Isolated menarche is an unusual presentation of the advanced sexual development relative to bone age found in some patients with juvenile hypothyroidism. [ncbi.nlm.nih.gov]

• Weakness

  Our review of the literature indicates that the claim of the relation between father absence and earlier menarche was based on weak statistical foundations. [ncbi.nlm.nih.gov]

  This is bad because the onset of a sudden threat, such as a deadly virus, can exploit a common weakness and wipe out an entire population. [livescience.com]

• Swelling

  We hereby present a rare case of transient, severe swelling of the optic discs during menarche, diagnosed as BIH. [ncbi.nlm.nih.gov]

  The straight-and-narrow slice of the world that was offered to me as truth-and-all when I began to menstruate, has, like the full moon, swelled with possibilities for Morissa and the young women of her generation. [myjewishlearning.com]

• Unconsciousness

  The persistence of early responses and particularly of unconscious emotional attitudes towards other people has been stressed especially by the psychoanalysts. Children 'identify' with parents and others, imitate them and assume their attitudes. [web.archive.org]

• Accelerated Growth

  Rapid growth during childhood is associated with short-term benefits such as lower risk of hospital admission and lower mortality, 23 but it appear to be a risk for health outcome in the long run. 11,17,19,21 Moreover, accelerated growth should be taken [scielo.br]

• Abdominal Pain

  Abstract An eleven year-old girl presented with right lower quadrant abdominal pain near menarche that coincided with the onset of her most recent menstrual period. [ncbi.nlm.nih.gov]

• Heart Disease

  The study pointed out that even though the research found a link concerning the time of menarche in women and risk of heart disease, it did not find any evidence of the timing of the first menstrual cycle and delayed timing for heart diseases, complications [techtimes.com]

  […] risk of incident coronary heart disease. [circ.ahajournals.org]

• Hypertension

  Benign intracranial hypertension has been described in association with hormonal imbalance. We hereby present a rare case of transient, severe swelling of the optic discs during menarche, diagnosed as BIH. [ncbi.nlm.nih.gov]

  Even the risk for hypertensive disease associated with late menarche, although significant, was relatively small. [circ.ahajournals.org]

• Osteoporosis

  Females with late menarche may achieve lower peak bone mass at some skeletal sites, which may put them at greater risk for osteoporosis in later life. [ncbi.nlm.nih.gov]

  They include numerous conditions such as dermatitis herpetiformis, anemia, dental enamel hypoplasia, recurrent oral aphthae, short stature, osteoporosis, arthritis, neurologic problems, unexplained elevation of transaminase levels, and female infertility [doi.org]

  Late menarche is associated with osteoporosis and increased fracture risk. Moreover, early menarche has been related to anxiety symptoms, depression, premature intercourse and violent behavior. [dx.doi.org]

• Suggestibility

  In the longitudinal study design, simulated data were not suggestive of an association, whereas a delay in pubertal onset with higher concentrations of BDE-47 was observed in the epidemiologic study. [ncbi.nlm.nih.gov]

• Stroke

  Canoy suggests that women who were obese as kids may also be at a higher risk of stroke or heart disease in the future. [techtimes.com]

  METHODS AND RESULTS: Prospective cohort study of 73 814 Nurses' Health Study following participants without CVD, defined as incident coronary heart disease or stroke, from 1980 through 2012. [ncbi.nlm.nih.gov]

  Several studies have suggested that early menarche is associated with increased risk of coronary heart disease 5 – 11 or stroke, 7 but findings have been inconsistent. 11 – 13 Some studies have shown associations between early menarche and coronary heart [circ.ahajournals.org]

• Mental Distress

  Lien L, Dalgard F, Heyerdahl S, Thoresen M, Bjertness E (2006) The Relationship Between Age Of Menarche And Mental Distress In Norwegian Adolescent Girls And Girls From Different Immigrant Groups In Norway: Results From An Urban City Cross-Sectional Survey [omicsonline.org]

• Behavior Problem

  An Early Period Often Means More Dating — And Behavior Problems Let's finish on something that will be easily evident to anybody who ever went to junior high. [bustle.com]

  Clarifying the Associations between Age at Menarche and Adolescent Emotional and Behavioral Problems. Journal of Youth and Adolescence, Vol. 44, Issue. 4, p. 922. CrossRef Google Scholar Wesselhoeft, R. Pedersen, C. B. Mortensen, P. B. [bjp.rcpsych.org]

