Presentation
On presentation, he had right sided wheezes on physical exam. [pulmonarychronicles.com]
Case presentations Patients A 12 year-old African American male with a one year history of GD refractory to medical management presented with a persistent tachycardia, fever, abdominal pain, vomiting, weakness and muscle aches after discontinuing methimazole [thyroidresearchjournal.biomedcentral.com]
Major changes have recently occurred in the clinical presentation, diagnosis, and management of primary lesions of the mediastinum. [ncbi.nlm.nih.gov]
Search for more papers by this author First published: April 1972 Cited by: 117 Abstract Three cases of multiple endocrine adenomatosis (MEA) associated with a mediastinal endocrine neoplasm are presented. [onlinelibrary.wiley.com]
Ascites and pleural effusion, even if malignant cells are present, do not constitute metastatic disease unless they are remote from the primary tumor. [radiologykey.com]
Respiratoric
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Mediastinal Disease
Mediastinal diseases are conditions that arise from tissues in this cavity. [utswmedicine.org]
Lymphadenopathy mediastinal - disease in the lymph nodes. Pericardial cysts which include growths that start in the lining of the heart. Tracheal tumors. Posterior mediastinal tumors include: Lymphadenopathy mediastinal - disease of the lymph nodes. [cedars-sinai.edu]
In 1888, Hare 1 collected 520 cases of mediastinal disease, over 50 per cent of which were due to tumors, mostly of the malignant type. [jamanetwork.com]
Use of video-assisted thoracoscopic surgery (VATS) technology has entered the armamentarium of the thoracic surgeon with respect to the treatment of numerous mediastinal diseases. [2, 3, 4] This modality is already used commonly for biopsy of masses and [emedicine.medscape.com]
Gastrointestinal
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Dysphagia
Respiratory symptoms and dysphagia can occur due to bronchial and esophageal obstruction respectively. [learn.pediatrics.ubc.ca]
Symptoms are usually related to local effects of the neoplasm, including compression and invasion, and can manifest as respiratory distress, dysphagia, diaphragm paralysis, or superior vena cava (SVC) syndrome. [radiologykey.com]
Symptoms Chest pain Dyspnea Cough Fever Weight loss Fatigue Dysphagia Night sweats 16. [slideshare.net]
Lesions in the posterior mediastinum may encroach on the esophagus, causing dysphagia or odynophagia. [msdmanuals.com]
For example, a mass compressing the airway can lead to lung infection or hemoptysis (coughing up blood), while a mass compressing the esophagus can cause dysphagia (difficulty swallowing). [nyp.org]
Face, Head & Neck
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Head and Neck Swelling
Great vessel compression can lead to superior vena cava syndrome, characterized by venous engorgement along with head and neck swelling. By contrast, posterior mediastinal masses can be quite large and yet asymptomatic. [intranet.tdmu.edu.ua]
Workup
There were 144 cases having abnormal mediastinal lesions detected on initial diagnostic workup on the chest radiology. [lungindia.com]
Follow-up of the patient includes clinical examination, chest radiographs, computed tomography, and metastatic workup every 6 to 12 months [10] and should be monitored closely for 10 years or less after primary diagnosis. [cancerjournal.net]
In many cases, no further workup is needed for diagnosis. Characterization of the mass on the CT scan is based on specific attenuation of water, air, fat, calcium, soft tissue, and vascular structures. [ncbi.nlm.nih.gov]
X-Ray
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Mediastinal Mass
The variation in these imaging findings played an important role in the differential diagnosis of this uncommon mediastinal mass. [ncbi.nlm.nih.gov]
Here we describe two patients with neoplastic anterior mediastinal masses associated with GD, illustrating that this may not be safe approach to all patients with anterior mediastinal masses and GD. [thyroidresearchjournal.biomedcentral.com]
Technetium-99m methylene diphosphonate bone scintigraphy showed intense uptake in both the T1 and marginal parts of the mediastinal mass. [ajnr.org]
Our case presented as a diagnostic challenge because of the difficulty of differentiating the primary mediastinal mass from a primary lung neoplasm. [pulmonarychronicles.com]
(NLM, Medical Subject Headings) ALSO IN ENCYCLOPEDIA : Mediastinal Mass Mediastinal Lymphangioma Mediastinal Lymph Node Mediastinal Liposarcoma Mediastinal Lipomatosis Mediastinal Lipoma Mediastinal Leiomyosarcoma Mediastinal Leiomyoma Mediastinal Hemorrhage [tititudorancea.com]
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Superior Mediastinal Mass
mediastinal mass present above the thoracic plane (upper side): Neoplastic and non-neoplastic pathology. [cancerwall.com]
