Delayed Nasdaq - 01:00 2022-11-25 pm EST 1.800 USD +4.05% X4 Pharmaceuticals : Q3 2022 Earnings Presentation 912.4 KB 11/03/2022 | 08:13am EST 3Q 2022 Earnings Call: The Road to 4WHIM Data and Beyond November 3, 2022 Forward-Looking Statements This presentation [marketscreener.com]

At present, the name applied by Tuerk, "malignant neutropenia," seems [jamanetwork.com]

In primary neutropenia disorders such as chronic granulomatous disease presents with recurrent infections affecting many organs since childhood. [ncbi.nlm.nih.gov]

The symptoms of infection can have an atypical presentation in patients with neutropenia due to the less local inflammation; hence pus and fluctuance may be absent. [news-medical.net]

Fever, thoracic pain, dyspnoea and cough were the most frequent presenting symptoms. At the onset, 89% patients were neutropenic (neutrophil counts < 0.5 x 10(9)/l) with a median duration of previous neutropenia of 14 d (range 6-60). [pubmed.ncbi.nlm.nih.gov]

• Fever

  Physicians should ask about symptoms such as weight loss, fever or night sweats, recent viral infections, medications and rheumatologic complaints. [news-medical.net]

  Any fever above 38.5°C/101.3°F must be taken very seriously and your nurse or physician should be informed. [neutropenianet.org]

  Fever, thoracic pain, dyspnoea and cough were the most frequent presenting symptoms. At the onset, 89% patients were neutropenic (neutrophil counts < 0.5 x 10(9)/l) with a median duration of previous neutropenia of 14 d (range 6-60). [pubmed.ncbi.nlm.nih.gov]

  Episodes of fever in neutropenia in pediatric patients with cancer in Bern, Switzerland, 1993-2012. Sci Data. 2019 Jan 15;6:180304. [PMC free article: PMC6335615] [PubMed: 30644854] 16. [ncbi.nlm.nih.gov]

• Sepsis

  PMID: 2033415 A randomized trial of granulocyte-macrophage colony-stimulating factor in neonates with sepsis and neutropenia. Bilgin K, Yaramiş A, Haspolat K, Taş MA, Günbey S, Derman O. Bilgin K, et al. [pubmed.ncbi.nlm.nih.gov]

  Serious infections and opportunistic infections: Serious infections such as pneumonia, staphylococcal bacteraemia, sepsis/septic shock (including fatal outcomes), and herpes zoster, and opportunistic infections such as Pneumocystis jiroveci pneumonia [epressi.com]

  […] tonsillitis Extensive cutaneous bacterial (Staphylococcal) infections Sore throat Purulent conjunctivitis Granuloma with catalase-positive organisms Skin abnormalities, e.g., pyodermitis Splenomegaly Diarrhea Recurrent abscess Aphthous stomatitis Urinary sepsis [ncbi.nlm.nih.gov]

• Recurrent Infection

  Failure to carry out this role leads to immunodeficiency, which is mainly characterized by the presence of recurrent infections. [ncbi.nlm.nih.gov]

  The pattern of recent or recurrent infections is significant in defining both the duration and clinical significance of existing neutropenia. [news-medical.net]

  Free article Abstract Individuals with severe forms of congenital neutropenia suffer from recurrent infections. [pubmed.ncbi.nlm.nih.gov]

• Lymphadenopathy

  Particular attention should be directed to the oropharynx and periodontium, sites of catheters and recent procedures, lymphadenopathy in various parts of the body, as well as external auditory canals. [news-medical.net]

• Withdrawn

  WITHDRAWN: Steroids, radiotherapy, chemotherapy and stents for superior vena caval obstruction in carcinoma of the bronchus. Cochrane Database Syst Rev. 2015; (3):CD001316. Batouty N, Sobh D, Gadelhak B, Sobh H, Mahmoud W. [revistas.upb.edu.co]

• Neutropenia

  Free article Abstract Individuals with severe forms of congenital neutropenia suffer from recurrent infections. [pubmed.ncbi.nlm.nih.gov]

  Abstract Neutropenia is frequently observed in the practice of oncology, usually resulting from the use of cytotoxic drugs. Less frequently, neutropenia is due to infiltration of the bone marrow by malignant disease. [eprints.gla.ac.uk]

  Neutropenia, with decreased production with marrow hypoplasia, can be primary and due to chronic benign neutropenia, cyclical neutropenia, and other congenital and familial neutropenias. [ncbi.nlm.nih.gov]

• Leukopenia

  Clozapine-induced agranulocytosis and leukopenia: incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in Thailand. Asian J Psychiatry. 2019; 41: 13-6. [ Links ] 20. Law A, Croucher M. [scielo.org.pe]

