Isolated menarche is an unusual presentation of the advanced sexual development relative to bone age found in some patients with juvenile hypothyroidism. [ncbi.nlm.nih.gov]

• Pain

  If you have very painful periods or the pain keeps getting worse over time, it can be a good idea to see a doctor. [ncbi.nlm.nih.gov]

  Midcyclic pain due to irritation. 33. Question 8 What are conditions associated with menstruation? 34. Fever--- progesterone Pain--- irritation. Headache. Fatigability Vomiting. [slideshare.net]

  This mineral may be effective in lessening menstrual pain over time, and reducing the need for pain medication. [helloclue.com]

• Precocious Puberty

  Precocious puberty or central precocious puberty can be very confusing and truly unexpected. After all who know children could go into puberty too early? There is treatment for this condition. [ncbi.nlm.nih.gov]

  Two different type of phenotype due to abnormal timing of the pubertal onset are described: advance of the pubertal onset also call central precocious puberty and delayed or absence of puberty. [endocrine-abstracts.org]

  Links: puberty (delayed) hypothalamus-pituitary-gonad axis (in menstrual cycle) amenorrhoea precocious puberty breast development pubic hair development axillary hair development [gpnotebook.co.uk]

  If a young girl has her first period before the age of 8 she likely has a condition known as precocious puberty. This is not normal and needs further medical attention. [pms.about.com]

• Underweight

  Based on these definitions 4.2% were underweight (BMI 90th percentile). [eje.bioscientifica.com]

  Nomograms are given for the prediction of these critical weights for height from a fatness index; these weights are useful clinically in the evaluation of nutritional amenorrhoea and the restoration of fertility in underweight women. [humrep.oxfordjournals.org]

  Many girls who are underweight or undernourished will not get their periods. It is generally thought that a certain weight (around 100 pounds) must be attained in order for your brain to send signals to your body to start menstruating. [epigee.org]

• Fever

  Fever--- progesterone Pain--- irritation. Headache. Fatigability Vomiting. [slideshare.net]

  […] are severe Your bleeding is excessive, lasts longer than 7 days, occurs often or at the wrong time of your cycle If you have not had your first period by age 16 If it has been 3 months since your last period You think you might be pregnant You develop fever [webmd.com]

• Asymptomatic

  Bone mineral affection in asymptomatic adult patients with celiac disease. Am. J. Gastroenterol. 89, 2130–2134 (1994). 34. Valdimarsson, T., Toss, G., Ross, I., Lofman, O. & Strom, M. Bone mineral density in coeliac disease. Scand. J. [doi.org]

  Thirty-one healthy, asymptomatic girls representing black ( n = 21), white/non-Hispanic ( n = 7), white/Hispanic ( n = 1) and Native American ( n = 2) racial/ethnic groups were enrolled between June 2009 and August 2011. [mbio.asm.org]

• Nausea

  It can cause nausea, vomiting or diarrhea in some women, as well as headaches or general discomfort. Women who have heavier periods often have more intense pain too. [ncbi.nlm.nih.gov]

  Some also notice nausea, diarrhea, irritability, headaches, and fatigue, among other symptoms. To ease cramping, try applying heat to your abdomen with a heating pad or hot water bottle. Taking a warm bath may also help. [webmd.com]

  The symptoms of the classical form of childhood CD are malabsorption related and include chronic diarrhea, steatorrhea, abdominal distension, fatigue, nausea, vomiting, anemia and growth retardation. [humupd.oxfordjournals.org]

• Abdominal Pain

  Abstract An eleven year-old girl presented with right lower quadrant abdominal pain near menarche that coincided with the onset of her most recent menstrual period. [ncbi.nlm.nih.gov]

• Lower Abdominal Pain

  A 13-year-old nulligravida girl, 158.5 cm in height and 76.0 kg in body weight, came to our department complaining of continuous right lower abdominal pain. [ncbi.nlm.nih.gov]

• No Pubic Hair

  METHODS: Demographic characteristics, age at menarche and menstrual duration, anthropometry (weight, height, BMI) and pubertal status (breast and pubic hair) were evaluated. [ncbi.nlm.nih.gov]

