As an example, two atypical primary and secondary progeroid laminopathies that show overlapping features of Hutchinson-Gilford progeria syndrome, restrictive dermopathy, dysplasia and even muscular laminopathies are presented. [infona.pl]

Thus the modifying effect of SUN mutations found in the present study helps to explain the clinical intra- and interfamilial variability observed in EDMD. [epub.ub.uni-greifswald.de]

This case provides the first evidence of human lamin A direct involvement in DNA repair and that increased DNA damage is a major pathophysiological factor in progeroid laminopathies. [epub.ub.uni-greifswald.de]