[…] diethylcarbamazine in onchocerciasis, most commonly an intensely pruritic rash, but sometimes also systemic manifestations such as fever, malaise, lymph node swelling, eosinophilia, arthralgias, tachycardia, and hypotension; if numerous microfilariae are present [medicine.academic.ru]

This presents acutely with fluctuating focal neurological signs and meningitis, with eosinophils in peripheral blood and cerebrospinal fluid. [europeanmedical.info]

Signs_and_symptoms Symptoms Typically, patient present with cutaneous symptoms including itching and dermatologic changes years before the onset of ocular symptoms. [flipper.diff.org]

Age Most patients presenting with the malignant form are 40-80 years. The average age at onset of the malignant form is about 60 years. [emedicine.medscape.com]

• Fever

  Even so, nearly one-fourth of patients treated with ivermectin develop isolated fever or pruritis without the remaining constellation of symptoms. [journals.lww.com]

  Clinical findings Intense pruritic rash, fever, malaise, lymphadenopathy, eosinophilia, arthralgia, tachycardia, hypotension, oedema, abdominal pain. Mazzotti, Luigi, Mexican parasitologist, 1900-1971. [medical-dictionary.thefreedictionary.com]

  The patient was hospitalized with fever, urticaria, abdominal pain and angioedema. Twelve hours after treatment with intravenous methylprednisolone he had complete resolution of his symptoms. [unboundmedicine.com]

• Camping

  His history is also significant for the consumption of partially cooked fish during a camping trip 6 months previously. A physical examination reveals a blood pressure of 140/60 mm Hg, pulse of 72 beats/min, and a respiratory rate of 16 breaths/min. [accesspharmacy.mhmedical.com]

  CASE REPORT A 13-year-old Liberian child arrived in the United States with his mother and 3 siblings after living in a refugee camp in Guinea for 3 years. On arrival, the patient was clinically well and had a normal physical examination. [journals.lww.com]

• Arthralgia

  Clinical findings Intense pruritic rash, fever, malaise, lymphadenopathy, eosinophilia, arthralgia, tachycardia, hypotension, oedema, abdominal pain. Mazzotti, Luigi, Mexican parasitologist, 1900-1971. [medical-dictionary.thefreedictionary.com]

  Mazzotti reactions can be life-threatening, and are characterized by fever, urticaria, swollen and tender lymph nodes, tachycardia, hypotension, arthralgias, oedema, and ab... [encyclo.co.uk]

  Abstract Dear Editor, The Mazzotti reaction, originally described by Mazzotti (1948), is a complex of symptoms characterized by fever/chills, swollen and tender lymph nodes (lymphadenitis), headache, myalgia, arthralgia, tachycardia, hypotension/shock [deepdyve.com]

• Pruritus

  Skin manifestations include pruritus, and papules, edema, wheal, vesicles, pustules as primary skin lesions and scales, excoriation, erosion, ulcer and crusts as secondary skin lesions. [deepdyve.com]

  Hypotension, fever, adenitis and pruritus were all correlated with infection intensity in these patients while… CONTINUE READING [semanticscholar.org]

  The drug patch is placed on the skin, and if the patient is infected with the microfilaria of O. volvulus, localized pruritus and urticaria are seen at the application site. [en.wikipedia.org]

  The drug patch is placed on the skin, and if the patient is infected with the microfilaria of O. volvulus, localized pruritus and urticaria are seen at the application site. Categories: Symptoms and signs: General Wikimedia Foundation. 2010. [enacademic.com]

  Hypotension, fever, adenitis and pruritus were all correlated with infection intensity in these patients while arthralgia and tachycardia were not. [ncbi.nlm.nih.gov]

• Angioedema

  The patient was hospitalized with fever, urticaria, abdominal pain and angioedema. Twelve hours after treatment with intravenous methylprednisolone he had complete resolution of his symptoms. [unboundmedicine.com]

  He had bulbar and palpebral conjunctival injection and angioedema of his face, with mild swelling of his lower extremities and penis. [journals.lww.com]

• Skin Patch

  The phenomenon is so common when DEC is used for the treatment of onchocerciasis that this drug is the basis of a skin patch test used to confirm that diagnosis. [en.wikipedia.org]

  patch test used to confirm that diagnosis. [journals.lww.com]

• Pruritic Rash

  Clinical findings Intense pruritic rash, fever, malaise, lymphadenopathy, eosinophilia, arthralgia, tachycardia, hypotension, oedema, abdominal pain. Mazzotti, Luigi, Mexican parasitologist, 1900-1971. [medical-dictionary.thefreedictionary.com]

  Mazzotti reaction the set of adverse reactions, which may be severe or rarely life-threatening, that accompany the administration of diethylcarbamazine in onchocerciasis, most commonly an intensely pruritic rash, but sometimes also systemic manifestations [medicine.academic.ru]

  Look at other dictionaries: Mazzotti reaction — the set of adverse reactions, which may be severe or rarely life threatening, that accompany the administration of diethylcarbamazine in onchocerciasis, most commonly an intensely pruritic rash, but sometimes [enacademic.com]

