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MALT Lymphoma

MALToma


Presentation

  • The patient is now alive 3 years after the first presentation.[ncbi.nlm.nih.gov]
  • Herein we present a case of an 84-year-old patient discovered to have a primary pulmonary MALT lymphoma presenting as a non-resolving pneumonia causing a clinical challenge.[ncbi.nlm.nih.gov]
  • Of these 54 patients, 17 patients (30%) presented with multiple involved mucosal sites; 37 patients (70%) presented with 1 involved mucosal site, but in 23 of these patients (44%), dissemination of the disease was due to bone marrow involvement; 12 patients[ncbi.nlm.nih.gov]
  • We report a case of a primary extranodal marginal zone of mucosa-associated lymphoid tissue (Malt Lymphoma) of the larynx in a 73-year-old non-smoker woman, presented as chronic cough, unresponsive to oral corticosteroid.[ncbi.nlm.nih.gov]
  • We present a case of a 56-year-old man with 3 synchronous gastric tumors.[ncbi.nlm.nih.gov]
Abdominal Lymphadenopathy
  • She was well until November 2008 when she developed abdominal lymphadenopathy and transabdominal excisional biopsy showed mixed cellularity classical Hodgkin lymphoma at stage II. She underwent standard combination chemotherapy.[ncbi.nlm.nih.gov]
Cervical Lymphadenopathy
  • In most cases, the presenting symptoms are hoarseness, dysphagia, dyspnea, and cervical lymphadenopathy. They consist mainly of non-Hodgkin lymphoma, especially of diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue.[ncbi.nlm.nih.gov]
Weight Loss
  • It commonly manifests with symptoms of weight loss, low-grade fever, constipation, melena, and hematochezia. Unlike gastric lymphoma, it is difficult to detect MALT-type lymphoma of the colon by imaging.[ncbi.nlm.nih.gov]
  • Left and Center: Lobulated, polypoid, proximal gastric mass, with several focal ulceratoins, seen at endoscopy in a 61 year-old man with adbominal discomfort, early satiety and weight loss.[endoatlas.com]
  • CASE REPORT A 56-year-old Hispanic woman presented to the clinic with symptoms of chronic epigastric pain for the past three years and a 13-pound weight loss over the past two months. The patient did not have any prior medical conditions.[ncbi.nlm.nih.gov]
  • Symptoms were present in 23/35 (65.7%) patients with the weight loss as the most common symptom. Gastric MALT lymphomas were usually localized in the stomach corpus and corpus and antrum (45.7% and 31.2%, respectively).[ncbi.nlm.nih.gov]
  • In multivariate analysis weight loss and increased erythrocyte sedimentation rate were significantly less frequent in low grade (45% and 22%) compared with high grade lymphoma (75% and 53%).[dx.doi.org]
Fatigue
  • A 50-year-old African American woman, with a history of hepatitis C and prior Mucosal Associated Lymphoid Tissue (MALT) lymphoma of the hard palate, presented to the Emergency Department with a chief complaint of fatigue and "bumps on my skin."[ncbi.nlm.nih.gov]
  • We present the case of a 48-year-old man who was admitted to hospital with a history of coughing, fever, fatigue and non-specific lesions on his chest X-ray. The patient was treated for pneumonia, but showed no improvement.[ncbi.nlm.nih.gov]
  • ., fatigue, weight loss) and an unremarkable physical exam. Diagnosis is based on histopathology and immunohistochemistry. In the case of gastric MALTomas, a biopsy should be performed by upper gastrointestinal (UGI) endoscopy.[amboss.com]
  • No grade 4 non-hematologic adverse events were reported; common mild adverse events included musculoskeletal pain, fatigue, cough/respiratory infection, diarrhea, and vertigo. Grade 3-4 neutropenia occurred in 18.8% of patients.[cancertherapyadvisor.com]
  • […] non-Hodgkin's lymphoma, small cell (diffuse) Corresponding ICD-10-CM Codes (U.S. only) C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT lymphoma] (effective October 01, 2015) Signs and Symptoms Drenching night sweats Fatigue[seer.cancer.gov]