  The first event is most often breast formation in 80%, but pubic and axillary hair growth is first in 20%. Breast development may continue until age 18 years and pubic hair grows until age 17 years. Menarche is a late feature of female puberty. [gpnotebook.co.uk]

  The appearance of pubic hair is commonly next. [pamf.org]

  The median ages at breast stages 2 through 5 are 9.65, 10.10, 11.75, and 14.17 years, respectively, and at pubic-hair stages 2 through 5 are 10.09, 11.19, 12.33, and 14.68 years, respectively. [doi.org]

• Hirsutism

  The Ferriman-Gallwey score was applied to evaluate hirsutism. [ncbi.nlm.nih.gov]

  The earliest symptoms of PCOD, like hirsutism (facial hair) and hyperpigmentation could be emotionally scarring for a teenager," he adds. [timesofindia.indiatimes.com]

• Fear

  Confirmatory factor analysis was used to fit four latent disorder categories: distress, eating, and externalizing, and fear disorders. [ncbi.nlm.nih.gov]

  Some feel full of fear and overwhelmed. Some struggle with mood swings, cramps, and bloating. Others cannot understand what all the fuss is about. Your daughter will handle her first time so much better if you have prepared her. [web.archive.org]

  The attitudes of societies toward menarche vary from delight and pride to fear and shame. Positive labels signify that the girl is an adult, capable of contributing to the ongoing society. [encyclopedia.com]

• Confusion

  Precocious puberty or central precocious puberty can be very confusing and truly unexpected. After all who know children could go into puberty too early? There is treatment for this condition. [ncbi.nlm.nih.gov]

  It is important to exclude a local labial or vaginal cause for the bleeding, and there is often confusion about whether this is related to sexual abuse. [health.am]

  Since our children are not educated about sex in the right way, the added confusion and tension over sexual feelings would further cause hormonal surges," he explains. #ElectionsWithTimes [timesofindia.indiatimes.com]

  Like many other changes associated with puberty, it can be confusing. Many girls experience fear and anxiety related to their first menstrual cycle, largely because of misinformation or, more frequently, lack of information. [wol.jw.org]

• Headache

  It can cause nausea, vomiting or diarrhea in some women, as well as headaches or general discomfort. Women who have heavier periods often have more intense pain too. [ncbi.nlm.nih.gov]

  Other signs of menarche include a slight headache, leg ache or backache for a few hours. The most common symptom of menarche, is cramping. You may feel abdominal cramping, similar to a stomachache for the first few days of your period. [epigee.org]

  Some also notice nausea, diarrhea, irritability, headaches, and fatigue, among other symptoms. To ease cramping, try applying heat to your abdomen with a heating pad or hot water bottle. Taking a warm bath may also help. [webmd.com]

• Amenorrhea

  However, these regimens result in delayed secondary sex characteristics and failure of ovarian function recovery, leading to amenorrhea and infertility. [ncbi.nlm.nih.gov]

  ‘age at menarche varies considerably between populations’ ‘Most women with the syndrome experience menarche at a normal age but have irregular menstrual periods that gradually become more abnormal, often leading to amenorrhea.’ [en.oxforddictionaries.com]

  When menarche has failed to occur for more than 3 years after thelarche, or beyond 16 years of age, the delay is referred to as primary amenorrhea. Menopaussi on menarken vastakohta. Menopause is the opposite of menarche. [fi.glosbe.com]

  ‘Most women with the syndrome experience menarche at a normal age but have irregular menstrual periods that gradually become more abnormal, often leading to amenorrhea.’ [oxforddictionaries.com]

• Dysmenorrhea

  Menstrual cycle Causes and risk factors Doctors distinguish between two types of period pain, called primary and secondary dysmenorrhea. Primary dysmenorrhea is where the period pain is caused by the womb muscle contractions alone. [ncbi.nlm.nih.gov]

  Primary dysmenorrhea (the clinical word for painful periods) is pain caused by the period itself. Secondary dysmenorrhea is period pain with another root cause, such as a health condition like endometriosis. [helloclue.com]

