Symptoma

Malignant Neoplasm of the Vulva

Vulvar Cancer

Less common presenting symptoms include vulvar bleeding, discharge, dysuria, and pain. The most common presenting sign of vulvar cancer is a vulvar lump or mass. Rarely, patients present with a large, fungating mass. [aafp.org]

The sentinel node was identified in all patients and three patients presented positive sentinel nodes. Two of those patients presented groin recurrences within the first 12 months of follow-up. [scielo.br]

[…] focally Perinuclear cytoplasmic vacuoles, characteristic of smooth muscle differentiation, are usually present at least focally Cigar shaped nuclei; atypical features of hyperchromasia to severe pleomorphism may be seen Foci of epithelioid cells may [pathologyoutlines.com]

Pain in the pelvis, especially during urination or sex. [7] Typically, a lesion presents in the form of a lump or ulcer on the labia majora and may be associated with itching, irritation, local bleeding or discharge, in addition to pain with urination [en.wikipedia.org]

  • Wound Infection

    infection and breakdown, and chronic leg edema. [aafp.org]

    Complications of surgery include wound infection, sexual dysfunction, edema and thrombosis, as well as lymphedema secondary to dissected lymph nodes. [32] Sentinel lymph node (SLN) dissection is the identification of the main lymph node(s) draining the [en.wikipedia.org]

    infections and postoperative complications. [dovepress.com]

  • Falling

    Most women who fall into the following groups won’t get it, while others who don’t might: Age. Your risk of getting vulvar cancer goes up as you grow older. More than half of all cases happen in women over age 70. [webmd.com]

  • Thrombosis

    View/Print Table TABLE 4 Complications of Radical Vulvar Surgery and Groin Lymphadenectomy Timing of complication Complication Early (up to six weeks fter surgery) Anesthesia of anterior thigh (secondary o femoral nerve injury) Deep venous thrombosis [aafp.org]

    Complications of surgery include wound infection, sexual dysfunction, edema and thrombosis, as well as lymphedema secondary to dissected lymph nodes. [32] Sentinel lymph node (SLN) dissection is the identification of the main lymph node(s) draining the [en.wikipedia.org]

  • Hypertension

    Hypertension, diabetes mellitus, and obesity have been found to coexist in up to 25 percent of patients, although they are not considered independent risk factors. 7 In the past, syphilis and other granulomatous diseases have been associated with vulvar [aafp.org]

    Diabetes mellitus, hypertension, and obesity seem to correlate with the incidence of vulvar cancer, but do not appear to be responsible. 11 Lichen sclerosus, a subgroup of VNED, is mooted as a predisposing risk factor in the development of HPV-negative [dovepress.com]

  • Skin Ulcer

    Most typical symptoms include : painful sexual intercourse bleeding pain and burning dark discoloration in cases of melanoma painful urination persistent itching rawness and sensitivity wart-like growths thickened skin ulceration Different types of vulvar [medicalnewstoday.com]

  • Dyspareunia

    […] femoral nerve injury) Deep venous thrombosis Groin wound infection and breakdown Hemorrhage Osteitis pubis Pulmonary embolism Seroma of the femoral triangle Urinary tract infection Wound necrosis Late (six weeks after surgery or later) Chronic leg edema Dyspareunia [aafp.org]

  • Urinary Stress Incontinence

    stress incontinence Prognosis The prognosis of patients with vulvar cancer is generally good when appropriate treatment is initiated in a timely fashion. [aafp.org]

  • Chancroid

    A number of diseases cause infectious lesions including herpes genitalis, human papillomavirus, syphilis, chancroid, granuloma inguinale, and lymphogranuloma venereum. [en.wikipedia.org]

A complete workup based on age, initial symptoms, tumor localization, presence of ulceration, postoperative stage, surgical procedure, and survival, was performed. [onlinelibrary.wiley.com]

Treatment Options by Stage For information about the treatments listed below, see the Treatment Option Overview section. [cancer.gov]

Information about the cancer’s stage will help the doctor recommend a specific treatment plan. The next section in this guide is Treatment Options. You may use the menu to choose a different section to read in this guide. [cancer.net]

The earlier vulvar cancer is diagnosed, the less likely an extensive surgery is needed for treatment. [mayoclinic.org]

Early diagnosis increases the chance of successful treatment dramatically, but without treatment, cancer can spread to other parts of the body. [medicalnewstoday.com]

