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Mazzotti Reaction


Presentation

  • […] diethylcarbamazine in onchocerciasis, most commonly an intensely pruritic rash, but sometimes also systemic manifestations such as fever, malaise, lymph node swelling, eosinophilia, arthralgias, tachycardia, and hypotension; if numerous microfilariae are present[medicine.academic.ru]
  • A generalized urticarial rash was present covering his arms, legs and trunk. He had bulbar and palpebral conjunctival injection and angioedema of his face, with mild swelling of his lower extremities and penis.[journals.lww.com]
  • This presents acutely with fluctuating focal neurological signs and meningitis, with eosinophils in peripheral blood and cerebrospinal fluid.[europeanmedical.info]
Fever
  • The patient was hospitalized with fever, urticaria, abdominal pain and angioedema. Twelve hours after treatment with intravenous methylprednisolone he had complete resolution of his symptoms.[ncbi.nlm.nih.gov]
  • Clinical findings Intense pruritic rash, fever, malaise, lymphadenopathy, eosinophilia, arthralgia, tachycardia, hypotension, oedema, abdominal pain. Mazzotti, Luigi, Mexican parasitologist, 1900-1971.[medical-dictionary.thefreedictionary.com]
  • Even so, nearly one-fourth of patients treated with ivermectin develop isolated fever or pruritis without the remaining constellation of symptoms.[journals.lww.com]
Chills
  • Abstract Dear Editor, The Mazzotti reaction, originally described by Mazzotti (1948), is a complex of symptoms characterized by fever/chills, swollen and tender lymph nodes (lymphadenitis), headache, myalgia, arthralgia, tachycardia, hypotension/shock[deepdyve.com]
Respiratory Distress
  • *Mazzotti reaction* Reaction to proteins released by dying onchocerca, including fevers, rashes, ocular damage, joint and muscle pain, and lymphangitis as well as hypotension, pyrexia, respiratory distress, and prostration.[quizmed.blogspot.com]
Pruritus
  • The drug patch is placed on the skin, and if the patient is infected with the microfilaria of O. volvulus, localized pruritus and urticaria are seen at the application site.[en.wikipedia.org]
  • Hypotension, fever, adenitis and pruritus were all correlated with infection intensity in these patients while… CONTINUE READING[semanticscholar.org]
  • Hypotension, fever, adenitis and pruritus were all correlated with infection intensity in these patients while arthralgia and tachycardia were not.[ncbi.nlm.nih.gov]
  • Skin manifestations include pruritus, and papules, edema, wheal, vesicles, pustules as primary skin lesions and scales, excoriation, erosion, ulcer and crusts as secondary skin lesions.[deepdyve.com]
Skin Patch
  • The phenomenon is so common when DEC is used for the treatment of onchocerciasis that this drug is the basis of a skin patch test used to confirm that diagnosis.[en.wikipedia.org]
  • patch test used to confirm that diagnosis.[journals.lww.com]
Arthralgia
  • Clinical findings Intense pruritic rash, fever, malaise, lymphadenopathy, eosinophilia, arthralgia, tachycardia, hypotension, oedema, abdominal pain. Mazzotti, Luigi, Mexican parasitologist, 1900-1971.[medical-dictionary.thefreedictionary.com]
  • Mazzotti reactions can be life-threatening, and are characterized by fever, urticaria, swollen and tender lymph nodes, tachycardia, hypotension, arthralgias, oedema, and ab... Found on Mazzotti reaction Synonym for Mazzotti test ...[encyclo.co.uk]
  • Mazzotti reactions can be life-threatening, and are characterized by fever, urticaria, swollen and tender lymph nodes, tachycardia, hypotension, arthralgias, oedema, and abdominal pain that occur within seven days of treatment of microfilariasis.[en.wikipedia.org]
Headache
  • Abstract Dear Editor, The Mazzotti reaction, originally described by Mazzotti (1948), is a complex of symptoms characterized by fever/chills, swollen and tender lymph nodes (lymphadenitis), headache, myalgia, arthralgia, tachycardia, hypotension/shock[deepdyve.com]
  • Drug-related headache and myalgia occurred in[web.stanford.edu]
  • Detailed monitoring identified some side effects in almost all patients: usually fever, headache, lightheadedness, myalgia, sore throat, or cough that occurred most prominently 18 to 36 hours after treatment.[jamanetwork.com]

Treatment

  • Twelve hours after treatment with intravenous methylprednisolone he had complete resolution of his symptoms.[ncbi.nlm.nih.gov]
  • This decrease was followed by a marked eosinophilia developing over the remaining 7 days of treatment and 14 days of follow-up.[ncbi.nlm.nih.gov]
  • Koji MAKINO, Hazuki NISHI and Hironobu IHN, Phenothrin Lotion Treatment in 5 Cases of 2 or 3 Year Old Children with Scabies, Nishi Nihon Hifuka, 79, 1, (59), (2017). Kate E. Mounsey, Charlotte Bernigaud, Olivier Chosidow, James S.[doi.org]