Fever
  • Tick-borne Rickettsia rickettsii Rocky Mountain spotted fever Rickettsia conorii Boutonneuse fever Rickettsia japonica Japanese spotted fever Rickettsia sibirica North Asian tick typhus Rickettsia australis Queensland tick typhus Rickettsia honei Flinders[en.wikipedia.org]
  • We present the case of a 48-year-old man who was admitted to hospital with a history of coughing, fever, fatigue and non-specific lesions on his chest X-ray. The patient was treated for pneumonia, but showed no improvement.[ncbi.nlm.nih.gov]
  • It commonly manifests with symptoms of weight loss, low-grade fever, constipation, melena, and hematochezia. Unlike gastric lymphoma, it is difficult to detect MALT-type lymphoma of the colon by imaging.[ncbi.nlm.nih.gov]
  • […] lymphoma, small cell (diffuse) Corresponding ICD-10-CM Codes (U.S. only) C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT lymphoma] (effective October 01, 2015) Signs and Symptoms Drenching night sweats Fatigue Fever[seer.cancer.gov]
  • Clinical features : arises from bronchus-associated lymphoid tissue (BALT). 40% are asymptomatic and present with a solitary pulmonary nodule on CXR. [ 1 ] There may be cough, dyspnoea, haemoptysis, fever, weight loss.[patient.info]
Anemia
  • Autoimmune neutropenia (AIN), resulting from granulocyte-specific autoantibodies, is much less frequent than other autoimmune hematologic disorders including autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP).[ncbi.nlm.nih.gov]
  • Her systemic examination was unremarkable, while her routine labs revealed mild anemia.[ncbi.nlm.nih.gov]
  • Stage, elevated LDH, anemia, elevated beta-2 microglobulin, plasmacytic differentiation, monoclonal gammopathy, or autoimmune disease did not influence the rate of disease progression nor did complete remission or partial remission from initial therapy[ncbi.nlm.nih.gov]
  • Center: 83 year-old woman with asymptomatic iron-deficiency anemia. Endoscopy demonstrated several small antral gastric ulcers with raised surrounding mucosa.[endoatlas.com]
  • Fatigue, weight loss Non-gastric MALTomas: Salivary MALToma: parotid enlargement Thyroid MALToma: may present with compression symptoms (e.g., dysphagia, hoarseness) References: [1] [4] Diagnostics General approach Blood analysis : anemia Histopathology[amboss.com]
Amyloidosis
  • Systemic amyloid light chain amyloidosis (AL amyloidosis) is usually seen in association with a plasma cell disorder.[ncbi.nlm.nih.gov]
  • Localized (primary) pulmonary amyloidosis associated with pulmonary low-grade B cell lymphoma is rarely occurred.[ncbi.nlm.nih.gov]
  • The histomorphological, immunohistochemical and flow cytometric features were consistent with primary gastric amyloidosis associated with extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT lymphoma).[ncbi.nlm.nih.gov]
  • After follow-up for two years, the nodule was diagnosed as MALT lymphoma associated with plasma cell differentiation and amyloidosis by the fourth FNAC.[ncbi.nlm.nih.gov]
  • Lim J K, Lacy M Q, Kurtin P J. et al Pulmonary marginal zone lymphoma of MALT type as a cause of localised pulmonary amyloidosis. J Clin Pathol 2001 54 642–646. [ PMC free article ] [ PubMed ] [ Google Scholar ] 24. Hyjek E, Smith W J, Isaacson P G.[ncbi.nlm.nih.gov]
Abdominal Pain
  • An 86-year-old female was referred to our hospital manifesting obstructive jaundice and abdominal pain.[ncbi.nlm.nih.gov]
  • The patient presented with complaints of abdominal pain of variable intensity that had increased in severity over the past several months.[ncbi.nlm.nih.gov]
  • A 74-year-old woman with lower abdominal pain was diagnosed with MALT lymphoma by endoscopic mucosal resection (EMR). She was diagnosed as stage IE (Ann Arbor) MALT lymphoma by diagnostic work-up and review of EMR specimens.[ncbi.nlm.nih.gov]
