Two years after surgery, the neoplasm recurred as left cervical lymphadenopathy and an intra-abdominal mass. Despite predonine and radiation therapy, the disease progressed, and the patient died. [ncbi.nlm.nih.gov]

Diagnosis of mastocytosis can be confirmed only by the pathologist who should use a combined immunohistochemical and molecular approach. [els.net]

A diagnosis of ALK-negative anaplastic large cell lymphoma was favored by the submitting pathologist. On referral, additional immunostains ( Figure 3, Table 2 ) confirmed a diagnosis of mast cell sarcoma. [nature.com]

Most pathologists support the idea of a myogenous origin for ASPS because of the presence of MyoD1, myogen, and desmin in many lesions. [emedicine.medscape.com]

It is critical that clinicians and pathologists are aware that neoplastic mast cells in patients with SM can infiltrate the mucosa throughout the GI tract and that this infiltration can lead to symptoms and findings that can mimic inflammatory bowel disease [thedoctorsdoctor.com]

Constitutional symptoms also can result from high levels of mast cell mediators in the blood stream. [web.archive.org]

Insect bites, jelly fish stings, snake bites. Infection (bacterial, fungal or viral). [patient.info]

Abstract Two novel stem cell factor (SCF) dependent human mast cell lines, designated LAD 1 and 2, were established from bone marrow aspirates from a patient with mast cell sarcoma/leukemia. [ncbi.nlm.nih.gov]

Mast cells represent less than 20% of the cells in smears of bone marrow aspirate; and 2. No mast cells are identified in their circulating blood and the patient does not fit criteria for aggressive mastocytosis. [web.archive.org]

The mast cells expressed LCA, KP1, and c-kit in immunohistochemical stains done on the core biopsy and CD15, CD33 and c-kit in flow cytometric immunoanalysis done on the marrow aspirate. [bloodjournal.org]

Diagnosis: Biopsies Bone marrow biopsy Obtained by bone marrow biopsy and aspiration procedure Stained with Giemsa and tryptase stains Tested with antibodies for CD117, CD2, CD25 and CD34 Looking for clusters of mast cells in groups of 15 or more Looking [mastattack.org]

Bone marrow biopsy/aspirate. Other tests include: Chromosomal analysis: 20% of patients with systemic mastocytosis have an abnormal karyotype. Molecular testing for KIT D816V mutation is always positive but JAK2 V617F is rarely positive. [patient.info]

Mast cells produce histamine, a chemical that can cause itching, sneezing, congestion, swelling, and wheezing. About mastocytosis Mastocytosis describes a group of disorders that are caused by too many mast cells in the body. [cancer.net]

Two years after surgery, the neoplasm recurred as left cervical lymphadenopathy and an intra-abdominal mass. Despite predonine and radiation therapy, the disease progressed, and the patient died. [ncbi.nlm.nih.gov]

When you rub or scratch them, the lesions respond with a Darier’s sign. A Darier’s sign looks like hives. It’s caused by the release of histamine from the mast cells. In most children, UP goes away by puberty. [healthline.com]

The lesions blister when rubbed (Darier's sign) and become red, swollen and itchy. This confirms the presence of mastocytosis. Rarely, anaphylactic reactions can occur after mechanical/thermal stimulation of skin lesions. [patient.info]

Urticaria pigmentosa (also known as maculopapular cutaneous mastocytosis) lesions are small, brownish, flat or elevated spots that may be surrounded by reddened, itchy skin when scratched and is known as Darier’s sign. [rarediseases.org]

The number of skin lesions and dermal mast cells, the presence of Darier's sign, the intensity of pruritus, and quality of life measures were evaluated before, at the end of treatment, and 2 and 6 months later. [thedoctorsdoctor.com]

[…] slightly raised papules -Skin is normal to yellowish brown, thickened, and may exhibit discoloration with a peau d’orange appearance -Generalized erythroderma may be present -Onset usually before age 3 years -Yellow and cream-colored papules (resemble xanthomas [slideshare.net]

The World Health Organization classification of fibrous histiocytomas is as follows: Benign Fibrous histiocytoma Dermatofibroma Deep histiocytoma Juvenile xanthogranuloma Reticulohistiocytoma Xanthoma Intermediate Atypical fibroxanthoma Dermatofibrosarcoma [emedicine.medscape.com]

Mast cell sarcoma should not be confused with extracutaneous mastocytoma, a rare benign mast cell tumor without destructive growth. [en.wikipedia.org]

People with a mast cell sarcoma have no skin lesions, and pathology examination of the tumor shows it to be very malignant with an aggressive growth pattern. [2] Mast cell sarcoma should not be confused with extracutaneous mastocytoma, a rare benign mast [ipfs.io]

Am J Surg Pathol 2000;24:703-709 Abstract quote Mast cell disease (MCD) is a rare proliferation that may be easily confused with other hematopoietic tumors. Several paraffin section antibodies immunoreact with mast cells but most are not specific. [thedoctorsdoctor.com]

Fibrosarcomas arise from fibroblasts and may be confused with other tumors with a prominent spindle cell component and collagen production; these include malignant fibrous histiocytoma, spindle cell carcinoma, malignant schwannoma, and synovial sarcoma [emedicine.medscape.com]