Presentation
We present three patients with DMPM, without a history of asbestos exposure and without ascites, who presented with complete bowel obstruction. All patients underwent emergency operations, and palliative surgical procedures were performed. [ncbi.nlm.nih.gov]
Entire Body System
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Fatigue
The most common symptoms are breathlessness, chest pain, fatigue and weight loss. In most cases the first sign of something being wrong is when breathlessness or pain in the chest occur as a result of an effusion. [mesothelioma.uk.com]
Symptoms Clinical symptoms at the time of presentation may include abdominal pain, abdominal mass, increased abdominal girth, distention of the abdomen, ascites (fluid in the abdomen), fever, weight loss, fatigue, anemia and digestive disturbances. [mesotheliomaweb.org]
[…] chemical irritation from pancreatitis, infectious or autoimmune serositis, or an inflammatory response associated with peritoneal carcinomatosis. 1 Case Report A 45-year-old otherwise healthy African American man presented with a chief complaint of fatigue [acgcasereports.gi.org]
Other symptoms include: Abdominal Pain Loss of Appetite Blood Clots Fatigue Fluid Buildup (Ascites) Nausea Abdominal Swelling Fever or Sweating Tissue Lumps in the Abdomen Anemia Seizures Bowel Problems In most cases, peritoneal mesothelioma does not [mesotheliomaguide.com]
Mesothelioma of Peritoneum may include: The presence of large-sized tumors that are nodular in appearance, in the peritoneal region Low-grade fever and profuse sweating Abdominal pain, swollen abdomen Nausea and vomiting Change in bowel habits Tiredness or fatigue [dovemed.com]
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Intravenous Administration
Unfortunately, intraperitoneal bleomycin was accompanied by pulmonary toxicity, but at a higher total dose than known for intravenous administration. [ncbi.nlm.nih.gov]
administration followed by 2 drug-free weeks). [mesorfa.org]
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Mucosal Edema
The combination of transverse ridging with convergence on double-contrast radiography and mucosal edema without epithelial lesions on endoscopy was consistent with a disorder involving the serosa. [ncbi.nlm.nih.gov]
Gastrointestinal
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Abdominal Pain
Significant prognostic factors were age, performance status (PS), abdominal pain, serum albumin level, thrombocytosis, and treatment strategy on univariate analysis, while only age, abdominal pain, and treatment strategy hold statistical significance [ncbi.nlm.nih.gov]
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Nausea
There was no nausea, vomiting, diarrhea, abdominal pain, or abdominal distension. Many broad spectrum antibiotics were given without relief of fever. [ncbi.nlm.nih.gov]
Symptoms of malignant peritoneal mesothelioma include the following: Abdominal pain, acute to severe Swelling of the abdominal region due to fluid accumulation Breathing difficulties Loss of appetite resulting in weight loss Bowel obstruction Nausea Vomiting [tenlaw.com]
He had no abdominal pain, nausea/vomiting, or dysphagia. His physical examination was within normal limits except for mild ascites and muscle wasting. His laboratory data revealed mild anemia and mild hypoalbuminemia (albumin 2.9 g/dL). [shmabstracts.com]
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Left Flank Pain
A 56-year-old man with no past history of asbestos exposure, chronic viral hepatitis, or alcoholic liver injury was admitted to our hospital with left flank pain and abdominal tumor. [ncbi.nlm.nih.gov]
Workup
Abstract We present a case illustrating the workup and diagnosis of peritoneal sarcomatous mesothelioma as an unusual etiology of intestinal obstruction and high-protein ascites in an otherwise healthy man. [acgcasereports.gi.org]
A patient with increasing abdominal distension with weight loss and loss of lean muscle should raise suspicion for malignant ascites and a possible peritoneal malignancy, so should undergo further workup. [ncbi.nlm.nih.gov]
X-Ray
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Pulmonary Infiltrate
A patient with malignant peritoneal mesothelioma and a diffuse pulmonary infiltrate is described. Computed tomographic scanning suggested lymphangitis carcinomatosa. This was confirmed on transbronchial biopsy to be due to metastatic mesothelioma. [ncbi.nlm.nih.gov]
Treatment
CONCLUSIONS: CRS and HIPEC represent the standard treatment strategy for selected patients with MPM, and patients with unresectable tumors can benefit from the combined treatment of chemotherapy, radiotherapy, and immunotherapy. [ncbi.nlm.nih.gov]
Prognosis
An abdominal or pelvic mass was associated with a reduced prognosis and an absence of radiologic abnormalities with an improved prognosis. [ncbi.nlm.nih.gov]
Etiology
In malignant mesothelioma without prior asbestos exposure, the etiology and prognostic significance is still unclear. Further study is needed to clarify this point. [ncbi.nlm.nih.gov]
Etiology The relationship between peritoneal mesothelioma and asbestos exposure is unclear, especially in women, and has not been established unlike in malignant pleural mesothelioma. [orpha.net]
Evaluation at an outside facility did not determine a cause of ascites and was negative for hepatic and cardiac etiologies. He denied abdominal pain or fevers. History was positive for early satiety, nausea, and muscle wasting. [acgcasereports.gi.org]
Epidemiology
No previous studies have examined the national epidemiology of MPeM in Nordic countries. This study aimed to clarify the epidemiology of MPeM in Finland over a 12-year period. [ncbi.nlm.nih.gov]
Prevention
Data have shown that knowledgeable patient selection is required to prevent patients unlikely to benefit from undergoing these interventions. [ncbi.nlm.nih.gov]
There are 4 goals of screening: (i) to identify high risk groups, (ii) to target preventive actions, (iii) to discover occupational diseases, and (iv) to develop improved tools for treatment, rehabilitation and prevention. [sjweh.fi]
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. [atsdr.cdc.gov]
When mesothelioma develops in the pleura, the delicate layers of the pleura thicken and may press on the lung, preventing it from expanding when breathing in (inhaling). [cancervic.org.au]