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Measles Virus


Presentation

  • A case of RT-PCR detection of MV in the placenta of a 38-year-old woman who presented with premature rupture of membranes at 16 weeks' gestation is presented.[ncbi.nlm.nih.gov]
  • Children presenting with symptoms of measles infection in general hospitals and health centers in the states of southern and western Nigeria were recruited for this study.[ncbi.nlm.nih.gov]
  • We describe clinical presentations and investigations of the cause. We analysed case reports and laboratory findings for the patients (age 37-43 years, two men, one woman) that were provided by the clinicians in charge.[ncbi.nlm.nih.gov]
  • We report the case of a child presenting with nonfebrile seizures 6 and 13 days after the first vaccination with a measles, mumps, rubella, and varicella (MMRV) combination vaccine.[ncbi.nlm.nih.gov]
  • The present study shows that a recombinant MV expressing MERS-S is genetically stable and induces strong humoral and cellular immunity against MERS-CoV in vaccinated mice.[ncbi.nlm.nih.gov]
Collapse
  • These findings demonstrate a novel strategy of MeV during infection, which causes the collapse of host cellular functions. IMPORTANCE: Measles virus (MeV) is one of the most important pathogens in humans.[ncbi.nlm.nih.gov]
  • Our observation that MeV engagement of SLAMF1 induces gross morphological changes and collapse of the cytoskeleton highlights a new physiological role for SLAMF1.[jvi.asm.org]
Anemia
  • Grade 3-4 adverse events in both cohorts at all dose levels were: neutropenia (n 9); leukocyte count decreased (n 5); thrombocytopenia (n 2); and CD4 lymphocytes decreased, anemia and lymphopenia (each n 1).[ncbi.nlm.nih.gov]
Oliguria
  • Clinical features were fever, vomiting, oliguria or anuria, bilateral facial weakness, impaired hearing, blindness, proximal and distal areflexic limb paralysis, and respiratory paralysis. No patient had a macropapular rash.[ncbi.nlm.nih.gov]

Workup

Pulmonary Infiltrate
  • In the present paper, we describe a 27-yr-old male who developed fever, skin rash typical of measles, and diffuse pulmonary infiltrates associated with respiratory failure.[ncbi.nlm.nih.gov]
CD4 Lymphocytes Decreased
  • Grade 3-4 adverse events in both cohorts at all dose levels were: neutropenia (n 9); leukocyte count decreased (n 5); thrombocytopenia (n 2); and CD4 lymphocytes decreased, anemia and lymphopenia (each n 1).[ncbi.nlm.nih.gov]
Trophoblastic Cells
  • Immunohistochemical study revealed measles virus antigen in the syncytial trophoblastic cells and decidua but not in the fetus. Results suggest that fetal death was caused by measles virus infection in the placenta.[ncbi.nlm.nih.gov]
Lymphocytic Infiltrate
  • The rash is a manifestation of the MeV-specific type 1 CD4 and CD8 T cell adaptive immune response with lymphocyte infiltration into tissue sites of MeV replication and coincides with clearance of infectious virus.[ncbi.nlm.nih.gov]
Cytoplasmic Inclusion Bodies
  • An amino acid of human parainfluenza virus type 3 nucleoprotein is critical for template function and cytoplasmic inclusion body formation. J.[ncbi.nlm.nih.gov]

Treatment

  • A second episode of encephalitis occurred when she had been off all antileukaemic treatment for three years and this left her with a right hemiparesis.[ncbi.nlm.nih.gov]
  • Abstract Oncolytic virotherapy is a distinctive antitumor therapy based on the cancer-cell-specific infectivity and killing activity of viruses, which exert a considerable antitumor effect with only a few treatments.[ncbi.nlm.nih.gov]
  • These results demonstrate feasibility of oncolytic measles virus therapy for MPNST patients and the possibility of a novel treatment for patients with NF1 tumors. Copyright 2015 Elsevier B.V. All rights reserved.[ncbi.nlm.nih.gov]
  • The main bottleneck in the administration of oncolytic MV to cancer patients is the production process, because very large doses of virus particles are required for each treatment.[ncbi.nlm.nih.gov]
  • But to date, none of the viruses have been turned into treatments.[arstechnica.com]

