite, weight loss, fever, fatigue) are not specific. In many people, the cancer has already spread beyond the original site by the time they have symptoms and seek medical attention. [oncologica.com]

  Tell your care team or GP as soon as possible if you have possible signs of an infection, such as a high temperature (fever) of 38C (100.4F) or more, or you suddenly feel generally unwell. [nhsinform.scot]

  It causes coughing and shortness of breath as well as fever but in most cases calls for no specific treatment and gets better within two to four weeks. [radiologyinfo.org]

• Cough

  Early Symptoms Coughing, especially if it persists or becomes intense Pain in the chest, shoulder, or back unrelated to pain from coughing A change in color or volume of sputum, saliva and mucus that is coughed up from the respiratory tract Shortness [iaslc.org]

  […] ache or pain when breathing or coughing You should see a GP if you have these symptoms. [nhs.uk]

  Symptoms of primary lung cancers include cough, coughing up blood, chest pain, and shortness of breath. A new cough in a smoker or a former smoker should raise concern for lung cancer. [emedicinehealth.com]

  Coughing up blood. Lung cancer can cause bleeding in the airway, which can cause you to cough up blood (hemoptysis). Sometimes bleeding can become severe. Treatments are available to control bleeding. Pain. [mayoclinic.org]

  When lung cancer does cause signs in its early stages, they may vary from person to person but commonly include: A new cough that is persistent or worsens, or a change in an existing chronic cough Cough that produces blood Pain in the chest, back or shoulders [cancercenter.com]

• Pleural Effusion

  Treatments are available to drain the fluid from your chest and reduce the risk that pleural effusion will occur again. Cancer that spreads to other parts of the body (metastasis). [mayoclinic.org]

  Pneumonia, pleural effusion, wheeze, lymphadenopathy are not uncommon. Other symptoms may be secondary to metastases (bone, contralateral lung, brain, adrenal glands, and liver, in frequency order for NSCLC 12 ) or paraneoplastic syndromes. [radiopaedia.org]

  Patients with persistent pleural effusion may regain some independence and reduced hospital visits with permanent indwelling pleural drains or after a talc pleurodesis procedure. [guidelinesinpractice.co.uk]

  Shortness of breath usually results from a blockage to the flow of air in part of the lung, collection of fluid around the lung ( pleural effusion ), or the spread of tumor throughout the lungs. [emedicinehealth.com]

  Fluid which may accumulate between the lung and chest wall (pleural effusion). This can cause worsening shortness of breath. [patient.info]

• Hemoptysis

  Unless severe hemoptysis is occurring, a chest X-ray will most likely be performed first to look for a cause of the respiratory symptoms. The X-ray may or may not show an abnormality. [emedicinehealth.com]

  Lung cancer can cause bleeding in the airway, which can cause you to cough up blood (hemoptysis). Sometimes bleeding can become severe. Treatments are available to control bleeding. Pain. [mayoclinic.org]

  Common NSCLC symptoms include: Persistent coughing, particularly without any known cause A cough that produces blood or red-colored phlegm (hemoptysis) Chest pain or painful breathing Difficulty breathing or shortness of breath Fatigue or feeling unusually [cancercenter.com]

  Squamous cell carcinomas often present with hemoptysis within 4 to 6 months of symptom onset, due to mucosal irritation and ulceration. [pulmonologyadvisor.com]

• Chronic Cough

  When lung cancer does cause signs in its early stages, they may vary from person to person but commonly include: A new cough that is persistent or worsens, or a change in an existing chronic cough Cough that produces blood Pain in the chest, back or shoulders [cancercenter.com]

  Further, lung cancer often emerges on a background of chronic respiratory disease and symptoms of chronic cough—typically in patients who smoke. [nature.com]

  Some of the symptoms of less advanced cancer include chronic cough, coughing up blood, chest pain, hoarseness, shortness of breath, wheezing, chest pain, weight loss, and loss of appetite.[14] A few more symptoms associated with the early progression [en.wikipedia.org]

• Dyspnea

  Symptoms are nonspecific and may include cough, hemoptysis, fever/pneumonia, pain, or dyspnea, wheezing, depending on the intrathoracic location of the disease. [pulmonologyadvisor.com]

• Loss of Appetite

  Like many other types of cancer, lung cancer may also cause systemic symptoms, like loss of appetite or general fatigue. [cancercenter.com]

