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Medial Sclerosis


Presentation

  • The patient was asymptomatic, and the image is identical to that presented in Keats (5-109). Osteitis condensans : Rare. Invariably unilateral. Primarily affects women between the ages of 20 to 60.[roentgenrayreader.blogspot.com]
  • CLINICAL PRESENTATION An individual is usually asymptomatic unless severe. However, if severe, it is a poor prognostic sign for diabetics and heart patients due to the stiffening of vessel.[medrx-education.com]
  • Five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. ‎ Seite 29 - B.[books.google.de]
  • Congenital means that the condition was present at birth. Cortical dysplasia occurs when the top layer of the brain does not form properly before a child is born, and it is one of the most common causes of epilepsy.[inova.org]
  • All patients presented epilepsy. There was no predominance regarding gender (22 M/22 F); 83.7% of the patients presented their first seizure (febrile or non febrile) up to the age of five years.[scielo.br]
Asymptomatic
  • CLINICAL PRESENTATION An individual is usually asymptomatic unless severe. However, if severe, it is a poor prognostic sign for diabetics and heart patients due to the stiffening of vessel.[medrx-education.com]
  • Clinical findings Medial cystic sclerosis is usually asymptomatic, but may be associated with atherosclerosis, hypertension, diabetes, and chronic kidney disease.[newmedicalterms.com]
  • Clinical findings Medial cystic sclerosis is usually asymptomatic, but may be associated with atherosclerosis, hypertension, diabetes and chronic kidney disease.[medical-dictionary.thefreedictionary.com]
  • The patient was asymptomatic, and the image is identical to that presented in Keats (5-109). Osteitis condensans : Rare. Invariably unilateral. Primarily affects women between the ages of 20 to 60.[roentgenrayreader.blogspot.com]
  • CONCLUSION Herein, we report two rare cases of Monckeberg’s medial sclerosis in a 60-year-old man and 57-year- old woman, They both had asymptomatic, pulsatile, subcutaneous nodules on the cheek.[cheapmedicinechest.com]
Soft Tissue Swelling
  • May see joint space narrowing, bone destruction, periosteal reaction, and soft tissue swelling. Friedrich disease : Rare. Ischemic necrosis of the medial clavicular epiphysis.[roentgenrayreader.blogspot.com]
  • Osteophyte formation with soft tissue swelling and subchondral sclerosis is noted at the 2nd and 3rd DIP joints compatible with Heberden's nodes (open arrows).[aafp.org]
Hypersomnia
  • Seite 30 - In children, consider failure to make expected weight gains 4 Insomnia or hypersomnia nearly every day 5 Psychomotor agitation or retardation nearly every day (observable by others, not merely subjective feelings of restlessness or being slowed[books.google.de]
Pathologist
  • SNOMED CT (R) was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO."[doctor.am]
Italian
  • Pronunciation Italian Pronunciation Italian Pronunciation Italian Pronunciation Italian Pronunciation Japanese Pronunciation Japanese Pronunciation Japanese Pronunciation Japanese Pronunciation Korean Pronunciation Korean Pronunciation Norwegian Pronunciation[pronouncekiwi.com]
Vascular Disease
  • See also Vascular disease. References Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 7. ISBN 978-1416002741.[librepathology.org]
  • ] I73.8 Other specified peripheral vascular diseases Acrocyanosis Acroparaesthesia: · simple [Schultze's type] · vasomotor [Nothnagel's type] Erythrocyanosis Erythromelalgia I73.9 Peripheral vascular disease, unspecified Intermittent claudication Spasm[apps.who.int]
  • .- ) Diseases of the circulatory system I70 ICD-10-CM Diagnosis Code I70 Atherosclerosis 2016 2017 2018 2019 Non-Billable/Non-Specific Code Includes arteriolosclerosis arterial degeneration arteriosclerosis arteriosclerotic vascular disease arteriovascular[icd10data.com]
  • Differentiation of multipotent vascular stem cells contributes to vascular diseases. Nat Commun, 3 (2012), pp. 875 [19] G. Lefthériotis, L. Omarjee, O. Le Saux, D. Henrion, P. Abraham, F. Prunier, et al.[elsevier.es]
  • Genetically, there are also several defined vascular diseases associated with primarily medial calcification.[cjasn.asnjournals.org]
Bounding Pulse
  • Areas affected are “pulseless” due to the calcified encasement; areas beyond the sclerosis have a “bounding pulses”.[newmedicalterms.com]
  • Areas affected are “pulseless” due to the calcified encasement; areas beyond the sclerosis have a “boundingpulse.[medical-dictionary.thefreedictionary.com]
  • Typically calcification is observed in the arteries of the upper and lower limb although it has been seen in numerous other medium size arteries. [5] In the radial or ulnar arteries it can cause "pipestem" arteries, which present as a bounding pulse at[en.wikipedia.org]
Family History of Heart Disease
  • A family history of heart disease also increases your risk to develop this disease. More[sharecare.com]
Skin Lesion
  • lesions. medial calcific sclerosis medial calcific sclerosis A type of dystrophic calcification in which calcium is deposited in the tunica media of arteries.[medical-dictionary.thefreedictionary.com]
  • lesions, is associated with degeneration of elastic tissue in medium-sized arteries and focal calcification of the internal elastic lamina. 9 In the orbital and temporal arteries, internal elastic lamina calcification has also been thought to be related[nature.com]
Subcutaneous Nodule
  • CONCLUSION Herein, we report two rare cases of Monckeberg’s medial sclerosis in a 60-year-old man and 57-year- old woman, They both had asymptomatic, pulsatile, subcutaneous nodules on the cheek.[cheapmedicinechest.com]
Indecisiveness
  • Seite 30 - Diminished ability to think or concentrate, or indecisiveness, nearly every day (either by subjective account or as observed by others) 9 Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without a specific plan[books.google.de]
Feeling of Worthlessness
  • […] of worthlessness or excessive or inappropriate guilt (which may be delusional) nearly every day (not merely self-reproach or guilt about being sick... ‎[books.google.de]
Suicidal Ideation
  • Seite 30 - Diminished ability to think or concentrate, or indecisiveness, nearly every day (either by subjective account or as observed by others) 9 Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without a specific plan[books.google.de]
Lip Smacking
  • ., lip smacking, chewing, swallowing) and manual automatisms (e.g., picking, fumbling, patting).[casemed.case.edu]
  • These may range from gagging, lip smacking, running, screaming, crying, or laughing. You may be tired or sleepy after the seizure. This is called the postictal period. Generalized seizure A generalized seizure occurs in both sides of the brain.[hopkinsmedicine.org]
Deja Vu
  • The most common aura involves feelings, such as deja vu, impending doom, fear, or euphoria. Or you may have visual changes, hearing abnormalities, or changes in your sense of smell.[hopkinsmedicine.org]
Spastic Paraplegia
  • It may be primary, with spastic paraplegia, rigidity of the limbs, and increase of the tendon reflexes but no sensory disturbances, or secondary to myelitis, with paraplegia and sensory disturbance. tuberous sclerosis a congenital heredofamilial disease[medical-dictionary.thefreedictionary.com]
Mental Deterioration
  • ., adj sclerot ic. familial centrolobar sclerosis a progressive familial form of leukoencephalopathy marked by nystagmus, ataxia, tremor, parkinsonian facies, dysarthria, and mental deterioration. hippocampal sclerosis loss of neurons in the region of[medical-dictionary.thefreedictionary.com]