  Association of clinical complications with nutritional status and the prevalence of leukopenia among arsenic patients in Bangladesh. Int J Environ Res Public Health. 2004 Sep;1(2):74-82. [PubMed: 16696181] 24. [ncbi.nlm.nih.gov]

Treatment by Cancer Type NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) are posted with the latest update date and version number. The NCCN Guidelines are copyrighted by the NCCN. All rights reserved. [nccn.org]

[…] stem cell transplantation is not a treatment option ADCETRIS is indicated for the treatment of adult patients with relapsed or refractory systemic anaplastic large cell lymphoma (sALCL). [epressi.com]

An analysis of factors influencing outcome demonstrated that the resolution of chemotherapy-induced neutropenia and prolonged treatment with amphotericin B and, if feasible, radical surgical debridement treatment, were significantly correlated with recovery [pubmed.ncbi.nlm.nih.gov]

Review of evolving etiologies, implications and treatment strategies for the superior vena cava syndrome. Springerplus. 2016; 29;5:229. Oh IJ, Park CK, Kim YC. [revistas.upb.edu.co]

Without treatment, neutropenia is associated with a high risk of death. [ncbi.nlm.nih.gov]

prognosis of neutropenia disorders depends on the cause and organs involved. [ncbi.nlm.nih.gov]

Extensive and aggressive diagnostic and therapeutic procedures are essential to improve the prognosis in these patients. [pubmed.ncbi.nlm.nih.gov]

This activity reviews the etiology, presentation, evaluation, and management/prevention of neutropenia, and reviews the role of the interprofessional team in evaluating, diagnosing, and managing the condition. [ncbi.nlm.nih.gov]

Review of evolving etiologies, implications and treatment strategies for the superior vena cava syndrome. Springerplus. 2016; 29;5:229. Oh IJ, Park CK, Kim YC. [revistas.upb.edu.co]

Meta- analysis examining the epidemiology of clozapine-associated neutropenia. Acta Psychiatr Scand. 2018; 138(2): 101-9. [ Links ] 17. Inada K, Oshibuchi H, Ishigooka J, Nishimura K. [scielo.org.pe]

A shift has been noted in the epidemiology infectious agents since the widespread use of empiric antibiotic therapy – highly lethal, gram-negative bacilli were superseded by indolent, gram-positive bacterial and fungal pathogens. [news-medical.net]

Metastatic spinal cord compression: Incidence, epidemiology and prognostic factors. Rev Clin Esp. 2019; 219(7):386-9. Silva G, Bergmann A, Thuler L. [revistas.upb.edu.co]

Chronic Granulomatous Disease: Epidemiology, Pathophysiology, and Genetic Basis of Disease. J Pediatric Infect Dis Soc. 2018 May 09;7(suppl_1):S2-S5. [PMC free article: PMC5946813] [PubMed: 29746675] 9. [ncbi.nlm.nih.gov]

Chronic Granulomatous Disease: Epidemiology, Pathophysiology, and Genetic Basis of Disease. J Pediatric Infect Dis Soc. 2018 May 09;7(suppl_1):S2-S5. [PMC free article: PMC5946813] [PubMed: 29746675] 9. [ncbi.nlm.nih.gov]

A "hyper-dense" population of immune cells in the bone marrow, reducing the ability to achieve a healthy immune response No targeted therapies approved to treat underlying cause / pathophysiology Current treatments do not address mechanism of disease [marketscreener.com]

Diagnosis, pathophysiology and management of hypercalcemia in malignancy: A review of the literature. Horm Metab Res 2019; 51(12):770-8. Pfennig CL, Slovis CM. Electrolyte disorders. In Marx J, Hockberger R, Walls R. [revistas.upb.edu.co]

Adverse effects of clozapine in older patients: epidemiology, prevention and management. Drugs Aging. 2014; 31(1): 11-20. [ Links ] 8. Haddad PM, Sharma SG. Adverse effects of atypical antipsychotics: differential risk and clinical implications. [scielo.org.pe]

Therapeutic use of these cytokines among patients hospitalized for established neutropenia may complement the recommended prophylactic use of these agents for the prevention of neutropenic episodes. [news-medical.net]

This activity reviews the etiology, presentation, evaluation, and management/prevention of neutropenia, and reviews the role of the interprofessional team in evaluating, diagnosing, and managing the condition. [ncbi.nlm.nih.gov]

[…] underlying cause / pathophysiology Current treatments do not address mechanism of disease Treatments include antibiotics, G-CSF, and immunoglobulins; do not correct lymphopenia, are not effective against HPV related- disease, have no effect on cancer prevention [marketscreener.com]

NCCN Clinical Practice Guidelines in Oncology: Prevention and Treatment of Cancer-Related Infections. v2.2017 [Internet]. 2017 [citado el 5 de febrero de 2021]. Disponible en: https://www.nccn.org/professionals/physician_gls/pdf/infections.pdf. [revistas.upb.edu.co]