  Three ‘red-flag’ symptoms were also included (haemoptysis, loss of appetite, and weight loss) as well as other symptoms that might herald a diagnosis of lung cancer. [bjgp.org]

  However, signs can include: Persistent cough Coughing up mucus or blood Shortness of breath Loss of appetite Chest pain. When to come to us? There are a number of initial tests needed to diagnose lung cancer. [theloc.com]

  […] of appetite or unexplained weight loss If you experience any of these, you should see your GP. [express.co.uk]

  […] of appetite and loss of weight difficulty swallowing feeling extremely tired (fatigue) and lethargy the ends of the fingers becoming larger or looking more rounded (clubbing) swelling of the lymph nodes (glands) in the neck area. [christie.nhs.uk]

• Dysphagia

  […] sitting down can be a sign of SCLC (Image: GETTY) Less common symptoms of lung cancer include: Changes in the appearance of your fingers, such as becoming more curved or their ends becoming larger (this is known as finger clubbing) Difficulty swallowing (dysphagia [express.co.uk]

  Esophageal Cancer causes signs and symptoms that may include: Difficulty swallowing (dysphagia) Unexplained weight loss Chest pain or pressure Indigestion or heart burn Coughing or hoarseness Esophageal Cancer is classified according to the type of cells [iaslc.org]

  Side effects Side effects of radiotherapy to the chest include: chest pain fatigue persistent cough that may bring up blood-stained phlegm (this is normal and nothing to worry about) difficulties swallowing (dysphagia) redness and soreness of the skin [nhsinform.scot]

• Chest Pain

  Signs and symptoms of thymoma and thymic carcinoma include: A nagging, persistent cough Chest pain Trouble breathing Factors that may affect patient outcomes include: The stage of the disease The type of cancer cell Whether the tumor can be removed by [iaslc.org]

  […] coughing, shortness of breath, chest pain, fatigue and/or unintentional weight loss. [my.clevelandclinic.org]

  Common NSCLC symptoms include: Persistent coughing, particularly without any known cause A cough that produces blood or red-colored phlegm (hemoptysis) Chest pain or painful breathing Difficulty breathing or shortness of breath Fatigue or feeling unusually [cancercenter.com]

  However, signs can include: Persistent cough Coughing up mucus or blood Shortness of breath Loss of appetite Chest pain. When to come to us? There are a number of initial tests needed to diagnose lung cancer. [theloc.com]

  Chest pain is a symptom in about one-fourth of people with lung cancer. The pain is dull, aching, and persistent. [emedicinehealth.com]

• Bone Pain

  If the cancer has spread to the bones, it may cause bone pain, often in the vertebrae or ribs. Other symptoms include fractures, constipation or decreased alertness due to high calcium levels. [cancercenter.com]

  Signs and symptoms that might appear if the cancer has spread to other places include bone pain, headache, muscle weakness and/or eyelid drooping. [my.clevelandclinic.org]

  Signs and symptoms of lung cancer may include: A new cough that doesn't go away Coughing up blood, even a small amount Shortness of breath Chest pain Hoarseness Losing weight without trying Bone pain Headache When to see a doctor Make an appointment with [mayoclinic.org]

  These include severe chest or bone pain or coughing up blood. [medicalnewstoday.com]

• Atelectasis

  This may reveal an obvious mass, widening of the mediastinum (suggestive of spread to lymph nodes there), atelectasis (collapse), consolidation (pneumonia) or pleural effusion. [oncologica.com]

  This may reveal an obvious mass, the widening of the mediastinum (suggestive of spread to lymph nodes there), atelectasis (lung collapse), consolidation ( pneumonia ), or pleural effusion. [7] CT imaging is typically used to provide more information about [en.wikipedia.org]

• Thrombocytosis

  3000, Australia Correspondence to: R D Neal R.D.Neal{at}leeds.ac.uk What you need to know Most lung cancers present with non-specific symptoms; haemoptysis is a feature in only 20% Consider a chest x ray for patients who have persistent symptoms or thrombocytosis [bmj.com]

  Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data. Br J Gen Pract 2017; 67 (659): e405–e413. Crosbie P, Balata H, Evison M et al. [guidelinesinpractice.co.uk]

• Pleural Effusion

  Treatments are available to drain the fluid from your chest and reduce the risk that pleural effusion will occur again. Cancer that spreads to other parts of the body (metastasis). [mayoclinic.org]