Workup

Joint Space Narrowing
  • Osteoarthritis : Joint space narrowing and subchondral sclerosis and subchondral cysts on both sides of the joint. Sternoclavicular hyperostosis : Rare. Typically bilateral.[roentgenrayreader.blogspot.com]
  • (Top) The first film, obtained in 1997, demonstrates bilateral, superolateral joint space narrowing (arrows) at the hips that is worse on the left side.[aafp.org]
Microalbuminuria
  • Psyrogiannis et al. found that microalbuminuria was strongly associated with medial arterial sclerosis, irrespective of the presence or absence of neuropathy. Fig. 3.[cheapmedicinechest.com]
Ventricular Hypertrophy
  • M6nckeberg sclerosis can lead to significant adverse cardiovascular outcomes such as arterial stiffness, increased pulse and left ventricular hypertrophy.[ncbi.nlm.nih.gov]
  • Medial calcification is characterized by diffuse mineral deposition ( 5 ) and is associated with arterial stiffness, systolic hypertension, and left ventricular hypertrophy ( 2 , 6 ).[cjasn.asnjournals.org]
  • Also, there was an eccentrical left ventricular hypertrophy, severe mitral and tricuspid regurgitation. There was no abnormality in the right ventricle.[bmccardiovascdisord.biomedcentral.com]
  • hypertrophy, peripheral vascular disease, and altered coronary perfusion. 3, 28, 30 Increasing amounts of calcification detected by computed tomography (CT) predict the likelihood of future coronary events. 31 Yet, CT lacks the ability to distinguish[nature.com]