  This means, with declining age at menarche, there is increased morbidity due to dysmenorrhea, with more disruptions in the daily activities of post-pubescent females. [journals.plos.org]

• Vaginal Discharge

  Other early signs of puberty are body odor and vaginal discharge. Again, these early changes can occur a year or more before the appearance of secondary sex characteristics (i.e., breast development and pubic hair). [pamf.org]

  Between six months to a year before menarche, you may experience white vaginal discharge that turns yellow upon contact with underwear. [soc.ucsb.edu]

  Clinically, vulvar and vaginal complaints such as vulvovaginitis are common among premenarcheal girls and are often ascribed to poor hygiene or physiologic leukorrhea (vaginal discharge due to estrogen stimulation) ( 16 – 18 ). [mbio.asm.org]

• Irregular Menstruation

  In addition, a child who has irregular menstruation that continues into adulthood develops polycystic ovarian disorder (PCOD) due to imbalance in hormones, which often leads to problems conceiving a child. [timesofindia.indiatimes.com]

  As a result, irregular menstruation, reduced fertility and/or adverse pregnancy outcomes may be the initial clinical feature that ultimately results in a diagnosis of CD. [humupd.oxfordjournals.org]

During treatment with hydrocortisone, breasts progressed from Tanner stage one to three within 6 months and menarche occurred after 10 months. [ncbi.nlm.nih.gov]

Diagnosis, management, and prognosis. J. Am. Acad. Dermatol. 64, 1027–1033 (2011). 59. Jaskowski, T. D. et al. IgA anti-epidermal transglutaminase antibodies in dermatitis herpetiformis and pediatric celiac disease. J. Invest. [doi.org]

The etiology remains unclear and various hypotheses have been put forward. This is the first time that a series of ultrasound patients with prepubertal menarche whose investigation has included imaging with ultrasound has been described. [ncbi.nlm.nih.gov]

Etiologies and predictors of diagnosis in nonresponsive celiac disease. Clin. Gastroenterol. Hepatol. 5, 445–450 (2007). 61. Ludvigsson, J. F., Lindelof, B., Zingone, F. & Ciacci, C. [doi.org]

Further Reading Elbers CC, van Eijk KR, Franke L et al. (2009) Using genome‐wide pathway analysis to unravel the etiology of complex diseases. Genetic Epidemiology 33: 419–431. [els.net]

[…] bias in the epidemiological associations with BDE-47 due to pharmacokinetics. [ncbi.nlm.nih.gov]

Disease, NHLI, Imperial College London, Emmanuel Kaye Building, 1B Manresa Road, SW3 6LR, London, UK. 6 MRC-PHE Centre for Environment and Health, London, UK. 7 School of Social and Community Medicine, University of Bristol, Bristol, UK. 8 UMR 1152, Pathophysiology [ncbi.nlm.nih.gov]

Recent advances have improved our understanding of the neuroendocrine, genetic and environmental factors controlling pubertal development, and hence inform the pathophysiology of delayed puberty. [doi.org]

The pathophysiology is largely unknown. Iatrogenic - hormones used for contraception or hormone replacement therapy (HRT) or management of other conditions. [patient.info]

Therefore, it is likely that increased apoptosis of EVT may contribute to the pathophysiology of human miscarriage and IUGR ( Hadziselimovic et al., 2007 ; Minas et al., 2007 ), which are characteristic placental-related complications, found at higher [humupd.oxfordjournals.org]

Electronic address: [email protected]. 7 Centers for Disease Control and Prevention, 4770 Buford Hwy, MS-F17, Atlanta, GA 30341, USA. [ncbi.nlm.nih.gov]

This approach strongly supports the Centers for Disease Control and Prevention’s “Guidelines for School Health Programs to Prevent Tobacco Use and Addiction,” which call for tobacco-use prevention education in kindergarten through 12 th grades (30). [cdc.gov]

Canoy advises that middle-aged women should focus more on treatment or prevention of the associated factors of heart diseases such as high cholesterol, smoking and more. [techtimes.com]