A previously unreported case of localized leukocytoclastic vasculitis of the left colon resulting in the impressive presentation of megacolon, without the presence of any precipitating factor or associated systemic disease is presented here, with an overview [ncbi.nlm.nih.gov]

[…] with megacolon, taking into account the possibility of adverse effects.48 Special Populations HIV/AIDS patients An aggressive exploration of infectious and noninfectious etiology is a must, including radiological imaging and early limited endoscopic workup [dovepress.com]

(See also Etiology, Presentation, and Workup.) Toxic Megacolon. A 72-year-old woman presented with vomiting and abdominal distention. [emedicine.medscape.com]

Abstract Persistent megacolon that results from frequent episodes of fecal impaction without adequate treatment is a rare and seldom reported condition in the elderly. [ncbi.nlm.nih.gov]

Toxic megacolon is a life-threatening condition that needs immediate treatment. [hopkinsmedicine.org]

Abstract Intestinal microvillous disorders are an uncommon cause of severe diarrhea, with very poor prognosis. [ncbi.nlm.nih.gov]

Treatment and prognosis Specific management depends on the underlying etiology and may involve a combination of supportive, pharmacological, and surgical management. References Promoted articles (advertising) [radiopaedia.org]

Prognosis The mortality rates for TM are inconsistent. [dovepress.com]

[…] incidence of toxic megacolon in patients with C difficile colitis rapidly increased from 0.4% to 3% before 1990 to 4.3% after 1990, due to the rising use of broad spectrum antibiotics and the development of a hypervirulent Crohn disease strain. [4, 35, 37] Prognosis [emedicine.medscape.com]

There are three etiological types of megacolon: acute, chronic, and toxic megacolon. [amboss.com]

Treatment and prognosis Specific management depends on the underlying etiology and may involve a combination of supportive, pharmacological, and surgical management. References Promoted articles (advertising) [radiopaedia.org]

The timing of surgery in TM is still a matter of controversy and varies by the underlying etiology of the TM. [dovepress.com]

Mycobacterium avium subspecies paratuberculosis is a candidate etiological agent of Crohn's disease. Definitive causal connection between Mycobacterium avium subspecies paratuberculosis infection and Crohn's disease has not been demonstrated. [ncbi.nlm.nih.gov]

CONCLUSIONS: The percentage of asymptomatic Chagas' patients who had a specific AAB pattern and had a beta1-AAB level above a defined cutoff point mirrors very well the epidemiological situation, which showed that clinical manifestations develop in nearly [ncbi.nlm.nih.gov]

Chagas megacolon. [3] Of the 34% of asymptomatic patients who demonstrated similar patterns of autoantibodies, 84% of these individuals also had levels of beta1 autoantibody that are typical for Chags cardiomyopathy, which the authors stated mirrored the epidemiologic [emedicine.medscape.com]

Epidemiology The exact prevalence of TM is underreported. However, the prevalence continues to increase with age. [dovepress.com]

Complications and management of fecal impaction and the pathophysiology of megacolon in the literature are reviewed and discussed. [ncbi.nlm.nih.gov]

Novel concepts in the diagnosis, pathophysiology and management of idiopathic megabowel. Colorectal Dis. 2008; 10 (6): p.531-538. doi: 10.1111/j.1463-1318.2007.01457.x. | Open in Read by QxMD Beattie GC, Peters RT, Guy S, Mendelson RM. [amboss.com]

The pathophysiology of chronic megacolon is incompletely understood. It likely represents an amalgam of primary disorders involving muscular and nervous systems of the intestine. Much basic science work has been performed in this area. [emedicine.medscape.com]

Following your doctor’s advice will help control the symptoms of IBD, prevent infections, and reduce the likelihood that you’ll develop toxic megacolon. [healthline.com]

You may receive antibiotics to prevent sepsis (a severe infection). If the condition does not improve, it can be fatal. Colon surgery is usually needed in such cases. [medlineplus.gov]

CONCLUSION: A timely surgical intervention in recalcitrant fecal impactions may prevent possible stercoral ulcer perforation with a high mortality. [ncbi.nlm.nih.gov]