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Mazindol


Presentation

  • Two patients with Prader-Willi syndrome, including gross obesity with food-related behavior and mild mental retardation, are presented.[ncbi.nlm.nih.gov]
  • The purpose of the present investigation was 1) to assess, before any therapeutic trial, the natural growth hormone (GH) rhythm during physiological sleep in DMD patients and in normal control boys of comparable age; 2) to evaluate the effect of different[ncbi.nlm.nih.gov]
  • The present results suggest that complex interactions reported between cocaine and mazindol in inhibiting dopamine transport are beyond the level of ligand recognition.[ncbi.nlm.nih.gov]
  • Abstract The present study addresses the possibility that there are different cocaine-related and mazindol-related binding domains on the dopamine transporter (DAT) that show differential sensitivity to cations.[ncbi.nlm.nih.gov]
  • A 54-year-old man presented with visual disturbance and polydipsia. Magnetic resonance imaging disclosed a cystic mass which extended from the intrasellar to the suprasellar region.[ncbi.nlm.nih.gov]
Down Syndrome
  • The activity of CuZnSOD is increased in patients who suffer from Down's Syndrome, Alzheimer's disease, and in Parkinson's disease.[ncbi.nlm.nih.gov]
Hypothermia
  • Mazindol also demonstrated potent but incomplete antagonism of reserpine-induced hypothermia in mice, antagonism of tetrabenazine catalepsy in rats, and suppression of mouse-killing behavior of rats.[ncbi.nlm.nih.gov]
Myopathy
  • Riggs, An injury model myopathy mimicking dystrophy: Implications regarding the function of dystrophin, Medical Hypotheses, 35, 4, (358), (1991). Mayana Zatz, Debora Rapaport, Jane Maria Leite Rocha, Mariz Vainzof and Rita C. M.[oadoi.org]
Formication
  • Chromatographic separation was achieved on a Capcell Pak MGII C(18) column using an isocratic mobile phase, consisting of acetonitrile-20mM ammonium formate in water (50:50, v/v, adjusted to pH 3.5 with formic acid) at a flow-rate of 0.2mL/min.[ncbi.nlm.nih.gov]
Depersonalization
  • The differences of a score measuring derealisation and depersonalization associated with a positive basic mood were significantly correlated with the change in the [ 11 C]raclopride binding in the limbic striatum.[ncbi.nlm.nih.gov]
Urethral Discharge
  • Two case reports are described of male patients experiencing a semen-like urethral discharge during micturition, suspected to be induced by mazindol.[ncbi.nlm.nih.gov]

Workup

Triglycerides Decreased
  • In the placebo treated group only serum triglycerides decreased significantly. The variations of plasma insulin and serum cholesterol were found to be correlated to the magnitude of weight loss.[ncbi.nlm.nih.gov]
Cortisol Increased
  • In addition, plasma cortisol increased, without a change in the plasma aldosterone levels after mazindol administration to normal subjects.[ncbi.nlm.nih.gov]

Treatment

  • Similar proportions of treatment and placebo groups dropped out (20% vs 22%; P .34); however, overall dropout rates were higher in parallel trials (25% vs 9% for crossover trials).[ncbi.nlm.nih.gov]
  • Eight-one percent of subjects completed the 12-week course of treatment. Overall, cocaine use during the study was comparatively low-17% of the urine screens submitted were positive for cocaine metabolite.[ncbi.nlm.nih.gov]
  • The mean M value reflecting insulin sensitivity in the whole body determined by euglycemic glucose clamping was increased significantly after mazindol treatment (from 4.92 /- 0.30 mg/kg/min to 6.36 /- 0.43 mg/kg/min).[ncbi.nlm.nih.gov]
  • Abstract Detailed endocrine studies were carried out in 95 hospitalized obese patients during their treatment with diet and the tricyclic anoretic mazindol.[ncbi.nlm.nih.gov]
  • There was no significant difference in weight loss between mazindol treatment and placebo but the former group reported feeling less hungry.[ncbi.nlm.nih.gov]

Etiology

  • Etiologic subtypes of attention deficit/and hyperactivity disorder: brain imaging, molecular genetic and environmental factors the dopamine hypothesis. Neuropsychol Rev. 2007;17:39–59. 11. Findling RL, Biederman J, Wilens TE, et al.[dovepress.com]

Epidemiology

  • Growth dysregulation and ADHD: an epidemiologic study of children in France. J Atten Disord. 2011;15:516–524. 14. Vitiello B, Emslie G, Clarke G, et al.[dovepress.com]
Sex distribution
Age distribution

Pathophysiology

  • Abstract Hypodopaminergic and hyponoradrenergic pathophysiology may be a basis for primary and/or secondary negative symptoms in schizophrenia.[ncbi.nlm.nih.gov]
  • الصفحة 660 - Corticotropin releasing hormone in the pathophysiology of melancholic and atypical depression and in the mechanism of action of antidepressant drugs. ‏[books.google.com]

Prevention

  • Pimozide pretreatment prevents the rotation induced by Mazindol in rats with unilateral nigro-striatal lesions. The involvement of dopamine in the mechanism whereby Mazindol elicits anorexia and turning behaviour is discussed.[ncbi.nlm.nih.gov]
  • Abstract We conducted a double-blind, randomized clinical trial of mazindol (n 37) for the prevention of relapse to cocaine abuse in methadone-maintained patients who were in the "action" stage of change, i.e., had a history of cocaine dependence but[ncbi.nlm.nih.gov]
  • Mazindol works in two ways: it prevents the reuptake of the neurotransmitters serotonin, norepinephine and dopamine while also promoting a receptor called orexin-2, which helps regulate sleep and eating.[biopharmadive.com]
  • Phen375 • speeds up metabolism • breaks down accumulated fat • converts fats into energy • increases the rate of fat burningv • prevents muscle tissue loss • increases thermogenesis Due to the fact that Phen375 contains caffeine, which naturally suppresses[buyphen375mg.com]

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