The study presented here addresses the immunomodulatory properties of several common progestins with a potential to replace DMPA. [ncbi.nlm.nih.gov]

Presently women have a multitude of options when it comes to their control of fertility, options not given to their grandmothers. [hindawi.com]

• Weight Gain

  RESULTS: Cmax CONCLUSIONS: PK evaluation may help identify adolescents at risk of excessive DMPA-associated weight gain. Copyright © 2014 Elsevier Inc. All rights reserved. [ncbi.nlm.nih.gov]

  Gain Bone Density Additional relevant MeSH terms: Layout table for MeSH terms Bone Diseases Uterine Hemorrhage Weight Gain Body Weight Changes Body Weight Uterine Diseases Hemorrhage Pathologic Processes Musculoskeletal Diseases Medroxyprogesterone Acetate [clinicaltrials.gov]

• Swelling

  and facial swelling. [rxlist.com]

• Fatigue

  Adverse effects Acne, dysmenorrhoea, birth defects if taken during pregnancy, headache, breast tenderness, increased facial hair, decreased scalp hair, insomnia, abdominal pain/discomfort, dizziness, asthenia (weakness or fatigue), and weight changes. [medical-dictionary.thefreedictionary.com]

  A 39-year-old woman was admitted to our hospital with symptoms of general fatigue, nausea, and vomiting that appeared three months after she stopped seven years of medroxyprogesterone acetate (MPA) medication for endometrial stromal sarcoma. [ncbi.nlm.nih.gov]

  Overdosage of estrogen plus progestin therapy may cause nausea and vomiting, breast tenderness, dizziness, abdominal pain, drowsiness/fatigue and withdrawal bleeding may occur in women. [pfizermedicalinformation.com]

  […] uterine bleeding, weight or menstrual or cervical changes, breast tenderness, mastodynia, galactorrhea, thromboembolic disorders, acne, hirsutism, alopecia, edema, neuro-ocular lesions, depression, insomnia, somnolence, dizziness, headache, rash, pyrexia, fatigue [empr.com]

  Miscellaneous Hypersensitivity reactions (for example, anaphylaxis and anaphylactoid reactions, angioedema), rash (allergic) with and without pruritus, change in weight (increase or decrease), pyrexia, edema/fluid retention, fatigue, decreased glucose [rxlist.com]

• Falling

  The fall in progesterone levels following delivery is one of the triggers for milk production. Progesterone has an effect upon vaginal epithelium and cervical mucus. -- Wikipedia. [hmdb.ca]

  A 39-year-old woman on depot medroxyprogesterone acetate for 17 years developed multiple fractures after falling from a stationary horse. Densitometry revealed significant osteopenia. [ncbi.nlm.nih.gov]

  The fall in progesterone levels following delivery is one of the triggers for milk production. [foodb.ca]

  If not, levels of oestrogen and progesterone fall and the endometrium is shed (menstruation). Endometriosis is the growth of endometrial tissue outside the uterus which behaves in the same way as uterine endometrium. [inhousepharmacy.vu]

  HRT does not provide contraception for women who fall within this group. If you could get pregnant while taking this HRT, you should use a non-hormonal method of contraception (eg condoms or contraceptive foam ). [netdoctor.co.uk]

• Infertility

  OBJECTIVE: A recent retrospective study demonstrated that anovulatory infertile women who did not have a progestogen-induced withdrawal bleed before treatment with clomiphene citrate (CC) had higher pregnancy rates than women who had a withdrawal bleed [ncbi.nlm.nih.gov]

  Patient & Family Education Be aware that after repeated IM injections, infertility and amenorrhea may persist as long as 18 mo. Learn breast self-examination. Review package insert to ensure complete understanding of progestin therapy. [robholland.com]

  Gynaecology, infertility and cancers This section includes RHL summaries of published systematic reviews on menopause, gynaecological problems, gynaecological cancers, and infertility. [apps.who.int]

  Journal of International Dental and Medical Research 10 (Special Issue), 551-554, 2017 32017Genotype distribution of methylenetetrahydrofolate reductase A1298C and C677T gene in Indonesian infertile men DA Suryandari, Yurnadi, B Wiweko, L Yunaini Medical [scholar.google.com]