"What are the treatment options?". Society of Gynecologic Oncology. [en.wikipedia.org]

Click to enlarge the image There are multiple types of squamous epithelial carcinoma, which vary in prognosis and etiology. [oncolex.org]

Knowing the stage helps the doctor to decide if additional treatment may be necessary and can help predict a patient's prognosis, which is the chance of recovery. There are different stage descriptions for different types of cancer. [cancer.net]

Lymph node involvement is the most important predictor of prognosis. [35] Thus, early diagnosis is important. [en.wikipedia.org]

Verrucous carcinoma is an uncommon subtype that's important to recognize because it's slow-growing and tends to have a good prognosis (outlook). [cancer.org]

The prognosis of patients with vulvar cancer is generally good when appropriate treatment is initiated in a timely fashion. [aafp.org]

There are two types, differing both in treatments and in etiology. Differentiated VIN. [oncolex.org]

The etiologic role of HPV in vulvar squamous cell carcinoma fine tuned. Cancer Epidemiol Biomarkers Prev 2009; 18:2061–2067 [Google Scholar] 6. van Beurden M, ten Kate FJ, Smits HL, et al. [ajronline.org]

VIN can also be classified into viral and nonviral etiologies. Younger women are more commonly affected by viral VIN than older women and are also more likely to exhibit multifocal disease. [accessmedicine.mhmedical.com]

To the Editor: Lichen sclerosus (LS) is a chronic inflammatory disorder of unknown etiology that most commonly affects the anogenital region. [mdedge.com]

Etiology The high-risk (HR) human papillomaviruses (HPVs) infections have been identified as an essential although not sufficient factor in the pathogenesis of vulval and vagina carcinoma. [atlasgeneticsoncology.org]

Carcinoma of the vulva: epidemiology and pathogenesis. Obstet Gynecol. 1992;79:448–54. 4. Creasman WT, Phillips JL, Menck HR. The National Cancer Data Base report on early stage invasive vulvar carcinoma. [aafp.org]

Title Human papillomavirus infections: epidemiology, pathogenesis, and therapy. [genome.jp]

"Epidemiology of vulvar neoplasia in the NIH-AARP Study". Gynecologic Oncology. 145 (2): 298–304. doi : 10.1016/j.ygyno.2017.02.030. PMC 5629039. PMID 28236455. "Vulvar Cancer". Gynecologic Neoplasms. Armenian Health Network, Health.am. 2005. [en.wikipedia.org]

Definition / general Only 1 - 3% of vulvar tumors are sarcomas Of these, leiomyosarcomas are the most common type Epidemiology Usually diagnosed in women older than 40 years of age but may be found in younger women Sites Most common site is labia majora [pathologyoutlines.com]

Carcinoma of the vulva: epidemiology and pathogenesis. Obstet Gynecol. 1992;79(3):448–454. 11. Sugiyama VE, Chan JK, Shin JY, Berek JS, Osann K, Kapp DS. Vulvar melanoma: a multivariable analysis of 644 patients. [dovepress.com]

Pathophysiology: Functional Alterations in Human Health. Lippincott Williams & Wilkins. ISBN 9780781762502. Rubin, Emanuel; Reisner, Howard M. (2009). Essentials of Rubin's Pathology. Lippincott Williams & Wilkins. [en.wikipedia.org]

View Article : Google Scholar : PubMed/NCBI 23 Smith YR and Haefner HK: Vulvar lichen sclerosus: pathophysiology and treatment. Am J Clin Dermatol. 5:105–125. 2004. [spandidos-publications.com]

Asian Pacific Journal of Cancer Prevention. 2012; 13(8): 3653-3656 [cancerjournal.net]

Prevention Reduce your risk of sexually transmitted infections To reduce your risk of vulvar cancer, reduce your risk of the sexually transmitted infection HPV: Limit your number of sexual partners. [mayoclinic.org]

It is important to seek early diagnosis and treatment, to prevent the spread of cancer. Treatment The types of treatment normally used for vulvar cancer are surgery, chemotherapy, radiation therapy, and biologic therapy. [medicalnewstoday.com]

The vulva serves to direct urine flow, prevent foreign bodies from entering the urogenital tract, as well as being a sensory organ for sexual arousal. [dovepress.com]

Primary care physicians can identify women at risk and prevent serious, advanced disease by properly educating their peers and patients. [aafp.org]