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Mazzotti Reaction


Presentation

  • […] diethylcarbamazine in onchocerciasis, most commonly an intensely pruritic rash, but sometimes also systemic manifestations such as fever, malaise, lymph node swelling, eosinophilia, arthralgias, tachycardia, and hypotension; if numerous microfilariae are present[medicine.academic.ru]
  • Excellent quick refresher for practitioners and nurses Presents coverage of major drugs as well as new arrivals Geared toward use in pharmacology courses Appendix discusses areas in pharmacology that are difficult for students (e.g., cardiac action potential[books.google.com]
  • A generalized urticarial rash was present covering his arms, legs and trunk. He had bulbar and palpebral conjunctival injection and angioedema of his face, with mild swelling of his lower extremities and penis.[journals.lww.com]
  • This presents acutely with fluctuating focal neurological signs and meningitis, with eosinophils in peripheral blood and cerebrospinal fluid.[europeanmedical.info]
Fever
  • The patient was hospitalized with fever, urticaria, abdominal pain and angioedema. Twelve hours after treatment with intravenous methylprednisolone he had complete resolution of his symptoms.[ncbi.nlm.nih.gov]
  • Even so, nearly one-fourth of patients treated with ivermectin develop isolated fever or pruritis without the remaining constellation of symptoms.[journals.lww.com]
  • Mazzotti reactions can be life-threatening, and are characterized by fever, urticaria, swollen and tender lymph nodes, tachycardia, hypotension, arthralgias, oedema, and ab... Found on Mazzotti reaction Synonym for Mazzotti test ...[encyclo.co.uk]
  • Clinical findings Intense pruritic rash, fever, malaise, lymphadenopathy, eosinophilia, arthralgia, tachycardia, hypotension, oedema, abdominal pain. Mazzotti, Luigi, Mexican parasitologist, 1900-1971.[medical-dictionary.thefreedictionary.com]
Camping
  • CASE REPORT A 13-year-old Liberian child arrived in the United States with his mother and 3 siblings after living in a refugee camp in Guinea for 3 years. On arrival, the patient was clinically well and had a normal physical examination.[journals.lww.com]
Pruritus
  • Hypotension, fever, adenitis and pruritus were all correlated with infection intensity in these patients while arthralgia and tachycardia were not.[ncbi.nlm.nih.gov]
  • Skin manifestations include pruritus, and papules, edema, wheal, vesicles, pustules as primary skin lesions and scales, excoriation, erosion, ulcer and crusts as secondary skin lesions.[deepdyve.com]
  • The drug patch is placed on the skin, and if the patient is infected with the microfilaria of O. volvulus , localized pruritus and urticaria are seen at the application site.[en.wikipedia.org]
  • Asthenia/fatigue (0.9%), abdominal pain (0.9%) Gastrointestinal : Anorexia (0.9%), constipation (0.9%), diarrhea (1.8%), nausea (1.8%), vomiting (0.9%) Nervous System/Psychiatric : Dizziness (2.8%), somnolence (0.9%), vertigo (0.9%), tremor (0.9%) Skin : Pruritus[web.stanford.edu]
Skin Patch
  • patch test used to confirm that diagnosis.[en.wikipedia.org]
  • Patch test skin patch test is used to confirm the diagnosis. The drug patch is placed on the skin, and if the patient is infected with O. volvulus microfilaria, localized pruritus and urticaria are seen at the application site. p .![flipper.diff.org]
Arthralgia
  • Mazzotti reactions can be life-threatening, and are characterized by fever, urticaria, swollen and tender lymph nodes, tachycardia, hypotension, arthralgias, oedema, and ab... Found on Mazzotti reaction Synonym for Mazzotti test ...[encyclo.co.uk]
  • Clinical findings Intense pruritic rash, fever, malaise, lymphadenopathy, eosinophilia, arthralgia, tachycardia, hypotension, oedema, abdominal pain. Mazzotti, Luigi, Mexican parasitologist, 1900-1971.[medical-dictionary.thefreedictionary.com]
  • Hypotension, fever, adenitis and pruritus were all correlated with infection intensity in these patients while arthralgia and tachycardia were not.[ncbi.nlm.nih.gov]
  • Abstract Dear Editor, The Mazzotti reaction, originally described by Mazzotti (1948), is a complex of symptoms characterized by fever/chills, swollen and tender lymph nodes (lymphadenitis), headache, myalgia, arthralgia, tachycardia, hypotension/shock[deepdyve.com]
Headache
  • Abstract Dear Editor, The Mazzotti reaction, originally described by Mazzotti (1948), is a complex of symptoms characterized by fever/chills, swollen and tender lymph nodes (lymphadenitis), headache, myalgia, arthralgia, tachycardia, hypotension/shock[deepdyve.com]
  • Drug-related headache and myalgia occurred in[web.stanford.edu]
  • Abdominal discomfort, particularly pain and nausea, diarrhea, headache, dizziness, and drowsiness may occur shortly after taking praziquantel; these direct effects are transient and dose related.[slideshare.net]
  • General reaction: hypotension, orthostatic, collapse, respiratory distress, vertigo, fever, arthralgia, myalgia, and headache have been described. These manifestations may be intense and persist for several days.[healthician.org]