Treatment

  • The first step in treatment of cortical dysplasia is controlling the seizures. Anti-seizure medications are often prescribed as a treatment for cortical dysplasia.[inova.org]
  • Surgical Treatments for Mesial Temporal Sclerosis Mesial temporal sclerosis treatments generally consist of managing the epilepsy symptom by using either anticonvulsant medication or, if medication is not effective, surgery.[nspc.com]
  • Treatment for medial compartmental OA requires a combination of medications and exercises. Weight loss can also help. Below are some specific treatment plans for people with arthritis of the knee.[healthline.com]
  • Patients with mesial temporal lobe epilepsy often are excellent candidates for surgical treatment, with 70% to 90% becoming free of disabling seizures after treatment.[medlink.com]
  • Other treatments If medicine doesn’t work well enough for you, your healthcare provider may advise other types of treatment.[hopkinsmedicine.org]

Prognosis

  • OBJECTIVE: To analyze retrospectively a series of patients with temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS), and the association of patterns of hippocampal sclerosis with clinical data and surgical prognosis.[ncbi.nlm.nih.gov]
  • Prognosis Multiple sclerosis can have severe debilitating effects within 20-25 years of onset.[eyewiki.aao.org]
  • Prognosis Largely unknown. In neurosurgical series, initially, patients have a rather mild or uneventful course of hippocampal seizures that may be controlled with medication.[epilepsy.com]
  • The appearance of oligoclonal bands in the early stages of the disease indicates a poor prognosis ![amboss.com]
  • Treatment and prognosis TLE is initially managed medically with anti-epileptic agents. In patients who are refractory to medical management temporal lobectomy or selective amygdalohippocampectomy may be performed.[radiopaedia.org]

Etiology

  • As a possible etiologic factor inducing these two responses, hyperphosphatemia among various metabolic disturbances recognized in uremia may play an important role in the development of MMS in uremia.[ncbi.nlm.nih.gov]
  • The etiology of mesial temporal sclerosis is controversial. It is thought to possibly result from an early injury to the brain or congenital malformation.[casemed.case.edu]
  • Although its etiology is still not known, its presence can predict the risk of cardiovascular events and leg amputation in diabetic patients. There have also been a few cases where healthy young men have had the medial calcification.[cheapmedicinechest.com]
  • Applicable To Mönckeberg's (medial) sclerosis Use Additional Use Additional Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10data.com]
  • This book is organized into three sections encompassing 15 chapters that also cover the etiology of acute cardiopulmonary diseases and chronic pulmonary hypertension.[books.google.ro]

Epidemiology

  • Epidemiological observations link medial sclerosis not only to diabetes, but also to other disease states commonly encountered in the population, such as osteoporosis and chronic kidney disease.[jrdiabet.ro]
  • Epidemiological studies have used the ratio of ankle to brachial blood pressure ( ankle brachial pressure index, ABPI or ABI) as an indicator of arterial calcification with ABPI 1.3 to 1.5 being used as a diagnostic criterion depending on the study. [[en.wikipedia.org]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiology of Monckeberg’s arteriosclerosis is still unclear, but it can be induced in animal models by injecting adrenalin, nicotine, parathyroid hormone, and vitamin D. 2 In addition, lumbar sympathectomy has been shown to promote occurrence[bjo.bmj.com]
  • Despite the foregoing, recent pathophysiological studies have suggested that there are inflammatory and genetic alterations closely related with the medial vascular calcification.[elsevier.es]
  • Etiology Pathophysiology Immune-mediated damage Most common sites of demyelination in MS Periventricular areas Brainstem Cerebellum Spinal cord References: [2] Clinical features Optic neuritis (most often the earliest manifestation ): impaired vision[amboss.com]
  • There are some specific aspects in the pathophysiology that are more relevant to intimal or medial calcification. For example, a localized inflammatory response is observed in intimal calcification but not in medial calcification ( 13 ).[cjasn.asnjournals.org]
  • Although the underlying cause remains unclear, factors such as decreased sun exposure and low levels of vitamin D have been proposed to explain the latitudinal gradient. [1] Pathophysiology MS is thought to be an autoimmune disease and this theory is[eyewiki.aao.org]

Prevention

  • Strengthening the quad muscles, which are the muscles in your thigh, may help stabilize your knee and reduce or prevent pain.[healthline.com]
  • Because medial sclerosis reduces or prevents compressibility of the arteries, the ankle artery pressures measured are very high. Therefore, at an ABI greater than 1.3, the tentative diagnosis of medial sclerosis can be rendered.[enverdis.com]
  • Prevention of atherosclerosis with Ramipril. J Am Coll Cardiol 36:438–443 PubMed CrossRef 38.[springermedizin.de]
  • Alternatively, treatment with intravenous dissodic pamidronate was attempted to stop the phenomenon of calcification and prevent further airway obstruction.[bmccardiovascdisord.biomedcentral.com]
  • Treatment Summary of step-wise therapy for multiple sclerosis Treatment of acute exacerbations Disease-modifying MS therapy ( prevention of exacerbations ) Disease-modifying drugs (DMDs) Medication Mechanism of action Route of application Indications[amboss.com]

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