CASE PRESENTATION: A 66-year-old Caucasian woman presented with vertical double vision for the previous 3 weeks. At 6-weeks follow up this had resolved. However, she presented with a new third and sixth cranial nerve palsy. [ncbi.nlm.nih.gov]

• Cervical Lymphadenopathy

  Most patients with metastasis to the head and neck region present with cervical lymphadenopathy; however, spread to the upper aerodigestive tract has been described previously. [ncbi.nlm.nih.gov]

• Hypoxemia

  Laboratory examinations revealed a high frequency of monocytes, higher levels of serum alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and C-reactive protein as well as mild hypoxemia and hypocarbia. [ncbi.nlm.nih.gov]

• Intravenous Drugs

  S-1, an oral combination of fluorouracil derivatives, is widely used in Japan and is more convenient than intravenous drugs. However, little is known about the combination of S-1 and trastuzumab in patients with HER2-positive MBC. [ncbi.nlm.nih.gov]

• Lymphadenopathy

  Most patients with metastasis to the head and neck region present with cervical lymphadenopathy; however, spread to the upper aerodigestive tract has been described previously. [ncbi.nlm.nih.gov]

• Acute Abdomen

  A female patient, 64-years old, presented to the emergency department with symptoms of biliary colic and acute abdomen. During the emergency cholecystectomy, we diagnosed the gallbladder empyema with thickened wall. [ncbi.nlm.nih.gov]

• Early Satiety

  She had also developed Raynaud's phenomenon (during the summer months), fatigue and abdominal discomfort with early satiety. [ncbi.nlm.nih.gov]

• Dysphagia

  To our knowledge, our report represents the first case of metastatic breast carcinoma presenting as severe dysphagia. [ncbi.nlm.nih.gov]

• Biliary Colic

  A female patient, 64-years old, presented to the emergency department with symptoms of biliary colic and acute abdomen. During the emergency cholecystectomy, we diagnosed the gallbladder empyema with thickened wall. [ncbi.nlm.nih.gov]

• Skin Lesion

  A metastatic infiltrating breast cancer poorly differentiated (G3) with satellite skin lesions (T4b), ipsilateral axillary and supraclavicular lymph nodes (N3), lung metastasis bilateral with pleural effusion and hepatic metastasis (M1), were diagnosed [ncbi.nlm.nih.gov]

• Skin Thickening

  She was found to have sclerodactyly with skin thickening over the knees, upper arms, face and chest wall together with nodularity at the scar site and distortion of the left breast. [ncbi.nlm.nih.gov]

• Neglect

  We report an unusual case of a neglected 69-year-old woman with an intensely malodorous right breast, back pain, and shooting pain in both of her legs. [ncbi.nlm.nih.gov]

Subsequent workup revealed widespread metastatic disease, for which the patient was treated with chemoradiotherapy. [ncbi.nlm.nih.gov]

Referred to oncologist for standard diagnostic workup. [targetedonc.com]

• Chlamydia

  However, she had no evidence of infection with mycoplasma pneumoniae, chlamydia, pneumocystis, tuberculosis, influenza A virus, and was negative for serum galactomannan (GM) antigen assay. [ncbi.nlm.nih.gov]

Remarkable improvements have been made in the treatment of hormone receptor positive (HR ) and Her2 positive MBC and currently targeted treatment strategies represent a valid first line treatment. [ncbi.nlm.nih.gov]

Systemic treatment plus surgery versus systemic treatment [doi.org]

Our study confirms CTCs as being strong predictors of prognosis in our population of MBC patients. KEYWORDS: Breast cancer; CTC; CellSearch; Filtration; Overall survival [ncbi.nlm.nih.gov]

The stage of your breast cancer when you’re diagnosed plays an important role in your prognosis. [healthline.com]

Coakley, Frequency and etiology of unexplained bilateral hydronephrosis in patients with breast cancer: results of a longitudinal CT study, Clinical Imaging, 36, 4, (263), (2012). [doi.org]

METHODS: Using linked Surveillance, Epidemiology, and End Results and Medicare data, we identified women with incident metastatic BCa diagnosed during 2005-2009. [ncbi.nlm.nih.gov]

Ueno Epidemiology First Online: 29 May 2015 Abstract Inflammatory breast cancer (IBC) is a rare and aggressive disease. [doi.org]

Since 1973 and 1992 respectively, the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute (NCI) the CDC’s National Program of Cancer Registries, have been collecting population-based information on cancer cases [change.org]

The development of a risk stratification score to assess the need for hospitalization or close observation of these patients and the documentation of appropriate preventive strategies could help prevent such fatal occurrences. [ncbi.nlm.nih.gov]

These discoveries have, in turn, led to the development of novel therapies and preventive measures that have already revolutionized cancer care. [cancerres.aacrjournals.org]