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2.1
Membranous Glomerulonephritis
Extramembranous Glomerulopathy

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WIKIDATA, CC BY-SA 3.0
WIKIDATA, CC BY-SA 3.0

Presentation

Presenting identifying characteristics ( versus group 2) are few with the exception of a lower median urine protein at presentation. [doi.org]

We briefly present this first case of choriocarcinoma causing membranous glomerulonephritis. [ncbi.nlm.nih.gov]

Entire Body System

  • Hodgkin Lymphoma

    In this article, an exceptional renal involvement of Hodgkin's lymphoma is discussed in light of the related literature. [ncbi.nlm.nih.gov]

    Minimal change nephrotic syndrome and classical Hodgkin's lymphoma: report of 21 cases and review of the literature. Kidney Int. 2006 Jun. 69(12):2251-60. [Medline]. Humphreys BD, Vanguri VK, Henderson J, Antin JH. [emedicine.medscape.com]

    In a phase II trial of 58 patients with non-Hodgkin's lymphoma who received rituximab (375 mg/m 2 ), no patient developed HACA ( 113 ). [cjasn.asnjournals.org]

  • Anemia

    Evaluation of patients diagnosed with membranous nephropathy usually includes the following: A search for occult cancer, particularly in a patient who has lost weight, has unexplained anemia or heme-positive stools, or is older Consideration of drug-induced [merckmanuals.com]

    Apparent anemia occurred in two female patients with rheumatoid arthritis; normal peripheral blood white cell count and platelet count were observed in all patients. Four patients were ANA-positive. [doi.org]

Cardiovascular

  • Hypotension

    Attempts to increase lisinopril a further resulted in postural hypotension. In December 2004, the patient returned for follow-up. BP was 107/58 mmHg, and his pulse rate was 69. [cjasn.asnjournals.org]

Urogenital

  • Hematuria

    CASE: We present the case of a 49-year-old man who had fatigue, flank pain, hematuria and renal failure. Serology was positive for anti-GBM antibodies; crescentic glomerulonephritis was seen on renal biopsy. [ncbi.nlm.nih.gov]

    When they were first evaluated, 9 patients had microscopic hematuria, 5 had peripheral edema, 5 had nephrotic-range proteinuria, and 3 patients were hypertensive. [biomedcentral.com]

  • Kidney Failure

    Corticosteroids: They have been tried with mixed results, with one study showing prevention of progression to kidney failure without improvement in proteinuria. [en.wikipedia.org]

    She was admitted because of acute kidney failure, bloody diarrhea, and gastrointestinal symptoms. Further evaluation confirmed the diagnosis of ulcerative colitis. [ncbi.nlm.nih.gov]

Workup

The two can be distinguished by clinical, laboratory, and histological features (see Presentation and Workup ). [1] Successful treatment of the underlying cause may be curative in secondary forms. [emedicine.medscape.com]

The diagnosis of idiopathic membranous nephropathy was established by renal biopsy as part of the routine clinical workup for the investigation of proteinuria. 8 The studies were approved by the relevant institutional review boards in the three countries [doi.org]

Treatment

Fifteen patients were randomized for early treatment (group A) and 14 for postponed treatment (group B). [doi.org]

Treatment of secondary membranous nephropathy is guided by the treatment of the original disease. For treatment of idiopathic membranous nephropathy, the treatment options include immunosuppressive drugs and non-specific anti-proteinuric measures. [en.wikipedia.org]

There is no specific treatment for membranous nephropathy. [cjasn.asnjournals.org]

Prognosis

Persistent proteinuria at diagnosis predicts poor prognosis. [ncbi.nlm.nih.gov]

Long-term prognosis is guarded because approximately 50% of patients may have evidence of progressive kidney disease. [biomedcentral.com]

Si-Xuan Qian, Jian-Yong Li, Ming Hong, Wei Xu and Hong-xia Qiu, Nonhematological autoimmunity (glomerulosclerosis, paraneoplastic pemphigus and paraneoplastic neurological syndrome) in a patient with chronic lymphocytic leukemia: Diagnosis, prognosis [doi.org]

Etiology

Author information 1 Department of Internal Medicine, Gaziantep University, School of Medicine, Gaziantep, Turkey. [email protected] Abstract Adult onset Still's Disease (ASD) is a systemic inflammatory disorder of unknown etiology characterized by [ncbi.nlm.nih.gov]

C3 glomerulonephritis is similar in etiology to dense deposit disease, arising as a result of alternate complement activation or mutations in the complement-regulating proteins. C3NeF is commonly present. [emedicine.medscape.com]

Epidemiology

Epidemiology Frequency United States In preadolescents, minimal-change nephrotic syndrome (MCNS) makes up 85-95% of all cases of nephrotic syndrome. [emedicine.medscape.com]

Department of Epidemiology, Johns Hopkins University, Baltimore (A.K.); Department of Systemic Ecology, University of Bucharest, Bucharest, Romania (L.D.); Departments of Nephrology (J.M.H., J.F.M.W.), Human Genetics (M.J.H.C.), Epidemiology, Biostatistics [doi.org]

Epidemiology Frequency United States Biopsy reveals an underlying glomerular lesion in 25% of adults with nephrotic syndrome. However, in patients older than 60 years, the incidence rate is 35%. [emedicine.com]

Pathophysiology

Author information 1 Pathophysiology of Renal Diseases, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan. 2 Department of Nephrology, Tokyo Medical University Kasumigaura Hospital, Ami, Ibaraki, [ncbi.nlm.nih.gov]

Prevention

He was started on an angiotensin-converting enzyme inhibitor to reduce proteinuria and an oral anticoagulant to prevent thromboembolic events. [ncbi.nlm.nih.gov]

Corticosteroids: They have been tried with mixed results, with one study showing prevention of progression to kidney failure without improvement in proteinuria. [en.wikipedia.org]

The binding of NFa to C3b,Bb stabilizes the complex, preventing degradation by its normal inactivators, resulting in complement activation and chronic consumption of C3. [emedicine.medscape.com]

Penny MJ, Boyd RA, Hall BM (1998) Mycophenolate mofetil prevents the induction of active Heymann nephritis: association with Th2 cytokine inhibition. J Am Soc Nephrol 9:2272–2282 PubMed Google Scholar 27. [doi.org]

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