Due to worsening painful splenomegaly, likely as a result of sequestration, splenectomy was performed. Following splenectomy, pancytopenia resolved and patient has since been transfusion-independent. [ncbi.nlm.nih.gov]

Symptoms include obesity of the face and body, weight gain, skin fragility, and stopping growth in childhood. Cushing’s syndrome is treated by removing the affected glands or with medicine. [houghton.moneomed.com]

In infants, it may present with a low birth weight and poor weight gain. In older children, Cushing syndrome usually leads to poor growth and abnormal weight gain, especially in the face and trunk. [magicfoundation.org]

gain, obesity of the face and trunk, skin fragility and cessation of growth in children Treatment: removal of adrenal glands or use of drugs that block cortisol synthesis Bone Disease (polyostotic fibrous dysplasia): Abnormal fibrous tissue growth in [en.wikibooks.org]

Some of the symptoms may include: obesity weight gain around the abdomen wasting of the limbs a hump of fat high on the back round, red and puffy face thin, easily bruised skin slow healing of skin wounds skin ulcers arrested growth in childhood. [betterhealth.vic.gov.au]

This further causes weight gain around face as well as mid-section and weight loss in arms and legs. Gigantism as a Result of McCune-Albright Syndrome: It occurs due to excess of growth hormone within the body. [epainassist.com]

Jaffe-Lichtenstein syndrome is entered under Henry Lewis Jaffé, American pathologist, 1896-1979. Bibliography A. Weill: Pubertas praecox und Knochenbrüchigkeit. Klinische Wochenschrift, Berlin, 1922, 1: 2114-2115. [whonamedit.com]

A case of fibrous dysplasia protuberans is hereby presented, manifesting as an exudative pleural effusion in a 49 years old male with history of McCune-Albright syndrome. [ncbi.nlm.nih.gov]

A male, 8-year-old patient was examined at the Department of Orthodontics of the University of L'Aquila for a problem of anterior open-bite. [ncbi.nlm.nih.gov]

People with neurofibromatosis often have more than 6 light brown spots -- cafe-au-lait spots -- larger than 1.5 centimeters. This is a picture of a giant cafe-au-lait spot on a person with neurofibromatosis. [mountsinai.org]

McCune-Albright syndrome (MAS) is characterized by the triad of fibrous dysplasia (FD), cafe-au-lait spots and precocious puberty (PP). We report a 14-year-old girl with MAS who has been followed-up for 8 years. [ncbi.nlm.nih.gov]

McCune-Albright syndrome ( MAS ) is a genetic disorder characterized by the association of: endocrinopathy: precocious puberty polyostotic fibrous dysplasia: more severe than in sporadic cases cutaneous pigmentation: coast of Maine ' cafe au lait ' spots [radiopaedia.org]

The pattern of terminal hair on the skin following the administration of the drug and the exclusion of other causes suggested tamoxifen-induced hirsutism. [ncbi.nlm.nih.gov]

A–C, Patient 6 as neonate with no clinical signs of cortisol excess (A); at age 3 months, with frequent infections and hirsutism of forehead (B); and at age 6 months, with resolved hirsutism (C). [academic.oup.com]

Physical Examination Her physical exam revealed a conscious, fully oriented female child, with feminine facies and body contour, antalgic gait, thyroid gland not enlarged, normal hair distribution, Marshall & Tanner stage: A0 P1 B3, There was no hirsutism [asean-endocrinejournal.org]

Brown et al. reviewed all the published cases of Cushing’s syndrome in MAS ( n 30) and listed the following signs and symptoms: small for gestational age (50%), round facies (66.7%), failure to thrive (60%), hypertension (33.3%), nephrocalcinosis (30%), hirsutism [jmedicalcasereports.com]

On examination, his height was 196 cm, he had macroglossia, acral enlargement, seborrhoea, hyperhidrosis-suggesting acrogigantism. He had facial asymmetry, wind-swept deformity of lower limbs and a café-au-lait macule over his trunk. [ncbi.nlm.nih.gov]

Skeletal survey showed dysplastic changes involving multiple bones and advanced bone age. Reports of MAS in a boy with unilateral macroorchidism are scarce. [ncbi.nlm.nih.gov]

Precocious puberty may result in an advanced bone age, which could potentially limit growth potential and final adult height. Precocious puberty is more common in females than males with more than 50% of females experiencing precocious puberty. [rarediseases.org]

It is important to diagnose hyperthyroidism in MAS, as hyperthyroidism can advance bone age, which may already be a problem in children with precocious puberty, lead to or exacerbate osteoporosis, and cause a plethora of other metabolic derangements. [ojrd.biomedcentral.com]

She had a history of precocious puberty, diagnosed at the age of 6 years and treated with cyproterone acetate until the age of 10 years; then she developed central puberty with severe oligomenorrhea. [ncbi.nlm.nih.gov]

The young girl experienced bilateral breast enlargement, vaginal discharge, and multiple areas of "cafe-au-lait" pigmentation on the skin. The skeletal radiographs showed multiple bone lesions which were suggestive of polyostotic fibrous dysplasia. [ncbi.nlm.nih.gov]

An ultrasonic examination showed that he had left-pleural effusion, which disappeared after almost a year without special treatment. Genomic DNA was isolated from the peripheral blood, bone tissue, skin lesion and pleura samples of the patient. [ncbi.nlm.nih.gov]

A case of fibrous dysplasia protuberans is hereby presented, manifesting as an exudative pleural effusion in a 49 years old male with history of McCune-Albright syndrome. [ncbi.nlm.nih.gov]