  Pneumonia, pleural effusion, wheeze, lymphadenopathy are not uncommon. Other symptoms may be secondary to metastases (bone, contralateral lung, brain, adrenal glands, and liver, in frequency order for NSCLC 12 ) or paraneoplastic syndromes. [radiopaedia.org]

  Patients with persistent pleural effusion may regain some independence and reduced hospital visits with permanent indwelling pleural drains or after a talc pleurodesis procedure. [guidelinesinpractice.co.uk]

  Shortness of breath usually results from a blockage to the flow of air in part of the lung, collection of fluid around the lung ( pleural effusion ), or the spread of tumor throughout the lungs. [emedicinehealth.com]

  Fluid which may accumulate between the lung and chest wall (pleural effusion). This can cause worsening shortness of breath. [patient.info]

Targeted therapy Targeted therapy drugs may be used alone or in combination with other targeted therapy drugs or treatments, such as chemotherapy, radiation or interventional pulmonology. Learn more about treatments for lung cancer [cancercenter.com]

Doctor’s Response More than half of lung cancer patients will die within one year of diagnosis even with treatment. Without treatment, patients may die even sooner. For any hope of survival, medical or surgical treatment is necessary. [emedicinehealth.com]

Doctors may also use these scans to track the progress of treatment or to ensure cancer has not returned, following a course of treatment. Share on Pinterest Imaging can help display a lung tumor or track the progress of treatment. [medicalnewstoday.com]

Treatment and prognosis vary not only with stage but also with cell type. [radiopaedia.org]

Stages and Outlook (Prognosis) After a cancer diagnosis, staging provides important information about the extent of cancer in the body and anticipated response to treatment. [cancer.org]

What is the prognosis for lung cancer without treatment? Doctor’s Response More than half of lung cancer patients will die within one year of diagnosis even with treatment. Without treatment, patients may die even sooner. [emedicinehealth.com]

Learn More About Treatment for Asbestos-Related Lung Cancer Prognosis and Survival Rates The prognosis for lung cancer depends on the type and subtype of the disease. [asbestos.com]

The prognosis and outlook for lung cancer depend upon the cancer type and the spread. People should talk to their doctor who can provide a more accurate prognosis, taking into account the individual's overall health and the extent of their cancer. [medicalnewstoday.com]

[from NCI ] Etiology Eur J Cardiothorac Surg 2017 Dec 1;52(6):1041-1048. doi: 10.1093/ejcts/ezx272. [ncbi.nlm.nih.gov]

It is important to distinguish the different etiologies because treatment varies widely, from observation for granulomas or hamartomas to surgery for malignancies like carcinoid tumor and solitary metastasis. [pulmonologyadvisor.com]

The authors also noted that a smooth inner wall to the cavity was more commonly observed in lesions of benign etiology. [cancernetwork.com]

Etiology The predominant cause of small cell lung cancer (SCLC) (and non-SCLC) is tobacco smoking. [emedicine.medscape.com]

"Lung cancer: epidemiology, etiology, and prevention". Clinics in Chest Medicine. 32 (4): 605–44. doi : 10.1016/j.ccm.2011.09.001. PMC 3864624. PMID 22054876. Goodman GE (November 2002). "Lung cancer. 1: prevention of lung cancer". [en.wikipedia.org]

Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol. 2006 Oct 1. 24(28):4539-44. [Medline]. American Cancer Society. [emedicine.medscape.com]

A review of the epidemiology of lung adenocarcinoma". International Journal of Epidemiology. 26 (1): 14–23. doi : 10.1093/ije/26.1.14. PMID 9126499. Archived from the original on 5 December 2008. Kadara H, Kabbout M, Wistuba II (January 2012). [en.wikipedia.org]

Pathophysiology Small cell lung carcinoma (SCLC) arises in peribronchial locations and infiltrates the bronchial submucosa. [emedicine.medscape.com]

In the 1990s, two techniques that focus on vascularity, pathophysiologic features, and pharmacodynamics have been applied to the diagnosis of the solitary pulmonary nodule. [cancernetwork.com]

[…] immunosuppression and increase the survival of cancer-fighting T cells ICOS : activating this co-stimulatory pathway on T cells can help enhance immune responses against cancer IDO : blocking this enzyme’s activity can help prevent cancer-fighting T [cancerresearch.org]

Q: What is the best way to prevent lung cancer? A: The best way to prevent lung cancer is not to smoke cigarettes or to quit smoking if you are a smoker. Adithya Cattamanchi, MD Answers represent the opinions of our medical experts. [medicalnewstoday.com]