• Nausea

  Chemotherapy-induced nausea and vomiting (CINV) is one of the most distressing side effects in systemic chemotherapies. [ncbi.nlm.nih.gov]

  The common side effects of using Medroxyprogesterone acetate are headache, nausea (feeling sick), weight gain, breast pain, and unusual vaginal bleeding or spotting. Most of these symptoms are temporary. [1mg.com]

  Gastrointestinal Nausea, cholestatic jaundice. Skin Sensitivity reactions consisting of urticaria, pruritus, edema and generalized rash have occurred. [rxlist.com]

  Side Effects Nausea, bloating, headache, changes in appetite, weight gain, tiredness, swelling, acne, hot flashes, breast tenderness, or irritation/pain at the injection site may occur. [webmd.com]

• Pyrosis

  Toxicity was frequent, occurring in 83% vs. 74% of patients: increased appetite, nausea and dizziness in more than 20%, and a preponderance of pyrosis and breathlessness on MA and hot flashes, sweating and tremors on MPA. [rug.nl]

• Jaundice

  Also contraindicated in patients with undiagnosed abnormal genital bleeding and in patients with liver dysfunction or disease (such as history of hepatic adenoma or carcinoma), or history of cholestatic jaundice of pregnancy or jaundice with prior hormonal [glowm.com]

  Gastrointestinal Nausea, cholestatic jaundice. Skin Sensitivity reactions consisting of urticaria, pruritus, edema and generalized rash have occurred. [rxlist.com]

  Serious side effects of Medroxyprogesterone include: fever pain or swelling in legs or hands weakness jaundice chest pain, cough, rapid breathing In case of Menopause it may also lead to vaginal bleedings breast lump severe pelvic pain lupus, asthma, [lybrate.com]

  If ocular exam shows papilledema or retinal vascular lesions, drug should be discontinued. • Evaluate liver function tests. ☞ Watch for abdominal pain, fever, malaise, jaundice, darkened urine, and clay-colored stools. [medical-dictionary.thefreedictionary.com]

• Thrombosis

  Cardiovascular Deep and superficial venous thrombosis; pulmonary embolism; thrombophlebitis; myocardial infarction; stroke; increase in blood pressure. [rxlist.com]

  Scientific - Search for medroxyprogesterone TCI - Search for medroxyprogesterone Most-cited Publications Medroxyprogesterone Acetate Antagonizes Inhibitory Effects of Conjugated Equine Estrogens on Coronary Artery Atherosclerosis (Arteriosclerosis, Thrombosis [api.chemchart.com]

• Decrease in Height

  […] in height difficult or labored breathing difficulty with breathing difficulty with swallowing dimpling of the breast skin dizziness or lightheadedness dull ache or feeling of pressure or heaviness in the legs fainting fast, pounding, or irregular heartbeat [mayoclinic.org]

• Eye Irritation

  Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. [api.chemchart.com]

• Uterine Hemorrhage

  Hemorrhage Weight Gain Body Weight Changes Body Weight Uterine Diseases Hemorrhage Pathologic Processes Musculoskeletal Diseases Medroxyprogesterone Acetate Medroxyprogesterone Contraceptives, Oral, Hormonal Contraceptives, Oral Contraceptive Agents, [clinicaltrials.gov]

  vaginal cysts, vaginal hemorrhage, and uterine hemorrhage. [ncbi.nlm.nih.gov]

  Corpus Carcinoma / Stage I Uterine Corpus Cancer / Stage II Uterine Corpus Cancer / Stage III Uterine Corpus Cancer / Stage IV Uterine Corpus Cancer 1 2 Completed Treatment Endometriosis 1 2 Completed Treatment Epilepsies / Menopause 1 2 Completed Treatment [drugbank.ca]

• Headache

  ☞ Assess for visual disturbances and headache. [medical-dictionary.thefreedictionary.com]

  The common side effects of using Medroxyprogesterone acetate are headache, nausea (feeling sick), weight gain, breast pain, and unusual vaginal bleeding or spotting. Most of these symptoms are temporary. [1mg.com]

  Central Nervous System Mental depression, insomnia, somnolence, dizziness, headache, nervousness. [rxlist.com]

  Side Effects Nausea, bloating, headache, changes in appetite, weight gain, tiredness, swelling, acne, hot flashes, breast tenderness, or irritation/pain at the injection site may occur. [webmd.com]

