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Meropenem

Merrem I.V.


Presentation

  • When subjected to meropenem, they presented retraction of the cytoplasmic material, rupture of the cell wall and extravasation of the cytoplasmic content.[ncbi.nlm.nih.gov]
  • We present two cases administering intravenous (IV) meropenem and ticarcillin-clavulanate by CI in pediatric CF patients.[ncbi.nlm.nih.gov]
  • A case is presented of a breast-feeding mother receiving meropenem treatment for a postpartum urinary tract infection caused by extended-spectrum beta-lactamase producing Escherichia coli.[ncbi.nlm.nih.gov]
  • We present a case of a neurosurgical patient who developed ventriculoperitoneal shunt-associated ventriculitis due to ceftazidime-resistant Klebsiella pneumoniae susceptible to cefepime, imipenem, meropenem, and polymyxin B only.[ncbi.nlm.nih.gov]
  • We present three cases administering intermittent extended infusion doripenem in pediatric CF patients for the treatment of an APE in the case of replacing meropenem due to shortage.[ncbi.nlm.nih.gov]
Intravenous Administration
  • administration 30 mL (1g meropenem) injection vial for intravenous administration 100 mL (500mg meropenem) vial: powder for reconsitution for intravenous administration 100 mL (1g meropenem) vial: powder for reconsitution for intravenous administration[antimicrobe.org]
  • METHODS: AMK-I ELF exposures and the ELF profile of meropenem achieved after intravenous administration were evaluated in an in vitro pharmacodynamic model. Nine ACBN with amikacin/meropenem MICs of 2-512/2 to 64 mg/L were utilized.[ncbi.nlm.nih.gov]
  • Meropenem for injection is a sterile, pyrogen-free, synthetic, ultra-broadspectrum , Carbapenem antibiotic for intravenous administration.[srspharma.com]
  • administration is associated with lower mortality than bolus intravenous infusion in persons with whose infections are severe, or caused by bacteria that are less sensitive to meropenem, such as Pseudomonas aeruginosa. [9] [10] Side effects [ edit ][en.wikipedia.org]
Intravenous Drugs
  • The peripheral veins of intravenous drug addicts, and of cancer patients undergoing chemotherapy, become sclerotic and difficult to access over time, sometimes forming a hard, painful “venous cord”. [ edit ] Infiltration occurs when an IV fluid or medication[en.wikipedia.org]
Learning Difficulties
  • The patient, who had a background of dialysis dependent renal failure, epilepsy and learning difficulties, was admitted to the intensive care unit following laparotomy and large bowel resection.[ncbi.nlm.nih.gov]

Workup

Hypertriglyceridemia
  • Thereafter, the possibility that antibiotics may have had a role in the hypertriglyceridemia was considered, and meropenem was discontinued.[ncbi.nlm.nih.gov]

Treatment

  • 1 2 Recruiting Treatment Complicated Urinary Tract Infections / Pyelonephritis 1 2 Recruiting Treatment Other Infectious Diseases 1 2 Recruiting Treatment Pulmonary Tuberculosis (TB) 1 2 Terminated Treatment Infections, Intestinal 1 2 Terminated Treatment[drugbank.ca]
  • Actinomycetomas can cause profound disability, and despite long-term chemotherapy, treatment failure is common. We investigated the efficacy of a novel drug regimen for the treatment of a severe case of Nocardia actinomycetoma of the leg.[ncbi.nlm.nih.gov]
  • During ceftazidime treatment of the wild-type strain (PAO1), fully resistant mutants overproducing AmpC were selected rapidly and they completely replaced wild-type cells in the population.[ncbi.nlm.nih.gov]
  • The delivery of beta-lactam antibiotics via intermittent extended infusion should be considered in order to optimize the pharmacodynamics of beta-lactams in the treatment of an APE.[ncbi.nlm.nih.gov]

Prognosis

  • Incidence, risk and prognosis factors of nosocomial pneumonia in mechanically ventilated patients. Am Rev Respir Dis 1990 ;142:523-52. [ Links ] Address to correspondence Dr. Carlos R. V.[scielo.br]
  • Optimal treatment requires rapid bactericidal activity within the CSF, because delayed CSF sterilization is associated with a poor prognosis and a high risk of sequelae in children ( 19 ).[aac.asm.org]

Etiology

  • This case highlights above all a primary etiology of HS is stimulus of immune system's over-reaction in HS to the bacterial microbiome.[ncbi.nlm.nih.gov]
  • It is difficult to identify a single etiology of the seizures.[ncbi.nlm.nih.gov]
  • However, many etiologies have been reported,and several drugs have been implicated.[ncbi.nlm.nih.gov]
  • P. aeruginosa was the etiological agent in 3 cases (27.3%), though the susceptibility was tested in only 1 isolate. S. aureus was the etiological agent in 2 cases (18.2%), 1 case susceptible to meropenem.[scielo.br]

Epidemiology

  • Copyright 2016 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.[ncbi.nlm.nih.gov]
  • Barts Healthcare NHS Trust, London, UK These authors contributed equally to this work. 2 Division of Infectious Diseases, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium These authors contributed equally to this work. 3 Clinical Epidemiology[ncbi.nlm.nih.gov]
  • Author information 1 Division of Infection, Barts Healthcare NHS Trust, London, UK These authors contributed equally to this work. 2 Clinical Epidemiology and Medical Statistics Unit, Dept of Biomedical Sciences, University of Sassari - Research, Medical[ncbi.nlm.nih.gov]
  • BACKGROUND: Epidemiology of fosfomycin susceptibility and the plasmid-mediated fosfomycinase genes of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates in Taiwan remain unclear.[ncbi.nlm.nih.gov]
  • The epidemiology and therapeutic considerations of these antimicrobial resistant organisms are discussed, as well as the clinical and heal What people are saying - Write a review We haven't found any reviews in the usual places.[books.google.com]
Sex distribution
Age distribution

Pathophysiology

  • This thoroughly updated Third Edition covers newly approved drugs, has separate chapters on drugs affecting fungal and viral infections, and includes more pathophysiology information.[books.google.ro]
  • Severe pathophysiological changes in critical illness can lead to dramatically altered antimicrobial pharmacokinetics (PK). The additional effect of obesity on PK potentially increases the challenge for effective dosing.[ncbi.nlm.nih.gov]
  • Roberts DOI: 10.1128/AAC.00531-16 ABSTRACT Severe pathophysiological changes in critical illness can lead to dramatically altered antimicrobial pharmacokinetics (PK).[aac.asm.org]
  • Melioidosis: epidemiology, pathophysiology, and management. Clin. Microbiol. Rev. 18 : 383 -416. Chimata, M., M. Nagase, Y. Suzuki, M. Shimomura, and S. Kakuta. 1993.[doi.org]

Prevention

  • For the treatment outcome, including the prevention of resistance development, it would be beneficial for the antibiotic concentration to remain above the mutant prevention concentration for a longer period of time than it does in present regimens.[ncbi.nlm.nih.gov]
  • The objective of these studies was to identify the concentrations of both agents associated with the selection or prevention of single-step mutations leading to reduced sensitivity to the combination and to characterize the selected mutations.[ncbi.nlm.nih.gov]
  • (via heterocyclic antibiotic ) drug allergen Any drug which causes the onset of an allergic reaction. antibacterial drug A drug used to treat or prevent bacterial infections.[ebi.ac.uk]
  • It works by killing the bacteria or preventing their growth. This medicine will not work for colds, flu, or other virus infections. This medicine is to be given only by or under the direct supervision of your doctor.[mayoclinic.org]

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