Treatment

  • Twelve hours after treatment with intravenous methylprednisolone he had complete resolution of his symptoms.[ncbi.nlm.nih.gov]
  • This decrease was followed by a marked eosinophilia developing over the remaining 7 days of treatment and 14 days of follow-up.[ncbi.nlm.nih.gov]
  • Reference is easy thanks to a unique 3-part structure covering general aspects of treatment; reviews of every agent; and details of treatments of particular infections.[books.google.com]
  • Coadministration of albendazole is also recommended for presumptive treatment of other intestinal parasites.[journals.lww.com]

Prognosis

  • Reactive angioendotheliomatosis has a good prognosis and usually regresses when the underlying disease, if discovered, is successfully treated. The disease sometimes regresses spontaneously. The prognosis depends on the underlying cause.[emedicine.medscape.com]

Etiology

  • […] visitors to endemic areas Requires exposure in endemic area for at least a few months Age: usually occurs in 20-40 y/o Sex: 80% of cases are males Race: Indians are most susceptible Possible relationship to Tropical Myocardial Fibrosis (unclear though) Etiology[mdnxs.com]
  • Laboratory Diagnosis Pruritus is a common and complex problem in the tropics, and may be the result of many infectious and noninfectious etiologies. Skin snips and scrapings are commonly obtained whenever infection is considered.[isradiology.org]
  • Etiology Different triggers (eg, subacute bacterial endocarditis; circulating immune complexes; fibrin; cholesterol emboli; viruses, such as hepatitis C; atriovenous fistula [17] ; atherosclerotic emboli; trauma; metal implants [ 18 ] ; drugs such as[emedicine.medscape.com]

Epidemiology

  • However, the cost is justifiable only when epidemiological data indicate that more than 5% of the population is infected. Simple diagnostic blood tests can be used to estimate the prevalence of microfilaraemia.[apps.who.int]
  • Epidemiology Most common in Southeast Asia, India, South Pacific Africa, South America (but cases have occurred in North American and European visitors to endemic areas Requires exposure in endemic area for at least a few months Age: usually occurs in[mdnxs.com]
  • He has since completed further training in emergency medicine, clinical toxicology, clinical epidemiology and health professional education.[lifeinthefastlane.com]
  • Bayer, Leverkusen Google Scholar Hendricks MK, Moore SW, Milla AJ (1997) Epidemiological aspects of liver abscesses in children in the Western Cape Province of South Africa.[link.springer.com]
Sex distribution
Age distribution

Pathophysiology

  • They also address the consequences of drug interactions and the basic pathophysiology of central nervous system toxicity.[books.google.com]
  • (African_River_Blindness)#Pathophysiology Signs and symptoms Adult worms remain in subcutaneous nodules, limiting access to the host's immune system.[flipper.diff.org]
  • Pathophysiology The pathogenesis of reactive angioendotheliomatosis is still not fully elucidated.[emedicine.medscape.com]

Prevention

  • Pretreatment with low-dose dexamethasone--prior to beginning DEC therapy--prevents the development of the Mazzotti reaction and greatly reduces the microfilaricidal activity.[ncbi.nlm.nih.gov]
  • Prevention and control An international onchocerciasis control programme is under way, using mass treatment of whole populations with ivermectin and doxycycline. Lymphatic filariasis is prevented by mosquito-control measures.[what-when-how.com]
  • In the summer of 2005, the United States Centers for Disease Control and Prevention (CDC) released recommendations that all refugees from Somalia and Sudan be treated presumptively for schistosomiasis and strongyloidiasis with praziquantel and ivermectin[journals.lww.com]

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