A previously unreported case of localized leukocytoclastic vasculitis of the left colon resulting in the impressive presentation of megacolon, without the presence of any precipitating factor or associated systemic disease is presented here, with an overview [ncbi.nlm.nih.gov]

• Collapse

  The second case was a 16-year-old adolescent girl with recent diarrhea who collapsed after showering. She, too, had a long history of chronic constipation. [ncbi.nlm.nih.gov]

• Abdominal Mass

  METHOD: A 39-year-old male patient with constipation presented with a firm, mobile, abdominal mass of six-months duration. Investigations revealed an isolated, giant fecaloma in a redundant sigmoid megacolon. [ncbi.nlm.nih.gov]

• Absent Bowel Sounds

  Findings may include: Tenderness in the abdomen Reduced or absent bowel sounds The exam may reveal signs of septic shock, such as: Increased heart rate Mental status changes Rapid heart rate Low blood pressure The provider may order any of the following [medlineplus.gov]

• Purpura

  Systemic leukocytoclastic vasculitis, usually coexisting with Henoch-Schonlein purpura, commonly affects the small bowel with clinical evidence of ischemia or bleeding. Colon involvement is infrequently reported in the context of systemic disease. [ncbi.nlm.nih.gov]

• Myopathy

  All the samples were stained with hematoxylin-eosin (HE), Hu C/D antibody, and CD117 antibody to assess degenerative myopathy, degenerative neuropathy, inflammatory neuropathy, hypoganglionosis, and mesenchymopathy according to the London Classification [ncbi.nlm.nih.gov]

  diabetic neuropathy, spinal cord injury, Parkinson's disease) [8] Myopathies (e.g., Duchenne's muscular dystrophy, myotonic muscular dystrophy) Connective tissue disorders (e.g., scleroderma, systemic lupus erythematosus, dermatomyositis) Chronic Chagas [amboss.com]

• Stupor

  A volvulus of the sigma was found at surgical intervention.Case report 2: a 59-year-old man with a medical history of oligophrenia was admitted to our hospital for acute abdomen.He presented stupor and closed alvus with abdominal distension. [ncbi.nlm.nih.gov]

[…] with megacolon, taking into account the possibility of adverse effects.48 Special Populations HIV/AIDS patients An aggressive exploration of infectious and noninfectious etiology is a must, including radiological imaging and early limited endoscopic workup [dovepress.com]

(See also Etiology, Presentation, and Workup.) Toxic Megacolon. A 72-year-old woman presented with vomiting and abdominal distention. [emedicine.medscape.com]

Abstract Persistent megacolon that results from frequent episodes of fecal impaction without adequate treatment is a rare and seldom reported condition in the elderly. [ncbi.nlm.nih.gov]

Treatment may include: Breathing machine (mechanical ventilation) Dialysis for kidney failure Drugs to treat low blood pressure, infection, or poor blood clotting Fluids given directly into a vein Oxygen If rapid widening is not treated, an opening or [medlineplus.gov]

Abstract Intestinal microvillous disorders are an uncommon cause of severe diarrhea, with very poor prognosis. [ncbi.nlm.nih.gov]

Treatment and prognosis Specific management depends on the underlying etiology and may involve a combination of supportive, pharmacological, and surgical management. References Promoted articles (advertising) [radiopaedia.org]

Prognosis The mortality rates for TM are inconsistent. [dovepress.com]

[…] incidence of toxic megacolon in patients with C difficile colitis rapidly increased from 0.4% to 3% before 1990 to 4.3% after 1990, due to the rising use of broad spectrum antibiotics and the development of a hypervirulent Crohn disease strain. [4, 35, 37] Prognosis [emedicine.medscape.com]

The etiology was established by means of laboratory and histological features. Based on epidemiological data, the authors concluded that vertical transmission was the most probable route of acquisition. [ncbi.nlm.nih.gov]

There are three etiological types of megacolon: acute, chronic, and toxic megacolon. [amboss.com]

Treatment and prognosis Specific management depends on the underlying etiology and may involve a combination of supportive, pharmacological, and surgical management. References Promoted articles (advertising) [radiopaedia.org]

Based on epidemiological data, the authors concluded that vertical transmission was the most probable route of acquisition. This diagnosis should be considered in children presenting similar complaints, even those living away from endemic areas. [ncbi.nlm.nih.gov]

Chagas megacolon. [3] Of the 34% of asymptomatic patients who demonstrated similar patterns of autoantibodies, 84% of these individuals also had levels of beta1 autoantibody that are typical for Chags cardiomyopathy, which the authors stated mirrored the epidemiologic [emedicine.com]

Complications and management of fecal impaction and the pathophysiology of megacolon in the literature are reviewed and discussed. [ncbi.nlm.nih.gov]

The pathophysiology of chronic megacolon is incompletely understood. It likely represents an amalgam of primary disorders involving muscular and nervous systems of the intestine. Much basic science work has been performed in this area. [emedicine.com]

You may receive antibiotics to prevent sepsis (a severe infection). If the condition does not improve, it can be fatal. Colon surgery is usually needed in such cases. [medlineplus.gov]

CONCLUSION: A timely surgical intervention in recalcitrant fecal impactions may prevent possible stercoral ulcer perforation with a high mortality. [ncbi.nlm.nih.gov]