• Headache

  Abstract Dear Editor, The Mazzotti reaction, originally described by Mazzotti (1948), is a complex of symptoms characterized by fever/chills, swollen and tender lymph nodes (lymphadenitis), headache, myalgia, arthralgia, tachycardia, hypotension/shock [deepdyve.com]

  Symptoms: nausea, vomiting, headache, dizziness, drowsiness and severe convulsions Conduct, medical supervision and symptomatic treatment Pregnancy Studies in the animal have not demonstrated any teratogenic effect. [healthician.org]

  Abdominal discomfort, particularly pain and nausea, diarrhea, headache, dizziness, and drowsiness may occur shortly after taking praziquantel; these direct effects are transient and dose related. [slideshare.net]

  Drug-related headache and myalgia occurred in [web.stanford.edu]

Coadministration of albendazole is also recommended for presumptive treatment of other intestinal parasites. [journals.lww.com]

Twelve hours after treatment with intravenous methylprednisolone he had complete resolution of his symptoms. [unboundmedicine.com]

This decrease was followed by a marked eosinophilia developing over the remaining 7 days of treatment and 14 days of follow-up. [ncbi.nlm.nih.gov]

PMID: 6760823 Prognosis Awadzi K, Opoku NO, Addy ET, Quartey BT Trop Med Parasitol 1995 Jun;46(2):131-7. PMID: 8525285 Ackerman SJ, Kephart GM, Francis H, Awadzi K, Gleich GJ, Ottesen EA J Immunol 1990 May 15;144(10):3961-9. [ncbi.nlm.nih.gov]

Reactive angioendotheliomatosis has a good prognosis and usually regresses when the underlying disease, if discovered, is successfully treated. The disease sometimes regresses spontaneously. The prognosis depends on the underlying cause. [emedicine.medscape.com]

Etiology Trop Med Parasitol 1995 Jun;46(2):131-7. PMID: 8525285 Duke BO Acta Leiden 1990;59(1-2):9-24. PMID: 2198761 Büttner DW, von Laer G, Mannweiler E, Büttner M Tropenmed Parasitol 1982 Dec;33(4):201-12. [ncbi.nlm.nih.gov]

[…] visitors to endemic areas Requires exposure in endemic area for at least a few months Age: usually occurs in 20-40 y/o Sex: 80% of cases are males Race: Indians are most susceptible Possible relationship to Tropical Myocardial Fibrosis (unclear though) Etiology [mdnxs.com]

Laboratory Diagnosis Pruritus is a common and complex problem in the tropics, and may be the result of many infectious and noninfectious etiologies. Skin snips and scrapings are commonly obtained whenever infection is considered. [isradiology.org]

Etiology Different triggers (eg, subacute bacterial endocarditis; circulating immune complexes; fibrin; cholesterol emboli; viruses, such as hepatitis C; atriovenous fistula [17] ; atherosclerotic emboli; trauma; metal implants [18] ; drugs such as trabectedin [emedicine.medscape.com]

The etiology and incidence of anaphylaxis in Rochester, Minnesota: a report from the Rochester Epidemiology Project. J Allergy Clin Immunol 2008; 122: 1161–1165 PubMedCentral PubMed CrossRef Google Scholar 14. [doi.org]

International classification of ultrasound images in cystic echinococcosis for application in clinical and field epidemiological settings. Acta Trop 2003;85:253–261. [doi.org]

However, the cost is justifiable only when epidemiological data indicate that more than 5% of the population is infected. Simple diagnostic blood tests can be used to estimate the prevalence of microfilaraemia. [apps.who.int]

He has since completed further training in emergency medicine, clinical toxicology, clinical epidemiology and health professional education. [lifeinthefastlane.com]

International classification of ultrasound images in cystic echinococcosis for application in clinical and field epidemiological settings. Acta Trop. 2003; 85 :253–261. [ PubMed ] [ Google Scholar ] [ncbi.nlm.nih.gov]

They also address the consequences of drug interactions and the basic pathophysiology of central nervous system toxicity. [books.google.com]

Onchocerciasis River_Blindness -Pathophysiology (African_River_Blindness)#Pathophysiology Primary prevention Global preventative efforts are currently concentrated in population-based prophylactic treatment through programs such as the African Programme [flipper.diff.org]

Pathophysiology The pathogenesis of reactive angioendotheliomatosis is still not fully elucidated. [emedicine.medscape.com]

Clinical observations on the pathophysiology and treatment of anaphylactic cardiovascular collapse. Anaesth Intensive Care 1986; 14: 17–21 PubMed Google Scholar 32. Pumphrey RS, Roberts IS. Postmortem findings after fatal anaphylactic reactions. [doi.org]

Prevention and control An international onchocerciasis control programme is under way, using mass treatment of whole populations with ivermectin and doxycycline. Lymphatic filariasis is prevented by mosquito-control measures. [biocyclopedia.com]

These reactions may be attenuated or prevented by the institution of a progressive dosage and the addition of corticosteroids. [healthician.org]

Pretreatment with low-dose dexamethasone--prior to beginning DEC therapy--prevents the development of the Mazzotti reaction and greatly reduces the microfilaricidal activity. [ncbi.nlm.nih.gov]