Case Report A 50-day-old female child presented with a skin colored raised lesion on the dorsal aspect of the left wrist [ Figure 1 ] since the age of 10 days, which gradually increased in size to attain the present size. [ncbi.nlm.nih.gov]

There are a number of cases in which more than one mastocytoma was present. Demis 2 states that four lesions may be present. I describe, herein, a patient with nine mastocytomas. [jamanetwork.com]

Asymptomatic solitary cutaneous mastocytoma: A rare presentation. Indian J Dermatol 2014; 59(6): 634. [10] Krishnan KR, Ownby DR. A solitary mastocytoma presenting with urticaria and angioedema in a 14-year-old boy. [eurekaselect.com]

A case of an adult with severe prolidase deficiency who developed cutaneous mastocytoma of the eyelid was presented. To the authors’ knowledge, adult-onset solitary mastocytoma of the eyelid has never been reported previously. [journals.lww.com]

• Asymptomatic

  Abstract A 50-day-old female child presented with asymptomatic skin colored raised lesion on the dorsal aspect of the left wrist since the age of 10 days. [ncbi.nlm.nih.gov]

  Asymptomatic solitary cutaneous mastocytoma: A rare presentation. Indian J Dermatol 2014; 59(6): 634. [10] Krishnan KR, Ownby DR. A solitary mastocytoma presenting with urticaria and angioedema in a 14-year-old boy. [eurekaselect.com]

• Recurrent Infection

  Prolidase deficiency is an inherited connective tissue disorder that has systemic sequelae, such as intractable skin ulceration, poor wound healing, recurrent infections, and intellectual impairment. [journals.lww.com]

• Abdominal Cramps

  Her bowel movements are normal and she has no abdominal cramping or reflux. Cutaneous examination of her right abdomen showed an 8 x 4 mm brown patch with irregular borders ( Figure 1 ). [ncbi.nlm.nih.gov]

• Darier's Sign

  By the end of third month, complete subsidence of the lesion was noticed with residual hyperpigmentation, negative Darier's sign, and no signs of atrophy. [ncbi.nlm.nih.gov]

• Flushing

  Symptoms may be localized to include pruritus or blistering of the lesion or generalized with flushing and rarely urticaria. [ncbi.nlm.nih.gov]

  A 6-month old with total body flushing and a macular-papular lesion. Pediatr Emerg Care 2007; 23(5): 321-3. [23] Horny HP, Sotlar K, Valent P. Mastocytosis: State of the art. Pathobiology 2007; 74(2): 121-32. [24] Bourji L, Kurban M, Abbas O. [eurekaselect.com]

• Hyperpigmentation

  By the end of third month, complete subsidence of the lesion was noticed with residual hyperpigmentation, negative Darier's sign, and no signs of atrophy. [ncbi.nlm.nih.gov]

• Cutaneous Manifestation

  Objective: To familiarize physicians with the clinical manifestations, diagnosis, evaluation, and management of a solitary cutaneous mastocytoma. [eurekaselect.com]

  However, in a recent consensus report on the cutaneous manifestations in patients with mastocytosis, the investigators recommended that the term ‘cutaneous mastocytoma’ be used to describe mastocytosis of the skin in individuals with 3 or less isolated [ncbi.nlm.nih.gov]

• Skin Atrophy

  These immunomodulators offer advantages over corticosteroids in terms of a more selective action, no associated systemic side-effects, and the absence of associated skin atrophy, depigmentation and telangiectasia. [ncbi.nlm.nih.gov]

• Suggestibility

  This might suggest that the mastocytoma requires therapy. This is not the case. Mastocytomas are self-limited and usually don´t need therapy. The most important management is the avoidance of known trigger factors. [ncbi.nlm.nih.gov]

Prucha H, Schnopp C, Akdis C, et al. : Pimecrolimus, a topical calcineurin inhibitor used in the treatment of atopic eczema. [ncbi.nlm.nih.gov]

Treatment is mainly symptomatic. Reassurance and avoidance of triggering factors suffice in most cases. [eurekaselect.com]

Treatment and prognosis of cutaneous mastocytosis. In: Post TW, Ed. Up To DateWaltham, MA. (Accessed on March 30, 2018) [32] Chantorn R, Shwayder T. [eurekaselect.com]

Fortunately, the vast majority of children with solitary mastocytomas have a good prognosis with reduction or complete resolution of symptoms by puberty.[ 10 ] Due to spontaneous involution, solitary mastocytomas rarely remain symptomatic in older children [ncbi.nlm.nih.gov]

Mastocytosis (cutaneous and systemic): Epidemiology, pathogenesis, and clinical manifestations. In: Post TW, Ed. Up To DateWaltham, MA. (Accessed on March 30, 2018) [18] Koh MJ, Chong WS. Red plaque after hepatitis B vaccination. [eurekaselect.com]

Albeit less common, solitary mastocytomas have been described in 16 adults: 8 men and 6 women; 2 individuals did not have any epidemiologic features reported. [ncbi.nlm.nih.gov]

Update on mastocytosis (Part 1): pathophysiology, clinical features, and diagnosis. Actas Dermosifiliogr 2016; 107(1): 5-14. [6] Klaiber N, Kumar S, Irani AM. Mastocytosis in Children. [eurekaselect.com]

Pathogenetically and from the mechanism of action of tacrolimus, which prevents mast cell degranulation, an improvement of mastocytoma can be expected. [ncbi.nlm.nih.gov]