Clinical presentation included abdominal distension (96%), bilious vomiting (49%), and delayed passage of meconium (36%). A family history of CF was present in 4 cases (8%). [ncbi.nlm.nih.gov]

• Poor Growth

  The observed poor growth among our MI patients was not because of poor dietary intakes, but was related to surgical treatment for MI and poor essential fatty acid status. [ncbi.nlm.nih.gov]

• Severe Clinical Course

  CONCLUSIONS: Our results suggest that the history of MI in children with CF may predispose them to more severe clinical course of disease in early childhood: insufficient weight gain and liver disturbances at the time of diagnosis, higher risk of developing [ncbi.nlm.nih.gov]

• Liver Firm

  ABDOMINAL EXAMINATIONINSPECTION-• Distended, Flanks full• Girth- 34cm• No scars, sinuses or dilated veins• No visible lumps, pulsations or peristaltic movements• Umblicus- evertedPALPATION-• Liver- Firm, rounded, felt 1cm below the costal margin• No splenomegaly [slideshare.net]

• Anuria

  The clinical diagnosis was oligohydramnios and abruptio placentae, respiratory failure, and anuria refractory to treatment. The autopsy revealed meconium ileus and meconium peritonitis. [ncbi.nlm.nih.gov]

Workup usually involves abdominal radiography, which may direct further evaluation with fluoroscopic examination such as an UGI contrast study or contrast enema. [dovepress.com]

Management • It consists of pre operative stabilization and Surgical Management • Preoperative stabilization and workup – Nil per orally ryles tube aspiration – Intravenous fluids – Intravenous antibiotics – inj vitamin K – Warmth care – Rule out associated [slideshare.net]

Abstract Various options are available for the surgical treatment of meconium ileus (MI). This paper examines the use of resection and primary anastomosis as the favoured option for the treatment of complicated meconium ileus. [ncbi.nlm.nih.gov]

METHODS: We identified areas of interest including pathophysiology, prenatal diagnosis, nonoperative and operative management, postoperative management, and prognosis. [ncbi.nlm.nih.gov]

Prevention, and Complications Prognosis low risk of mortality with treatment likely to develop other conditions in life bowel obstructions Complications intussusception segmental volvulus meconium peritonitis Please rate topic. [step1.medbullets.com]

Ultrasound Prenatal ultrasound findings associated with meconium ileus include echogenic bowel, which can be dilated and thick walled polyhydramnios fetal ascites peritoneal wall calcifications intra-abdominal cysts Treatment and prognosis Water-soluble [radiopaedia.org]

[…] by gastrogrfin instillation Resection of the affected segment and termino-terminal restoration of the intestinal continuity Ileostomy Lateral ileostomy Y ileostomy whitth adjacent intestinal loop exteriorized to the abdominal wall Mikulicz ileostomy Prognosis [pathologyreviewer.blogspot.com]

The ultimate prognosis depended upon the severity of the pulmonary lesion which usually developed during the first few months of life. [pediatrics.aappublications.org]

However, other rare and challenging etiologies such as congenital chloride diarrhea (CCD) should be included in differential diagnosis of such presentation. [ncbi.nlm.nih.gov]

Etiology Almost all cases are associated with an underlying diagnosis of cystic fibrosis (CF). Conversely, meconium ileus is the initial presentation of 10 to 15% of CF cases. [radiologykey.com]

Meconium ileus (& Hirschprung, Malrotation) Meconium ileus is the third most common etiology of neonatal small bowel obstruction, accounting for 9% to 33% of cases. [johnsarm.net]

Epidemiology: Meconium ileus is seen mostly in two populations: Cystic fibrosis (CF) patients. CF patients tend to have thick secretions in their intestines as a result of their disease. Preterm infants. [eapsa.org]

2018 Calificadores Permitidos Inglés : BL blood CF cerebrospinal fluid CI chemically induced CL classification CO complications CN congenital DI diagnosis DG diagnostic imaging DH diet therapy DT drug therapy EC economics EM embryology EN enzymology EP epidemiology [decs.bvs.br]

Epidemiology of cystic fibrosis. Clin Chest Med 2016; 37 (01) 1-8 10 Boczar M, Sawicka E, Zybert K. Meconium ileus in newborns with cystic fibrosis - results of treatment in the group of patients operated on in the years 2000-2014. [thieme-connect.com]

[1] References: [1] Epidemiological data refers to the US, unless otherwise specified. [amboss.com]

Summary Epidemiology HSCR has an estimated annual incidence of 1/5,000 births. Short segment HSCR is more frequent in males. [orpha.net]

METHODS: We identified areas of interest including pathophysiology, prenatal diagnosis, nonoperative and operative management, postoperative management, and prognosis. [ncbi.nlm.nih.gov]

Pathophysiology • Primary pathology importantly involve proximal Bowel • Ischemic insult and dilation resulting secondary to obstruction impair motility of bowel • Blind ending proximal bowel is dilated, hypertrophied and shows abnormal peristalsis • [slideshare.net]

Newborn Surgery, Third Edition provides a comprehensive compendium of the pathophysiology, investigation and management of neonatal disorders. [books.google.ro]

Comparing CFTR expression in different lines revealed that approximately 20% of wild-type CFTR mRNA largely prevented meconium ileus. This model may be of value for understanding CF pathophysiology and testing new preventions and therapies. [ncbi.nlm.nih.gov]

Fluid is replaced intravenously to prevent dehydration. If two or three enemas do not dislodge the obstruction, surgery is necessary. [medical-dictionary.thefreedictionary.com]