• Hyperactivity

  Societal pressure plus a cocktail of sexuality steroids creates more hyperactivity and aggression. Altogether, not fun. [bustle.com]

  Co-occurring symptoms of attention deficit hyperactivity disorder (ADHD) in a population-based sample of adolescents screened for depression. [bjp.rcpsych.org]

• Clumsiness

  Meanwhile a clumsy child may sit neglected, falling farther and farther behind. It is as though we made a point of giving tall children better food and starving the short children. [web.archive.org]

• Dysmenorrhea

  Menstrual cycle Causes and risk factors Doctors distinguish between two types of period pain, called primary and secondary dysmenorrhea. Primary dysmenorrhea is where the period pain is caused by the womb muscle contractions alone. [ncbi.nlm.nih.gov]

  Primary dysmenorrhea (the clinical word for painful periods) is pain caused by the period itself. Secondary dysmenorrhea is period pain with another root cause, such as a health condition like endometriosis. [helloclue.com]

  This means, with declining age at menarche, there is increased morbidity due to dysmenorrhea, with more disruptions in the daily activities of post-pubescent females. [journals.plos.org]

• Hypercholesterolemia

  Women with earlier menarche were more likely to have reported hypertension, diabetes mellitus, and hypercholesterolemia at recruitment than those with later menarche. [circ.ahajournals.org]

During treatment with hydrocortisone, breasts progressed from Tanner stage one to three within 6 months and menarche occurred after 10 months. [ncbi.nlm.nih.gov]

Diagnosis, management, and prognosis. J. Am. Acad. Dermatol. 64, 1027–1033 (2011). 59. Jaskowski, T. D. et al. IgA anti-epidermal transglutaminase antibodies in dermatitis herpetiformis and pediatric celiac disease. J. Invest. [doi.org]

The etiology remains unclear and various hypotheses have been put forward. This is the first time that a series of ultrasound patients with prepubertal menarche whose investigation has included imaging with ultrasound has been described. [ncbi.nlm.nih.gov]

Etiologies and predictors of diagnosis in nonresponsive celiac disease. Clin. Gastroenterol. Hepatol. 5, 445–450 (2007). 61. Ludvigsson, J. F., Lindelof, B., Zingone, F. & Ciacci, C. [doi.org]

Further Reading Elbers CC, van Eijk KR, Franke L et al. (2009) Using genome‐wide pathway analysis to unravel the etiology of complex diseases. Genetic Epidemiology 33: 419–431. [els.net]

[…] bias in the epidemiological associations with BDE-47 due to pharmacokinetics. [ncbi.nlm.nih.gov]

Disease, NHLI, Imperial College London, Emmanuel Kaye Building, 1B Manresa Road, SW3 6LR, London, UK. 6 MRC-PHE Centre for Environment and Health, London, UK. 7 School of Social and Community Medicine, University of Bristol, Bristol, UK. 8 UMR 1152, Pathophysiology [ncbi.nlm.nih.gov]

Recent advances have improved our understanding of the neuroendocrine, genetic and environmental factors controlling pubertal development, and hence inform the pathophysiology of delayed puberty. [doi.org]

The pathophysiology is largely unknown. Iatrogenic - hormones used for contraception or hormone replacement therapy (HRT) or management of other conditions. [patient.info]

Therefore, it is likely that increased apoptosis of EVT may contribute to the pathophysiology of human miscarriage and IUGR ( Hadziselimovic et al., 2007 ; Minas et al., 2007 ), which are characteristic placental-related complications, found at higher [humupd.oxfordjournals.org]

Electronic address: [email protected] 7 Centers for Disease Control and Prevention, 4770 Buford Hwy, MS-F17, Atlanta, GA 30341, USA. [ncbi.nlm.nih.gov]

This approach strongly supports the Centers for Disease Control and Prevention’s “Guidelines for School Health Programs to Prevent Tobacco Use and Addiction,” which call for tobacco-use prevention education in kindergarten through 12 th grades (30). [cdc.gov]

Canoy advises that middle-aged women should focus more on treatment or prevention of the associated factors of heart diseases such as high cholesterol, smoking and more. [techtimes.com]