Presenting identifying characteristics ( versus group 2) are few with the exception of a lower median urine protein at presentation. [doi.org]

DISCUSSION: Simultaneous anti-GBM disease and membranous glomerulonephritis is the most common temporal presentation of this rare entity. [ncbi.nlm.nih.gov]

• Enuresis

  Less common symptoms were abdominal pain noted in 2 patients and nocturnal enuresis in 1 patient. At presentation, all patients had a normal serum creatinine concentration and the GFR e was 155 34 mL/min/1.73 m 2. [biomedcentral.com]

• Blurred Vision

  METHODS: A 44-year-old tennis instructor presented with a 1-week history of blurred vision in the left eye. Examination of the left eye demonstrated a best-corrected visual acuity of 20/40 and an inferior hemiretinal vein occlusion. [ncbi.nlm.nih.gov]

• Dysarthria

  After 3 months, the patient complained of increasing physical exhaustion, reduction of his walking distance, worsening of the residual dysphagia, and dysarthria with an inability to swallow. [ncbi.nlm.nih.gov]

• Kidney Failure

  Corticosteroids: They have been tried with mixed results, with one study showing prevention of progression to kidney failure without improvement in proteinuria. [en.wikipedia.org]

  She was admitted because of acute kidney failure, bloody diarrhea, and gastrointestinal symptoms. Further evaluation confirmed the diagnosis of ulcerative colitis. [ncbi.nlm.nih.gov]

• Vaginal Bleeding

  Abstract A 26-year-old woman presented at our hospital with pretibial edema, swelling, and vaginal bleeding. [ncbi.nlm.nih.gov]

• Nocturnal Enuresis

  Less common symptoms were abdominal pain noted in 2 patients and nocturnal enuresis in 1 patient. At presentation, all patients had a normal serum creatinine concentration and the GFR e was 155 34 mL/min/1.73 m 2. [biomedcentral.com]

The two can be distinguished by clinical, laboratory, and histological features (see Presentation and Workup ). [1] Successful treatment of the underlying cause may be curative in secondary forms. [emedicine.medscape.com]

The diagnosis of idiopathic membranous nephropathy was established by renal biopsy as part of the routine clinical workup for the investigation of proteinuria. 8 The studies were approved by the relevant institutional review boards in the three countries [doi.org]

• Liver Function Tests Abnormal

  Other exclusion criteria were systemic diseases, pregnancy or inadequate contraception, active infection, unstable angina pectoris, diabetes mellitus, clinical evidence of renal vein thrombosis, liver function test abnormalities ( 2 times the upper limit [doi.org]

• Polyps

  The polyps were histologically consistent with those in Cronkhite-Canada syndrome (CCS). Interestingly, the patient also had colon cancer, as well as portal thrombosis and a high concentration of antinuclear antibody. [ncbi.nlm.nih.gov]

• Liver Biopsy

  A subsequent liver biopsy also showed evidence of iron overload but without fibrotic changes. Genetic studies including C282Y HFE, ferroportin and DMT1 studies were also negative. [ncbi.nlm.nih.gov]

Fifteen patients were randomized for early treatment (group A) and 14 for postponed treatment (group B). [doi.org]

Treatment of secondary membranous nephropathy is guided by the treatment of the original disease. For treatment of idiopathic membranous nephropathy, the treatment options include immunosuppressive drugs and non-specific anti-proteinuric measures. [en.wikipedia.org]

There is no specific treatment for membranous nephropathy. [cjasn.asnjournals.org]

Prognosis is variable, with 50% of patients reaching endpoints of ESRD or death. [ncbi.nlm.nih.gov]

Long-term prognosis is guarded because approximately 50% of patients may have evidence of progressive kidney disease. [biomedcentral.com]

Si-Xuan Qian, Jian-Yong Li, Ming Hong, Wei Xu and Hong-xia Qiu, Nonhematological autoimmunity (glomerulosclerosis, paraneoplastic pemphigus and paraneoplastic neurological syndrome) in a patient with chronic lymphocytic leukemia: Diagnosis, prognosis [doi.org]

Author information 1 Department of Internal Medicine, Gaziantep University, School of Medicine, Gaziantep, Turkey. [email protected] Abstract Adult onset Still's Disease (ASD) is a systemic inflammatory disorder of unknown etiology characterized by [ncbi.nlm.nih.gov]

Changing etiologies of unexplained adult nephrotic syndrome: a comparison of renal biopsy findings from 1976-1979 and 1995-1997. Am J Kidney Dis. 1997 Nov. 30(5):621-31. [Medline]. Hogan SL, Muller KE, Jennette JC, et al. [emedicine.medscape.com]

Epidemiologic data showed that mercury poisoning mainly resulted from occupational contact with mercury, abuse of mercury-containing compounds, or skin-lightening cosmetics ( 8, 9 ). [doi.org]

Epidemiology Frequency United States Biopsy reveals an underlying glomerular lesion in 25% of adults with nephrotic syndrome. However, in patients older than 60 years, the incidence rate is 35%. [emedicine.medscape.com]

Author information 1 Pathophysiology of Renal Diseases, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan. 2 Department of Nephrology, Tokyo Medical University Kasumigaura Hospital, Ami, Ibaraki, [ncbi.nlm.nih.gov]

He was started on an angiotensin-converting enzyme inhibitor to reduce proteinuria and an oral anticoagulant to prevent thromboembolic events. [ncbi.nlm.nih.gov]

Corticosteroids: They have been tried with mixed results, with one study showing prevention of progression to kidney failure without improvement in proteinuria. [en.wikipedia.org]

Penny MJ, Boyd RA, Hall BM (1998) Mycophenolate mofetil prevents the induction of active Heymann nephritis: association with Th2 cytokine inhibition. J Am Soc Nephrol 9:2272–2282 PubMed Google Scholar 27. [doi.org]

The binding of NFa to C3b,Bb stabilizes the complex, preventing degradation by its normal inactivators, resulting in complement activation and chronic consumption of C3. [emedicine.medscape.com]