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Metastatic Melanoma


Presentation

  • However, there is a consensus in most studies that low LDH values ( 1,6,7 .In the case herein presented, the disease was visceral, the pre-operation LDH value was over 200 U/L and the initial lesion thickness was 0.75 mm, yet, the patient has presented[scielo.br]
  • DISCUSSION We report a unique presentation of an extremely rare case of isolated metastatic melanoma to the tail of the pancreas. This patient presented with abdominal pain 8 years after having a curative Mohs procedure done for cheek melanoma.[pancreas.imedpub.com]
  • Case Presentation A 57-year-old-male, nonsmoker, presented with left upper extremity weakness, slurred speech, and facial droop that began 12 hours before presentation.[cureus.com]
  • Figure 1 B presents an example BWS question.[futuremedicine.com]
  • Design/Methods: 67 year old male with history of Stage III melanoma (status-post resection 3 years ago) presented with headaches, nausea, fatigue and weight loss since 1 month.[n.neurology.org]
Weight Gain
  • gain or weight loss dizziness or fainting changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness hair loss feeling cold constipation voice gets deeper excessive thirst or lots of urine Kidney problems, including nephritis[opdivo.com]
  • Signs and symptoms that your glands are not working properly may include: persistent or unusual headaches; unusual sluggishness; feeling cold all the time; weight gain; changes in mood or behavior such as decreased sex drive, irritability, or forgetfulness[yervoy.com]
Sputum
  • Tumor in the lungs may cause shortness of breath, cough, and bloody sputum. Tumor in the brain may cause headaches, dizziness, and seizures. Tumor in bone may cause bone pain or unusual fractures.[emedicinehealth.com]
Respiratory Distress
  • Blood 2013 121:721; doi: A 60-year-old man was hospitalized for weakness, back pain, and respiratory distress. Multiple lymph nodes, liver, and spleen enlargements were palpable.[bloodjournal.org]
Black Stools
Jaundice
  • Patients should be advised to tell their health care provider if they have yellow skin (jaundice), weakness or dizziness, or shortness of breath. Tafinlar, in combination with Mekinist, can cause new or worsening high blood pressure (hypertension).[novartis.com]
Flushing
  • […] look out for may include: blurry vision, double vision, or other vision problems eye pain or redness OPDIVO can cause serious side effects, including: Severe infusion reactions — Things to look out for may include: chills or shaking itching or rash flushing[opdivo.com]
  • Tell your doctor or nurse right away if you get these symptoms during an infusion of YERVOY: chills or shaking; itching or rash; flushing; difficulty breathing; dizziness; fever; and feeling like passing out.[yervoy.com]
Muscle Weakness
  • weakness chest pain Additional serious side effects observed during a separate study of YERVOY alone include: Nerve problems that can lead to paralysis — Things to look out for may include: unusual weakness of legs, arms, or face numbness or tingling[opdivo.com]
Eye Pain
  • […] that can lead to paralysis — Things to look out for may include: unusual weakness of legs, arms, or face numbness or tingling in hands or feet Eye problems — Things to look out for may include: blurry vision, double vision, or other vision problems eye[opdivo.com]
  • Symptoms may include: blurry vision, double vision, or other vision problems; and eye pain or redness. Severe infusion reactions.[yervoy.com]
  • Patients should be advised to call their health care provider right away if they get: blurred vision, loss of vision, or other vision changes, seeing color dots, halo (seeing blurred outline around objects), eye pain, swelling, or redness.[novartis.com]
Blurred Vision
  • Patients should be advised to call their health care provider right away if they get: blurred vision, loss of vision, or other vision changes, seeing color dots, halo (seeing blurred outline around objects), eye pain, swelling, or redness.[novartis.com]
Kidney Failure
  • failure; skin problems; inflammation of the brain (encephalitis); problems in other organs; and severe infusion reactions.[opdivo.com]
  • Kidney problems, including nephritis and kidney failure. Signs of kidney problems may include: decrease in the amount of urine; blood in your urine; swelling in your ankles; and loss of appetite. Inflammation of the brain (encephalitis).[yervoy.com]
Dizziness
  • Patients should be advised to tell their health care provider if they develop high blood pressure, their blood pressure worsens, or if they have severe headache, lightheadedness, blurry vision, or dizziness.[novartis.com]
  • […] than usual decreased energy Hormone gland problems (especially the thyroid, pituitary, adrenal glands, and pancreas) — Things to look out for may include: headaches that will not go away or unusual headaches extreme tiredness weight gain or weight loss dizziness[opdivo.com]
  • Tell your doctor or nurse right away if you get these symptoms during an infusion of YERVOY: chills or shaking; itching or rash; flushing; difficulty breathing; dizziness; fever; and feeling like passing out.[yervoy.com]
  • Tumor in the brain may cause headaches, dizziness, and seizures. Tumor in bone may cause bone pain or unusual fractures.[emedicinehealth.com]
Irritability
  • […] pituitary, adrenal glands, and pancreas) — Things to look out for may include: headaches that will not go away or unusual headaches extreme tiredness weight gain or weight loss dizziness or fainting changes in mood or behavior, such as decreased sex drive, irritability[opdivo.com]
  • Signs and symptoms that your glands are not working properly may include: persistent or unusual headaches; unusual sluggishness; feeling cold all the time; weight gain; changes in mood or behavior such as decreased sex drive, irritability, or forgetfulness[yervoy.com]
Tremor
  • Exam was noted for confusion, slow speech and left upper extremity tremor.[n.neurology.org]
Slow Speech
  • Exam was noted for confusion, slow speech and left upper extremity tremor.[n.neurology.org]

