Presentation
We present two cases of gestational choriocarcinoma, showing some of these unusual presentations of a primarily gynecological problem. [ncbi.nlm.nih.gov]
However, the guidance in the Index can be overridden if one of the descriptors mentioned above is present. The Tabular must be reviewed for the complete diagnosis code. [icdlist.com]
Respiratoric
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Respiratory Insufficiency
Immediately after HE, the patient developed diffuse pulmonary metastases and died of respiratory insufficiency after two courses of MTX-therapy. The autopsy confirmed metastatic CCA. [ncbi.nlm.nih.gov]
If the uterus is enlarged more than 14–16 weeks' gestational size or the patient has pregnancy-induced hypertension, arterial blood gases should be measured preoperatively because many of these patients will develop respiratory insufficiency after evacuation [glowm.com]
Psychiatrical
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Suggestibility
Aminopeptidase A (AP-A), a cell-surface metallopeptidase hydrolyzing peptide with N-terminal acidic residues, has been proved to be identical to the B cell differentiation antigen BP-1 and to the kidney differentiation antigen gp160, suggesting recognition [ncbi.nlm.nih.gov]
Workup
Prognosis of gestational choriocarcinoma largely depends upon early diagnosis of the disease, comprehensive metastatic workup, selection of appropriate regimen of chemotherapy from outset and carefully planned follow up. [ayubmed.edu.pk]
See Workup for more detail. Management Patients with GTN are subdivided into 2 groups: those with a WHO score of less than 7 (low-risk) and those with a score of 7 or higher and who are at high risk of therapy failure. [emedicine.medscape.com]
X-Ray
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Mediastinal Mass
Following computed tomography imaging, a mediastinal mass was histologically determined to be a gestational choriocarcinoma. [ncbi.nlm.nih.gov]
In the present study, the patient experienced a biochemical remission and had a relatively long survival time, though a small solid component remained in the residual cystic mediastinal mass and two small lesions remained in the lung. [spandidos-publications.com]
Other Pathologies
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Trophoblastic Cells
An aggressive malignant tumor arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. [icd10data.com]
Choriocarcinoma is a highly malignant neoplasm resulting from the malignant transformation of proliferating trophoblastic cells and the molecular mechanisms leading to this transformation remain to be characterized. [ncbi.nlm.nih.gov]
Thymus ICD-O-3 topography code: C37 ICD10: C37 An aggressive malignant tumour arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. [codes.iarc.fr]
Treatment
Cancer itself rarely harms the baby, and some cancer treatments are safe during pregnancy. You and your health care provider will work together to find the best treatment. [icdlist.com]
The patient had no detectable metastasis or evidence of recurrence 15 months after treatment, which involved surgery without adjuvant chemotherapy. [ncbi.nlm.nih.gov]
Prognosis
Non-gestational choriocarcinoma carries a bad prognosis than GCO. We present a case of NGCO who had pulmonary metastasis. [ncbi.nlm.nih.gov]
Etiology
Differentiation between two etiologies of primary choriocarcinoma can be achieved with DNA polymorphic analysis and it is necessary to distinguish between them to approach to an appropriate treatment of a patient. [ncbi.nlm.nih.gov]
Etiology Etiology is not known. Diagnostic methods Histologically, choriocarcinoma is characterized by trophoblast proliferation, absence of chorionic villi and tissue necrosis with bleeding. [orpha.net]
Etiology In the case of gestational choriocarcinoma, approximately 5% of cases of complete hydatidiform mole are followed by choriocarcinoma. Only about half the cases of choriocarcinoma arise from a complete hydatidiform mole. [radiopaedia.org]
Etiology, pathogenesis 50% cases of choriocarcioma arise in complete mole, 25% follow normal term pregnancy, 25% follow spontaneous abortion. Extremely rare are cases arising in ectopic pregnancy. [atlases.muni.cz]
Epidemiology
METHODS: Overall and 5-year average age-adjusted incidence rates were computed with the Surveillance, Epidemiology, and End Results program public-use database. [ncbi.nlm.nih.gov]
Summary Epidemiology Annual incidence and prevalence are not known. [orpha.net]
Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 2010;203(6):531-9. [aulamedica.es]
Clinical and Epidemiological Investigations, Brian E. Henderson, C. Paul Morrow, Charles B. Hammond, Ernest I. Kohorn and Donald F. [cancerres.aacrjournals.org]
Pathophysiology
Pathophysiology and Etiology Choriocarcinoma recapitulates placental tissue development. [emedicine.medscape.com]
(Lurain, 2010) return to top Pathophysiology Choriocarcinoma is an invasive, highly vascular, anaplastic trophblastic tissue made up of cytotrophoblasts and syncitotrophoblasts that secrete human chorionic gonadotropin (hCG) in high amounts (Goldstein [sharinginhealth.ca]
Pathophysiology Hydatidiform mole Hydatidiform moles are chromosomally abnormal gestations caused by faulty fertilization of the oocyte. [clinicaladvisor.com]
Prevention
One of the major unresolved problems in high-risk choriocarcinoma is the prevention of hemorrhage from tumor necrosis during chemotherapy. [ncbi.nlm.nih.gov]
Prevent and plan for potential complications associated with the advancing age of pregnant women. [books.google.com]
Prevention There is no known means of prevention. However, early detection of the symptoms and prompt medical treatment can improve the odds of survival. Key terms Biopsy — A sample of an organ taken to look for abnormalities. [medical-dictionary.thefreedictionary.com]
Prophylactic chemotherapy for women who have had complete moles to prevent GTN is not recommended [ 8 ]. [patient.info]