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Marburg Virus


Presentation

  • The case presented to Mpigi District Health Center on 17 September 2014, and transferred to Mengo Hospital, Kampala, on 23 September 2014.[who.int]
  • In the present study we analyzed the impact of late domains present in NP on the release of VLPs. We observed that the ESCRT I protein Tsg101 was recruited by NP into NP-induced inclusions in the perinuclear region.[ncbi.nlm.nih.gov]
  • Here, we present the 3.6 Å crystal structure of Marburg virus GP in complex with a cross-reactive antibody from a human survivor, and a lower resolution structure of the antibody bound to Ebola virus GP.[ncbi.nlm.nih.gov]
  • In the present paper, we provide evidence that GP undergoes an additional posttranslational modification; it is phosphorylated at its ectodomain. Phosphorylation takes place at serine residues between amino acid 260 and 273.[ncbi.nlm.nih.gov]
  • Furthermore, this is the first report of Marburg virus being present in this area of Africa, thus extending the known range of the virus.[ncbi.nlm.nih.gov]
Hypothermia
  • Successful treatment of severe Crimean-Congo hemorrhagic fever with supportive measures without ribavirin and hypothermia. J Clin Virol . 2009 Feb. 44(2):181-2. [Medline] . Zampieri CA, Sullivan NJ, Nabel GJ.[emedicine.com]
Aspiration
  • Occasionally urine samples were collected directly from the bladder by aspiration with a syringe. The schedule for sample collection is given in Table 1.[doi.org]
Regurgitation
  • After a gestation period of 105–7 days, females usually give birth to a single pup which is carried attached to a nipple on the female for 6 weeks, then left at the roosting site and fed with regurgitated food for 9–10 weeks, before flying and fending[doi.org]
Hypotension
  • As disease progresses, systemic (prostration, lethargy), gastrointestinal (anorexia, vomiting, abdominal pain, diarrhea), respiratory (chest pain, breath shortness, cough, nasal discharge), vascular (conjunctival injection, postural hypotension, edema[ncbi.nlm.nih.gov]
Insect Bite
  • Animals found in the Goroumbwa mine included bats, rodents, shrews, frogs, snakes, cockroaches, crickets, spiders, wasps, and moth flies, although there was no history of direct exposure to animals or insect bites in any patient with Marburg hemorrhagic[doi.org]
Stroke
  • For all lab exposures which involve BSL-4 pathogens (needle sticks, punctures, cuts, scratches, etc.) and for all medical events which require immediate evaluation and treatment (traumatic injury, heart attack, stroke, seizure, etc.): Medical Campus:[bu.edu]

Workup

Pericardial Effusion
  • Gross pathologic lesions included maculopapular cutaneous rash; pulmonary congestion and edema; pericardial effusion; enlarged, congested, and/or hemorrhagic lymphoid tissues; enlarged friable fatty liver; and pyloric and duodenal congestion and/or hemorrhage[ncbi.nlm.nih.gov]
Fibrinogen Decreased
  • Other factors, including increased fibrinogen, decreased protein C activity, thrombocytopenia, and coagulation disorder were observed in the hamster model. The target organs were the mesenteric lymph node, spleen, liver, and adrenal gland.[ncbi.nlm.nih.gov]
Enlargement of the Liver
  • Gross pathologic lesions included maculopapular cutaneous rash; pulmonary congestion and edema; pericardial effusion; enlarged, congested, and/or hemorrhagic lymphoid tissues; enlarged friable fatty liver; and pyloric and duodenal congestion and/or hemorrhage[ncbi.nlm.nih.gov]
Viral Inclusion Body
  • KEYWORDS: dual-color imaging; reverse genetics; viral inclusion bodies[ncbi.nlm.nih.gov]

Treatment

  • The antisense treatment also reduced serum viremia and inflammatory cytokines in all treatment groups compared to vehicle controls. The antibody immune response to virus was preserved and tissue viral antigen was cleared in AVI-7288 treated animals.[ncbi.nlm.nih.gov]
  • Studies performed with other MARV strains assessed candidate treatments at times shortly after virus exposure, before signs of disease are detectable.[ncbi.nlm.nih.gov]
  • "The difference is that that study examined treatment shortly after exposure. It did not look at initiating treatment at signs of illness."[news.nationalgeographic.com]
  • Treatment and vaccines There is as yet no proven treatment available for MVD. Supportive care – rehydration with oral or intravenous fluids – and treatment of specific symptoms, improves survival.[citizentv.co.ke]
  • Most work to find a treatment has involved only a few strains of Ebola virus and testing of relatively small drug libraries or compounds that have shown efficacy against other virus types.[ncbi.nlm.nih.gov]

