About 1% of newborns presents congenital nevi. Removal of nevi is not usually required except in cases of giant congenital nevi and clinically atypical nevi. [analesdepediatria.org]

While present in all ethnic groups examined to date and in both genders, there is a slight female predominance. Clinical description CMN develop during the first trimester of pregnancy. [orpha.net]

Fong, MD, of Calgary, Alberta, write that congenital melanocytic nevi are present in 1% to 2% of newborns.1 Lesions may be brown or black and may be flat, nodular, or verrucose. [consultant360.com]

An unusual presentation of multiple congenital melanocytic nevi with a whole-body distribution. Indian J Pathol Microbiol 2018;61:155-6 How to cite this URL: Liu HP, Zhang D. [ijpmonline.org]

Images of Nevus, Congenital Melanocytic Overview A birthmark (congenital melanocytic nevus, CMN) is a mole that is present at birth or shortly thereafter. [skinsight.com]

The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]

Treatment of this case is challenging. Total excision of so many nevi is apparently difficult and impractical. [ijpmonline.org]

Treatments Your Physician May Prescribe A skin biopsy may be done if there is suspicion of malignant change to the birthmark. [skinsight.com]

Excision is the first-line treatment option for all large and giant hairy CMN due to the associated risk of malignant transformation, although the magnitude of this risk is debated. [cureus.com]

If the mole bothers you, talk to your doctor about which treatment options would work best for the size of your mole and your skin type. [healthline.com]

Prognosis The majority of patients have normal adult lives without any complications. The documents contained in this web site are presented for information purposes only. [orpha.net]

The interpretation of tumor infiltrating lymphocytes is a debatable prognostic feature; however, its presence is thought to portray a better prognosis. [musculoskeletalkey.com]

Etiology LCMN is a neurocristopathy (a disorder of the development of the embryonic neural crest) but its etiology is unknown. Diagnostic methods The diagnosis is clinical. [orpha.net]

Epidemiological studies confirm an increasing epidemic of melanoma in adults and evidence exists that this worldwide epidemic is also affecting the teenage population. [analesdepediatria.org]

Summary Epidemiology LCMN has a prevalence of about 1/20,000, while GCMN is estimated to occur in 1/50,000 to 1/500,000 births, becoming increasingly rare as more body surface is implicated. [orpha.net]

[…] with those of acquired melanocytic nevi, the nevomelanocytes in CMN tend to extend deeper into the dermis and subcutaneous tissues, to be arranged single file between collagen bundles, and to track along skin appendages and neurovascular structures Epidemiology [pedclerk.bsd.uchicago.edu]

Epidemiology Prevalence: Up to 2% of newborns III. Pathophysiology Neural crest Melanocytes and their precursors with disrupted migration IV. [fpnotebook.com]

Pathophysiology Neural crest Melanocytes and their precursors with disrupted migration IV. [fpnotebook.com]

Pediatricians play an important role in the prevention and early diagnosis of these lesions. [analesdepediatria.org]

Removal by excision or shaving when desired Excision of high-risk lesions Prophylactic removal of all atypical moles is not effective in preventing melanoma and is not recommended. [msdmanuals.com]

Early diagnosis and surgical excision are usually recommended in congenital melanocytic nevus to prevent the future risk of malignant transformation which is higher in larger lesions, especially in giant forms (>20 cm in size). [jsstd.org]