Presentation
Neurologic
- Dysmetria
A progressive spinocerebellar degeneration with gait ataxia, dysmetria, and dysarthria; b. A demyelinating sensorimotor and axonal peripheral neuropathy with hyporeflexia and diminished vibration and position sense; c. [ncbi.nlm.nih.gov]
- Pyramidal Tract Signs
Rarely, pyramidal tract signs; and d. Rarely, cranial nerve involvement [ Kane & Havel 1995, Tarugi & Averna 2011 ]. 3. Results in a chorea syndrome resembling Huntington disease 4. [ncbi.nlm.nih.gov]
- Gait Ataxia
A progressive spinocerebellar degeneration with gait ataxia, dysmetria, and dysarthria; b. A demyelinating sensorimotor and axonal peripheral neuropathy with hyporeflexia and diminished vibration and position sense; c. [ncbi.nlm.nih.gov]
- Cranial Nerve Involvement
Rarely, cranial nerve involvement [ Kane & Havel 1995, Tarugi & Averna 2011 ]. 3. Results in a chorea syndrome resembling Huntington disease 4. [ncbi.nlm.nih.gov]
- Absent Deep Tendon Reflex
However, almost all individuals with MLS have absent deep tendon reflexes as an indication of a (mostly subclinical) sensorimotor axonopathy [ Danek et al 2001a, Jung et al 2001a ]. [ncbi.nlm.nih.gov]