Prognosis

  • Clinical Syndrome Seiten 1-9 Clinical Course and Prognosis of Marburg Virus (“Green-Monkey”) Disease Stille, W. (et al.) Seiten 10-18 Clinical Picture of Two Patients Infected by the Marburg Vervet Virus Todorovitch, K. (et al.)[springer.com]
  • Limited evidence suggests that the prognosis for neonates born to mothers with EVD is poor, and most die within 19 days of birth.[wwwnc.cdc.gov]
  • Prognosis Case-fatality rates are typically over 80%, although it was only 22% in one outbreak in Europe stemming from imported monkeys.[orpha.net]
  • Clinical course and prognosis of Marburg virus (“green monkey”) disease. In: Martini GA, Siegert R, eds. Marburg virus disease. Berlin: Springer-Verlag, 1971:10-8. 22. Egbring R, Slenczka W, Baltzer G.[doi.org]
  • Clinical course and prognosis of Marburg virus (‘Green-Monkey’) disease. In: Martini G.A., Siegert R., editors. Marburg virus disease. Springer Verlag; New York: 1971. pp. 10–18. [ Google Scholar ] 11. Todorovitch K., Mocitch M., Klasnja R.[ncbi.nlm.nih.gov]

Etiology

  • The etiological agent was isolated and identified by the combined efforts of virologists in Marburg and Hamburg within the very short time of 3 months.[ncbi.nlm.nih.gov]
  • The filoviruses (Lake Victoria marburgvirus and the ebolaviruses) are etiological agents of severe hemorrhagic fevers with extraordinary high case-fatality rates for humans, chimpanzees, gorillas, and probably other animals.[books.google.com]
  • Etiology Over 25 different viruses cause viral hemorrhagic fever. Marburg virus is a member of the virus family Filoviridae, along with Ebola virus. Numerous strains have been identified, putatively with different degrees of lethality.[orpha.net]
  • This occurred through close contact with patients when infection control precautions were not strictly practiced or haemorrhagic viral etiology not recognized.[ecdc.europa.eu]
  • Introduction The genera Marburgvirus and Ebolavirus comprise the family Filoviridae, which contains the etiological agents that cause Marburg virus (MARV) disease and Ebola virus (EBOV) disease, respectively.[jem.rupress.org]

Epidemiology

  • The analysis was severely hampered by a lack of completeness in epidemiologic data.[ncbi.nlm.nih.gov]
  • Here, we present results of epidemiological and laboratory investigations.[ncbi.nlm.nih.gov]
  • The topics addressed include the molecular biology of filoviruses, pathogenesis, epidemiology, immune response, as well as clinical aspects and diagnostic measures.[books.google.com]
  • Author information 1 Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Kita-20, Nishi-10, Kita-ku, Sapporo 001-0020, Japan.[ncbi.nlm.nih.gov]
  • Author information 1 Division of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology Once the virus enters the body though breaks in the skin or mucous membranes, it infects dendritic cells and macrophages which then carry it to lymph nodes.[centerforhealthsecurity.org]
  • We hope that further research facilitates progress toward elucidating the disease pathophysiology and developing prophylactic and therapeutic measures against EHF and MHF.[ncbi.nlm.nih.gov]
  • Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes. Lipids 44, 477–487 (2009) 24. Rodriguez-Lafrasse, C. et al.[doi.org]
  • Novel viruses have recently been identified. [6, 7] Pathophysiology Although common themes occur, the different viruses display variable pathophysiology.[emedicine.com]
  • Elaboration of laboratory strains of Ebola virus and study of pathophysiological reactions of animals inoculated with these strains. Acta Trop. 2003; 87 :321–329. [ PubMed ] [ Google Scholar ] 7.[ncbi.nlm.nih.gov]

Prevention

  • Fever, Ebola/prevention & control Humans Macaca fascicularis Marburg Virus Disease/immunology Marburg Virus Disease/prevention & control Marburgvirus/immunology* Mice Mice, Inbred BALB C Plasmids/immunology Rabbits Reverse Transcriptase Polymerase Chain[ncbi.nlm.nih.gov]
  • Additionally, there are currently no licensed vaccines available to prevent filovirus outbreaks.[ncbi.nlm.nih.gov]
  • Currently, treatment of disease is only supportive, and no vaccines are available to prevent spread of MARV infections.[ncbi.nlm.nih.gov]
  • Author information 1 Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia. 2 Uganda Ministry of Health. 3 Uganda Virus Research Institute. 4 World Health Organization. 5 Viral Special Pathogens Branch, Centers for[ncbi.nlm.nih.gov]
  • Abstract Recently, tetherin has been identified as an effective cellular factor that prevents the release of human immunodeficiency virus type 1.[ncbi.nlm.nih.gov]

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