• Irritability

  Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. [api.chemchart.com]

  irritation, lumps, redness or scarring in the place where the medication was injected Some side effects can be serious. [medlineplus.gov]

  Central Nervous System Headache; migraine; dizziness; mental depression; chorea; nervousness; mood disturbances; irritability; exacerbation of epilepsy, dementia. [rxlist.com]

  ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits acrid smoke and irritating fumes. [cameochemicals.noaa.gov]

  Side Effects Nausea, bloating, headache, changes in appetite, weight gain, tiredness, swelling, acne, hot flashes, breast tenderness, or irritation/pain at the injection site may occur. [webmd.com]

• Progesterone Decreased

  Progesterone decreases contractility of the uterine musculature. The fetus metabolizes placental progesterone in the production of adrenal mineralo and glucosteroids. [hmdb.ca]

  If pregnancy does not occur, progesterone levels will decrease leading to menstruation in the human. [foodb.ca]

• Hyperinsulinemia

  Hyperinsulinemia caused by insulin resistance and its related signaling pathways, the PI3K/Akt and mitogen-activated protein kinase (MAPK) pathways, play an important role in carcinogenesis [ 6, 7 ]. [annonc.oxfordjournals.org]

However, the weight gain was due to increased body fat, while fat-free mass was not significantly influenced by MPA treatment. [dx.doi.org]

Adenocarcinoma, Prostate 1 3 Completed Treatment Hypermenorrhea 1 3 Completed Treatment Menopause / Osteoporosis 1 3 Completed Treatment Metastatic Renal Cell Carcinoma 1 3 Completed Treatment Osteoporosis 1 3 Completed Treatment Rejection, Transplant [drugbank.ca]

Although six of seven patients were negative for FOXO-1 before and after treatment, all the patients showed increased developments of FOXO-1 during MPA treatment. [ncbi.nlm.nih.gov]

The prognosis of breast cancer patients with liver metastases is extremely poor. [ncbi.nlm.nih.gov]

Multimedia: Slideshows, Images & Quizzes Related Disease Conditions Endometriosis (Symptoms, Causes, Treatments, and Prognosis) Endometriosis implants are most commonly found on the ovaries, the Fallopian tubes, outer surfaces of the uterus or intestines [medicinenet.com]

Among such diseases, malignant tumors have widely been studied with respect to their relation to neovascularization, and it has come to be elucidated that neovascularization is crucial in the metastasis and prognosis of malignant tumors. [patents.google.com]

AIP Conference Proceedings 2092 (1), 040022, 2019 2019Decreased Expression of CDC25A in Azoospermia as the Etiology of Spermatogenesis Failure DA Suryandari, YH Midoen, L Yunaini, S Setyaningsih, HJ Freisleben Journal of reproduction & infertility 19 [scholar.google.com]

While the etiology of PCOS is complex and not completely understood, the syndrome is characterized by oligo/anovulation with polycystic ovaries and increased androgen secretion resulting in acne and hirsutism [2]. [pulsus.com]

Author information 1 Department of Global Health, University of Washington, 325 Ninth Avenue, Box 359927, Seattle, WA, 98104, USA. [email protected]. 2 Department of Epidemiology, University of Washington, Seattle, WA, USA. [email protected]. 3 Department [ncbi.nlm.nih.gov]

Methods : After reviewing its pathophysiology and preclinical studies, the main clinical trials on the use of medroxyprogesterone acetate in cancer cachexia, are reviewed. [dx.doi.org]

Leptin: physiology and pathophysiology. Clin Physiol 1998;18:399–419. ↵ Hardie L, Trayhurn P, Abramovich D, Fowler P. Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. [erj.ersjournals.com]

Also, the disturbances in the endothelial function play an important role in the pathophysiology of cardiovascular disease, and several lines of evidence suggest that interventions in the endothelial function could modify the progression of cardiovascular [scielo.br]

Recently, several effective agents have been developed to prevent CINV, and CINV can be prevented in 70%-80% of patients receiving chemotherapies. [ncbi.nlm.nih.gov]

Medroxyprogesterone acetate is used primarily as a contraceptive; it is injected every three months, inhibiting gonadotropin secretion which, in turn, prevents follicular maturation and ovulation, and causes endometrial thinning. [medical-dictionary.thefreedictionary.com]