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Medroxyprogesterone

MP


Presentation

  • At present, 11 years after the diagnosis of metastatic liver involvement, the patient is alive, free of cancer, and fully ambulatory.[ncbi.nlm.nih.gov]
  • The study presented here addresses the immunomodulatory properties of several common progestins with a potential to replace DMPA.[ncbi.nlm.nih.gov]
  • An evaluation and treatment strategy for sexual dysfunction post traumatic brain injury is presented.[ncbi.nlm.nih.gov]
  • METHODS: We conducted a prospective cohort study of women presenting for medical or surgical abortion at a single health center in North Carolina. Eligible women were 18 years or older and fluent in English or Spanish.[ncbi.nlm.nih.gov]
  • Salvage treatments for refractory emesis are necessary, but there are few effective treatments at present. We consider medroxyprogesterone acetate to be a potentially promising agent for refractory emesis.[ncbi.nlm.nih.gov]
Plethora
  • Since then there has been an increased interest in bioidentical HT; today there are a plethora of websites touting their benefits. However, no peer-reviewed articles support these claims.[ncbi.nlm.nih.gov]
Overeating
  • CONCLUSION: Users of hormonal and non-hormonal contraceptive methods gained a significant amount of weight over the years. DMPA users gained more weight over the treatment period of up to ten years than women fitted with either a LNG-IUS or a Cu-IUD.[ncbi.nlm.nih.gov]
  • The overall response rate was 35% in all 40 patients and there were 10 patients (25%) with continued complete or partial response for over 5 years.[ncbi.nlm.nih.gov]
  • One hundred two women initiated antiretroviral therapy, contributing 925 follow-up visits over a median of 34 months.[ncbi.nlm.nih.gov]
  • Three chronic pedophiliac sex offenders were treated individually with medroxyprogesterone acetate (MPA) over a minimum of 3 months.[ncbi.nlm.nih.gov]
  • A 51-year-old woman was admitted to our hospital for further investigation of chest X-ray films which showed multiple shadows that had been growing slowly over 2 years. Her only symptom was hemosputa.[ncbi.nlm.nih.gov]
Cesarean Section
  • The patient then became pregnant and was delivered of a live-born male infant at 37 weeks gestation by cesarean section for placenta previa. At cesarean section there were no abnormal findings in the uterine cavity or other pelvic organs.[ncbi.nlm.nih.gov]
Oligomenorrhea
  • METHODS: We conducted a pilot randomized trial in which women with infertility and oligomenorrhea or amenorrhea were randomly assigned to take either CC after a withdrawal bleed induced by medroxyprogesterone acetate (MPA) 10 mg daily for 10 days or to[ncbi.nlm.nih.gov]

Workup

Trophoblastic Cells
  • We also found that the MPA-pTHP-1 promoted the decidualization of endometrial stromal cells and the invasion of trophoblast cells.[ncbi.nlm.nih.gov]

Treatment

  • Although six of seven patients were negative for FOXO-1 before and after treatment, all the patients showed increased developments of FOXO-1 during MPA treatment.[ncbi.nlm.nih.gov]
  • Adjunctive MPA treatment provided greater and more rapid improvement in mania symptoms compared with adjunctive placebo and tamoxifen treatment.[ncbi.nlm.nih.gov]
  • No treatment-related complications arose. CONCLUSIONS: Combined oral MPA/LNG-IUS treatment is considered to be a reasonably effective fertility-sparing treatment of grade 2 stage IA endometrial cancer.[ncbi.nlm.nih.gov]
  • However, the weight gain was due to increased body fat, while fat-free mass was not significantly influenced by MPA treatment.[dx.doi.org]

Prognosis

  • The prognosis of breast cancer patients with liver metastases is extremely poor.[ncbi.nlm.nih.gov]
  • The prognosis of patients with metastasizing leiomyosarcoma is poor because of its low sensitivity to chemotherapy; however, some types of leiomyosarcoma are hormone-sensitive.[ncbi.nlm.nih.gov]
  • Multimedia: Slideshows, Images & Quizzes Related Disease Conditions Endometriosis (Symptoms, Causes, Treatments, and Prognosis) Endometriosis implants are most commonly found on the ovaries, the Fallopian tubes, outer surfaces of the uterus or intestines[medicinenet.com]

Epidemiology

  • WHAT IS KNOWN ALREADY: Although progesterone is associated with growth of leiomyoma, previous epidemiological studies have shown a protective association for DMPA use.[ncbi.nlm.nih.gov]
  • Author information 1 Department of Global Health, University of Washington, 325 Ninth Avenue, Box 359927, Seattle, WA, 98104, USA. rheffron@uw.edu. 2 Department of Epidemiology, University of Washington, Seattle, WA, USA. rheffron@uw.edu. 3 Department[ncbi.nlm.nih.gov]
  • Epidemiological data show a significant association between usage of DMPA-IM and increased HIV-1 acquisition but no such association from limited data for NET-EN.[ncbi.nlm.nih.gov]
  • Author information 1 Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California, USA. 2 Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA. 3[ncbi.nlm.nih.gov]
  • BACKGROUND: Epidemiological studies suggest that medroxyprogesterone acetate (MPA) may increase the risk of HIV-1. The current studies were designed to identify potential underlying biological mechanisms.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Methods : After reviewing its pathophysiology and preclinical studies, the main clinical trials on the use of medroxyprogesterone acetate in cancer cachexia, are reviewed.[dx.doi.org]

Prevention

  • Recently, several effective agents have been developed to prevent CINV, and CINV can be prevented in 70%-80% of patients receiving chemotherapies.[ncbi.nlm.nih.gov]
  • Women at risk for HIV-1 choosing DMPA could maintain this contraceptive method and add PrEP to achieve prevention of unintended pregnancy and HIV-1.[ncbi.nlm.nih.gov]
  • CONCLUSION(S): The results show that MPA is an effective oral alternative for the prevention of premature LH surge in woman undergoing COH.[ncbi.nlm.nih.gov]
  • OBJECTIVE: To describe medroxyprogesterone acetate (MPA) levels among Kenyan depot medroxyprogesterone acetate (DMPA) users in the FEM-PrEP HIV prevention trial, and to compare MPA levels between ARV for HIV prevention (treatment) and placebo groups.[ncbi.nlm.nih.gov]
  • Medicine, Monash University and Alfred Hospital, Victoria 3004, Australia. 6 Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University and Alfred Hospital, Victoria 3004, Australia.[ncbi.nlm.nih.gov]

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