  • A 34-year-old woman presented abdominal pain and melena. Colorectal and small intestinal endoscopes revealed multiple tumors and ulcers of the entire ileum. Biopsy was taken.[ncbi.nlm.nih.gov]
  • Right: Gastric fundic tumor, shown here at retroflexion, in a 76 year old woman with loss of appetite, early satiety, weight loss and anemia, but no abdominal pain. The lesion was focally ulcerated and bleeding.[endoatlas.com]
Nausea
  • Steroids: this is to reduce the side effects of anti-cancer drugs such as nausea and vomiting. Surgery: if the disease is located in one region and can be taken out surgically, surgery can be used to remove part or whole of the particular organ.[myvmc.com]
  • Nonspecific symptoms include fatigue, low-grade fever, nausea, constipation, weight loss and anaemia. Recurrent respiratory tract infections. Orbital MALT lymphomas may present with blurred vision and visual field defects.[patient.info]
  • These include but are not limited to medications to counteract nausea and vomiting, intravenous fluids to treat dehydration, pain medications, antacids to lower the risk of ulcers, and bone marrow stimulating drugs to reverse the low white blood cell[rarediseases.org]
  • […] development of ulcers or open sores It is thought to be related to either an undetected injury at the time of the original 4 Answers – Posted in: creon 20 pancreatitis chronic pancreatitis pain – Answer: heartburn gas loose stools problems much too bloating nausea[telefot.eu]
  • Other symptoms at registration included nausea/vomiting (10%), pain/dyspepsia (55%) and anorexia (10%). Associated autoimmune disease was present in 7% (Hashimoto thyroiditis 2%, rheumatoid arthritis 1%, other 4%), and 8% had a second tumour.[ncbi.nlm.nih.gov]
Epigastric Pain
  • CASE REPORT A 56-year-old Hispanic woman presented to the clinic with symptoms of chronic epigastric pain for the past three years and a 13-pound weight loss over the past two months. The patient did not have any prior medical conditions.[ncbi.nlm.nih.gov]
  • The most common presenting symptoms of MALT lymphoma are nonspecific dyspepsia and epigastric pain, whereas constitutional B symptoms and gastric bleeding are rare[ 15 ].[doi.org]
  • Clinical features Diagnosis and staging The most common presenting symptoms of low-grade gastric MALT lymphomas are nonspecific dyspepsia and epigastric pain. Constitutional B symptoms are exceedingly uncommon.[bloodjournal.org]
Constipation
  • It commonly manifests with symptoms of weight loss, low-grade fever, constipation, melena, and hematochezia. Unlike gastric lymphoma, it is difficult to detect MALT-type lymphoma of the colon by imaging.[ncbi.nlm.nih.gov]
  • Nonspecific symptoms include fatigue, low-grade fever, nausea, constipation, weight loss and anaemia. Recurrent respiratory tract infections. Orbital MALT lymphomas may present with blurred vision and visual field defects.[patient.info]
  • The link between PPIs and hert Treatment of Chronic Constipation in Children Getting Started. Share: Heartburn or Indigestion.[telefot.eu]
Abdominal Mass
  • Intermediate- and high-grade lymphomas may result in the following examination findings: Rapidly growing and bulky lymphadenopathy Splenomegaly Hepatomegaly Large abdominal mass: Usually in Burkitt lymphoma Testicular mass Skin lesions: Associated with[emedicine.medscape.com]
Angioedema
  • In the 138 courses assessed for toxicity, 20 patients experienced 29 adverse events (most commonly the expected infusion-related side effects, including hypotension, angioedema, bronchospasm, skin rash, fever).[doi.org]
Subcutaneous Nodule
  • Cytology from one of these subcutaneous nodules was consistent with extranodal marginal zone B cell lymphoma.[ncbi.nlm.nih.gov]
Adnexal Mass
  • We describe the unusual case of a patient with an adnexal mass secondary to MALT lymphoma with associated amyloid deposition.[ncbi.nlm.nih.gov]