Prognosis

  • Abstract Pancreatic cancer is one of the most intractable cancers and has a devastating prognosis; over the past three decades the 5-year survival rate has been 2016 The Authors.[ncbi.nlm.nih.gov]
  • Abstract Malignant peripheral nerve sheath tumors (MPNSTs) are devastating soft tissue sarcomas that can arise sporadically or in association with neurofibromatosis type I, have a poor prognosis, and have limited treatment options.[ncbi.nlm.nih.gov]
  • Prognosis of recovery in these patients is poor. Between 10-30% of all cases are fatal; 20-50% develop significant damages.[ibl-international.com]
  • The aggressive growth, propensity to disseminate along the neuroaxis, and young age at diagnosis contribute to the poor prognosis.[ncbi.nlm.nih.gov]
  • Background: Glioblastoma (GBM) is the most common primary malignant brain tumor and has a dismal prognosis.[ncbi.nlm.nih.gov]

Etiology

  • It is necessary to do more research about other causal theories to clarify its etiology and prevention.[ncbi.nlm.nih.gov]
  • Recognizing the infectious etiology of concomitant infections is important for both clinicians and epidemiologists.[ncbi.nlm.nih.gov]
  • THE etiologic agent has reportedly been recovered from the urine of patients with a number of different viral infections (rabies, 1 lymphocytic choriomeningitis, 2 Russian spring-summer encephalitis, 3 Newcastle disease, 4 mumps, 5 cytomegalic-inclusion[nejm.org]
  • Schrauwen I, Van Camp G: The etiology of otosclerosis: a combination of genes and environment. Laryngoscope. 2010; 120 (6): 1195–202. PubMed Abstract Publisher Full Text 69.[f1000research.com]

Epidemiology

  • Genotyping and further molecular epidemiological analyses were performed with the direct nucleotide sequence data of appropriate PCR products.[ncbi.nlm.nih.gov]
  • PCR products generated from blood, oral fluid, urine, or nasopharyngeal-swab samples were sequenced for molecular epidemiology studies.[ncbi.nlm.nih.gov]
  • Within Europe, there is a target for eliminating endemic measles in 2015, with molecular epidemiology required on 80% of cases for inclusion/exclusion of outbreak transmission chains.[ncbi.nlm.nih.gov]
  • The changing epidemiology of measles with mild measles cases increasingly being recognised in previously-vaccinated individuals, suggests that more asymptomatic or subclinical cases might be occurring.[ncbi.nlm.nih.gov]
  • Genetic characterization of wild-type measles virus (MV) strains is a critical component of measles surveillance and molecular epidemiology.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • […] immune status of individuals to the measles virus using IgG antibody testing Documentation of previous infection with measles virus in an individual without a previous record of immunization to measles virus Clinical Information Discusses physiology, pathophysiology[mayomedicallaboratories.com]

Prevention

  • The constraints on the virus that prevent the emergence of antigenic variants are unclear.[ncbi.nlm.nih.gov]
  • Alendronate slows bone loss while increasing bone mass, which may prevent bone fractures. Alendronate is used to treat or prevent postmenopausal osteoporosis and steroid-induced osteoporosis.[emedicinehealth.com]
  • It is necessary to do more research about other causal theories to clarify its etiology and prevention.[ncbi.nlm.nih.gov]
  • Clinical specimens were used to validate the RT-LAMP-LFD in provincial Center for Disease Control and Prevention (CDC) (n 245) and six municipal CDCs (n 249). The results obtained using RT-LAMP-LFD and real-time RT-PCR were highly concordant.[ncbi.nlm.nih.gov]
  • These results indicate that measles virus persistence in SSPE is correlated with different defects of several genes which probably prevent assembly of viral particles in SSPE-infected brain tissue.[ncbi.nlm.nih.gov]

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