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Mediastinal Irradiation

Irradiation of Mediastinum


Presentation

  • A review of the literature and a summary of treatment options for cardiac complications after irradiation of the mediastinum for Hodgkin's lymphoma are presented.[ncbi.nlm.nih.gov]
  • We present a patient with critical aortic and mitral valve stenosis after mediastinal irradiation and discuss the natural history, treatment, and prognosis of radiation-associated valvular heart disease. (c) 2004 Wiley-Liss, Inc.[ncbi.nlm.nih.gov]
  • We present a detailed review of pericardial sarcomas. CONCLUSIONS: We believe this to be the first report of a radiation-induced pericardial sarcoma.[ncbi.nlm.nih.gov]
  • A 49-year-old woman presented with a sternal tumor 17 years after surgery plus mediastinal irradiation (50 Gy) for a stage III thymoma. On biopsy, this second tumor was diagnosed as a radiation-induced osteosarcoma.[ncbi.nlm.nih.gov]
  • We describe a 58-year-old female patient, without any of the traditional coronary risk factors, who presented with inferior infarction 23 years after radiotherapy for Hodgkin's lymphoma of the mediastinum.[ncbi.nlm.nih.gov]
Deglutition Disorder
  • Keywords: Esophagus; Humans; Mediastinal Neoplasms; Deglutition Disorders; Esophageal Motility Disorders; Radiation Injuries; Esophagoscopy; Prospective Studies; Manometry; Aged; Aged, 80 and over; Middle Aged; Female; Male RMID: 0030004935 DOI: 10.1136[digital.library.adelaide.edu.au]
  • Key words Cancer Radiotherapy Esophagus Deglutition Deglutition disorders This is a preview of subscription content, log in to check access. Preview Unable to display preview. Download preview PDF. References 1. Goolden AWG: Radiation cancer.[link.springer.com]

Workup

  • Staging workup consisted of a chest X-ray; B-HCG, alpha-fetoprotein, and CT scan of the abdomen and pelvis in all patients. Lymphangiogram was done in 23 (66%) of 35 patients for further evaluation of the retroperitoneal lymph nodes.[aboutcancer.com]
Hyperlucent Lungs
  • This case represents a late and uncommon complication of mediastinal irradiation manifesting as a unilateral hyperlucent lung.[ncbi.nlm.nih.gov]

Treatment

  • Abstract Mediastinal irradiation is considered as a long term cardiac risk factor, although no myocardial dysfunction can usually be documented during long term follow-up of the patients having undergone this treatment.[ncbi.nlm.nih.gov]
  • Radiotherapy is used widely in cancer treatment. Mediastinal irradiation is associated with valvular regurgitation; however, stenosis is rare.[ncbi.nlm.nih.gov]
  • Treatment with Ct was not a significant risk factor for cardiac events but the number of patients whose treatment included adriamycin and with a follow-up exceeding 10 years is to low for a definitive evaluation.[ncbi.nlm.nih.gov]
  • Despite this patient, the study indicates that treatment with MOPP/ABVD and low-dose mediastinal irradiation entails low risk for cardiac complications.[ncbi.nlm.nih.gov]
  • A review of the literature and a summary of treatment options for cardiac complications after irradiation of the mediastinum for Hodgkin's lymphoma are presented.[ncbi.nlm.nih.gov]

Prognosis

  • We present a patient with critical aortic and mitral valve stenosis after mediastinal irradiation and discuss the natural history, treatment, and prognosis of radiation-associated valvular heart disease. (c) 2004 Wiley-Liss, Inc.[ncbi.nlm.nih.gov]
  • The treatment of these tumors is very difficult and is associated with a poor prognosis.[ncbi.nlm.nih.gov]
  • The purpose of this study was to determine the prevalence of diastolic dysfunction and its association with prognosis in asymptomatic patients after mediastinal irradiation.[ncbi.nlm.nih.gov]

Etiology

  • Since this delayed complication may occur in patients of such age that the relation between the AVB and the chest irradiation is questionable, we propose the following etiologic criteria; high radiation dose (over 4,000 rads); delay of 10 years or more[ncbi.nlm.nih.gov]

Epidemiology

  • Risk Elevations by Field and Dose Standardized incidence ratios (SIR) for breast cancer compared with expected number of breast cancer cases in the general U.S. population using age- and calendar year-specific rates from the Surveillance, Epidemiology[ascopost.com]
Sex distribution
Age distribution

Prevention

  • Anderson Cancer Center, Houston, Texas, USA. 3 Department of Internal Medicine, College of Medicine, Chosun University Hospital, Kwangju, Korea. 4 Department of Preventive Medicine, College of Medicine, Chosun University Hospital, Kwangju, Korea. 5 Department[e-roj.org]
  • As the radiation therapy is currently the standard treatment for a number of malignancies, routine screening of these patients and optimal cardiac prevention during radiotherapy are the only ways to minimize the incidence of radiation-induced heart disease[ispub.com]
  • This suggests that these effects are slow to develop and may be partially preventable with the control of other cardiac risk factors in the time before the development of overt cardiac disease.[bloodjournal.org]
  • 25(31):4987-92.) 5-year outcome: brain first failure PCI 8% vs no PCI 35% (SS); any brain failure 9% vs. 27% (SS) Toxicity: no difference; slightly decreased neurocognition in both groups compared to age-matched controls Conclusion: PCI effective in preventing[en.wikibooks.org]

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