Symptoma

Marburg Virus

In the present study we analyzed the impact of late domains present in NP on the release of VLPs. We observed that the ESCRT I protein Tsg101 was recruited by NP into NP-induced inclusions in the perinuclear region. [ncbi.nlm.nih.gov]

The case presented to Mpigi District Health Center on 17 September 2014, and transferred to Mengo Hospital, Kampala, on 23 September 2014. [who.int]

  • Hypothermia

    Successful treatment of severe Crimean-Congo hemorrhagic fever with supportive measures without ribavirin and hypothermia. J Clin Virol. 2009 Feb. 44(2):181-2. [Medline]. Zampieri CA, Sullivan NJ, Nabel GJ. [emedicine.com]

  • Aspiration

    Occasionally urine samples were collected directly from the bladder by aspiration with a syringe. The schedule for sample collection is given in Table 1. [doi.org]

  • Regurgitation

    After a gestation period of 105–7 days, females usually give birth to a single pup which is carried attached to a nipple on the female for 6 weeks, then left at the roosting site and fed with regurgitated food for 9–10 weeks, before flying and fending [doi.org]

  • Hypotension

    As disease progresses, systemic (prostration, lethargy), gastrointestinal (anorexia, vomiting, abdominal pain, diarrhea), respiratory (chest pain, breath shortness, cough, nasal discharge), vascular (conjunctival injection, postural hypotension, edema [ncbi.nlm.nih.gov]

  • Insect Bite

    Animals found in the Goroumbwa mine included bats, rodents, shrews, frogs, snakes, cockroaches, crickets, spiders, wasps, and moth flies, although there was no history of direct exposure to animals or insect bites in any patient with Marburg hemorrhagic [doi.org]

  • Pericardial Effusion

    Gross pathologic lesions included maculopapular cutaneous rash; pulmonary congestion and edema; pericardial effusion; enlarged, congested, and/or hemorrhagic lymphoid tissues; enlarged friable fatty liver; and pyloric and duodenal congestion and/or hemorrhage [ncbi.nlm.nih.gov]

  • Fibrinogen Decreased

    Other factors, including increased fibrinogen, decreased protein C activity, thrombocytopenia, and coagulation disorder were observed in the hamster model. The target organs were the mesenteric lymph node, spleen, liver, and adrenal gland. [ncbi.nlm.nih.gov]

  • Enlargement of the Liver

    Gross pathologic lesions included maculopapular cutaneous rash; pulmonary congestion and edema; pericardial effusion; enlarged, congested, and/or hemorrhagic lymphoid tissues; enlarged friable fatty liver; and pyloric and duodenal congestion and/or hemorrhage [ncbi.nlm.nih.gov]

The antisense treatment also reduced serum viremia and inflammatory cytokines in all treatment groups compared to vehicle controls. The antibody immune response to virus was preserved and tissue viral antigen was cleared in AVI-7288 treated animals. [ncbi.nlm.nih.gov]

"The difference is that that study examined treatment shortly after exposure. It did not look at initiating treatment at signs of illness." [news.nationalgeographic.com]

With no treatment available, doctors struggled to help as the virus killed 329 of 374 infected patients. [sciencedaily.com]

Treatment and vaccines There is as yet no proven treatment available for MVD. Supportive care – rehydration with oral or intravenous fluids – and treatment of specific symptoms, improves survival. [citizentv.co.ke]

Clinical Syndrome Seiten 1-9 Clinical Course and Prognosis of Marburg Virus (“Green-Monkey”) Disease Stille, W. (et al.) Seiten 10-18 Clinical Picture of Two Patients Infected by the Marburg Vervet Virus Todorovitch, K. (et al.) [springer.com]

Prognosis Case-fatality rates are typically over 80%, although it was only 22% in one outbreak in Europe stemming from imported monkeys. [orpha.net]

Limited evidence suggests that the prognosis for neonates born to mothers with EVD is poor, and most die within 19 days of birth. [wwwnc.cdc.gov]

Clinical course and prognosis of Marburg virus (“green monkey”) disease. In: Martini GA, Siegert R, eds. Marburg virus disease. Berlin: Springer-Verlag, 1971:10-8. 22. Egbring R, Slenczka W, Baltzer G. [doi.org]

Clinical course and prognosis of Marburg virus (‘Green-Monkey’) disease. In: Martini G.A., Siegert R., editors. Marburg virus disease. Springer Verlag; New York: 1971. pp. 10–18. [ Google Scholar ] 11. Todorovitch K., Mocitch M., Klasnja R. [ncbi.nlm.nih.gov]

The etiological agent was isolated and identified by the combined efforts of virologists in Marburg and Hamburg within the very short time of 3 months. [ncbi.nlm.nih.gov]

The filoviruses (Lake Victoria marburgvirus and the ebolaviruses) are etiological agents of severe hemorrhagic fevers with extraordinary high case-fatality rates for humans, chimpanzees, gorillas, and probably other animals. [books.google.com]

Etiology Over 25 different viruses cause viral hemorrhagic fever. Marburg virus is a member of the virus family Filoviridae, along with Ebola virus. Numerous strains have been identified, putatively with different degrees of lethality. [orpha.net]

This occurred through close contact with patients when infection control precautions were not strictly practiced or haemorrhagic viral etiology not recognized. [ecdc.europa.eu]

Introduction The genera Marburgvirus and Ebolavirus comprise the family Filoviridae, which contains the etiological agents that cause Marburg virus (MARV) disease and Ebola virus (EBOV) disease, respectively. [jem.rupress.org]

The analysis was severely hampered by a lack of completeness in epidemiologic data. [ncbi.nlm.nih.gov]

The topics addressed include the molecular biology of filoviruses, pathogenesis, epidemiology, immune response, as well as clinical aspects and diagnostic measures. [books.google.com]

Pathophysiology Once the virus enters the body though breaks in the skin or mucous membranes, it infects dendritic cells and macrophages which then carry it to lymph nodes. [centerforhealthsecurity.org]

We hope that further research facilitates progress toward elucidating the disease pathophysiology and developing prophylactic and therapeutic measures against EHF and MHF. [ncbi.nlm.nih.gov]

Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes. Lipids 44, 477–487 (2009) 24. Rodriguez-Lafrasse, C. et al. [doi.org]

Novel viruses have recently been identified. [6, 7] Pathophysiology Although common themes occur, the different viruses display variable pathophysiology. [emedicine.com]

Fever, Ebola/prevention & control Humans Macaca fascicularis Marburg Virus Disease/immunology Marburg Virus Disease/prevention & control Marburgvirus/immunology* Mice Mice, Inbred BALB C Plasmids/immunology Rabbits Reverse Transcriptase Polymerase Chain [ncbi.nlm.nih.gov]

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