Prognosis

  • PMID: 6760823 Prognosis Awadzi K, Opoku NO, Addy ET, Quartey BT Trop Med Parasitol 1995 Jun;46(2):131-7. PMID: 8525285 Ackerman SJ, Kephart GM, Francis H, Awadzi K, Gleich GJ, Ottesen EA J Immunol 1990 May 15;144(10):3961-9.[ncbi.nlm.nih.gov]
  • Reactive angioendotheliomatosis has a good prognosis and usually regresses when the underlying disease, if discovered, is successfully treated. The disease sometimes regresses spontaneously. The prognosis depends on the underlying cause.[emedicine.medscape.com]

Etiology

  • Etiology Trop Med Parasitol 1995 Jun;46(2):131-7. PMID: 8525285 Duke BO Acta Leiden 1990;59(1-2):9-24. PMID: 2198761 Büttner DW, von Laer G, Mannweiler E, Büttner M Tropenmed Parasitol 1982 Dec;33(4):201-12.[ncbi.nlm.nih.gov]
  • […] visitors to endemic areas Requires exposure in endemic area for at least a few months Age: usually occurs in 20-40 y/o Sex: 80% of cases are males Race: Indians are most susceptible Possible relationship to Tropical Myocardial Fibrosis (unclear though) Etiology[mdnxs.com]
  • Laboratory Diagnosis Pruritus is a common and complex problem in the tropics, and may be the result of many infectious and noninfectious etiologies. Skin snips and scrapings are commonly obtained whenever infection is considered.[isradiology.org]
  • The etiology and incidence of anaphylaxis in Rochester, Minnesota: a report from the Rochester Epidemiology Project. J Allergy Clin Immunol 2008; 122: 1161–1165 PubMedCentral PubMed CrossRef Google Scholar 14.[doi.org]
  • Etiology Different triggers (eg, subacute bacterial endocarditis; circulating immune complexes; fibrin; cholesterol emboli; viruses, such as hepatitis C; atriovenous fistula [17] ; atherosclerotic emboli; trauma; metal implants [18] ; drugs such as trabectedin[emedicine.medscape.com]

Epidemiology

  • Epidemiology of anaphylaxis. Chem Immunol Allergy 2010; 95: 12–21 PubMed CrossRef Google Scholar 11. Moneret-Vautrin DA, Morisset M, Flabbee J, Beaudouin E, Kanny G. Epidemiology of life-threatening and lethal anaphylaxis: a review.[doi.org]
  • International classification of ultrasound images in cystic echinococcosis for application in clinical and field epidemiological settings. Acta Trop 2003;85:253–261.[doi.org]
  • International classification of ultrasound images in cystic echinococcosis for application in clinical and field epidemiological settings. Acta Trop. 2003; 85 :253–261. [ PubMed ] [ Google Scholar ][ncbi.nlm.nih.gov]
  • However, the cost is justifiable only when epidemiological data indicate that more than 5% of the population is infected. Simple diagnostic blood tests can be used to estimate the prevalence of microfilaraemia.[apps.who.int]
  • Epidemiology Most common in Southeast Asia, India, South Pacific Africa, South America (but cases have occurred in North American and European visitors to endemic areas Requires exposure in endemic area for at least a few months Age: usually occurs in[mdnxs.com]
Sex distribution
Age distribution

Pathophysiology

  • They also address the consequences of drug interactions and the basic pathophysiology of central nervous system toxicity.[books.google.com]
  • Clinical observations on the pathophysiology and treatment of anaphylactic cardiovascular collapse. Anaesth Intensive Care 1986; 14: 17–21 PubMed Google Scholar 32. Pumphrey RS, Roberts IS. Postmortem findings after fatal anaphylactic reactions.[doi.org]
  • Pathophysiology The pathogenesis of reactive angioendotheliomatosis is still not fully elucidated.[emedicine.medscape.com]

Prevention

  • Pretreatment with low-dose dexamethasone--prior to beginning DEC therapy--prevents the development of the Mazzotti reaction and greatly reduces the microfilaricidal activity.[ncbi.nlm.nih.gov]
  • Prevention and control An international onchocerciasis control programme is under way, using mass treatment of whole populations with ivermectin and doxycycline. Lymphatic filariasis is prevented by mosquito-control measures.[biocyclopedia.com]
  • Prevention of anaphylactoid reactions after radiographic contrast media infusion by combined histamine H1- and H2-receptor antagonists: results of a prospective controlled trial.[doi.org]

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