Workup

  • Infectious diseases team was consulted, and broad spectrum antibiotics empirically started; however thorough infectious workup was subsequently negative. Brain biopsy was performed for definitive diagnosis.[n.neurology.org]
  • Additional workup at that time did not reveal any evidence of nodal involvement or metastatic disease. The cheek melanoma was completely excised using a Mohs surgical technique in 2008 and considered cured.[pancreas.imedpub.com]

Treatment

  • Your cancer treatment should not be “one-size-fits-all.” Through the Melanoma Program, we work with you to create a plan that may include one or a combination of treatments.[pennmedicine.org]
  • Treatment is not thought to affect micrometastasis (too small to find) already present at the time of the eye treatment. This is why patients need periodic general medical examinations (surveys) after treatment for their intraocular melanoma.[eyecancer.com]
  • How long treatment is given depends on the type of drug used and how well the cancer responds to the treatment.[cancer.ca]
  • […] duration of treatment after complete response was 7 months (range 0.5–41 months).[ascopost.com]

Prognosis

  • Metastatic melanoma has a poor prognosis due to its aggressive nature and survival rates depend upon the staging of the disease.[radiopaedia.org]
  • The prognosis is poorer with higher numbers of involved nodes and with metastases to internal organs and distant sites.[dermnetnz.org]
  • Accurate diagnosis of a pancreatic lesion or mass is critical because prognosis, survival, and management are all affected. In order to diagnose pancreatic lesions, effective sampling and immunocytochemistry is required.[pancreas.imedpub.com]

Etiology

  • CONCLUSION: T2*-weighted images improve lesion detection in patients with melanoma metastases, and in conjunction with T1-weighted sequences, can suggest melanoma as the etiology of an intracranial mass.[ajnr.org]

Epidemiology

  • Epidemiology, high-risk groups, clinical strategies, and diagnostic technology." J Am Acad Dermatol 71.4 Oct. 2014: 599.e1-599.e12; quiz 610, 599.e12. Mayer, J.E., S.M. Swetter, T. Fu, and A.C. Geller.[emedicinehealth.com]
  • Disease progression in patients with thin cutaneous melanomas (tumour thickness 0.75 mm): clinical and epidemiological data from the Tumour Center Munich 1977-98. Br J Dermatol. 2003;149:788-93. [ Links ] 15. Schuchter LM, Green R, Fraker D.[scielo.br]
  • Malignant melanoma in the 21st century, part 1: epidemiology, risk factors, screening, prevention, and diagnosis. Mayo Clin Proc 2007; 82:364-380. Back to Top[clevelandclinicmeded.com]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiological significance of such histiocyte PD-L1 expression remains unclear but has been reported for several cancers. 12 Evaluating PD-L1-positivity on tumour and immune cells is more reliable and reproducible than tumour cells alone.[nature.com]
  • These syndromes include xeroderma pigmentosa and familial atypical mole-melanoma syndrome (also known as dysplastic nevus syndrome). 2,3 Back to Top Pathophysiology Evidence from epidemiologic studies shows that exposure to solar irradiation is the main[clevelandclinicmeded.com]

Prevention

  • I had had some minor health issues that prevented me from working and Steve's new job enabled me to stay home and focus on getting better. One day in December 2011, Steve asked me to feel a strange lump on his neck.[mdanderson.org]
  • Clinical trials look at new ways to prevent, find and treat cancer. Find out more about clinical trials. infusion A procedure in which a fluid, other than blood, is introduced into the body through a vein.[cancer.ca]
  • This is why most eye cancer specialists believe destroying or removing an eye cancer offers the best method to prevent future spread from that tumor.[eyecancer.com]
  • All these medications have significant side effects, including life-threatening ones, and are indicated only for stage 3 tumors to try to prevent recurrence and spread, and stage 4 metastatic tumors which are no longer amenable to surgery.[emedicinehealth.com]
  • It can be given to individuals who have had surgery to remove melanoma in order to prevent the melanoma from coming back. It can also be used for late-stage melanoma that cannot be removed by surgery.[webmd.com]

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