Presentation
These metabolic derangements present significant risk factors for cardiovascular disease, which is commonly recognized as the primary clinical outcome, although other outcomes are possible. [ncbi.nlm.nih.gov]
Entire Body System
- Weight Gain
Olanzapine (Zyprexa) - weight gain, hyperglycemia Sodium valproate and valproic acid (Depakote) - weight gain Clozapine (clozaril) - weight gain, hyperglycemia Quetiapine (Seroquel) - weight gain, hyperglycemia Risperidone (Risperdal) - weight gain, hyperglycemia [verywellhealth.com]
In addition to weight gain, higher consumption of SSBs is associated with development of metabolic syndrome and type 2 diabetes. [ncbi.nlm.nih.gov]
SSBs are thought to lead to weight gain by virtue of their high sugar content and incomplete compensation for total energy at subsequent meals after intake of liquid calories ( 7 ). [doi.org]
- Coronary Atherosclerosis
The notion that people can be "fat but fit" is being challenged by a study showing a high prevalence of subclinical coronary atherosclerosis in obese subjects with no evidence of metabolic syndrome. [medpagetoday.com]
The metabolic syndrome, its component risk factors, and progression of coronary atherosclerosis. Archives of Internal Medicine 170, 478 – 484. Begg, CB, Mazumdar, M ( 1994 ). Operating characteristics of a rank correlation test for publication bias. [doi.org]
Scandinavian Simvastatin Survival Study (4S) and the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS). [care.diabetesjournals.org]
Skin
- Xanthelasma
[…] shortness of breath: Suggesting the rise of cardiovascular and other complications Acanthosis nigricans, hirsutism, peripheral neuropathy, and retinopathy: In patients with insulin resistance and hyperglycemia or with diabetes mellitus Xanthomas or xanthelasmas [emedicine.medscape.com]
- Hyperhidrosis
Skin infections Candida albicans Tinea infections Erythrasma Folliculitis, furunculosis Altered collagen structure and function Impaired wound healing Sweating Hyperhidrosis Bromhidrosis Intertrigo Polycystic ovary syndrome Acne Hirsutism Androgenetic [dermnetnz.org]
Workup
(See Prognosis, Workup, Treatment, and Medication .) [emedicine.medscape.com]
Furthermore, advanced cardiovascular indicators such as lipoprotein (a), homocysteine, and C reactive protein (an indicator of endothelial inflammatory response) should be part of the routine workup of anyone suspected of Metabolic Syndrome. [drlam.com]
Serum
- Glucose Increased
This means you have type 2 diabetes, impaired fasting glucose, or impaired glucose tolerance. The impaired glucose tolerance test measures the body's response to sugar. [urmc.rochester.edu]
Treatment
To investigate the link between insulin resistance and the metabolic syndrome how to develop treatment approaches. [ncbi.nlm.nih.gov]
[…] tool=bestpractice.com [2] National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). [bestpractice.bmj.com]
Prognosis
ALMS may have an adverse prognosis and is often underdiagnosed. Its mild form, which allows a long survival, may also be associated with the late complications of the metabolic syndrome, leading to increased vascular risk. [ncbi.nlm.nih.gov]
Long Term Prognosis Long term prognosis is good, if the syndrome is treated. [liversupport.com]
Etiology
Therefore, the pathogenic etiology may be akin to aspects of the metabolic syndrome via microvascular injury and neoangiogenesis. [ncbi.nlm.nih.gov]
Applicable To Dysmetabolic syndrome X Use Additional Use Additional Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10data.com]
Based on these considerations the possibility is raised that resistance to insulin-stimulated glucose uptake and hyperinsulinemia are involved in the etiology and clinical course of three major related diseases— NIDDM, hypertension, and CAD. [diabetes.diabetesjournals.org]
Epidemiology
Copyright information: Copyright 2007 Journal of Epidemiology and Community Health Linked Articles In this issue Journal of Epidemiology & Community Health 2007; 61 657-657 Published Online First: 13 Jul 2007. [jech.bmj.com]
Pratley From the Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases Phoenix, AZ Search for other works by this author on: Clifton Bogardus From the Phoenix Epidemiology and Clinical Research [aje.oxfordjournals.org]
This review provides summary of literature related to the syndrome's definition, epidemiology, underlying pathogenesis, and treatment approaches of each of the risk factors comprising metabolic syndrome. [ncbi.nlm.nih.gov]
Pathophysiology
We present 3 cases of extreme syndromic insulin resistance: lipodystrophy, autoantibodies to the insulin receptor, and mutations in the insulin receptor gene, with accompanying discussion of pathophysiology and treatment. [ncbi.nlm.nih.gov]
Over the last couple of decades, studies exploring these diseases have uncovered some of the complex pathophysiological mechanisms involved, resulting in the identification of a plethora of interconnected physiological, pathophysiological, biochemical [newswise.com]
Prevention
Metformin treatment was about half as potent as lifestyle change for type 2 diabetes prevention and even less effective for metabolic syndrome prevention. [doi.org]
Author information 1 Experimental Vascular Medicine, Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, 80336 Munich, Germany. [ncbi.nlm.nih.gov]