Workup

  • For the diagnostic workup and optional management of this rare coexistence, a multidisciplinary approach and close surveillance are needed.[ncbi.nlm.nih.gov]
  • Our patient was referred to an oncologist for an extensive workup; the oncologist detected no other organ involvement or lymphadenopathy.[aao.org]
  • Early detection and accurate stage workup is essential for treatment of MALT lymphoma.[doi.org]
  • Although a variety of laboratory and imaging studies are used in the evaluation and staging of suspected NHL (see Workup ), a well-processed hematoxylin and eosin (H&E)–stained section of an excised lymph node is the mainstay of pathologic diagnosis.[emedicine.medscape.com]
Hyperviscosity
  • Furthermore, patients with MALT lymphoma should be screened for Waldenström macroglobulinemia and hyperviscosity syndrome.[ncbi.nlm.nih.gov]
  • At diagnosis, the WM patient had monoclonal IgM with cryoglobulinemia and hyperviscosity syndrome.[ncbi.nlm.nih.gov]
  • We report in this article central retinal vein occlusion (CRVO) caused by hyperviscosity syndrome (HVS) in a young patient with mucosa-associated lymphoid tissue (MALT) lymphoma and Sjögren's syndrome (SjS).[ncbi.nlm.nih.gov]
Decreased Peak Expiratory Flow Rate
  • A decreased peak expiratory flow rate was noted at least 3 years before the diagnosis, and was attributed to an insufficient effort by the patient.[ncbi.nlm.nih.gov]

Treatment

  • CONCLUSIONS: Patients with early stage gastric MALT lymphoma negative for H pylori might still benefit from antibiotic treatment as the sole treatment modality.[ncbi.nlm.nih.gov]
  • Two patients in arm B died of disease progression after histologic transformation, which occurred during treatment. Table 2 provides the results of response assessment at the end of the study treatment according to treatment arm.[doi.org]
  • Responders to treatment were defined as patients whose post-treatment biopsies showed complete histological response (ChR) or probable minimal residual disease (pMRD).[ncbi.nlm.nih.gov]
  • Table 2 summarizes the treatment results by previous treatment and primary site of lymphoma involvement.[doi.org]
  • Owing to its B cell lineage, it appears to be a potential target for treatment with the CD20 antibody rituximab. We present an analysis of our experience with rituximab for treatment of patients with advanced MALT lymphoma.[ncbi.nlm.nih.gov]

Prognosis

  • CONCLUSION: VCP could be a useful marker for predicting the prognosis of primary orbital MALT lymphoma.[ncbi.nlm.nih.gov]
  • Prognosis of MALT lymphoma MALT lymphoma is considered an indolent non-Hodgkin’s lymphoma, hence it has better prognosis as compared to T cell lymphoma. Generally speaking, MALT lymphoma has a fairly good prognosis.[myvmc.com]
  • In many cases, primary MALT lymphoma of the breast is low grade lymphoma, localized in the breast with indolent behavior and good prognosis. Here we report a case of spontaneous regression of primary MALT lymphoma of the breast.[ncbi.nlm.nih.gov]
  • Gastrointestinal lymphoma represent a heterogenous group with differences in pathogenesis, treatment and prognosis. Gastric MALT lymphoma is the most common entity. Helicobacter pylori has been identified as its decisive pathogenetic factor.[ncbi.nlm.nih.gov]
  • Treatment and prognosis MALT lymphoma is considered an indolent disease with a good prognosis. Treatment should be tailored to the affected organ and may consist of surgery, chemotherapy and/or radiation therapy 2 .[radiopaedia.org]