Treatment
Your doctor will tailor your treatment to your type of mediastinal tumor. Talk to your doctor to get more accurate information about your prognosis. [healthline.com]
Int J Clin Exp Pathol 8(5):5650–5657 PubMed PubMedCentral Google Scholar Haugnes HS, Stephenson AJ & Feldman DR (2014) Beyond stage I germ cell tumors: current status regarding treatment and long-term toxicities. [link.springer.com]
Prognosis
Prognosis Prognosis after resection of a mediastinal tumor varies widely depending on the type of lesion resected. After resection of mediastinal cysts and benign tumors, the prognosis is generally excellent. [emedicine.medscape.com]
They are clinically and biologically distinct from primary testicular tumors and seem to have a worse prognosis. Due to the rarity of the disease, the choice of treatment is a matter of debate. [link.springer.com]
Talk to your doctor to get more accurate information about your prognosis. [healthline.com]
Etiology
Additional diagnostic testing, usually imaging and biopsy, is indicated to determine etiology. CT with IV contrast is the most valuable imaging technique. [msdmanuals.com]
Although our team decided that it was more likely to obtain the etiology of the lung micronodules by histo-pathological analysis from nodule resection using tho-racic surgery, the patient refused the procedure. [pneumologia.eu]
Mediastinal masses in children are often symptomatic and can have a varied symptomatology and etiology. The most common symptoms at presentation are dyspnea, cough, fever, aching pain and general malaise. [learn.pediatrics.ubc.ca]
In this new 8th edition an outstanding editorial team from world-renowned medical centers continues to hone the leading edge forged in previous editions, with timely information on biology, immunology, etiology, epidemiology, prevention, screening, pathology [books.google.es]
Etiology Neurogenic tumors of the mediastinum arise from cells of the nerve sheath, paraganglionic tissue, and autonomic ganglia, all of which originate embryonically from the neural crest. [emedicine.medscape.com]
Epidemiology
This in turn has clarified the classification and thus the epidemiology of tumours of the mediastinum, and modern radiotherapy, chemotherapy and surgery has led to improved survival of patients at risk. [books.google.com]
The epidemiology of the thyroid carcinoma. Crit. Rev. Oncog. 1993, 4 : 25–52. PubMed Google Scholar 27. Shore R.E. Issues and epidemiological evidence regarding radiation-induced thyroid cancer. Radiat. Res. 1992, 131 : 98–111. [link.springer.com]
[…] surgery and chemotherapy, no vascular invasion, no yolk sac or choriocarcinoma components Gross description Unencapsulated, homogenous fleshy mass with indistinct boundaries and invasion of adjacent structures, hemorrhage or necrosis Choriocarcinoma Epidemiology [pathologyoutlines.com]
[…] anterosuperior mediastinal mass Pain in the chest, abdomen, or bone s (for no known reason) Skin rash or itchy skin Weight loss (for no known reason) Diagnostic Exams Flow cytometry Immunohistochemistry Immunophenotyping Progression and Transformation None Epidemiology [seer.cancer.gov]
In this new 8th edition an outstanding editorial team from world-renowned medical centers continues to hone the leading edge forged in previous editions, with timely information on biology, immunology, etiology, epidemiology, prevention, screening, pathology [books.google.es]
Pathophysiology
Staging of Alberto de Hoyos 2177 Less Common Malignant Tumors of the Diagnostic Investigation of Mediastinal 2195 The Use of Prosthetic Grafts to Replace 195 Poorly Differentiated Carcinoma of the Mediastinum 2411 2261 Benign and Malignant Neurogenic 2415 Pathophysiology [books.google.com]
Pathophysiology Tumors and cysts of the mediastinum can produce abnormal effects at both systemic and local levels. [emedicine.medscape.com]
Prevention
Reasons for Procedure Cancerous tumors must be removed to prevent local tissue damage and the spread of cancer. Without removal or treatment, the cancer could spread to other areas of the body. [winchesterhospital.org]
The pleomorphic aspect of the mesenchymal cell population prevented a clear classification of the tumour but revealed a high malignancy mesenchymal mediastinal neoplasia. [veterinarymedicinejournal.usamv.ro]
These type of tumors cannot be prevented. Mediastinal Tumor Menu The mediastinum is divided into three sections What are mediastinal tumors? Tumors (also called neoplasms) are masses of cells. They can be benign (not cancer) or malignant (cancer). [my.clevelandclinic.org]
In cases where the tumor is malignant the prognosis is guarded and care should be taken to prevent the tumor from invading other organs of the body and complicating things as a result of Mediastinal Tumors, although with appropriate treatment and taking [epainassist.com]