Edit concept Question Editor Create issue ticket

Malignant Pleural Mesothelioma

Mesothelioma of Pleura


Presentation

  • The present study aimed to report a rare presentation of metastatic malignant mesothelioma (MM). The patient was an elderly man who presented with small bowel (jejunal) perforation secondary to metastatic pleural mesothelioma deposits.[ncbi.nlm.nih.gov]
Fever
  • The patient presented with fever and left chest pain. A computed tomography scan (CT) of the chest showed a small amount of left pleural effusion and slight left pleural thickening that remained unchanged for 1 year.[ncbi.nlm.nih.gov]
  • Symptoms include chest pain, breathlessness, weight loss, fatigue, fever, and night sweats. These symptoms can be caused by the cancer or by the accumulation of fluid around the lungs.[sydneyheartandlung.com.au]
  • There was no associated cough or fever but he reported having stumbled against a table the previous day, after which his symptoms started. Chest X-ray on admission showed a massive pleural effusion, obliterating his right lung field.[imj.ie]
Low Fever
  • Anamnesis revealed professional asbestos exposure and the patient presented dyspnea, dry cough, right sited chest pain, low fever and loss of weight.[ncbi.nlm.nih.gov]
Weight Gain
  • Physicians should be aware of this side effect in patients presenting with edema and weight gain and initiate prompt renal function testing, serum albumin and urinalysis followed by steroid treatment if pembrolizumab-related MCD is suspected.[ncbi.nlm.nih.gov]
Cough
  • Anamnesis revealed professional asbestos exposure and the patient presented dyspnea, dry cough, right sited chest pain, low fever and loss of weight.[ncbi.nlm.nih.gov]
  • There was no associated cough or fever but he reported having stumbled against a table the previous day, after which his symptoms started. Chest X-ray on admission showed a massive pleural effusion, obliterating his right lung field.[imj.ie]
  • Unfortunately, many of the more serious symptoms, such as painful breathing, coughing blood and difficulty swallowing, aren’t noticeable until the cancer has reached its later stages, when treatment options are usually more limited.[pleuralmesothelioma.com]
Abdominal Pain
  • Though local recurrence is more frequent in LMPM, the possibility of distant metastasis should not be ignored in patients with non-specific abdominal pain.[ncbi.nlm.nih.gov]
  • A chest wall mass, weight loss, sweating, abdominal pain and ascites (due to peritoneal involvement) are less common presentations.[orpha.net]
  • pain Abdominal swelling Nausea Unexplained weight loss Other forms of mesothelioma Signs and symptoms of other types of mesothelioma are unclear, since these forms of the disease are very rare.[mayoclinic.org]
  • Learn more about Pleural Mesothelioma Peritoneal Mesothelioma Location: Lining of the abdomen Symptoms: Abdominal pain and swelling, bloating and bowel changes Prognosis: 52 percent live at least five years after surgery with HIPEC Peritoneal accounts[asbestos.com]
Arthralgia
  • FINDINGS: As of June 20, 2016, 25 patients received pembrolizumab. 16 (64%) patients reported a treatment-related adverse event; the most common adverse event were fatigue (six [24%]), nausea (six [24%]), and arthralgia (five [20%]).[ncbi.nlm.nih.gov]
Fracture
  • This is a case report of malignant pleural mesothelioma metastatic to the femur with a pathologic fracture of femoral neck.[ncbi.nlm.nih.gov]
Subcutaneous Nodule
  • Four months after the initial admission, a subcutaneous nodule was found in the left chest wall and a biopsy was taken.[ncbi.nlm.nih.gov]
Lacrimation
  • Magnetic resonance imaging showed an aggressive lacrimal gland tumour with bony erosion. A biopsy concluded a diagnosis of metastatic mesothelioma of the lacrimal gland.[ncbi.nlm.nih.gov]
Diplopia
  • A 55-year-old woman with an untreated malignant biopsy-proven pleural mesothelioma presented with right proptosis, diplopia and hypoglobus. Magnetic resonance imaging showed an aggressive lacrimal gland tumour with bony erosion.[ncbi.nlm.nih.gov]
Neck Mass
  • A neck mass was apparent and was identified pathologically as a lymph node metastasis of malignant mesothelioma. F-18 fluorodeoxyglucose positron emission tomography/CT established the diagnosis of malignant pleural mesothelioma.[ncbi.nlm.nih.gov]
Ataxia
  • Ataxia-telangiectasia (AT) is a hereditary disorder characterized by progressive neurological dysfunction, oculocutaneous telangiectasia, immunodeficiency, cancer susceptibility, and radiation sensitivity.[ncbi.nlm.nih.gov]

