Computed tomography (CT) scan revealed an aggressive lesion in the right mandible with local soft tissues extension and cervical lymphadenopathy ( Figure 1 ). [omicsonline.org]

These complications or their symptoms, such as difficulty breathing, chest pain, poor growth or weight loss, and infection have sometimes been the first indications of the condition. The specific cause of Gorham's disease remains unknown. [en.wikipedia.org]

Aviv RI, McHugh K, Hunt J. Angiomatosis of bone and soft tissue: a spectrum of disease from diffuse lymphangiomatosis to vanishing bone disease in young patients. Clin Radiol. 2001 Mar;56(3):184-90. [lgdalliance.org]

Case History: A 40-year-old male patient presented himself in 2000 with a right-sided hearing loss and tinnitus for about nine month. He also developed dysphonia and dysphagia followed by headache and neck pain with nausea and emesis. [ashg.org]

[…] vertical height of the mandibular body with the resorption extended towards the basal bone [1] [Figure 1]. [jomfp.in]

& cervical spine Lump in temporal region, head-ache, deafness, paraplegia, & Arnold-Chiari malformation Pamidronate, laminectomy, & RT Progression of disease; death from chylothorax Lekovic et al. (2006) 10 10 M Clivus, petrous, & C1–2 Painful neck, torticollis [jstage.jst.go.jp]

Peculiar clinical episodes of a foul body odor with fever and erythematous skin lesions, presence of radiographic findings such as acro-osteolysis and periarticular erosions, and the absence of angiomatous or lymphangiomatous dysplasias at autopsy, indicate [ncbi.nlm.nih.gov]

Upon examination, there were bilateral palpable submandibular lymph nodes with no obvious facial swelling. [omicsonline.org]

They further stated that their histopathological study provided good evidence that osteolytic changes seen in Gorham's disease are the result of hyperactive osteoclastic bone. [en.wikipedia.org]

Delling Hamburg University School of Medicine, Hamburg, Germany X Study provides good evidence of hyperactive osteoclastic bone resorption causing osteolytic changes. [psykick.de]

They further stated that their histopathological study provided good evidence that osteolytic changes seen in Gorham’s disease are the result of hyperactive osteoclastic bone. [lgdalliance.org]

Typical histological findings include local osteoclastic hyperactivity and proliferation of small thin-walled arterial or lymphatic vessels (angiomatosis) [ 3 – 7 ]; radiological features include massive progressive osteolysis that does not respect anatomical [hindawi.com]

Deep tendon reflexes were hyperactive and equal bilaterally in both upper and lower limbs. Bowel and bladder function was normal. Radiographs of the cervical spine revealed atlantoaxial dislocation due to osteolysis. [jstage.jst.go.jp]

These lesions were accompanied by neurologic manifestations in both the upper and lower extremities. Bone matrix collagen and noncollagenous proteins in this rare syndrome were analyzed. The pathogenesis of this rare phenomenon is discussed. [ncbi.nlm.nih.gov]

He then presented with facial hypoesthesia, deglutition disorder, and spastic gait. MRI revealed spinal cord and medulla oblongata compression at the level of the basilar impression. [jstage.jst.go.jp]

disorder Biopsy Progression of disease; death from transection of spinal cord at C4 Hoffman et al. (1980) 7) 7 F Petrous, sphenoid, & C1–2 Cerebrospinal fluid rhinorrhea, meningitis, torticollis, & headache RT AD; remineralization Kurczynski et al. [jstage.jst.go.jp]

J Oral Surg 29: 659–663, 1971 5) Girn HR, Towns G, Chumas P, Holland P, Chakrabarty A: Gorham’s disease of skull base and cervical spine—confusing picture in a two year old. [jstage.jst.go.jp]