The 17th case of an intracranial meningeal melanocytoma is presented in a 67-year old man. It is the 6th melanocytoma arising from the cavum Meckeli and the first presenting with seizures. [ncbi.nlm.nih.gov]

• Intermittent Claudication

  Our patient experienced numbness and tingling in her left leg for 8 years, and low back pains with intermittent claudication for the previous 2 months. A histologically benign 20-mm tumour was totally resected. Radiation therapy was not given. [ncbi.nlm.nih.gov]

• Fecal Incontinence

  The patient's presenting symptoms were characteristic of a large bifrontal lesion and included headaches, personality change, lethargy, and urinary and fecal incontinence. [ncbi.nlm.nih.gov]

• Malocclusion

  Here, we report a case of a 39-year-old Japanese man who had a history of pain and numbness on the left side of his face and malocclusion for 3 months before the initial visit. [ncbi.nlm.nih.gov]

• Progressive Hearing Loss

  Two women, aged 21 and 30 years, were admitted to the hospital 60 years apart: the first because of progressive paraplegia and the second because of slowly progressive hearing loss. [ncbi.nlm.nih.gov]

• Facial Numbness

  The diplopia and left facial numbness still persisted at a follow up of one-and-a-half years. [neurologyindia.com]

• Incontinence

  The patient's presenting symptoms were characteristic of a large bifrontal lesion and included headaches, personality change, lethargy, and urinary and fecal incontinence. [ncbi.nlm.nih.gov]

  After approximately seven months of therapy without resolution of symptoms, the patient developed bowel and bladder urgency without frank incontinence, which prompted a return visit to his primary care physician. [pagepress.org]

• Urinary Retention

  A 68-year-old female presented symptoms of urinary retention, loss of strength and lower limb dysesthesias of about 20 days’ evolution. [elsevier.es]

• Meningism

  Meningeal melanocytoma is an essentially benign melanotic tumor, derived from the melanocytes of the leptomeninges, and may occur anywhere in the cranial and spinal meninges. [ncbi.nlm.nih.gov]

• Tingling

  Our patient experienced numbness and tingling in her left leg for 8 years, and low back pains with intermittent claudication for the previous 2 months. A histologically benign 20-mm tumour was totally resected. Radiation therapy was not given. [ncbi.nlm.nih.gov]

• Hyperreflexia

  The neurologic examination revealed that the patient had left-sided lower extremity weakness of 4+, decreased sensation on the right side, and hyperreflexia in both legs. Department of Neuroradiology interpreted CT and MR imaging as meningiom. [ncbi.nlm.nih.gov]

• Motor Symptoms

  In the present study, a 58 year old lady presented with bilateral sensory and motor symptoms in the lower limbs. [ncbi.nlm.nih.gov]

• Foster-Kennedy Syndrome

  Fundoscopy showed left optic nerve atrophy and right papilledema consistent with Foster-Kennedy syndrome. Neurological exams were otherwise normal. [ncbi.nlm.nih.gov]

The histological workup following subtotal tumor resection of the initial tumor had revealed the typical features of a fibrous melanocytic meningioma without increased proliferation. [thejns.org]

It is important to differentiate primary melanin-containing lesions of the CNS from metastatic melanoma, because these lesions require a different patient workup and alternate therapeutic options. [pubs.rsna.org]

• Hyperprolactinemia

  Endocrine tests disclosed normal endocrine function except for slight hyperprolactinemia. Magnetic resonance imaging revealed a sellar lesion. The patient underwent a successful total transsphenoidal removal of the tumor without neurologic sequelae. [ncbi.nlm.nih.gov]

The treatment of choice for SPMM is complete surgical resection via a transsphenoidal approach. For patients with a partially resected tumor, radiotherapy is an effective complementary treatment modality. [ncbi.nlm.nih.gov]

In the end, she was sent to the oncology department of her reference hospital to be assessed for other treatment options. [elsevier.es]

The prognosis of this tumor is not always favorable with occasional local recurrence. Total resection is the best treatment, but gamma knife radiosurgery is effective for the residual tumor following partial resection. [ncbi.nlm.nih.gov]

This has been published on very few occasions; consequently, the prognosis is uncertain in this case. [elsevier.es]

Etiology of Increased ICP Intracranial hypertension is defined as a sustained (> 5 min) elevation of ICP of > 20 mmHg. Image : “MRI showing injury due to brain herniation in a patient with choriocarcinoma.” By Rocque BG, Başkaya MK (2008). [lecturio.com]

The -nal diagnosis was chronic intracerebral hemorrhage of unknown etiology with reactive changes of the surrounding brain tissue and perifocal extramedullary erythropoiesis. [docslide.com.br]

When no inflammatory, infectious or tumoral etiology or evidence of intracranial hypotension is present, a diagnosis of idiopathic pachymeningitis is considered, with possible dural calcifications. [em-consulte.com]

The lesion was excised and diagnosed as a malignant melanoma EP Conclusion TE D M AN U SC The etiology and pathogenesis of nevi of Ota and Ito are not known. [docksci.com]

Several theories for the etiology of melanotic schwannomas have been proposed, including the melanomatous transformation of neoplastic Schwann cells, phagocytosis of melanin by Schwann cells, and the simultaneous presence of two distinct neoplastic populations [pubs.rsna.org]

Their epidemiological features, natural history and response to treatment remain poorly understood, even if, in the last 2 years, some reviews have been published about it. [ncbi.nlm.nih.gov]

Changes in glycosaminoglycans, which fill the cell free space in early embryologic development, may play an important role in the neural crest migration, leading to dermal melanosis.[17] Exact pathophysiology is not yet known. [docksci.com]

Radiation therapy is important to prevent relapse of the tumor, especially in cases of incomplete surgical resection. [ncbi.nlm.nih.gov]

Radiation therapy is important to prevent relapse of the tumor when complete surgical resection is not possible. However the management of melanocytoma has no definite guidelines. [omicsonline.org]

Followers: 3) Advances in Microbial Physiology (Followers: 5) Advances in Molecular Oncology (Followers: 2) Advances in Molecular Toxicology (Followers: 9) Advances in Parkinson's Disease (Followers: 2) Advances in Phytomedicine (Followers: 2) Advances in Preventive [journaltocs.ac.uk]

This is helpful for the prevention of the impending complications. [lecturio.com]

Hydrocephalus is usually treated with placement of a ventriculoperitoneal shunt, but a filter must be added to the apparatus to prevent spread in the rare event of malignant transformation (10). [ajnr.org]