Workup

  • ), Positron emission tomography-computed tomography (PET-CT) and ultrasound (US).The aim of this paper is to describe the imaging features of this malignancy, underlining the peculiarity of CXR, CT, MRI, PET-CT and US and also focusing on diagnostic workup[ncbi.nlm.nih.gov]
  • In combination with imaging methods, tumor markers have been suggested to improve the diagnostic workup and to enhance survival [ 7 , 8 ]. Three markers have been selected in this study to evaluate their potential to assist the diagnostic workup.[medsci.org]
Left Pleural Effusion
  • A 64-year-old man who had been exposed to asbestos was referred to our hospital for a detailed examination of left pleural effusion. A laboratory examination of the urine and blood revealed nephrotic syndrome.[ncbi.nlm.nih.gov]
Mediastinal Mass
  • A computed tomographic scan revealed a posterior mediastinal mass surrounding the lower portion of the esophagus. Endoscopic examination demonstrated narrowing of the lower esophagus without malignant mucosal lesions.[ncbi.nlm.nih.gov]
Posterior Mediastinal Mass
  • A computed tomographic scan revealed a posterior mediastinal mass surrounding the lower portion of the esophagus. Endoscopic examination demonstrated narrowing of the lower esophagus without malignant mucosal lesions.[ncbi.nlm.nih.gov]
Colitis
  • The most frequent immunotherapy related autoimmune reactions include dermatitis, pneumonitis, colitis, hypophysitis, uveitis, hypothyreodism, hepatitis and interstitial nephritis.[ncbi.nlm.nih.gov]
  • Results were presented at the American Society of Clinical Oncology and European Crohn’s and Colitis Organisation in 2007 62. No survival difference was observed between both arms, excepted for a trend favouring the vinorelbine sub-group.[erj.ersjournals.com]

Treatment

Prognosis

  • Additional chemotherapy should not be delayed in those with poorer prognosis node positive, nonepithelioid disease.[ncbi.nlm.nih.gov]

Etiology

  • Exposure to asbestos is the principal etiological agent of MPM. The disease is characterized by difficult stage classification and limited consensus on therapeutic approach.[ncbi.nlm.nih.gov]
  • Readers will gain knowledge of the etiology, immunopathology of this disease and will understand the rationale for new treatment methods. The initial section of the book gives the historical context of mesothelioma in medicine.[eurekaselect.com]
  • Etiology Mesothelioma is directly attributable to occupational asbestos exposure with a history of exposure in over 90% of cases.[orpha.net]
  • Definition / general Malignant mesothelioma arises from mesothelial lining of pleura, peritoneum, pericardium and tunica vaginalis - pleural mesothelioma is the most common of these Etiology Smoking is not a risk factor Risk factors include: Asbestos[pathologyoutlines.com]
  • Etiology asbestos -fiber exposure: causes majority of cases erionite-fiber exposure: naturally occurring mineral used in building, particularly in Turkey 12 simian virus 40 (SV40) 13 radiation exposure 13 Histology There are three histological types of[radiopaedia.org]

Epidemiology

  • 1 Department of Health Sciences, University of Piemonte Orientale, Novara, Italy. 2 Department of Medical Sciences, University of Turin, Turin, Italy; Human Genetics Foundation, HuGeF, Turin, Italy. 3 CPO-Piemonte and Unit of Medical Statistics and Epidemiology[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • These data highlight the role of claudins and TJ related proteins in the context of pleural physiology and pathophysiology.[journal.frontiersin.org]
  • MPM is considered an asbestos-related disease (ARD); in fact, pathophysiological processes are common to professional pneumoconiosis such as chronic inflammation resulting in pleural plaque formation due to asbestos fiber retention [ 37 ], promoting pro-inflammatory[oatext.com]
  • Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer. PLoS Comput Biol 11, e1004612 (2015). 50. Greco, S. & Martelli, F. MicroRNAs in Hypoxia Response.[nature.com]
  • In this study an overview of the epidemiology, etiology, mechanisms of pathophysiology and symptomatology of MPM is carried out. Keywords : Malignant pleural mesothelioma, Asbestos, Epidemiology, Pathogenesis, Symptomatology.[oncm.org]

Prevention

  • Here, we describe a sophisticated surgical technique of P/D without any pleural incision ("non-incisional P/D") to achieve en bloc removal of the entire pleura and tumor, which may improve postoperative survival by preventing tumor spread.[ncbi.nlm.nih.gov]
  • Side effects not only cause patients discomfort, but also may prevent the delivery of therapy at its planned dose and schedule.[cancer.unm.edu]
  • Berger: "Using bioinformatics, we were able to show that the increased formation of the protein bcl-2, which prevents cell death, reduces the effectiveness of trabectedin."[sciencedaily.com]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!