PMBS presents as digital clubbing and hypertrophic pulmonary osteoarthropathy. [cureus.com]

First published: 23 December 2004 Citations: 6 Abstract A 55‐year‐old man presented to our Department with a 10‐year history of coarsening of the facial features. [onlinelibrary.wiley.com]

As the pathophysiology of PMB's syndrome is mostly unknown we present some diagnostic hypotheses found in the medical literature. [ecronicon.com]

Hypertrophic osteoarthropathy has a variable clinical presentation, ranging from asymptomatic morphologic and radiographic findings to pain accompanying the changes of the fingers and toes 5. [radiopaedia.org]

• Mediastinal Lymphadenopathy

  For further characterization, a CT chest with contrast was ordered, demonstrating a 14 x 16 x 18 cm heterogenous right lung/thoracic mass arising from right hilum/middle mediastinum or right hemidiaphragm with mediastinal lymphadenopathy (Figure 2A, 2B [cureus.com]

• Heart Disease

  pleural fibroma mesothelioma cyanotic congenital heart disease gastrointestinal tract and liver inflammatory bowel disease gastrointestinal lymphoma Whipple disease celiac disease primary biliary cholangitis idiopathic Plain radiograph Typically seen [radiopaedia.org]

• Palpitations

  Hypoglycemia has many presentations, such as dizziness, lightheadedness, diaphoresis, anxiety, palpitations and syncope. It can often be the initial indicator that suggests a diagnosis of SFT [8]. [cureus.com]

• Arthralgia

  Clubbed fingers and arthralgia as a reversible paraneoplastic syndrome (Pierre-Marie-Bamberger syndrome) in non-small-cell bronchial carcinoma. Dtsch Med Wochenschr. 1998; 123 1507-1511 5 Friedel B, Grasshoff H, Korb K. [thieme-connect.com]

  The presentation of this syndrome is consistent with non-specific arthritic type symptoms such as joint stiffness, swelling, arthralgias and pain along the long bones. [cureus.com]

• Joint Stiffness

  The presentation of this syndrome is consistent with non-specific arthritic type symptoms such as joint stiffness, swelling, arthralgias and pain along the long bones. [cureus.com]

• Aggressive Behavior

  Final tissue diagnosis of SFT with high risk for aggressive behavior was made. Histochemical analysis showed a spindle cell lesion composed of sheets of spindle cells with oval or elongated nuclei separated by collagen. [cureus.com]

Further workup ruled out secondary causes of hypoglycemia. A morning cortisol 11.66 mg/dL, C-peptide 4.0 ng/mL, fasting insulin 21 uIU/mL, and Insulin-like growth factor 1 (IGF-1) of 73 ng/mL, were measured. [cureus.com]

• Mediastinal Mass

  A chest X-ray was obtained, showing a right lower lung diffuse opacity of unclear origin, likely a mediastinal mass vs. pulmonary mass (Figure 1). [cureus.com]

• Erythrocytosis

  Chronic hypoxia leads to erythrocytosis with formation of drumstick fingers and toes and watch glass nails and also to swelling in the area of the diaphyses, preferably on the long tubular bones. [altmeyers.org]

Another critical aspect of management of SFT is the treatment of hypoglycemia in patients with DPS. [cureus.com]

Nuclear medicine Tc-99m MDP bone scan symmetric linear increase in tracer accumulation along diaphyseal and metaphyseal surfaces of long bones 4 tram-track sign Treatment and prognosis The success of treatment depends on whether the hypertrophic osteoarthropathy [radiopaedia.org]

Treatment of the underlying disease. The symptoms can almost completely disappear after the end of therapy. Note(s) This section has been translated automatically. [altmeyers.org]

Treatment for this paraneoplastic syndrome is based on treating the cause, which mostly means cancer treatment (chemotherapy, surgery). [ecronicon.com]

Nuclear medicine Tc-99m MDP bone scan symmetric linear increase in tracer accumulation along diaphyseal and metaphyseal surfaces of long bones 4 tram-track sign Treatment and prognosis The success of treatment depends on whether the hypertrophic osteoarthropathy [radiopaedia.org]

The diagnostic approach to this case was complex, multi-layered and decisive for the course of the treatment and prognosis of our patient. [ecronicon.com]

[…] favorable response is observed with a decrease in tumor size and subsequently a reduction in IGF-2 and cytokine secretion, perhaps further chemotherapy and radiotherapy regimens can be studied to combat these tumors to give non-surgical candidates a better prognosis [cureus.com]

Alternatively, neurogenic etiology has been proposed 5. [radiopaedia.org]

Hodgkin inflammatory bowel disease Occupational (pneumatic hammer) for otherwise healthy persons Etiology This section has been translated automatically. [altmeyers.org]

The etiological back- ground of hypertrophic pulmonary osteoarthropa- thy (HOA) is not known. [semanticscholar.org]

OS HOMME OSTEOPATHIE PARANEOPLASIQUE SYNDROME ETIOLOGIE EPIDEMIOLOGIE PATHOLOGIE OSTEOARTICULAIRE Keyword (en) HYPERTROPHIC PULMONARY ARTHROPATHY TUMOR BRONCHOPULMONARY RESPIRATORY DISEASE RADIOGRAPHY BONE HUMAN BONE DISEASE PARANEOPLASTIC SYNDROME ETIOLOGY [pascal-francis.inist.fr]

Transthoracic echocardiography was ordered to rule out a cardiogenic etiology of his syncopal episode, showing a large mass compressing the right atrial cavity (Figure 3). [cureus.com]

OSTEOPATHIE PARANEOPLASIQUE SYNDROME ETIOLOGIE EPIDEMIOLOGIE PATHOLOGIE OSTEOARTICULAIRE Keyword (en) HYPERTROPHIC PULMONARY ARTHROPATHY TUMOR BRONCHOPULMONARY RESPIRATORY DISEASE RADIOGRAPHY BONE HUMAN BONE DISEASE PARANEOPLASTIC SYNDROME ETIOLOGY EPIDEMIOLOGY [pascal-francis.inist.fr]

Am J Clin Pathol. 1989, 92:561-565. 10.1093/ajcp/92.5.561 Chick JFB, Chauhan NR, Madan R: Solitary fibrous tumors of the thorax: nomenclature, epidemiology, radiologic and pathologic findings, differential diagnoses, and management. [cureus.com]

The hypertrophic chang- es of the bones, joints, and nails that occur in all cases of HOA suggest that a common mechanism is at the background of disease pathophysiology. [semanticscholar.org]

The pathophysiologic basis of nuclear medicine second edition. New York: Springer; 2006. For citation: Krylov A.S., Shchipakhina Y.A., Fedorova A.V., Shiryaev S.V., Ryzhkov A.D., Kochergina N.V., Goncharov M.O., Nered A.S., Bludov A.B. [russianradiology.ru]

As the pathophysiology of PMB's syndrome is mostly unknown we present some diagnostic hypotheses found in the medical literature. [ecronicon.com]

Reading Glasses to Prevent Myopia. PMID: 31080964 [PubMed] PMCID: PMC6508883 EC Gynaecology Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions. [ecronicon.com]

Based on prior studies, the team recommended initiating Prednisone 30 mg daily to prevent hypoglycemic episodes prior to definite treatment of surgical resection. [cureus.com]