Symptoms of Periodic fever, menstrual cycle-dependent Clinical features : Imported from Human Phenotype Ontology (HPO) Abnormality of metabolism/homeostasis Fever Abnormality of prenatal development or birth Recurrent spontaneous abortion Similar Topic [familydiagnosis.com]

Format Definition A condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. [uniprot.org]

[from OMIM ] Fever MedGen UID: 5169 • Concept ID: C0015967 • Sign or Symptom A condition characterized by an abnormally high body temperature. [ncbi.nlm.nih.gov]

Recurrent and periodic fever overview Unlike a fever of unknown origin, recurrent and periodic fevers occur regularly in repeated cycles or intermittently over a period of time. [mdedge.com]

The most common fever syndrome PFAPA does not have a genetic test, but ruling out fever syndromes that can have similar symptoms, such as HIDS, CAPS, FMF, Behcet-like familial autoinflammatory syndrome (HA20) and TRAPS is important when diagnosing PFAPA [saidsupport.org]

Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed [ncbi.nlm.nih.gov]

Attacks are accompanied by blood test abnormalities showing inflammation, including high white cells, and a very high C-reactive protein (CRP). [ucl.ac.uk]

Rarely, children have recurrent pericarditis (inflammation of the outer layer of the heart), myositis (muscle inflammation), meningitis (inflammation of the membrane surrounding the brain and spinal cord) and orchitis (testicular inflammation). [my.clevelandclinic.org]

C4025651 • Finding Overproduction of the hormone of cortisol by the adrenal cortex, resulting in a characteristic combination of clinical symptoms termed Cushing syndrome, with truncal obesity, a round, full face, striae atrophicae and acne, muscle weakness [ncbi.nlm.nih.gov]

A few have autoantibodies, or weak positive autoantibodies, such as: Lupus anticoagulant, anti dsDNA, anticardiolipin, RNP, ANA, Some also have HLA-B51, or HLA-B15, or HLA-B39/B44 noted. [autoinflammatory-search.org]

Dosage reduction is recommended in patients who develop weakness or GI symptoms (anorexia, diarrhea, nausea, vomiting) related to drug therapy. [emedicine.medscape.com]

In rare cases, it may cause muscle weakness. The blood count (white and red blood cells and platelets) may decrease occasionally, but recovers with dose reduction. Children taking colchicine grow normally. [my.clevelandclinic.org]

Dosage reduction is recommended in patients who develop weakness or GI symptoms (anorexia, diarrhea, nausea, vomiting) related to drug therapy. [emedicine.medscape.com]

Nausea, abdominal pain, anorexia, diarrhea (may be bloody). [43] Splenomegaly; lymphadenopathy. [43] 45% have arthralgias and/or arthritis–often the knees and/or ankles, but other joints can be affected. [autoinflammatory-search.org]

256000 603647 Autosomal recessive; Mitochondrial BDNF 11p14.1 {Obsessive-compulsive disorder, protection against} 164230 113505 Autosomal dominant BDNF 11p14.1 Central hypoventilation syndrome, congenital 209880 113505 Autosomal dominant BDNF 11p14.1 {Anorexia [mnglabs.com]

[…] idiopathic generalized, susceptibility to, 6} 611942 607904 CACNA1H 16p13.3 {Epilepsy, childhood absence, susceptibility to, 6} 611942 607904 CACNA1H 16p13.3 Hyperaldosteronism, familial, type IV 617027 607904 Autosomal dominant CACNA1S 1q32.1 {Malignant hyperthermia [mnglabs.com]

Onset [64] Frequent sinusitis or pneumonia, and respiratory infections. Concurrent autoimmune diseases. [64] [65] Onset in infancy-under 6 months of age. [autoinflammatory-search.org]

[…] differential diagnoses is long and includes the following, based on the initial presentation: Abdominal pain, lower quadrant predominant: Acute appendicitis, porphyria, hereditary angioedema, pancreatitis (with hypertriglyceridemia) Chest pain/pleurisy: Pneumonia [emedicine.medscape.com]

weakness, and other features. [ncbi.nlm.nih.gov]

In rare cases, it may cause muscle weakness. The blood count (white and red blood cells and platelets) may decrease occasionally, but recovers with dose reduction. Children taking colchicine grow normally. [my.clevelandclinic.org]

Some patients have a headache with the onset of the rash and fever, plus asthenia (muscle weakness) and tachycardia. [58] [61] Not noted. [58] [61] [62] Not noted. [58] [61] [62] Tachycardia. [autoinflammatory-search.org]

Migraine MedGen UID: 57451 • Concept ID: C0149931 • Disease or Syndrome Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms. [ncbi.nlm.nih.gov]

Severe headache occurs particularly in children, and rarely, in young boys, there can be pain and swelling of the testicles. [ucl.ac.uk]

Some patients have headaches with flares. [autoinflammatory-search.org]

Episodes are often heralded by chills and headache, a rising fever, abdominal pain, nausea, and vomiting. [emedicine.medscape.com]

About two-thirds of patients report headache, sore throat and/or mouth ulcers, and more than three quarters report swelling of the lymph nodes. About half experience abdominal pain or nausea. [mdedge.com]

[…] disease, recessive intermediate, A 608340 606598 Autosomal recessive GDAP1 8q21.11 Charcot-Marie-Tooth disease, axonal, type 2K 607831 606598 Autosomal dominant; Autosomal recessive GDAP1 8q21.11 Charcot-Marie-Tooth disease, axonal, with vocal cord paresis [mnglabs.com]