Etiology

  • […] complications Helicobacter Infections/drug therapy Helicobacter pylori Hepatitis C, Chronic/complications Hepatitis C, Chronic/drug therapy Humans Immunoproliferative Small Intestinal Disease/drug therapy Immunoproliferative Small Intestinal Disease/etiology[ncbi.nlm.nih.gov]
  • Biliary strictures at the hilum of the liver arise from heterogeneous etiologies. The majority is malignant entities, but some may have benign etiologies. It is difficult to distinguish between malignant and benign biliary strictures preoperatively.[ncbi.nlm.nih.gov]
  • This report describes etiologic data, diagnostic and treatment considerations, and sophisticated radiation therapy techniques aimed at reducing long-term toxicity in this indolent disease.[ncbi.nlm.nih.gov]
  • Intussusception is an extremely rare diagnosis in adults, with an etiologic process identified in the majority of cases.[ncbi.nlm.nih.gov]
  • Lymphoma, B-Cell, Marginal Zone/genetics* Male Middle Aged Neoplasm Staging Retrospective Studies Stomach Neoplasms/epidemiology Stomach Neoplasms/etiology Stomach Neoplasms/genetics* Translocation, Genetic* Treatment Failure Substances Adaptor Proteins[ncbi.nlm.nih.gov]

Epidemiology

  • Lymphoma, B-Cell, Marginal Zone/etiology Lymphoma, B-Cell, Marginal Zone/genetics* Male Middle Aged Neoplasm Staging Retrospective Studies Stomach Neoplasms/epidemiology Stomach Neoplasms/etiology Stomach Neoplasms/genetics* Translocation, Genetic* Treatment[ncbi.nlm.nih.gov]
  • The PET images were analyzed visually and semi-quantitatively by measuring the maximum standardized uptake value (SUVmax), lesion-to-liver SUVmax ratio, and lesion-to-blood pool SUVmax ratio and compared with Ann Arbor stage, epidemiological (age, sex[ncbi.nlm.nih.gov]
  • Epidemiology References: [1] Epidemiological data refers to the US, unless otherwise specified. Etiology Gastric MALTomas: multiple studies show an association with H. pylori infection.[amboss.com]
  • Gov't MeSH terms Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents/therapeutic use Biopsy Disease Progression Drug Therapy, Combination Epidemiologic Methods Female Helicobacter Infections/complications Helicobacter Infections/drug therapy[ncbi.nlm.nih.gov]
  • […] abdomen, or bone s (for no known reason) Skin rash or itchy skin Weight loss (for no known reason) Diagnostic Exams Flow cytometry Immunohistochemistry Immunophenotyping Progression and Transformation Recurrences may occur after many years and may involve Epidemiology[seer.cancer.gov]
Sex distribution
Age distribution

Pathophysiology

  • Sil, Unfolding the Mechanism of Proteases in Pathophysiology of Gastrointestinal Diseases, Pathophysiological Aspects of Proteases, 10.1007/978-981-10-6141-7_24, (583-603), (2017).[doi.org]
  • For discussion of individual subtypes of NHL, see the following: Pathophysiology NHLs are tumors originating from lymphoid tissues, mainly of lymph nodes.[emedicine.medscape.com]

Prevention

  • The LY03 trial was designed to establish whether chlorambucil after treatment for H. pylori would help prevent recurrence. Patients were treated with antibiotics for H. pylori infection.[ncbi.nlm.nih.gov]
  • CONCLUSION: Durable complete remission of low-grade gastric MALT lymphoma is achieved in a high percentage after eradication of H. pylori infection, thus preventing the formation of diffuse large-cell lymphoma and gastric adenocarcinoma.[ncbi.nlm.nih.gov]
  • CTFPHC REFERENCE BOOK Screening for Colorectal Cancer CTFPHC REFERENCE BOOK Screening for Cognitive Impairment CTFPHC REFERENCE BOOK Screening for Depression CTFPHC REFERENCE BOOK Screening for Developmental Delay CTFPHC Review Canadian Task Force on Preventive[qxmd.com]
  • Gastric and duodenal ulcers are thought to be caused, at least in part, by H. pylori infection, since the eradication of this microorganism prevents recurrences of these diseases 29,30.[doi.org]

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